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WO/1997/005883A1 |
The present invention concerns analogues of M6P for use in promoting the healing of wounds or fibrotic disorders with reduced scarring, together with methods for doing same.
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WO/1997/003701A2 |
The present invention discloses carbohydrates and carbohydrate analogs that bind to epidermal growth factor (EGF) receptors. Methods of using such carbohydrates or analogs for a variety of uses related to the EGF receptor are also provid...
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WO/1997/001352A1 |
This invention relates to the novel identification of myelin-associated glycoprotein ("MAG") as a potent inhibitor of neural regeneration. More particularly, this invention relates to compositions and methods useful for reversing inhibit...
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WO/1997/001569A1 |
Compounds of formula (I) in which X is the residue of a non-glycosidic aliphatic 1,2-diol; R1 is an S-configurated methyl substituted with one carboxyl residue and one other substituent; and R2 is hydrogen, C1-C12alkyl or C6aryl; as mime...
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WO/1996/040969A1 |
2-Ketoaldonic acid is synthesized by aldolase condensation reaction involving pyruvate and an aldose acceptor in the presence of excess pyruvate. After the reaction is substantially complete, the excess pyruvate is removed from the react...
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WO/1996/040169A1 |
The present invention is directed to a method of treating respiratory infections caused by a bacteria selected from the group consisting of S. pneumoniae, H. influenzae, H. parainfluenzae, Burkholderia (Pseudomonas cepacia) and a mixture...
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WO/1996/029339A1 |
Compounds of formula (I) wherein R is CH3 and R1 is a peptidic residue or R1 is OH and R is a peptidic residue have pharmacological activity as sialyl Lewis X mimetics, e.g. in the prevention or treatment of disorders or diseases which a...
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WO/1996/020717A1 |
Disclosed herein are antifungal compositions having an oligosaccharide that includes an N-acetylhexosamine residue linked 'beta'(1}4) to a hexose and a biologically acceptable carrier. The isolation of the fungal enzyme chitin glucan 'be...
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WO/1996/005211A1 |
A ganglioside GM3 analog having the sialic acid residue fluorinated at the 9-position, represented by general formula (I), and an intermediate therefor, wherein R represents lower aliphatic acyl; R1 represents hydrogen or lower alkyl; R2...
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WO/1996/002550A1 |
The invention describes 7-O-carbamoyl heptose derivatives of general formula (I) in which R is the substituent R1 or a group of general formula (II) in which R1 is a hydrogen atom, a methyl group or a suitable linker substituent suitable...
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WO/1996/001639A1 |
A class of molecules that alter cell adhesion. A cell adhesion affector according to the present invention essentially consists of an amino acid linked to a carbohydrate wherein the amino acid and the carbohydrate are linked to form a co...
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WO/1995/023605A1 |
A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of the following formula (I): (NeuAc-'alpha'(2-3)-pGal-'beta'(1)-(-X-)m-(-Y-)n-)p-Z ...
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WO/1995/023157A1 |
Novel azide groups containing sialosides and a process for their preparation is provided. The methods and resulting compounds may be of pharmaceutical interest for the inhibition of the influenza virus neuraminidase.
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WO/1995/017903A1 |
The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recogni...
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WO/1995/016049A1 |
A stereoselective synthesis of carbohydrates employs two key stereoselective steps, viz. an osmium-catalyzed asymmetric dihydroxylation (AD) of an alkene to form an aldol intermediate and an aldolase-catalyzed aldol addition reaction whe...
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WO/1995/010524A1 |
Novel mixed-chain alkyl (alkyl glycosid)uronates are mild, environmentally friendly nonionic surfactants useful in detergent compositions. The compounds are stable to enzyme hydrolysis and therefore may be used in enzymatic fabric washin...
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WO/1995/003809A2 |
A method of inhibiting the growth of tumour cells is provided, comprising contacting the cells with an inhibitor of glucokinase. The glucokinase enzyme, normally only found in liver and pancreatic 'beta'-cells, is found to be active in t...
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WO/1994/020448A1 |
In the method proposed for the production of monocarboxylic acids from carbohydrates, carbohydrate derivatives or primary alcohols, the carbohydrates, carbohydrate derivatives or primary alcohols are oxidized continuously in aqueous solu...
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WO/1994/014954A2 |
Aureobacterium barkerei strain KDO-37-2 (ATCC 49977) KDO aldolase (EC 4.1.2.23) isolated therefrom are disclosed. The DKDO aldolase is further disclosed to have a broad substrate specificity with respect to its reverse reaction, i.e. the...
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WO/1994/013685A1 |
D-psicofuranose and D-psicopyranose derivatives represented by general formulae (I) and (II), useful as the key intermediates in a novel process for producing hydantocidin; wherein R1 through R8 may be the same or different from one anot...
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WO/1994/003469A1 |
Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an acyl residue of an aliphatic, araliphatic, aromatic, alicyclic, or heterocyclic carboxylic acid, including carboxylic amides, their 2-hydrocarbyl-glyc...
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WO/1993/023029A1 |
A novel antitussive agent which has an antitussive effect comparable to that of codeine phosphate but is expected to be free from such side effects as those caused by the codeine, and an antitussive method using the same. The agent conta...
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WO/1993/016087A2 |
Novel Amadori reaction compounds have the formula R¿1?-NH-R¿2?, wherein R¿1? comprises the D-form of a 1-amino-1-deoxy-2-ketose radical derived from a sugar radical selected from the group of glucose, xylose, galactose, rhamnose, fruc...
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WO/1993/012800A1 |
An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53676. This novel antibiotic is useful as an anticoccidial in chicken...
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WO/1993/006227A1 |
The present invention provides a ketoaldonic acid such as an octulosonic or nonulosonic acid having formed stereogenic center of R configuration, as well as methods of synthesizing the same.
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WO/1993/005059A1 |
Imidazolidyl macrolides of general structural formula (I) have been prepared from suitable precursors by alkylation and/or arylation at C-3'' and/or C-4'' of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammali...
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WO/1993/002092A2 |
Galacturonic acid derivatives of formula (I); R1 being a linear or branched alkyl having from 2 to 22 carbon atoms, R being CH-CH(OH)-CO2R2 or -CH(OH)-CH-CO2R2, of which the carbon carrying the hydroxyl group is attached to the endocycli...
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WO/1992/022563A1 |
The present invention is drawn to methods for the synthesis of Lewis?a� derivatives modified at the C-2 and/or C-6 position of GlcNAc employing chemoenzymatic synthesis. The derivatives find use in the treatment and prevention of disea...
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WO/1992/021655A2 |
2-Methyl-5-hydroxymethyl- and 2,5-dimethyl-3,4-dihydroxypyrrolidines, their processes of preparation and use are disclosed. 5-Azido-5-deoxy-hexulose-1-phosphate compounds and processes of making the same are also disclosed.
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WO/1992/019632A1 |
The present invention discloses trifluorofucoses and methods of making the same. Also disclosed are trifluorofucose analogs of fucose-containing oligosaccharides, and conjugates of trifluorofucose. The compounds of the present invention ...
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WO/1992/018640A1 |
The invention concerns a method for preparing enantiomer- and diastereomer-pure ketoses by reacting aldehydes with dihydroxyacetone phosphate in the presence of an enzyme in aqueous medium and subsequent hydrolysis, characterized in that...
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WO/1992/018542A1 |
In a method of oxidising carbohydrates, particularly starch and dextrin, the oxidation is effected by molecular oxygen in an alkaline aqueous medium in the presence of a catalytic quantity of a metal ion selected from the metals of group...
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WO/1992/016203A1 |
Palytoxin and its naturally-occurring analogs are provided as derivatised prodrugs cleavable with a biological catalyst. These prodrugs are useful in protocols wherein the catalyst can be targeted to cells or tissues which are to be impa...
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WO/1992/016640A1 |
Oligosaccharide compounds that are substrates and inhibitors of glycosyltransferase and glycosidase enzymes and compositions containing such compounds are disclosed. A method of glycosylation is also disclosed. An $i(E. coli) transformed...
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WO/1992/007572A1 |
Identification of the sialyl Lewis X determinant as the determinant responsible for ELAM-1-dependent adhesion of neutrophils to endothelium has resulted in the development of a number of agents for binding to ELAM-1 and methods for treat...
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WO/1991/016320A1 |
Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid, pharmaceutical formulations thereof, methods for their preparation and their use in the treatment of viral infections, in particular influenza, are described.
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WO/1991/015214A1 |
The use of galacturonic acid and derivatives thereof for the production of a medicament for the treatment of hyperlipidaemia and/or atherosclerosis is described.
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WO/1991/009971A1 |
Chromogenic derivatives of neuraminic acid modified in the 5-position are used as substrates in colorimetric assays for human influenza neuraminidase activity in clinical specimens for the purpose of selectively diagnosing influenza infe...
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WO/1991/004988A1 |
A process is provided for preparing polyglucuronic acid, i.e. a polysaccharide which contains a large proportion of glucuronic acid units, by oxidizing glucose based polysaccharides, such as starch and derivatives thereof, in the presenc...
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WO/1991/002741A1 |
The invention provides a novel class of versatile intermediates, i.e. 1,4 cyclic sulfates of sugar alcohols having protected hydroxy groups, such as 1,4 cyclic sulfates of D-mannitol having protected 2-, 3-, 5- and 6-hydroxy groups and D...
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WO/1990/014350A1 |
A process for producing 1-fluoro-glycuronic acids which may contain protected amino groups and their salts, in which glycopyranosylfluorides of mono or oligo-saccharides with at least one primary OH function are oxidised in aqueous solut...
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WO/1990/010010A1 |
This invention relates to a new substance trehalostatin, a method of producing said substance, and an actinomycete producing said substance. Trehalostatin has the following physicochemical properties: form: white powder, solubility: solu...
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WO/1990/006755A1 |
A glycosaminoglycoside (GAG) composition predominantly of tetrasaccharide units derived from heparin/heparan sulfate has enhanced activity in preventing the profileration of smooth muscle cells. This GAG preparation is useful in the trea...
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WO/1989/010929A2 |
The present invention relates to new L-Fucose analogs, their method of preparation, the application of such analogs to the preparation of new glycals, anthracyclines obtained by using such glycals and utilization of such anthracyclines a...
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WO/1989/007602A1 |
Anion exchange resins which have been exchanged with molybdate at acid pH are effective catalysts for epimerizing compounds with structural unit (I). Chief among these are aldoses, especially aldopentoses and aldohexoses, as well as some...
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WO/1989/007591A1 |
Hydrogen cyanide addition to a monosaccharide results in a mixture of product cyanohydrins whose ratio can be changed by conducting the hydrogen cyanide addition in the presence of an agent which forms a complex with the monosaccharide. ...
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WO/1988/009794A1 |
The invention relates to novel cyclopolyglycuronic acid compounds which are useful in the treatment of symptom relief in human disease including acne, blackheads and other facial lesions. More particularly the invention relates to novel ...
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WO/1988/006450A1 |
An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 1:4. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have p...
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WO/1988/003925A1 |
A water-soluble square-planar cis-platinum(II) four-coordinate complex having the formula: trans-R,R-DACH Pt(II) X2 or trans-R,R-DACH Pt(II) Y, wherein X is a monovalent cation, two of which are present, selected from the group consistin...
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WO/1988/000591A1 |
Novel compounds DC-92B and DC-92D having an anthraquinone structure represented by planar structural formula (I) and a process for their preparation. These compounds are produced by cultivating microorganisms belonging to the genus Actin...
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