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JPH10501809A |
PCT No. PCT/US95/06641 Sec. 371 Date Oct. 30, 1996 Sec. 102(e) Date Oct. 30, 1996 PCT Filed May 25, 1995 PCT Pub. No. WO95/35102 PCT Pub. Date Dec. 28, 1995A method for the preparation of 2'-modified nucleosides is provided. The method c...
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JPH10501527A |
Staurosporin derivatives of formula (I), wherein R1 is an acyl radical having from 2 to 30 carbon atoms, an aliphatic hydrocarbon radical having up to 29 carbon atoms that is substituted by acyclic substituents, a cycloaliphatic or cyclo...
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JPH10501526A |
PCT No. PCT/EP95/01909 Sec. 371 Date Nov. 27, 1996 Sec. 102(e) Date Nov. 27, 1996 PCT Filed May 19, 1995 PCT Pub. No. WO95/32974 PCT Pub. Date Dec. 7, 1995The utility of known and novel staurosporin derivatives of formula I (I) wherein R...
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JP2705921B2 |
To obtain the subject derivative useful as a high degree sweetener, etc., by subjecting a sucrose alkyl 4,6-orthoacylate to mild aqueous acidic hydrolysis to provide a mixture of 4- and 6-monoesters of sucrose and then treating the ester...
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JPH10500394A |
Staurosporin derivatives of formula (I), wherein R1 is formyl, an aliphatic hydrocarbon radical having up to 29 carbon atoms that is unsubstituted or substituted by aryl, or is an aryl radical, R2 is an aliphatic, carbocyclic, carbocycli...
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JPH09506071A |
A method for protecting against mutational damage in mammalian cells induced by irradiation comprising administering a phosphorothioate or phosphorothiate metabolite selected from the group consisting S-2-(3-aminopropylamino)ethylphospho...
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JP2614407B2 |
Pharmaceutically acceptable compositions of matter comprising a lipophilic oligosaccharide antibiotic, e.g., the everninomicin-type antibiotic of Formula III, at least a stoichiometric amount of a base, e.g., NMG, an amount of, e.g., hyd...
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JPH09132585A |
To provide a new amino sugar suitable for the production of chitooligosaccharides and analogous oligosaccharides usable for pharmaceuticals, drug-delivery system materials, porous beads, surfactant, etc., by, e.g. the addition reaction i...
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JP2607897B2 |
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JP2607896B2 |
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JP2597618B2 |
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JP2582383B2 |
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JP2580538B2 |
PURPOSE: To selectively acetalize the specific sites of a saccharide in a good yield by reacting the saccharide with a bulky organic group-having thiocarbonyl compound in the presence of a base and a silver salt or a copper salt, while i...
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JP2569012B2 |
The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterified, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases.T...
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JPH093088A |
PURPOSE: To obtain a new aminodisaccharide comprising specific aminodisaccharides having oxazoline ring structure, capable of providing chitin or analogue polysaccharides by polyaddition reaction due to the action of chitinase and useful...
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JPH08325167A |
To obtain a reagent having an alkoxyl group having an unsaturated group at the β-position, e.g. propargyl, benzyl or allyl group and useful for cleaving an unsaturated alkoyloxycarbonyl functional group. (A) A reagent comprising (I) an ...
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JP2558051B2 |
PURPOSE: To provide the subject reagent having excellent selectivity and useful for peptide synthesis or the like comprising an aqueous phase, a specific catalyst and a nucelophilic compound soluble in water, which cleaves unsaturated al...
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JPH08245612A |
To prepare a specific hexene derivative useful for obtaining an intermediate for an antiviral agent in an excess of the erythro isomer by reacting an organometallic complex of a specified propene derivative with D- glyceraldehyde pentani...
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JP2528332B2 |
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JP2515261B2 |
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JPH08506321A |
Compounds of this invention are derivatives of pentose monosaccharides which exhibit anti-proliferative and anti-inflammatory activity as well as intermediates for the synthesis of these compounds. Methods of preparation, pharmaceutical ...
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JP2512400B2 |
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JP2512401B2 |
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JP2509189B2 |
A method of performing an oxidation reaction in which an alkali hypohalite is used as an oxidizing agent which comprises: carrying out the oxidation reaction in an aqueous medium with concurrently distilling off a solvent used in the rea...
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JP2505817B2 |
Sucrose 6-acylates, key intermediates in the preparation of sucralose, can be prepared by subjecting a sucrose alkyl 4,6-orthoacylate to mild aqueous acidic hydrolysis to provide a mixture of sucrose 4- and 6-acylates and then treating t...
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JPH08127588A |
PURPOSE: To stereoselectively and efficiently obtain galactofuranosides which exist in sugar chain part of an enzyme and cell wall lipopolysaccharide of bacteria by reacting a specific thioglycoside derivative with an alcohol derivative ...
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JPH08119985A |
PURPOSE: To provide a method for producing a sugar acetonide without using an inorganic acid, phosphorus pentoxide, iodine or a solid catalyst and without requiring the removal of water with an azeotropic mixture. CONSTITUTION: This meth...
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JPH08104651A |
PURPOSE: To provide a drug-delivery material composed of a polymer having a reduced-type sugar on the side chain and useful as an agent for promoting the absorption of drug through the mucosa of digestive system including the oral cavity...
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JPH0830075B2 |
PURPOSE:To obtain the titled compound useful as an intermediate for ascorbic acid, etc., on an industrial scale at a low cost, by reacting L-sorbose under the addition of acetone having low water-content in the presence of a ketalization...
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JPH0873484A |
To obtain the subject new compound comprising a specific saccharic compound having a tetrahydropyran structure, having a vascularization-inhibiting ability and low toxicity and useful for treating diabetic retinopathy, chronic rheumatoid...
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JPH0816116B2 |
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JPH08500112A |
This invention describes both known and novel compounds, some of which are protein kinase inhibitors, that may be combined with taxol type compounds. The combination of disclosed compounds plus taxol type compounds exhibits powerful syne...
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JPH07324060A |
PURPOSE: To carry out a position-selective cis-aminohydroxylation reaction different from conventional reactions to obtain the compound in which an N- substituted amino group is introduced to the sterically crowded side. CONSTITUTION: Th...
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JPH07316178A |
PURPOSE: To obtain new compounds having excellent saccharide hydroxidase- inhibiting activity and useful as antibestics, antidiabetics, insecticides and anti- HIV agents. CONSTITUTION: A compound of formula I (R1 is H or a saccharide res...
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JPH07316179A |
PURPOSE: To obtain a new compound having excellent radiation damage- protecting action. CONSTITUTION: A compound of the formula (R1 is an amino which may be substituted with a 1-6C alkyl, etc.; R2 is H or a 1-6C alkyl; R3 is a 1-6C alkyl...
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JPH07309885A |
PURPOSE: To obtain a dinucleoside analogue useful for treatment of virus diseases such as influenza, herpes and HIV and a mononucleoside analogue used for intermediates or the like for production of an oligonucleoside. CONSTITUTION: This...
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JPH07304783A |
PURPOSE: To obtain a novel phosphinate ester that is useful as a starting material for producing an antiviral agent and can eliminate the protecting group under mild basic conditions by reacting phosphinic acid with an alcohol or a chlor...
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JPH0762024B2 |
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JPH07504421A |
Compounds are described of formula (I), wherein R<1> represents a hydroxyl group or a group selected from -OCOCH=CHCH(CH3)(CH2)3CH3, -OCOCH=CHC(CH3)=CHCH(CH3)CH2CH3 or -OCO-X-CH2CH(CH3)CH2CH3[where X is -CH=CHCH(CH3)-, -CH2CH(OH)CH(CH3)-...
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JPH07504422A |
Compounds are described of formula (I), wherein R<1> represents a hydroxyl group or a group selected from -OCOCH=CHCH(CH3)(CH2)3CH3, -OCOCH=CHC(CH3)=CHCH(CH3)CH2CH3 or -OCO-X-CH2CH(CH3)CH2CH3 [where X is -CH=CHCH(CH3)-, -CH2CH(OH)CH(CH3)...
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JPH07112987A |
PURPOSE: To provide a novel compound having activities such as a platelet coagulation-inhibiting function, a vasodilative action, and an antiinflammatory action because of exhibiting an inhibiting action on myosin light chain kinase. CON...
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JPH0720919B2 |
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JPH075626B2 |
In the disclosed process, an O<2>,2 min anhydro-1-( beta -D-arabinofuranosyl)thymine is formed by condensing a 2-amino- beta -arabinofurano[1 min ,2 min :4,5,]-2-oxazoline with a compound of the formula wherein R1 is C1-C4 alkyl; X is ha...
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JPH06104677B2 |
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JPH06345791A |
PURPOSE: To obtain a new compound useful for the treatment or the like of diseases controlled by proteins, influenza, herpes, HIV or the like. CONSTITUTION: The compound of formula I [R1 is H, 1-20C alkyl, 2-20C alkenyl, formula II (R10 ...
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JPH0699437B2 |
N787-182 antibiotic compounds and derivatives of the formula:- wherein the substituents R, R<1>, R<2> and R<3> are as follows:- are antiparasitic agents active against insect pests, acari, free-living nematodes and endo- and ectoparasite...
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JPH0699433B2 |
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JPH06271580A |
PURPOSE: To provide new compds. useful for the treatment of epilepsy, etc., as a prodrug of anticonvulsant agents, which are converted to an active medicine exhibiting anticonvulsant activity in the body of mammals. CONSTITUTION: The der...
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JPH06234785A |
PURPOSE: To provide an improved method for preparing 1,2-5,6-diacetone-D- glucose. CONSTITUTION: The objective 1,2-5,6-diacetone-D-glucose is prepared by reacting α-D-glucose with diketene or 2,2,6-trimethyl-1,3-dioxine-4-one in acetone...
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JPH06505719A |
Compounds are described of the formula wherein R<1> represents a hydrogen atom or an acetyl group; R<2>, R<3> and R<4> may each independently represent a hydrogen atom or a methyl group; n represents an integer from 1 to 3; and the fluor...
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