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JP02174794 |
NEW MATERIAL: A compd. represented buy formula I (wherein X is a vinyl group substituted by a radioactive or non-radioactive halogen according to Z isomerization in a double bond; Y is OH and, in this case, its bonding ring is an aromati...
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JP02076897 |
NEW MATERIAL: A 17β-furyl, 15β-hydroxyl intermediate given by formula I. USE: An intermediate for remedy for cardiac disease. PROCESS: A 17-position steroid ketone given by formula II is treated with an alkali or alkaline earth metal Î...
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JP02073093 |
NEW MATERIAL:A compound expressed by formula I (R1 is H or acetyl; R2 is 1-6C alkoxy, cholestenyl, cholestanyl or halogen; R3 is H, 1-6C alkyl, aryl, aralkyl, alkali metal or NH+4). USE: The compound expressed by formula I has nerve acti...
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JP02036192 |
NEW MATERIAL: Compounds of formula I [wherein R is -COOX (X is H or a 1-8C alkyl) or CH2OH]. EXAMPLE: Methyl 3β-hydroxy-chola-5,23t-diene-24-carboxylate. USE: Prevention and a remedy of hypercholesterolemia, an HMG-COA reductase inhibit...
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JP02028194 |
NEW MATERIAL: Compd. of formula I [wherein W is formulas II or III (wherein R1 is H, hydroxy or acyloxy; R2 and R3 are each hydroxy or acyloxy; when R2 is acyloxy, R1 and R3 are each different from hydroxy]. EXAMPLE: (20S)-20-methylpregn...
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JP01311098 |
NEW MATERIAL: Compd. of formula I {wherein R is formula II (wherein R1 is a 1-16C alkyl, an alkoxy, a halogen, etc., and R4 and R5 are each H, CH3, CN, etc.), formula III (wherein R2 is a 1-16C alkyl), formula IV [wherein B is a 1-16C al...
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JP01233292 |
PURPOSE: To advantageously glycosylate hydroxyl groups of a sugar anomer in good yield of glycosides in a small number of reaction steps, by reacting the above-mentioned hydroxyl groups with a specific thiocarbonate to directly thioglyco...
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JP01221391 |
NEW MATERIAL: A compd. of formula I (where R is OH or H; R1 and R2 are each =CH2 or -CH2O-; R3 is H, OH, HSO3O or HOCOCH2CH2CO2; R4 is OH, HOC15H30CO2, AcO or H; when R3 is H, a double bond does not exist in the cyclopentane ring; R5 is ...
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JP01135795 |
NEW MATERIAL: A compd. of formula I [R1 is H, OH; methyl and HO at 6- and 7-positions respectively can be either in α or β configuration). EXAMPLE: 3-α-7-Dihydroxy-6-methyl-5-β-cholan-24-oic acid. USE: The compd. is useful for the tr...
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JP01104096 |
NEW MATERIAL: A compd. of formula I [where R and R3 and H or a 1-6C alkyl; R1 is H, a halogen or 1-6C alkyl; R2 is H or a 1-6C alkyl; R4 is H or F; and R5 is H, a 1-6C alkyl, (substd.) phenyl, acyl or an OH protecting group] or its salt....
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JP01093529 |
NEW MATERIAL:A compound shown by formula I or formula II. EXAMPLE: Sodium 3β-O-(4'-acetamido-2',4'-dideoxy-1'-carboxy-D-glycero-α-D-
galacto-1'-octopyranosyl)cholest-5-enate. USE: A remedy for demyelinating diseases. PREPARATION: 1mol...
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JP01085961 |
NEW MATERIAL: The compd. of the formula II (R is H, OH, O-acyl; Z is H, lower alkyl). EXAMPLE: 6-Methoxy-25-keto-27-nor-3,5-cyclivitamin D3. USE: A precursor of vitamin D3-like active compd. Useful as a vitamin D3 substitutive substance ...
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JP01025747 |
NEW MATERIAL: A compd. expressed by a formula I. USE: An intermediate for steroid synthesis. PROCESS: A compd. expressed by a formula I is obtained by treating a bicylic diketopropionic acid expressed by a formula II with pivaloyl chlori...
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JP01025772 |
PURPOSE: To obtain the compd. of a steroid compd. synthesizing intermediate useful as a gestagenic action agent, etc., which high yield by using a triketal compd. as a starting raw material and bringing this compd. into reaction with a b...
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JP63254179 |
PURPOSE: To obtain an antioxidant effective as foods and cosmetics, comprising a composition extracted from sponge cucumber. CONSTITUTION: The aimed antioxidant containing one or more ginsenosides shown by formula I (R is glucose or gluc...
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JP63196556 |
NEW MATERIAL:The compound of formula I (R1 is methyl or trifluoromethyl; R2 is trifluoromethyl when R1 is methyl or R2 is methyl when R1 is trifluoromethyl). EXAMPLE: 26,26,26,27,27,27-Hexafluoro-25-hydroxyvitamin D3. USE: Useful as a dr...
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JP63166900 |
NEW MATERIAL:A compound expressed by formula I [Y is -COOCH2- or -CO-CH2-, provided that -CO- group is linked to ring A; X is formula II or III (R1WR4 are H or acyl; R5 is 1W2C alkyl; * indicates the linking position of group X to the st...
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JP63099094 |
NEW MATERIAL:The compound of formula (glu is β-glucopyranosyl group). USE: A carcinostatic agent. PREPARATION: The compound of formula can be produced e.g. by (1) dissolving whole saponin of Gynostemma pentaphyllum containing 2-α-hy dr...
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JP63096197 |
NEW MATERIAL:The compound of formula. USE: Identification of bile acid and its derivative usable as an index for the investigation of metabolic path including the formation of bile acid. PREPARATION: A mold belonging to Cunninghamella ge...
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JP63063697 |
PURPOSE: To obtain the titled compound having immune adjusting actions, growing action on nerve projection of cell and differentiation introducing ability, by reacting a specific sialic acid derivative with cholesterol and hydrolyzing th...
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JP63054394 |
NEW MATERIAL:A compound expressed by formula I (R2 is H, OH or trifluoroacetoxy when R1 is methyl; R2 and R3 together form π bond; R1 and R2 together form methylene; R3 is H; R4 and R5 are H or R4 and R5 together form π bond; R6 is H o...
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JP63033393 |
PURPOSE: To crystallize a ginsenoside-Rg1 having central nervous activation activity, platelet agglutination controlling action, arterial sclerosis preventive action, etc., in high purity and high yield, by preparing an aqueous solution ...
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JP62242695 |
PURPOSE: To produce the titled compound useful as a synthetic intermediate for antihypercalcemic agent, osteogenesis promoting agent and tumor cell proliferation suppressing agent, by reducing an epoxy-hydroxycholest-en-oic acid ester. C...
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JP62240697 |
NEW MATERIAL:6α-[β-D-Galactopyranosyl-(1→4)-[β-D-fucopyrano
syl-(1→2)]β-D- glucopyranosyl-(1→4)-[β-D-quinovopyranosyl(1→2)]β-D-xy
lopyranosyl-(1→3)-β-D- quinovopyranosyl]-(20R, 22R, 23S, 24S)-22,23-epoxy-24-methyl-3β-su...
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JP62223188 |
PURPOSE: To industrially and advantageously obtain the titled substance useful as an intermediate for 25-hydroxyvitamin D3-lactone, etc., used for remedy for hypercalcemia, etc., by reacting epoxysteroids with a specific compound in the ...
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JP62209095 |
NEW MATERIAL:A compound shown by formula I [R1 is H, tri 1W7C hydrocarbon or group bonded to oxygen atom of OH to form acetal bond or ester bond; R2 is H or OR3 (R3 is R1)]. EXAMPLE: 3-β-Methoxymethoxy-cholesta-5,25-diene-26,23-lactone....
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JP62209094 |
NEW MATERIAL:A compound shown by formula I (R1 and R2 are COOH, lower alkoxycarboxyl, glucose, sterol or neuraminic acid derivative; R3 and R4 are H or acyl) and a salt thereof. EXAMPLE: Methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-2, 3-dib...
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JP62187485 |
PURPOSE: To obtain the titled compound useful as an intermediate for active vitamin D3 or such, industrially advantageously, by treating a cholesterol-24- sulfonate with a base. CONSTITUTION: 1mol 24,25-dihydroxycholesterol shown by form...
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JP62167795 |
NEW MATERIAL:A compound expressed by formula I [R1 and R2 are H or OH-protecting group; R5 and R6 are H, lower alkyl, cycloalkyl or (substituted) phenyl or R5 and R6, together with the carbon atom to which they are linked, may form a cyc...
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JP62026295 |
NEW MATERIAL:6-Linoleyl-β-D-glucopyranosyl-(1,3')-β-clerostero
l of formula. USE: Attractant for Dacus cucurbitae. PREPARATION: Raw fruit of balsam pear (Momordica charantia) is ground in the presence of water and extracted with methyl...
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JP61251698 |
NEW MATERIAL:A steroid of formula I (X is hydroxyl; Y is H: or X and Y forms oxo; R' is H, acyl, silyl, alkoxycarbonyl, benzyl or incorporate each other to form alkylidene or carbonyl; configurations in 22-, 23-positions are 22R, 23R or ...
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JP61243096 |
NEW MATERIAL:The compound of formula I (one of R1 and R2 is carboxyl or methoxycarbonyl and the other is group of formula II or III; R3 is H or acetyl). EXAMPLE: 5-Acetamido-2-O-acetyl-( 5-cholesten-3-β-yl )-3,5-dideoxy-α-D-glycero-D- ...
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JP61145196 |
NEW MATERIAL:A compound of formula I (R1, R2 are H, hydroxyl; R3 is H, acetyl; the bonds between the 4- and 5-positions and between the 5- and 6- positions are single or double where they are not double simultaneously). EXAMPLE: The comp...
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JP61030599 |
PURPOSE: The titled product useful as a drug or a food, etc. effective for psychosomatic diseases, etc., promoting adrenocortial hormone production, controlling normally its metabolism rhythm within day, comprising ginsenoside Rb1, ginse...
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JP61024597 |
PURPOSE: To provide an antidiabetic agent containing ginsenoside-Rb2 of ginseng saponins separated from ginseng, as an active component, having hypoglycemic activity, and administrable continuously for a long period without causing side ...
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JP60156699 |
PURPOSE: To glycosylate an alcohol, etc. efficiently by a simple operation without using a heavy metal such as mercury, etc., by reacting pyranosyl fluoride, etc. with an alcohol, etc. in the presence of tetrafluorosilicon, etc. CONSTITU...
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JP60136591 |
PURPOSE: To obtain the titled compound useful as a drug, agricultural chemical, etc. in high yield with forming a small amount of by-products under mild neutral conditions, by reacting a thiophosphinic acid ester derivative of C-1 positi...
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JP60130581 |
PURPOSE: To produce the titled compound useful for the remedy of hypercalcemia, etc., economically, by irradiating a novel 1α.3β.25-trihydroxycholesta-5.7- diene-26.23-lactone with ultraviolet radiation, thermally isomerizing the produ...
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JP60089496 |
NEW MATERIAL:A compound of the formula [R1 is β-D-glucopyranosyl(1→6)-β- D-glucopyranosyl, α-L-arabinopyranosyl(1→6)-β,D-glucopyranosyl, α-L-arabinofuranosyl(1→6)-β-D-glucopyranosyl or β-D-glucopyranosyl]. EXAMPLE: 3-O-[6-O-...
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JP60081199 |
NEW MATERIAL:A compound of formula I [R1 is β-D-glucopyranosyl(1→6)-β-D- glucopyranosyl, α-L-arabinopyranosyl( 1→6 )-β-D-glucopyranosyl, α-L-arabinofuranosyl(1→6)-β-D-glucopyranosyl or β-D-glucopyranosyl]. EXAMPLE: 3-O-[ 6-O...
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JP60081121 |
PURPOSE: A cosmetic having hair tonic effect, remedying effect on acne free from side effect, containing 4-androsten-3-one-17β-ethoxy derivative. CONSTITUTION: A cosmetic containing one or more 4-androsten-3-one-17β-ethoxy derivatives ...
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JP60061596 |
NEW MATERIAL:The compound of formula I (the group -NHBSA is bovine serum albumin residue; G is glucuronyl group of formula II). EXAMPLE: 6-Oxoestradiol-3-sulfate-17β-glucuronide-6-( O-carboxymethyl )-oxime- BSA adduct. USE: Antigen for ...
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JP60061597 |
NEW MATERIAL:The compound of formula I (the group -NHBSA is bovine serum albumin residue; G is glucuronyl group of formula II). EXAMPLE: 6-Oxoestriol-3-sulfate-16α-glucuronide-6-(O-carboxymethyl)-
oxime-BSA adduct. USE: Antigen for prod...
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JP60054310 |
PURPOSE: To provide a cosmetic having excellent hair tonic effect and acne- remedying effect, and free from undesirable side effects such as hormonic activity, by using a specific 4-estren-3-one-17β-ethoxy derivative as an active compon...
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JP60045590 |
NEW MATERIAL:The compound of formula I [R is H, CH3, CH2OH, OH, OCH2 Ph (Ph is phenyl), OCOCH3, OCH3, CH2OCH3, CH2OCPh3, CH2OCH2Ph, CH2 OCOCH3, NHCOCH3, >C(CH3)2 or >CHPh; R1 and R2 are (substituted) alkyl or aryl]. EXAMPLE: 2,3,4,6-Tetr...
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JP60045592 |
PURPOSE: To provide the titled compound useful in the fields of pharmaceuticals and agricultural chemicals, etc. as an antibiotic substance, carcinostatic agent, etc., economically in an industrial scale, by reacting a specific C-1 thiop...
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JP60038325 |
PURPOSE: To obtain a narcotic sedative agent by using a specific steroid saponin or its salt originated from starfish. CONSTITUTION: The narcotic and sedative agent containing the steroid saponin of formula I (R1 is group of formula II, ...
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JP60028987 |
NEW MATERIAL:The compound of formula I (R is -COOH or -CONHCH2COOH). EXAMPLE: 3β,12β,14β-Trihydroxy-5β,17β-etianic acid-3-tridigitoxide. USE: Useful as a hapten of hapten antigen for the preparation of antibody for the immunochemica...
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JP59231022 |
PURPOSE: A hypotensor to be related to parasympathetic nerve mechanism, comprising a steroid saponin derived from Asteroidea, or its salt, including a novel compound, as an active ingredient. CONSTITUTION: A steroid saponin shown by the ...
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JP59227823 |
PURPOSE: To provide a tonic having blood activating action and useful as an agent to suppress the hemorrhage, a fatigue releaving agent, etc., by using a panaxadiol glycoside obtained from the rhizome of Panax ginseng C.A. Meyer belongin...
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