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JP6147737B2 |
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also prov...
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JPWO2014125967A1 |
An object of the present invention is to provide a method for easily producing α-O-pyranoseid with a high selectivity and a pyranose donor used in the method, which is highly versatile and does not require setting strict reaction condit...
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JP6054900B2 |
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JP2016537349A |
The present invention relates to a 2 sugar intermediate and a synthesizing method for the same, belongs to the chemicals medicine manufacture field, and, more specifically, relates to the preparing method of the 2 sugar fragmentation whi...
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JP6027119B2 |
Disclosed herein is 10-α/β-D-Arabinofuranosylundecenes of general Formula (II) or pharmaceutically acceptable N salts thereof as anti-mycobacterial agents in vitro; (II) wherein R, R1 and R″ are as defined herein in the specification...
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JP5972867B2 |
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JP5965407B2 |
The invention is directed to compounds for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds, and methods of treating diseases and disorders related to deficiency or overex...
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JP5893738B2 |
Novel compounds of formula (I) wherein R1 to R4 and X have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.
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JP2016008183A |
To provide an efficient production method of an α-hydroxycarboxylic acid in a mild condition, and to provide a production method of a biodegradable plastic from a raw material containing the α-hydroxycarboxylic acid.In a synthesis meth...
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JP5803907B2 |
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JP5800729B2 |
To provide a pyranose compound to be used in a method for producing β-O-pyranoside with high selectivity and simply.A 2,4-O-bridged pyranose inversion compound is a compound represented by general formula (1) or its enantiomer.
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JP2015180682A |
To provide processes and intermediates for preparation of compounds having antiviral activity.Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl ...
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JP5771237B2 |
The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods...
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JP5767643B2 |
Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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JP5766334B2 |
Disclosed is a novel compound contained in blue rose. This novel compound, which is contained in blue rose, has a chemical structure represented by general formula (I): [wherein R 1 is a group as set forth in claim 1; and R 2 represents ...
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JP5764174B2 |
Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed. Particular inhibitors are compounds of formula I.
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JP2015078229A |
To provide lipids-therapeutic nucleic acid compositions useful for general therapeutic use.The present invention provides novel cationic lipids and lipid particles comprising the same. The lipid particles can further comprise active phar...
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JP5693052B2 |
To provide a method of producing a novel sugar derivative by utilizing C6 sugars such as glucose and C5 sugars such as xylose by using microorganisms.This method of producing chemical compound expressed by the following formula (1) compr...
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JP5670654B2 |
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JP5613168B2 |
The invention relates to methods for making deoxyribofuranose compounds such as compound (2) which are useful intermediates in the preparation of pharmaceutical compounds such as 5-amino-3-(2′-O-acetyl-3′-deoxy-β-D-ribofuranosyl)-3H...
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JP2014517032A |
The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the proc...
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JP5447964B2 |
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JP5441894B2 |
A method for preparing isofagomine, its derivatives, intermediates and salts thereof using novel processes to make isofagomine from D-(−)-arabinose and L-(−)-xylose.
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JP5429734B2 |
It is intended to develop a method of effectively synthesizing a glycolipid that has never been established so far. Thus, a method for synthesizing a glycolipid is provided. This method comprises the following steps: (a) the step wherein...
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JP5415767B2 |
The present invention is based, in part, on our discovery that certain types of therapeutic agents can be used in combination to treat a variety of neuropsychiatric and related disorders, including addiction (e.g., to a substance or to a...
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JP5380293B2 |
The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods...
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JP5301427B2 |
Disclosed is a process for producing an oxazoline derivative from a non-protected sugar in a simple manner. Also disclosed is a process for producing a glycoside by utilizing the product of the aforementioned process. A sugar oxazoline d...
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JP5258798B2 |
An object of the present invention is to provide a 3,6-O-bridged pyranose-inverted compound useful for being easy to produce beta-O-pyranosides selectively. The 3,6-O-bridged pyranose-inverted compound according to the present invention ...
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JP2013136625A |
To provide methods for preparing LPS antagonist lipodisaccharide B1287 and stereoisomers thereof, which compounds are useful in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of s...
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JP2013107885A |
To provide a method of conjugating peptides and proteins by means of glycosyltransferase.It is an object of the invention to provide means and methods which allow for a convenient synthesis or semisynthesis of therapeutic proteins, where...
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JP5154954B2 |
The invention comprises compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions containing the compounds or prodrugs of the compounds. The invention also comprises animal models and m...
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JPWO2011021398A1 |
Glucose, mannose, psicose, sorbose, tagatose, allose, altrose, growth, idose, and furanose derivatives and furanose derivatives represented by the following formulas (I) to (V) (in the formula, M)1Indicates a group having a specific poly...
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JP5099653B2 |
Disclosed is a novel compound contained in blue rose. This novel compound, which is contained in blue rose, has a chemical structure represented by general formula (I): [wherein R 1 is a group as set forth in claim 1; and R 2 represents ...
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JPWO2010150789A1 |
Provided is a new production method for synthesizing NC-type nucleosides efficiently, easily, and in high yield without requiring an unnecessary protecting group conversion step. Equation (I):Inverting the compound represented by, formul...
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JP5078108B2 |
The present invention provides a compound represented by the following formula (1): wherein X1 and X2 each independently represent a hydrogen atom or a hydroxyl-protecting group; Y represents a C7-20 aralkyl group which may optionally ha...
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JP2012528198A |
The present disclosure relates to the preparation of ketal compounds from anhydropentitols and oxocarboxylates; derivatives, homopolymers, and copolymers thereof; and various compositions, formulations, and articles derived therefrom.
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JP4992074B2 |
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JP4920163B2 |
Anticonvulsant derivatives useful for preventing the development of Type II diabetes mellitus and Syndrome X are disclosed.
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JP4892191B2 |
The present invention is directed to a continuous process for the preparation of fructopyranose sulfamate derivatives of the general formula (I)
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JP4877695B2 |
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JP4866515B2 |
New method for the preparation of saccharide oxazoline derivatives (II) comprises reacting an acylamino sugar (I) with a metal fluoride. New method for the preparation of saccharide oxazoline derivatives of formula (II) comprises reactin...
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JP4825353B2 |
Anticonvulsant derivatives useful in lowering blood pressure in overweight individuals.
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JP4825322B1 |
Compounds of Formula (I) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by sodium-glucose transporter inhibitors (in particular, SGLT2 inhibitors).
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JP4773336B2 |
The present invention provides methods for preparing LPS antagonist lipodisaccharide B1287 and stereoisomers thereof, which compounds are useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia...
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JP4726477B2 |
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JP4725976B2 |
The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein X, R1, R3, R4, R5 and R6 are as described in the specification.
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JP2011516478T |
In the medical treatment and prevention of the fall of microorganism infection and an immunity system, the disease from which the cell serves as an obligate anaerobiosis, and a cell-growth disease including cancer, the present invention ...
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JP2011516478A |
The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become obligately anerobic and cellular prolife...
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JP2011037885A |
To provide methods for preparing LPS (linear programming system) antagonist lipodisaccharide B1287 and stereoisomers thereof.The invention provides methods for preparing LPS antagonist lipodisaccharide B1287 useful in the prophylactic an...
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JP4610197B2 |
This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility,...
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