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JPS6254317B2 |
A process is disclosed for the preparation of 17 beta -hydroxy-3-oxo-l7 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone and 17 beta -hydroxy-3-oxo-17 alpha -pregna-4,6-diene-21-carboxylic acid gamma -lactone of the formula: wherein ...
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JPS6254119B2 |
Novel DELTA 4,9-gonadiene-21-ol-3,20-diones of the formula I wherein X is selected from the group consisting of hydrogen and tritium, R1 is alkyl of 1 to 3 carbon atoms, R2 is alkyl of 1 to 12 carbon atoms and R3 is alkyl of 1 to 4 carbo...
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JPS6253160B2 |
Sterol derivatives of the formula wherein R1 is a hydrogen atom and R2 is lower alkoxy, or R1 and R2 collectively are lower alkylenedioxy and R3 is a sterol hydrocarbon side chain are converted to the corresponding androsten-17-ones by t...
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JPS6252759B2 |
What is disclosed are steroid-21-halogeno-17-(alkyl carbonates), useful as medicaments for the treatment of inflammatory dermatoses, and a method for making them.
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JPS6251279B2 |
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JPS6247878B2 |
Novel steroids of the formula I wherein R1 is linear or branched alkyl of 1 to 12 carbon atoms, unsaturated alkyl of 2 to 8 carbon atoms optionally substituted, optionally substituted aryl of 6 to 12 carbon atoms, optionally substituted ...
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JPS6247199B2 |
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JPS6244560B2 |
This specification relates to the production of 9.alpha.-halo-11.beta.-hydroxy-corticosteroids, to intermediates used in the production of such steroids, and to the production of such intermediates themselves. The specification is partic...
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JPS6240359B2 |
A new process for the preparation of 17 beta -hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone is described herein. The process makes use of androst-4-ene-3,17-dione as the starting material and 17 alpha -ethynyl-17 ...
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JPS6239160B2 |
Novel 7-alkyl- DELTA 4-17 alpha -pregnene-3-ones of the formula I wherein R is selected from the group consisting of saturated and unsaturated alkyl of 2 to 8 carbon atoms, cycloalkyl alkyl of 4 to 8 carbon atoms and arylalkyl of 7 to 12...
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JPS62190195A |
10 beta -Alkynyl-4,9(11)-estradiene derivatives of formula (I): wherein R is hydrogen, C1-C4 alkyl or halogen; n is zero, 1 or 2; R1 and R2 are both hydrogen, or R1 and R2, taken together, form an oxo group or a methylene group; the symb...
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JPS62190196A |
10 beta -Halo-alkynyl estrene derivatives of formula (I): wherein X is halogen; n is zero, 1 or 2; Y is an oxo group or a methylene group; one of R1 and R2 is hydrogen and the other is hydrogen, C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkyny...
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JPS62158300A |
6-Substituted 10 beta -alkynylestrene derivatives of formula (I): wherein X is hydrogen, C1-C4 alkyl or halogen; n is zero, 1 or 2; Y is an oxo group or a methylene group; the symbol @ indicates a single bond or a double bond; R1 is halo...
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JPS6229439B2 |
A new process for the preparation of 17 beta -hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone is described herein. The process makes use of androst-4-ene-3,17-dione as the starting material and 17 alpha -ethynyl-17 ...
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JPS62142197A |
This specification relates to the production of 9.alpha.-halo-11.beta.-hydroxy-corticosteroids, to intermediates used in the production of such steroids, and to the production of such intermediates themselves. The specification is partic...
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JPS6225158B2 |
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JPS6222999B2 |
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JPS6214557B2 |
9 alpha ,21-Dihalo-11 beta ,17 alpha -dihydroxy-6 alpha -fluoro-16 alpha -methylpregna-1,4-diene -3,20-dione 17-esters of the formula in which X1 is chlorine or fluorine, X2 is bromine or chlorine, and Ac is an acyl group derived from a ...
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JPS6212799B2 |
Disclosed is a process for the preparation of a 4,6-dien-3-one steroid by brominating an enolic ether of a 4-en-3-one steroid in a water-containing organic solvent which is substantially free from acetic acid and sodium acetate to give a...
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JPS6212234B2 |
17-ketals of 3-alkoxyestra-2,5(10)-dien-17-ones are prepared by reacting 17-ketals of 3-alkoxyestra-1,3,5(10)-trien-17-ones with sodium or potassium, liquid ammonia and n tertiary alcohol in the presence of an alicyclic hydrocarbon and/o...
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JPS6211000B2 |
The present invention relates to a novel process for the preparation of 11 beta -hydroxy-18-alkyl-estrane compounds by reacting an 11 beta -hydroxy-13-methyl-gonane compound with an excess of an acylhypoiodite to give an estrano-18,11 be...
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JPS6210238B2 |
Novel 17-spirosultines of steroids and the corresponding gamma -hydroxy acids of the formula I wherein R1 is alkyl of 1 to 4 carbon atoms, A is hydrogen and B is hydrogen or hydroxyl of beta configuration or A and B together form a doubl...
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JPS629600B2 |
11-Methylene steroids of Formula I wherein R is hydrogen or acyl, and X is oxygen or two hydrogen atoms have valuable pharmacological properties.
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JPS625920B2 |
Pharmaceutically utilisable 3-ketosteroids which are disubstituted in position 16 and have the formula I in which R3 are alkyl radicals with 1 to 5 carbon atoms, alkenyl or cycloalkyl radicals with 3 to 6 carbon atoms or phenylalkyl radi...
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JPS6212796A |
11 beta -Substituted steroids of formula (I> wherein R1 and R2 are both hydrogen or, taken together, form the group oxo or =CH2; R3 is an alkyl, alkenyl or alkynyl substituent at C-6 or C-7; R5 is alkyl; R6 is hydroxy and R7 is hydrogen,...
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JPS61502960A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS6159320B2 |
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JPS6157808B2 |
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JPS61275294A |
NEW MATERIAL:A 17α-(3'-hydroxypropyl)-androsta-4,6-dien-17β-ol-3-onalkyl-
ene acetal shown by the formula I [Z is group shown by the formula II (A is H or methyl x is 0.1)]. USE: An intermediate for producing 1,2α-methylene-6,7α-difl...
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JPS61275293A |
PURPOSE: To obtain a steroid intermediate for a remedy for a pimple, etc., in high yield by enoletherifying the carbonyl of 20-spirox-4-en-3,21-dione at the 3-position, reducing and subjecting the lactone ring to ring opening, subjecting...
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JPS6156240B2 |
New spirolactones of the formula (I) wherein +tr R is a lower alkyl of up to 5 carbon atoms, and +tr
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JPS61251697A |
NEW MATERIAL:A compound of formula I (R is H, silyl, trityl, t-butyl, benzyl). EXAMPLE: 6,6-Ethylenedioxy-3-tert.-butyldimethylsilyl-20s-formyl-5α-
pregnane. USE: A synthetic intermediate of brassinolides, plant growth-accelerating horm...
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JPS6144879B2 |
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JPS6144880B2 |
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JPS6131115B2 |
Steroid esters of the Formula I I wherein the A, B, C, and D rings can be substituted in the usual manner, R10 is hydrogen or methyl; R13 is alkyl of 1-3 carbon atoms; R17 is 17 alpha -alkynyl or alkadiinyl of up to 4 carbon atoms or 17 ...
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JPS6131116B2 |
The active compounds correspond to the general formula I in which R1 denotes an alkanoyl group or cycloalkanoyl group having 1 to 8 carbon atoms or a benzoyl group and X represents a fluorine atome, a chlorine atom or an alkanoyloxy grou...
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JPS6129960B2 |
Derivatives of 9-chloroprednisolone of the formula in which R1 is alkanoyl with 1 to 8 carbon atoms or benzoyl, and X is fluorine, chlorine, hydroxyl, alkanoyloxy with 1 to 8 carbon atoms or benzoyloxy, are prepared. These compounds are ...
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JPS6126557B2 |
Novel 17-spirosultines and their corresponding gamma -hydroxy acids of the formula I wherein A is hydrogen and B is alkyl of 1 to 4 carbon atoms in the alpha - or beta -position or A and B form a methylene group in the 6 alpha , 7 alpha ...
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JPS6126554B2 |
Novel corticoids of formula I (I), wherein X is beta -hydroxymethylene, beta -fluoromethylene or carbonyl; Y is fluorine, chlorine, hydroxy, or acyloxy of 1-10 carbon atoms; and R1 is acyloxy of 1-10 carbon atoms, possess strong anti-inf...
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JPS6118559B2 |
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JPS6111238B2 |
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JPS611080B2 |
1368005 7-Carboxy steroids and related compounds G D SEARLE & CO 24 Aug 1972 [25 Aug 1971] 39401/72 Heading C2U Novel steroids have the formulµ wherein Z is H, alkali metal, alkaline earth metal/2, ammonium or alkyl; Z1 is H, alkali met...
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JPS615094A |
Novel, multiple-tritiated steroid-20,17- spirolactones of general Formula 1 wherein -A-B is -CH2-CH2-, -CH=CH- or and R is hydrogen or tritium and n is 0 or 1, are usable as tracer materials for the detection of mineralocorticoid receptors.
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JPS61359B2 |
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JPS61358B2 |
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JPS611699A |
C16-unsaturated corticoids are readily transformed to the corresponding 16 alpha -methyl-17 alpha -hydroxy corticoids by use of a DELTA 17(20)-20-silyl ether.
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JPS6050199B2 |
The invention relates to novel spirooxazolidines represented by the formula I (I) wherein R1 is alkyl having from 1 to 4 carbon atoms; R2 is hydrogen, alkyl having from 1 to 4 carbon atoms, alkenyl having from 1 to 4 carbon atoms, or dia...
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JPS60190793A |
The invention relates to the preparation of 9β, 10a-5,7- diene steroids by irradiating the corresponding 9a, 10β steroids with filtered ultraviolet light of an antimony lamp.
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JPS6040439B2 |
17 alpha -butyryloxy-11 beta -hydroxy-21-propionyloxy-4-pregnen-3,20-dione, i.e., hydrocortisone 17-butyrate 21-propionate of the present invention is prepared by acylating hydrocortisone 17-butyrate with propionic acid anhydride or hali...
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JPS60158198A |
The invention relates to novel steroids having the formula:whereinX = CH2-S-R3 or S-S-R4;R1 = 0 or H (βR5);R2 = 0 or H (βR6);R3 = H, acyl (1-18C) or alkyl (1-4C);R4 = H, acyl (1-18C) or hydrocarbyl (1-18C), the acyl or hydrocarbyl grou...
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