Steroids

Matches 451 - 500 out of 894	< 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 >

Document	Document Title
JP2004524325A	Use of steroid derivatives for the treatment of benign and / or malignant tumors The present invention relates to steroid derivatives for use as medicaments. More specifically, the invention also relates to the use of a steroid derivative of 5-androstene-, 5-pregnenolone or corresponding saturated derivatives (andros...
JP3549125B2	Corticoid 17,21-dicarboxylic acid ester and corticosteroid 17-carboxylic acid ester 21-carbonate ester, their manufacturing methods and pharmaceuticals containing these compounds Corticoid 17,21-dicarboxylic esters and corticoid 17-carboxylic esters 21-carbonic esters of the formula I with A equal to CHOH and CHClm CH2, C=0, 9(11) double bond; Y equal to H, F, Cl; Z equal to H, F, methyl, R(1) equal to aryl, heta...
JP3546886B2	Steroid derivatives, drug compositions containing them, and their use as antibiotics or disinfectants PCT No. PCT/US94/02397 Sec. 371 Date Aug. 18, 1994 Sec. 102(e) Date Aug. 18, 1994 PCT Filed Mar. 16, 1994 PCT Pub. No. WO94/20520 PCT Pub. Date Sep. 15, 1994Compounds having a broad range of antimicrobial activity generally have a struct...
JP2004518611A	Aldosterone blocker therapy to prevent or treat inflammation-related disorders Aldosterone blockers used for the treatment and prevention of inflammation are disclosed
JP2004107353A	FULVESTRANT FORMULATION To provide a new sustained release formulation containing a compound, 7α-[9-(4, 4, 5, 5, 5-pentafluoropentylsulphinyl)nonyl]oestra-1, 3, 5(10)-triene-3, 17β-diol, suitable for administration by injection.The pharmaceutical formulation ...
JP2004505990A	17β-Carbothioate-17α-arylcarbonyloxyloxyandrostane derivative as an anti-inflammatory agent According to one aspect of the invention, there is provided a compound of formula (I) and solvates thereof. There are also provided compositions containing the compound, processes for preparing it, and its use in therapy.
JP2004504403A	Oxidation method for the production of intermediate 6α, 9α-difluoro-11β, 17α-dihydroxy-16α-methyl-androsta-1,4-diene-3-one-17β-carboxylic acid The present invention relates to a process for the preparation of a compound of formula (I) which comprises the following step: wherein step (a) comprises oxidation of a solution containing the compound of formula (II) wherein the soluti...
JP3490470B2	BILE ACID SULFURATED DERIVATIVE PURPOSE: To obtain a new compd. showing increased metabolism stability, antioxidant property and radical scavenging activity in comparison with natural bile acid and useful as an anti-cholestasis agent, choleretic, a hepatocyte protectin...
JP3484197B2	INDUSTRIAL APPLICABILITY Amine-derived nucleosides and oligonucleosides. Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2'-, 3'-, 5'-, nucleobase and internucleotide linkage sites. The folate can be attached via the alpha...
JP3466651B2	NEW STEROID HAVING METHYLENE LACTONE GROUP ON 17-TH POSITION, ITS PRODUCTION, ITS INTERMEDIATE, ITS USE AS PHARMACEUTIC, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME PURPOSE: To obtain a new steroid which contains a methylene lactone group on 17-th position, which shows various hormonal activities and antihormonal activities and which is useful as a therapeutic drug for prostatic hyperfrophy, virilis...
JP3462515B2	17-SPIROFURAN-3'-YLIDENE STEROID PURPOSE: To obtain the subject new compounds that have notable affinity to progesterone receptors, have little affinity to mineral corticoids, and are useful as drugs contg. anti-progestin activity having improved selectivity. CONSTITUTI...
JP2003532420A	INDUSTRIAL APPLICABILITY: Production of adenine nucleotide translocator (ANT), novel ANT ligand and screening assay thereof. Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands an...
JP2003531148A	INDUSTRIAL APPLICABILITY A process for the preparation of a 7-α-hydroxy 3-amino-substituted steroid using an intermediate having an unprotected 7-α-hydroxy group. An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be...
JP3445271B2	[Title of the Invention] A novel 19-norsteroid having a thiocarbonate chain at the 11β position, a method for producing the same, an intermediate of the method, its use as a drug, and a composition. Compounds of formula (I), wherein R17 and R'17 are such that: either R17 and R'17 together form ketone, hydrazono, oxime or methylene, or R17 is hydroxyl, hydroxymethyl or acyloxy and R'17 is hydrogen, alkyl or optionally substitued alke...
JP3424978B2	MONOMERIC BILE ACID DERIVATIVE, ITS PREPARATION AND USAGE OF THE COMPOUND AS MEDICAMENT PURPOSE: To obtain a new compound usuful as a drug effective as hypolipidemic medicine with a small amount which suppress the bile acid absorption concentration-dependently and antagonistically, and has high affinity for the peculiar bil...
JP2003520238A	INDUSTRIAL APPLICABILITY The use of dehydroepiandrosterone, a precursor and a derivative thereof by oral administration as a wettable powder having a direct action. The invention concerns the use of at least a compound selected in the group consisting of dehydroepiandrosterone, its chemical precursors, its chemical derivatives, its biological precursors and metabolic derivatives, for preparing a com...
JP2003176297A	STEROID SULFATASE INHIBITOR To provide a pharmaceutical composition which is effective on the treatments of estrogen-dependent tumors.This pharmaceutical composition comprises a pharmaceutically acceptable carrier or diluent and a compound which contains a ring sys...
JP3418428B2	17-SPIROMETHYLENE STEROID PURPOSE: To provide the novel steroid compounds whose steroid skeleton is bound at carbon atom 17 to a spiromethylene ring having progestational activity and antiprogenstational activities, and useful as contraceptive medicines. CONSTITU...
JP2002543218A	[Title of the Invention] A 3α-hydroxy-3β methoxymethyl-21-heterocyclic substituted steroid having anesthetic activity. This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: R1 is H or methyl; R2 is 5alpha- or 5beta-H; R3 is an optionally substituted N-attached heteroaryl grou...
JP2002543069A	INDUSTRIAL APPLICABILITY: Enantiomers of mercaptolactones and methods for synthesizing them. An improved process for the preparation of single enantiomers of formula (I), and novel intermediates and processes thereto.
JP2002542255A	[Title of the Invention] Ent-steroid as an estrogen with selective activity This invention describes the new ent-steroids of general formula (I) in which R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, R<10>, R<11> and R<19> have the meanings that are indicated in the description, as pharmaceutical active ...
JP2002539134A	INDUSTRIAL APPLICABILITY: 22R-hydroxycholesta-8,14-diene derivative for inhibition of meiosis The invention relates to 22R-hydroxycholesta-8,14-diene derivatives having general formula (I) wherein R1 is OR, OS03H or =NOR; with R being H, (C1-6)alkyl or (C1-6)acyl; each of R2 and R3 is independently hydrogen or (C1-6)alkyl; R4 is ...
JP2002322168A	COMPOUNDS To provide pharmaceutical compounds which reduce undesirable effects occurred at the region where is apart from the target site.Pharmaceutical compounds represented by general formula (I) or their salts or solvates, which are effective i...
JP2002536455A	INDUSTRIAL APPLICABILITY: 16-Hydroxyestratriene as a selective estrogen 3,16-Dihydroxy-1,3,5(10)-estratriene derivatives (I) are new. 3,16-Dihydroxy-1,3,5(10)-estratriene derivatives of formula (I) are new: [Image] thick black line in ring = single or double bond; R 1>H, halo, OH, Me, CF 3, OMe or OEt; R 2>H...
JP2002308776A	MEDICINAL COMPOSITION FOR TREATING HUMAN PROSTATIC ADENOCARCINOMA To provide a medicinal composition useful in the therapy for human prostatic adenocarcinoma.The medical composition for treating human prostatic adenocarcinoma contains a 5-α-reductase inhibiting compound such as 17β-(N-t- butylcarboxy...
JP2002533471A	INDUSTRIAL APPLICABILITY The novel 7-alpha and 17-alpha-bis-alkylated testosterone derivatives and their use in long-term treatment of androgen-dependent diseases. The invention relates to new 7 alpha , 17 alpha , 17 beta -substituted testosterone derivatives of general formula (I) and their use as pure antiandrogens for the long-term therapy of androgen-dependent diseases, notably for the long-ter...
JP3328938B2	[Title of Invention] Androstenedione derivative The invention provides new androstene derivatives having anti-inflammatory activity, pharmaceutical compositions containing them, and methods of administering them to warm-blooded animals in the treatment of inflammation. The active comp...
JP2002255993A	STEROID SULFATASE INHIBITOR To obtain a pharmacological composition effective for treating an estrogen-dependent tumor.This pharmacological composition comprises a pharmacologically acceptable carrier or diluent and a compound which contains a ring system and a sul...
JP3295426B2	INDUSTRIAL APPLICABILITY [Title of Invention] Antihypercholesterolemia compound, related pharmaceutical composition, and method of use. Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has the structural formula (I) (I) wherein R is a C-17 side chain, R1 is -OH, =O, or the like, and X and Y are CH, C-OH, C-OCH3 or C-Z. Methods of using ...
JP2002510295A	INDUSTRIAL APPLICABILITY: Non-estrogen derivative of estradiol having antioxidant activity. New non-estrogenic derivative compounds of estradiol, which have no estrogenic activity and comparatively high anti-oxidative activity, are disclosed. These new non-estrogenic derivative compounds are potentially useful as non-estrogenic...
JP3256236B2	INDUSTRIAL APPLICABILITY [Titles] Thiol-derived nucleosides and oligonucleosides Nucleosides and linked nucleosides functionalized to include alkylthiol chemical functionality at ribofuranosyl positions, nucleosidic base positions, or on internucleoside linkages. In certain embodiments, the compounds of the invention...
JP2002047187A	TELOMERASE INHIBITOR To obtain a telomerase inhibitor and an antitumor medicine comprising a substance having telomerase inhibitory actions as an active ingredient.This telomerase inhibitor comprises a compound represented by the following general formula (I...
JP2001527552A	INDUSTRIAL APPLICABILITY The pharmaceutically acceptable salt and CNS disorder of 5-α-pregnane-3β, 16α-diol-20-one 3-sulfate ester useful as progestin. The invention provides a pharmaceutically acceptable salt of 5 alpha -pregnan-3 beta , 16 alpha -diol-20-one 3-sulfate ester, which is useful as a progestational agent.
JP2001527088A	[Title of the Invention] A method for producing a pharmaceutical preparation containing 11β-halogen-7α-substituted estratriene and the 11β-halogen-7α-substituted estratriene, and use of the pharmaceutical preparation for manufacturing a pharmaceutical product. This invention describes the new 11beta-halogen-7alpha-substituted estratrienes of general formula Iin whichR<11 >is a fluorine or chlorine atom, and the other substituents have the meanings that are explained in more detail in the descr...
JP2001526233A	INDUSTRIAL APPLICABILITY: Angiogenesis inhibitor and a composition for controlling ocular hypertension. Compositions of angiostatic agents for treating GLC1A glaucoma and methods for their use are disclosed.
JP2001526654A	INDUSTRIAL APPLICABILITY: Sulfate ester of B-ring estratriendiol This invention provides estrogenic agents having formula (I) wherein A and B are each, independently, (a), (b), (c), or (d), R is SO3<->X<+>; X<+> is alkali metal, alkaline earth metal, ammonium, alkylammonium containing 1-6 carbon atoms...
JP2001526673A	[Title of Invention] 20-Alalkyl-5α-pregnane derivative The invention relates to 20-aralkyl-5alpha-pregnane derivative having general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is (H,OR), (H,OSO3H) or NOR; R is H, (C1-6)alkyl or (C1-6)acyl; each of R2 and R3 is ind...
JP2001525805A	INDUSTRIAL APPLICABILITY: A salt of a 5-α-pregna-16-ene-3β-ol-20-one 3-sulfate ester having progestin activity. This invention provides a pharmaceutically acceptable salt of 5 alpha -pregn-16-en-3 beta -ol-20-one 3-sulfate ester, which is useful as a progestational agent.
JP2001525806A	INDUSTRIAL APPLICABILITY 19-Norandroste-17-one derivative having an estrogenic aromatic B ring. This invention provides 3 beta -hydroxy-5,7,9-estratriene-17-one and a pharmaceutically acceptable salt of its 3-sulfate ester, which is useful as an estrogen.
JP3237882B2	BILE ACID DERIVATIVE, ITS PRODUCTION AND USE OF THE COMPOUND AS MEDICINE PURPOSE: To prepare a bile acid derivative having high affinity for the specified bile acid transport system of the small intestine, inhibiting bile acid absorption in a concentration-dependent and competitive manner and effective for th...
JP3231909B2	NEW PREPARATION PROCESS FOR 20-KETO-21(S) HYDROXY STEROID COMPOUND AND INTERMEDIATE PURPOSE: To provide a new process for efficiently preparing the subject compound useful as a hormone agent, etc., by treating 21-(R,S)-acetoxy steroid compound with a diastereoselective hydrolyzing agent, sulfonylating the treated compou...
JP2001322995A	STEROID DERIVATIVE AND METHOD OF PRODUCING THE SAME To provide a steroid derivative that can be derived to a variety of estrane derivatives, for example, an estrane-3-O-sulfamate derivative that acts as an inhibitory substance against estrogen sulfatase that produces estrogens as a pathog...
JP2001523268A	INDUSTRIAL APPLICABILITY: Pregnane-3,20-diol mono and disulfate ester This invention provides a compound having formula (I) wherein R and R<1> are each, independently, hydrogen or SO3<->X<+>; X<+> is alkali metal, alkaline earth metal, ammonium, alkylammonium containing 1-6 carbon atoms, or dialkylammonium...
JP2001523266A	INDUSTRIAL APPLICABILITY The pharmaceutically acceptable salt of 3-hydroxy-estra-5 (10) -en-17-one 3-sulfate ester active as estrogen. This invention provides a pharmaceutically acceptable salt of 3 beta -hydroxy-5(10)-estrene-17-one 3-sulfate ester and a pharmaceutically acceptable salt of 3 alpha -hydroxy-5(10)-estrene-17-one 3-sulfate ester, which are useful as estro...
JP2001520235A	INDUSTRIAL APPLICABILITY: Estra-1,3,5 (10) -triene-7α-thioether The invention provides estrogens and antiestrogens of formula (I) having structure (I) wherein R is (II), (III), (IV), or (V); R<1> and R<2> are each, independently, alkyl of 1-6 carbon atoms, or are alkyl groups which are taken together...
JP2001518896A	INDUSTRIAL APPLICABILITY: Estrogen-active estra-5 (10), 7-diene This invention provides estra-5(10),7-dien-3 beta -ol-17-one or a pharmaceutically acceptable salt of its 3-sulfate ester, estra-5(10),7-dien-3 beta -ol-17-one 3-glucuronide or a pharmaceutically acceptable salt thereof, estra-5(10),7-di...
JP3219408B2	[Title of Invention] Steroid Sulfatase Inhibitor The present invention provides a pharmaceutical composition comprising a compound admixed with a pharmaceutically acceptable diluent or carrier; wherein the compound has the the formula wherein each of R1 and R2 is independently selected...
JP3205389B2	NEW STEROID HAVING SUBSTITUENT AT 6-POSITION AND THIOETHYL GROUP AT 10-POSITION, ITS PREPARATION, INTERMEDIATE IN ITS PREPARATION, ITS USE AS PHARMACEUTICAL AGENT AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME PURPOSE: To provide the new steroids having specific aromatase-inhibitory properties. CONSTITUTION: The steroids are compounds represented by the formula I (wherein: R is a substituent such as 1-4C alkyl or alkenyl group; Y is O or a res...
JP3202240B2	INDUSTRIAL APPLICABILITY: Method for producing 3-amino-substituted glycosylated bile acid The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Novel intermediates and related compounds are also disclosed.
JP2001509792A	INDUSTRIAL APPLICABILITY The method for producing 9,11-epoxy steroid and an intermediate useful for the method. Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein-A-A- represents the group -CHR4-CHR5- or -CR4=CR5-;R3, R4 and R5 are in...

Matches 451 - 500 out of 894	< 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 >