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JPS6220199B2 |
The present invention discloses a process for the production of androsta-4,9(11)-diene-3,17-dione type compounds from 9 alpha -hydroxyandrostenedione type compounds by non-aromatic oxygenated strong acid dehydration.
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JPS6212796A |
11 beta -Substituted steroids of formula (I> wherein R1 and R2 are both hydrogen or, taken together, form the group oxo or =CH2; R3 is an alkyl, alkenyl or alkynyl substituent at C-6 or C-7; R5 is alkyl; R6 is hydroxy and R7 is hydrogen,...
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JPS625992A |
The present invention relates to Compounds of formula (VI) or of formula (V) wherein Y sec is hydrogen, hydroxy or an OAc group, wherein Ac is an alkylcarbonyl group having from 1 to 4 carbon atoms in the alkyl moiety, and X is a bromine...
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JPS6159639B2 |
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JPS61204195A |
NEW MATERIAL:A compound of formula I [formula II is formula III (R' is 1W3C alkyl); Z is H, formula IV (R1WR3 are lower alkyl, phenyl)]. EXAMPLE: 6β-Methoy-24-trimethylsilyl-3α,5-cyclo-5α-chole-16-en-e-2
3-ine. USE: A synthetic interm...
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JPS6123799B2 |
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JPS6172798A |
A process for preparing a 17 alpha -hydroxy-20-keto steroid comprises contacting a DELTA <1><6>-20-keto steroid with a silylating agent in the presence of a catalyst, and contacting the resultant DELTA <17(20)>-20-silyl ether steroid (so...
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JPS6111239B2 |
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JPS6111237B2 |
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JPS6111238B2 |
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JPS611699A |
C16-unsaturated corticoids are readily transformed to the corresponding 16 alpha -methyl-17 alpha -hydroxy corticoids by use of a DELTA 17(20)-20-silyl ether.
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JPS6044318B2 |
1512400 16,17-Naphthopregnenes E R SQUIBB & SONS Inc 13 Nov 1975 [25 Nov 1974] 46902/75 Heading C2U The invention comprises #4 and #1'4 steroids of formula wherein R 1 is Cl, F or OH; R1 1 is H; or R 1 and R1 1 together are oxo; R 2 is H...
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JPS6069096A |
Steroids of the formulaand a therapeutic composition containing same which are useful as anti-cancer, anti-obesity, anti-hyperglycemic, anti-autoimmune and anti-hypercholesterolemic agents.
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JPS59206398A |
The invention relates to a new process for the introduction into steroids of a 17-side chain containing a 20-keto group under the simultaneous formation of an unsaturated bond between C16 and C17 by reaction of 17-(isocyano-sulfonylmethy...
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JPS5938240B2 |
Topical and systemic anti-inflammatory activity is exhibited by steroids having the formula AND THE 1,2-DEHYDRO DERIVATIVES THEREOF, WHEREIN R1 is phenyl, naphthyl, or substituted phenyl or naphthyl.
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JPS59161400A |
Topical and systemic anti-inflammatory activity is exhibited by steroids having the formula AND THE 1,2-DEHYDRO DERIVATIVES THEREOF, WHEREIN R1 is phenyl, naphthyl, or substituted phenyl or naphthyl.
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JPS597720B2 |
New triamino-androstanes with curare-type properties and a process for the preparation thereof are disclosed.
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JPS5855157B2 |
1504132 2 - Bromo - 6# - fluoro - pregnane compounds G PALLADINO 24 Feb 1975 [8 March 1974] 10443/74 Heading C2U Novel steroids have the formula wherein X is oxo, #-OH or #-Cl; Y is F or Cl but is not F when X is Cl; R1 is H or C 2-8 alk...
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JPS5855156B2 |
1504294 6#-Fluoro-pregnadienes G PALLADINO 24 Feb 1975 [5 March 1974] 9728/74 Heading C2U Novel steroids have the formula wherein R and R1 are each H or 2-8C alkanoyl; X is keto, #-OH or #-Cl; Y is F or Cl but is not F when X is Cl; Z is...
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JPS5862200A |
PURPOSE: An essence mainly containing steroid saponine is extracted from KINGINNASUBI (Solanum aculeatissimum Jacq.) and the saponine is hydrolyzed to give isonuatigenin, then the isonuatigenin is used as a starting compound to subject t...
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JPS5856693A |
The subject invention concerns a novel fermentation process for making the novel useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxyaldehyde (I). This compound can be used as in the synthesis of valuable corticoids.
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JPS5725560B2 |
1409239 3α-Hydroxy-steroids GLAXO LABORATORIES Ltd 8 Nov 1972 [11 Nov 1971] 52465/71 Heading C2U 3α-Hydroxy-5α-steroids, including the novel 3α - hydroxy - 19 - nor - 5α - pregnan - 20 - one, are prepared by reducing 3-oxo-5α-stero...
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JPS579800A |
New DELTA 1,4,9(11)-pregnatrien-3-one-2o-carboxlic acid compounds are described, corresponding to general formula I below: (I) in which X represents halogen, particularly chlorine or bromine or NH2. There is also described the process fo...
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JPS579798A |
A process for the partial reduction of C21-steroid carboxylic acids and their esters to C21-steroid alcohols and new C21-steroid alcohols DELTA 4,17(20)-C21-steroid carboxylic acids optionally containing further double bonds in the 1- an...
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JPS56169699A |
Novel halogenated steroids of the formula (A) in which X represents a halogen atom having a maximum atomic number of 17, Y represents a hydrogen atom or hydroxyl, and R represents an alkyl radical having a maximum of 6 carbon atoms, and ...
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JPS56147800A |
NEW MATERIAL:N1-Cholesteryloxycarbonyl-5-fluorouracil. USE: A carcinostatic agent. Having a small side effect and good absorption. PROCESS: For example, 5-fluorouracil is reacted with chloroformic ester of cholesterol in the presence of ...
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JPS56113798A |
A DELTA 1,4,17-BNC compound having the formula: wherein X is a substituent selected from the group consisting of OH and OCH3; as well as its process of production by microbiological side-chain splitting of a 17-C-side-chain steroid with ...
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JPS56103200A |
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JPS5619880B2 |
A method of preparing the 3,16α, 17 ξ -trihydroxy-11β-alkoxy-estra-1,3,5 (10) -triene of general formula I: **(See formula)** in which X represents a methyl or ethyl radical; R represents hydrogen or an unsaturated hydrocarbon radical...
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JPS5611719B1 |
Only the rings A and B of the steroid nucleus which take part in the reaction are indicated. X = Cl or Br; R = H, halogen, OH or (12 C) acyl, pref. acyloxy; R1 = (12 C) acyl. The 5alpha-bromo 6beta-hydroxy steroids prepared in the proces...
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JPS5544598B2 |
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JPS5527920B1 |
1379747 6# - Fluoro - 5α - bromo -13 - ethylsteroids SOBERING AG 20 Dec 1971 [30 Dec 1970] 59088/71 Heading C2U Novel 3#-(hydroxy or acyloxy)-6#-fluoro- 5α-bromo-13-ethyl-steroids are prepared by the addition of Br and F to the corresp...
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JPS5526158B2 |
New triamino-androstanes with curare-type properties and a process for the preparation thereof are disclosed.
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JPS5526156B1 |
Only the rings A and B of the steroid nucleus which take part in the reaction are indicated. X = Cl or Br; R = H, halogen, OH or (12 C) acyl, pref. acyloxy; R1 = (12 C) acyl. The 5alpha-bromo 6beta-hydroxy steroids prepared in the proces...
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JPS5549399A |
PURPOSE: To prepare the title compound useful as an intermediate of estriol, in single step reaction, in high yield, by reacting estrone with cupric bromide as bromination agent. CONSTITUTION: 3-Hydroxy-16-bromoestra-1, 3, 5(10)-trien-17...
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JPS5520789A |
11 beta ,21-Dihydroxypregna-1,4,17(20)-triene-3-one 21-acetate (0) is epoxidized, followed by ring opening and hydrolysis to give 11 beta ,20,21-trihydroxypregna-1,4,16-triene-3-one 21-acetate (III), an intermediate in the synthesis of b...
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JPS557295A |
Steroids having the formula wherein R1 is alkyl, aryl or arylalkyl; R2 and R3 are the same or different and are hydrogen, alkyl or aryl; R4 is hydrogen and R5 is hydroxy or together R4 and R5 are =O; and R6 is hydrogen, methyl or fluorin...
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JPS5442970B2 |
A compound of the formula (I) (I) wherein X is a halogen, Z1 and Z2 are both hydrogen, or Z1 is hydroxy and Z2 is chlorine, or Z1 and Z2 together stand for an alpha -epoxy group.
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JPS5492948A |
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JPS5412464B2 |
5 alpha , 17B-Diacetoxy-6 -chloro-2 alpha , 3 alpha ; 16 alpha , 17 alpha -diepoxy-androstane; 5 alpha , 17B-Dicetoxy-6 -chloro-androsta-2,16-diene; 5 alpha -Hydroxy-6 -chloro-17-oxo-androst-2-ene or a like intermediate in the production...
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JPS548651B2 |
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JPS5347102B2 |
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JPS53141281A |
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JPS53101357A |
Novel and biologically active 11 beta -substituted steroids of the oestrane series are disclosed having the formula (I) wherein (a) R1 is O or ( alpha Y)( beta Z), wherein Y is selected from the group consisting of H, unsaturated aliphat...
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JPS5330706B1 |
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JPS5371054A |
The present invention relates to a process for the manufacture of 17 alpha -hydroxy-21-acyloxy-progesterone, in particular of 17 alpha -hydroxy-21-acetoxy-progesterone (Reichstein's substance S acetate) which is of great importance as a ...
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JPS535150A |
A new process utilizing certain novel intermediates for the preparation of 17 beta -hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone is described herein. The procedure utilizes readily available and inexpensive sarsa...
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JPS52142057A |
Steroids having the structure and the 1,2-dehydro derivatives thereof, wherein R1 is hydrogen, hydroxy, fluorine, chlorine, or bromine; R2 is alkyl or aryl; R3 is aryl, cyano, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aryloxycarbonyl,...
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JPS52142056A |
A process for the preparation of steroids of the formula: *** in which R1 is a group -NraRb, in which Ra and Rb (which may be the same or different) are C1-6 alcoholic groups or C3 alkenyl- 6 (provided that Ra and Rb together contain 2-7...
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JPS5231922B2 |
Title cpds. (I) their salts and quaternary ammonium salts. (where R is H, or 1-6C acyl, R1 is 1-6C alkyl, vinyl, allyl, or hydroxyethyl, R2 is H, 1-6C-alkyl, allyl or benzyl, X is H Y is OH or 1-6C acyloxy or X + Y is O and salt forming ...
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