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Patent Searching and Data


Matches 301 - 350 out of 1,408

Document Document Title
WO/1993/022333A1
Invented are 17$g(a) and 17$g(b)-substituted acyl-3-carboxy aromatic A ring analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-$g...  
WO/1993/022334A1
Pharmaceutical compositions and methods are provided for the colon-specific delivery of corticosteroids (I). The corticosteroids are administered in the form of prodrugs which undergo reaction with enzymes produced by colonic microflora,...  
WO/1993/021198A1
Sialic acid derivatives of cortison, dexamethasone and vitamin D3 represented by general formula (I), wherein R1 represents a steroid residue selectd from among cortisone, dexamethasone and vitamin D3; R2 represents hydrogen or acetyl; a...  
WO/1993/018053A1
This invention provides a simplified method for converting pregnan-3,20-dione compounds to 3alpha-hydroxy,3beta-substituted-pregnanes. By selective use of reagents the unprotected dione is converted chemoselectively and diastereoselectiv...  
WO/1993/012137A1
Compounds of formula (I) in which the dotted line indicates the optional presence of a double bond joining the 6 and 7 positions, A is a divalent group having a chain of at least four atoms joining the oxy group and the group BX, which g...  
WO/1993/011772A1
Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes, either in admixture or as conjugates, are disclosed. A novel process for efficient synthesis of these glycosylated steroid de...  
WO/1993/010741A2
Inhibitors of sex steroid activity, for example those having general structure (A) may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress estrogen synthesis. Such pharmaceutical compositi...  
WO/1993/007167A1
Disclosed are novel saponins containing 5-C-hydroxymethylhexose and a sterol or triterpene. These materials, when consumed by humans and animals, lower the cholesterol level in the blood. These compounds can be administered as pharmaceut...  
WO/1993/005789A1
Saponin/antigen conjugates and the use thereof for enhancing immune responses in individuals are disclosed. The saponins may be substantially pure or mixtures of saponins.  
WO/1993/003732A1
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid recept...  
WO/1993/001821A1
Steroidal and non-steroidal glycosides and a method of producing them are provided, wherein aglycon compounds are glycosylated with tri-O-acyl glucal using molecular or ionized halogen as reaction catalyst. The aglycon, which may be a no...  
WO/1992/020699A1
A compound which can maintain a blood steroid level unchanged for long after administration, obtained by combining a steroid derivative with a polysaccharide directly or via a spacer. Desirable examples of the steroid derivative include ...  
WO/1992/019616A1
There is provided a novel method to improve the pesticidal and repellent properties of neem extracts or azadirachtin containing compositions comprising the synthesis of a new pesticide repellent. Neem extracts containing azadirachtins or...  
WO/1992/011277A1
Compounds have general formula (I), in which X stands for an oxygen atom or for the hydroxyimino grouping >N$m(k)OH; R?1¿ stands for a hydrogen atom or for a methyl group; G stands for a hydrogen, halogen atom, a C¿1?-C¿4? alkyl resid...  
WO/1992/011278A1
New compounds having the general formula (I), as well as their pharmacologically acceptable addition salts with acids, are disclosed. In the formula (I), either (Ia) R?11¿ stands for a hydrogen atom in the $g(b) position, whereas R?12¿...  
WO1990012577A3  
WO/1992/004047A1
Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy,...  
WO/1992/004365A1
The invention relates to the novel compound mometasone furoate monohydrate, process for its preparation and pharmaceutical compositions containing said compound.  
WO/1992/003465A1
Disclosed are 20-methyl-5,7-pregnadiene-3$g(b),21-diol derivatives of general formula (I), in which R¿1? is a hydrogen atom or a lower-alkyl group and R¿2? is a lower-alkyl group, or R¿1? and R¿2? together represent a tetramethylene ...  
WO/1992/000316A1
A novel bile alcohol of general formula (I), having an efficacious physiological activity and being specified in the configurations of particularly the 20-, 24- and 25-positions; formula (I) wherein one of the groups R1 and R2 represents...  
WO1991017176A3  
WO/1991/017176A2
The present invention discloses compounds useful for the screening or monitoring of hypertensive individuals, for correction of interference in the measurement of digoxin levels in patients, and as pressor agents, potassium sparing diure...  
WO/1991/014689A1
A process for synthesizing polyoxa heterocycle compounds and in particular the antimalarial agent known as quinghaosu or artemisinin and its analogs is disclosed. A family of new antimalerial analogs of quinghaosu is also disclosed.  
WO/1991/011452A1
For a production of glycosides, especially of steroidal glycosides, molecular iodine is used as a reaction catalyst, wherein an alcohol and/or phenol, especially a hydroxy-steroid, is glycosylated, such that the glycosylation is performe...  
WO/1991/010743A1
The invention is directed to the control of cellular autophagy, cellular agglutination and the immobilization of motile cells. Such control is useful in, for example, the treatment of cancer, contraception, termination of pregnancy, remo...  
WO/1991/002739A1
Methods of stereoselectively preparing a substituted 1,2-anhydrosugar wherein a substituted glycal is converted into a 1,2-anhydrosugar that is utilized to glycosylate a hydroxyl group containing glycal, are disclosed. Methods of prepari...  
WO/1991/000733A1
A method of treatment of androgen-related diseases such as prostate cancer in susceptible male animals, including humans, comprises administering novel antiandrogens and/or novel sex steroid biosynthesis inhibitors as part of a combinati...  
WO/1991/000732A1
Methods for treating sex steroid-dependent diseases by inhibiting sex steroid activity include administration of novel compounds which include an androgenic nucleus substituted at a ring carbon with at least one substituent specified her...  
WO/1990/012577A2
A method of inhibiting hair growth in mammals which comprises the topical administration of a composition comprising an anti-angiogenic effective amount of an angiostatic compound of formula (I). The formula (I) compound is present in an...  
WO1990009394A3  
WO/1990/009394A2
The process of the present invention is a process for the preparation of an 11-oxygenated steroid of formula (II) which comprises (1) contacting a 9alpha-halo steroid of formula (I) with a metal selected from the group consisting of tin ...  
WO/1990/009164A1
A composition for topical application in order to induce and promote hair growth and to reduce hair loss contains, in a physiologically acceptable alcohol-based solvent medium, at least 7-alpha-(acetylthio) 4', 5'-dihydrospiro[androst 4-...  
WO/1990/008315A1
Ginsenosides Rb1 and Rg1 enhance the availability of acetylcholine in the cortical and hippocampal regions of the brain and alleviate the symptoms of Alzheimer-type senile demential. The Rb1 or Rg1 may be administered together with a met...  
WO/1990/003184A1
The invention claims an iscom matrix which is not a lipid vesicle comprising at least one lipid and at least one saponim but no intentional antigenic determinants and optionally also adjuvants for use as an immunomodulating agent, medici...  
WO/1990/003385A1
New 11beta-phenyl-14betaH-steroids of general formula (I), where Z is an oxygen atom or the hydroxyimino-grouping N ~ OH, and M and N are either jointly a second compound or L is a hydrogen atom and M is an alpha-permanent hydroxy group ...  
WO/1990/000174A1
The invention concerns 13-Alkyl-11beta-phenylgonanes of general formula (I), wherein Z, R1, R2, R3 and R4 have the meaning given, a process for their preparation, pharmaceutical preparations containing these compounds, and their use for ...  
WO/1989/003839A1
The invention relates to the field of chemistry and more particularly to the field of therapeutic chemistry. Its specific subject matter concerns compounds of general formula (I), in which R is a hydrogen atom, a lower alkyl, methoxymeth...  
WO/1988/009336A1
Substantially pure saponins are disclosed. The saponins of the present invention are useful as immune adjuvants. Disclosed as well are immune response-provoking compositions comprising an antigen in admixture with the substantially pure ...  
WO/1988/007545A1
Pregnane derivatives represented by general formula (I) (wherein A1 represents a hydrogen atom or a hydroxy group, A2 represents a substituent such as a hydroxy group when A1 represents a hydrogen atom, or A2 represents a hydrogen atom w...  
WO/1988/007050A1
Process for the production of (+)-bicyclo-[3.3.0]octane-3-on-2-carboxylic acid steroid esters having the formula (I), in which X represents oxygen or the -O-(CH2)n-O- or the -O-CH2-C(CH3)2-CH2-O- residue; n represents 2 or 3; R2 represen...  
WO/1988/002252A1
A unique set of compositions of matter characterized by including defined active agents covalently bonded to carbonium ion base groups, as well as the method of creating the compositions. The covalently bonded compositions include base g...  
WO/1987/006706A1
Qualitative and quantitive electrochemiluminescent assays for analytes of interest present in multicomponent liquids. These methods comprise contacting a sample with a reagent labeled with an electrochemiluminescent chemical moiety and c...  
WO/1987/005028A1
Compounds of formula (I), wherein one X is COOR, CH2COOR, CH(COOR)2, CONHR, CH2CONHR, or CN; remaining X's are H, F, CH3, OH, COOR, CH2COOR, CH(COOR)2, CONHR, CH2CONHR, or CN; Y is (i1), (i2), (i3), (i4), or (i5); R is H, alkyl of 1-5 ca...  
WO/1987/002672A1
Novel tetrahydro steroids which are useful in inhibiting angiogenesis and have the following structure: A compound of formula (I), wherein R15 is = O or -OH; wherein R23 with R10 forms a cyclic phosphate of formula (II) or wherein R23 is...  
WO/1986/002078A1
New 24-homo-vitamin D compounds, methods for preparing the same and novel intermediate compounds. The compounds are characterized by vitamin D-like activity of the order of 1alpha,25-dihydroxyvitamin D3, the recognized circulating hormon...  
WO/1986/001208A1
Stereoisometrically pure DELTA2 compound of formula (I) wherein R1 is hydrogen or -(C=O)-R2, wherein R2 is an organic substituent selected from the group consisting of alkyls, alkenyls, alkynyls, cycloalkyls, cycloalkylalkylenes, haloalk...  
WO/1985/000818A1
New derivative of vitamin D, 23,23-difluoro-25-hydroxycholecalciferol, a method for preparing said compound and various new intermediates utilized in such process. The compound is characterized by vitamin D-like activity as evidenced by ...  
WO/1985/000819A1
New derivative of vitamin D, 23,23-difluoro-1,25-dihydroxycholecalciferol. The compound is characterized by vitamin D-like activityas evidenced by its ability to increase intestinal calcium transport. It is further characterized by its r...  
WO/1984/004041A1
A colon-specific drug delivery system based on the use of a synthetic drug glycoside prodrug composition which, when ingested by a mammal, undergoes reaction with glycosidases produced by colonic microflora to release a free drug capable...  
WO/1984/001155A1
Hydroxylated derivatives of vitamin D2., processes for preparing such compounds, intermediates utilized in such processes and certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivatives would find application in the tr...  

Matches 301 - 350 out of 1,408