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Matches 1 - 50 out of 2,987

Document Document Title
WO/2018/010932A1
The present invention relates to a method of reacting starting materials with an activating group, namely alkanes carrying a leaving group and/or olefins, with carbon dioxide under transition metal catalysis to give carboxyl group-contai...  
WO/2018/013615A1
Described herein are neuroactive steroids of Formula (I), Formula (V), or Formula (IX) or a pharmaceutically acceptable salt thereof; wherein each instance of R2, R3, R4, R5, R6, R7, R11a, R11b,R12, R16, R17, R19, and ----- are as define...  
WO/2018/013613A1
Described herein are neuroactive steroids or a pharmaceutically acceptable salt thereof. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a comp...  
WO/2017/211330A1
15β-substituted derivatives of estrone of general formula I wherein R1, R2, R3, R4, R5 are independently selected from the group consisting of: C1-C4 alkyl, C1-C4 alkoxy, C1-C4 halogenalkyl, halogen, COOR6 wherein R6 is C1-C4 alkyl; H, ...  
WO/2017/192668A1
Disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery. In particular, disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery based o...  
WO/2017/173358A1
Compounds are provided according to Formula (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein A, R1, and R5 are as defined herein. Compounds of the present invention are contemplated use...  
WO/2017/150723A1
Algae that generates a sterol and a sterol production method that uses the algae. According to the present invention, a sterol is produced by culturing algae, such as strain AJ7867 (FERM BP-22304) and strains derived therefrom, that has ...  
WO/2017/149091A1
The invention relates to a process for the preparation of 11 -methylene steroids through selective olefination of the ketone at position 11. The resulting products are useful intermediates in the preparation of several pharmaceutically a...  
WO/2017/149052A1
The invention pertains to a process for producing a compound of formula (11) wherein R7 and R8 are each independently selected from H, halogen, alkyl, aryl, or alkylaryl, R42 is H or a protective group, R43 is H or R3, wherein R3 is a pr...  
WO/2017/137931A1
The present application relates to amine salt of obeticholic acid. Specifically, the present application relates to (S)-α-methylbenzylamine and diethylamine salt of obeticholic acid. The present application also relates to a process for...  
WO/2017/112904A1
The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The s...  
WO/2017/112909A1
The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The s...  
WO/2017/112902A1
The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The s...  
WO/2017/057460A1
Provided is a method for producing an organic compound, wherein the organic compound is an industrially useful compound, and a deodorization step, for removing from a reaction solution odorants that are generated in or remaining after a ...  
WO/2017/041139A1
The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.  
WO/2016/165496A1
Disclosed is method for preparing a deoxycholic acid or ester thereof or pharmaceutically acceptable salt thereof. The compound is suitable for removing fat deposition.  
WO/2016/132355A1
Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes ...  
WO/2016/126875A1
The automated synthesis of clinically relevant amounts of 16β-18F-fluoro-5α-dihydrotestosterone (18F-FDHT) using a commercially available radiosynthesizer. Synthesis was performed in 90 minutes with a decay-corrected radiochemical yiel...  
WO/2016/054741A1
The invention relates to a microsphere composition comprising (a) a microsphere material; and (b) a lipidic liquid formulation comprising (i) an effective amount of a progestogen, and (ii) vitamin E or an analog of vitamin E, incorporate...  
WO/2016/033549A2
Described here are substantially pure (17-?)-3-Oxoandrost-4-en-17-yl tridecanoate compositions, methods of their preparation and uses thereof  
WO/2016/029888A1
The present invention provides amphiphilic compounds with tetradecahydrophenanthrene skeleton and their enantiomers, exhibiting neuroprotective effects, their use as medicaments for treating neuropsychiatric disorders associated with an ...  
WO/2016/009442A1
The invention discloses a novel method for preparing neuromuscular blocking agents using aryl esters as a reagent of di-acylation as well as highly regioselective mono-acylation of androstane-diols.  
WO/2015/181116A1
A process for preparing compounds of formula (I), or a salt, solvate or stereoisomer thereof, including Fulvestrant, which process comprises free radical to a compound of formula (III), or a salt, solvate or stereoisomer thereof. The inv...  
WO/2015/135061A1
Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low DHEA ...  
WO/2015/114518A3
Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of a crystalline intermediate that makes the process particularly suitable for im...  
WO/2015/102022A3
The present invention relates to an improved process for the preparation of abiraterone acetate. More specifically the invention relates to a process for the preparation of abiraterone acetate free from dimer and other impurities.  
WO/2015/098152A1
The present invention is a method that is for preparing a crystallography sample for determining the molecular structure of a metabolite and that is characterized by having a step in which, by means of contacting, to a solvent solution c...  
WO/2015/092647A1
The present invention relates to a new stereoselective process for the synthesis of 17(α)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as to the new intermediates of the process. The 17(α)-17-acetyl-17-hy droxy-estr-4-e...  
WO/2015/081827A1
Disclosed is a method for synthesizing a α-aryl, heteroaryl or alkenyl-α,α-2-fluoro allyl structure by palladium catalysis. Specifically, in the method of the present invention, a compound of formula A and a compound of formula B synt...  
WO/2015/064479A1
A levonorgestrel crystal mixture comprising polymorphic levonorgestrel crystals α which give an X-ray powder diffraction spectrum that has diffraction peaks at the following diffraction angles (α) in terms of 2θ and polymorphic levono...  
WO/2015/040051A1
The invention relates to a process for obtaining Estetrol or a salt or solvate thereof, the process comprising: a) reacting a compound of formula (IV) or a salt or solvate thereof, wherein R1 is a hydroxyl protecting group selected from ...  
WO/2015/018596A1
The invention relates to a method and a kit for colouring keratinous fibers especially human hair. The invention more particularly relates to generating black coloured hair while minimising the off odour generated when a conventional pen...  
WO/2015/006691A1
Various prodrug compounds having the general structure: Active agent- (acid)-(linker) - SO2NR1R2 are described herein. Compounds having this general structure were shown to be more orally active than the unmodified parent molecule.  
WO/2014/188353A3
The present application relates to a regioselective and stereoselective processes for the preparation of dehydroepiandrosterone (DHEA) and processes for its intermediates.  
WO/2014/175303A1
 Provided are a new crystalline form of levonorgestrel, which is useful as an emergency contraception, etc., a manufacturing method for the same, and a drug composition. The powder X-ray diffraction spectrum of this β crystalline po...  
WO/2014/175302A1
 Provided are a new form of levonorgestrel, which is useful as an emergency contraception, etc., a solid dispersion of levonorgestrel, a manufacturing method for the same, and a drug composition. The differential scanning calorimetry...  
WO/2014/175304A1
 Provided are a new crystalline form of levonorgestrel, which is useful as an emergency contraception, etc., a manufacturing method for the same, and a drug composition. The powder X-ray diffraction spectrum of this β crystalline po...  
WO/2014/169462A1
The present invention provides a class of fulvestrant ester derivatives and a preparation method thereof. Such a compound is an aliphatic ester compound formed by esterifying the -OH on positions C-3 and C-17 of the fulvestrant, having a...  
WO/2014/162230A1
The present invention provides a process for the purification of norethindrone (I) from a mixture of dimethylformamide (DMF) and water. The invention further provides two processes for the purification of norethindrone acetate (II) from ...  
WO/2014/154179A1
The present invention discloses compound 2β,3α,5α-trihydroxy-androst-6-one, having the structure of formula (I). The present invention also discloses a plurality of methods for preparing the compound and a use of the compound.  
WO/2014/127201A1
The present disclosure is generally directed to neuroactive enantiomeric 15-, 16- and 17- substituted steroids with additional optional substituents at carbons 3, 4, 6, 7, 10 and 13, and pharmaceutically acceptable salts thereof, for use...  
WO/2014/100228A1
The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorde...  
WO/2014/091158A1
The present invention relates to testosterone derivatives of formula (I): in which n is an integer between 1 and 10 and Y is an activated or ready-to-be-activated group which enables the formation of an amide bond with a primary amine of...  
WO/2014/075978A1
The present invention relates to a process for making abiraterone-3-acetate of formula (1) starting from dehydroepiandrosterone-3-acetate of formula (2) by converting it into the triflate of formula (5) in an inert solvent in the presenc...  
WO/2014/057957A1
Provided are: a novel steroid compound useful for a diagnostic medicine; and a medicine comprising the steroid compound. A steroid compound represented by formula (1) (wherein R1 represents a hydroxy group, a sulfonyloxy-type protected h...  
WO/2014/037873A1
There is described a process for the industrial synthesis of 11-methylene-18- methyl-estr-4-en-3, 17-dione, a compound having the structure formula (I) depicted below: (Formula I) (I) useful as intermediate compound in the synthesis of t...  
WO/2013/142873A3
The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically ...  
WO/2013/131305A1
Disclosed are four compounds of crystal form of androsta-3β,5α,6β-triol (YC-6 for short) (YC-6 of A crystal form, YC-6 of B crystal form, YC-6 of C crystal form, YC-6 of D crystal form) and a method for preparing same. The four compou...  
WO/2013/035943A1
The present invention relates to betulinic acid exhibiting anti-aging activity, wherein the betulinic acid according to the invention, functional foods containing the betulinic acid, or a pharmaceutical composition containing the betulin...  
WO/2013/034780A3
The invention relates to a process for obtaining Estetrol and derivatives thereof of formula (I) or a salt or solvate thereof, wherein R represents H or anhydroxyl protecting group; the process comprising reacting a compound of formula (...  

Matches 1 - 50 out of 2,987