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Matches 201 - 250 out of 1,379

Document Document Title
WO2001002020A3
Novel pro-drugs and methods for their use to alter the growth and biological characteristics of living cells, tissues, or whole organisms are described. The methods allow for selective activation of the pro-drugs at or near transformant ...  
WO/2001/049704A1
The present invention relates to the compounds of formula (I), a method for extracting it and a pharmaceutical composition containing it. The said extracting method includes: extracting the corpus radicis and/or radix fibrosa of a ginsen...  
WO/2001/042273A2
This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of down regulating the IL-9 pathway and allevi...  
WO/2001/032679A2
A novel glycoside compound for use in treating or preventing cardiovascular disease and it's underlying conditions such as atherosclersis and hypercholeterolemia comprises a carbohydrate moiety and a non-carbohydrate moiety wherein the c...  
WO/2001/030802A2
The present invention provides methods and compositions to prevent or treat a hematopoietic disorder such as thrombocytopenia or neutropenia by administering to a subject an effective amount of a steroid such as 3,7,16,17-tetrahydroxy-an...  
WO/2001/027132A1
A conjugated prodrug of an estradiol compound conjugated to a biological activity modifying agent.  
WO/2001/015717A1
Medicinal compositions and preparations for administration comprising ginseng, which is useful as a cell protecting agent and a remedy for nerve trauma, its extract, ginseng components, metabolites thereof or salts thereof (for example, ...  
WO2000047215A3
The present invention provides novel methods, pharmaceutical compositions, and articles of manufacture for treating tumors that involve administering an effective amount of a cardiac glycoside, or a pharmaceutical salt thereof, wherein t...  
WO/2001/002020A2
Novel pro-drugs and methods for their use to alter the growth and biological characteristics of living cells, tissues, or whole organisms are described. The methods allow for selective activation of the pro-drugs at or near transformant ...  
WO/2001/000653A1
Novel phystosterol and/or phytostanol derivatives, including salts thereof, are represented by general formulae: (I), (II), (III), wherein R is a phytosterol or phytostanol moiety, R2 is derived from ascorbic acid and R3 is hydrogen or a...  
WO/2000/066612A1
Androgen glycosides provide free, circulatory androgen on oral administration as they are subject to less, first pass breakdown by the liver.  
WO/2000/066611A1
Steroid derivatives of this invention interact with nuclear liver X receptor (LXR) and ubiquitous receptor (UR) and can be used to treat a variety of LXR- or UR-mediated disorders.  
WO/2000/056757A1
The invention provides compositions comprising formula 1 steroids, e.g., 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one hemihydrate and one or more excipients, typically wherein the composition comprises less than about 3% water. Th...  
WO/2000/048608A1
Efficacious preparations for intravenous administration containing ginsenoside Rb¿1? or its salt which are useful as vascular regeneration/reconstruction promoters and nerve tissue secondary degeneration inhibitors. These preparations a...  
WO/2000/047215A2
The present invention provides novel methods, pharmaceutical compositions, and articles of manufacture for treating tumors that involve administering an effective amount of a cardiac glycoside, or a pharmaceutical salt thereof, wherein t...  
WO/2000/039148A1
The invention relates to new 7$g(a), 17$g(a), 17$g(b)-substituted testosterone derivatives of general formula (I) and their use as pure antiandrogens for the long-term therapy of androgen-dependent diseases, notably for the long-term ant...  
WO/2000/037481A1
Preparations for efficaciously administering ginsenoside Rb¿1? or its salt useful as cell-protective agents. More particularly, medicinal compositions for inhibiting apoptosis or apoptosis-like cell death or medicinal compositions for p...  
WO/2000/034306A1
The invention is directed to a novel class of 17$g(b)-acyl-17$g(a)-propynyl steroids which exhibit potent antiprogestational activity.  
WO/2000/032197A1
Compositions and methods for the treatment of retina and optic nerve head neuropathy are disclosed. The compositions and methods are particularly directed to the use of neurotrophic factor stimulators, such as AIT-082 (neotrofin), in the...  
WO/2000/021977A1
This invention provides 5$g(a)-pregnane-3$g(b), (20S), 21-triol, 20-O-$g(b)-glucuronide and 5$g(a)-pregnane-3$g(b),20R-diol, 20-O-$g(b)-glucuronide and pharmaceutically acceptalbe salts thereof which are useful as progestational agents.  
WO/2000/011019A1
The present invention relates to novel compounds comprising a steroid hormone linked to a DNA-interacting molecule that target nucleic acids to the cell nucleus. Further, the invention relates to a method for introducing nucleic acids in...  
WO/2000/011018A1
The present invention relates to novel compounds comprising a steroid hormone linked to a DNA-interacting molecule that target nucleic acids to the cell nucleus. Further, the invention relates to a method for introducing nucleic acids in...  
WO/1999/062928A1
The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.  
WO/1999/052931A1
A medicine which contains a sialic acid derivative represented by formula (I) and is excellent in solubility and absorbability. It is a solid dispersion comprising a water-soluble polymer such as hydroxypropylmethylcellulose and disperse...  
WO/1999/047542A1
Drugs containing as the active ingredient compounds having the following structure. These drugs are provided to develop compounds appropriate as anti-inflammatory agents suitable for topical administration (i.e., anti-inflammatory agents...  
WO1999001467A3
There are described therapeutically active compounds or salts or solvates thereof, hydrolysable in human or animal blood to compounds with reduced therapeutic activity. There is also described a method of identifying a compound capable o...  
WO/1999/016449A1
The present invention relates to Ca?2+¿ channel blockers and more particularly to the R-type Ca?2+¿ channel blockers. More specifically, the invention relates to Ca?2+¿ channel blockers activity of $i(Mandevilla velutina) and $i(Mande...  
WO/1999/016786A1
The present invention relates to the use of steroid saponin compounds of formula (I) to prophylactic and therapeutic treatment of senility, for example Alzheimer's disease, and to novel steroid saponin compounds of formula (II), and the ...  
WO1998046243A3  
WO/1999/001467A2
There are described therapeutically active compounds or salts or solvates thereof, hydrolysable in human or animal blood to compounds with reduced therapeutic activity. There is also described a method of identifying a compound capable o...  
WO/1998/051702A1
Compounds having an ansamycin antibiotic, or other moiety which binds to hsp90, coupled to a targeting moiety which binds specifically to a protein, receptor or marker can provide effective targeted delivery of the ansamycin antibiotic l...  
WO/1998/050412A1
This invention provides 3$g(b)-hydroxy-5,7,9-estratriene-17-one and a pharmaceutically acceptable salt of its 3-sulfate ester, which is useful as an estrogen.  
WO/1998/046243A2
A pharmaceutical composition contains an extract obtainable from a plant of the genus $i(Trichocaulon) or $i(Hoodia) containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for s...  
WO/1998/045315A1
This invention provides estra-5(10),7-dien-3$g(b)-ol-17-one or a pharmaceutically acceptable salt of its 3-sulfate ester, estra-5(10),7-dien-3$g(b)-ol-17-one 3-glucuronide or a pharmaceutically acceptable salt thereof, estra-5(10),7-dien...  
WO/1998/040399A1
Sterol compounds represented by general formula (I), wherein R represents nonyl or decyl. The sterol compounds can be synthesized by a technique or organic synthetic chemistry, and have improved antitumor activities.  
WO/1998/009935A1
A process for preparing a compound having structure (I) wherein n is an integer from 1-5; each of R�1? and R�2? independently is optionally substituted C�1?-C�6? alkyl; each of W and X is independently hydrogen or C�1?-C�6? a...  
WO/1998/002450A2
Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have...  
WO/1997/048401A1
A method of treating supraventricular arrhythmia and/or atrial fibrillation using a safe and effective amount of deoxy and oxygen-substituted sugar-containing 14-aminosteroid compounds and the pharmaceutically acceptable acid, salts or e...  
WO/1997/045441A1
The present invention relates to the novel 7'alpha'-(5-methylaminopentyl)-estratrienes of the general formula (I), in which R2 is a hydrogen or fluorine atom, R17 is a hydrogen atom, a methyl or ethynyl group, n is 2, 3 or 4, and x is 0,...  
WO/1997/038005A1
An antifungal and antilipemic agent comprising substance MK6059 of the following general formula (I) which is prepared by culturing a MK6059 strain belonging to the genus Ellisiodothis in a conventional nutrient medium for microbes, and ...  
WO/1997/031933A1
The present invention relates to novel ginseng saponin compounds having a potent anti-tumor activity, which are represented by formulae (I) and (II). The compounds (I) and (II) above are novel and can be produced by heating plants of gin...  
WO/1997/031013A1
This invention relates to ginsenoside Mc with formula (I), an intestinal flora metabolite of ginseng saponin and anticancer agent containing it as an active ingredient. In addition to a novel compound, the anticancer agent of this invent...  
WO/1997/027209A1
The invention relates to compounds of formula (I) in which R1, R2, R3, R4, R5, R6, X and n are as defined in the specification, and to pharmaceutical compositions containing them. These compounds are potent progestogens which are devoid ...  
WO/1997/024365A1
Compounds of the androstane series are described having general formula (I) and solvates thereof, in which R1 represents O, S or NH; R2 individually represents OC(=O)C1-6 alkyl; R3 individually represents hydrogen, methyl (which may be i...  
WO1997014696A3  
WO/1997/018824A1
The present invention relates to a vasodilating composition comprising ginsenoside Rg3 and/or Rg5, one of the saponin components of ginseng, as an active ingredient. Since ginsenoside Rg3 and Rg5, the active ingredient of the composition...  
WO/1997/014696A2
The invention concerns compounds of general formulae (Ia) and (Ib), in which R1 and R2, which may be identical or different, designate hydrogen, C1-C6 lower alkyl, straight-chain or branched, or an aryl group, optionally substituted by e...  
WO1996040043A3  
WO/1997/010256A1
Hitherto unknown compounds of formula (II) wherein R1 is hydrogen or methyl; R2 is hydrogen, methyl, CH2OH, CH2OR3, CHO, CH=CH2, COOH or COOR4; R3 is alkyl, aralkyl, aryl, alkanesulfonyl, arene-sulfonyl; alkanoyl or aroyl, optionally sub...  
WO/1996/040152A1
The present invention is related to a method for preventing or reducing the effects of ischemia. The ischemia may be associated with injury or reperfusion injury, such as occurs as a result of infarctions, thermal injury (burns), surgica...  

Matches 201 - 250 out of 1,379