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WO/2012/027957A1 |
Bufalin derivatives of formula I and the pharmaceutical compositions thereof are provided, wherein the radicals have the meanings as defined in the invention. The use of these derivatives is also provided.
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WO/2011/132045A2 |
The present invention provides novel process for preparation and purification of dienogest (I). The present invention provides dienogest (I) substantially free of impurities.
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WO/2011/119194A1 |
The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. New compounds and methods for treating these conditions are disclosed. Embodiments of the instant invention disclose meth...
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WO/2011/036557A1 |
Compositions, methods and compounds useful for enhancing the uptake of a lipid particle b\ a cell are described In particular embodiments, the methods of the invention include contacting a cell with a lipid particle and a compound that b...
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WO/2011/029639A2 |
The invention features compounds, pharmaceutical compositions and methods useful for the treatment of neoplasia. In particular embodiments, the compounds of the invention are useful for the treatment of multidrug resistant neoplasia.
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WO/2010/136940A1 |
This invention relates to novel glucocorticoid receptor agonists of formula (I) and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to th...
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WO/2010/128472A1 |
Process for preparing glycocholic acid comprising the following steps: a) making a mixed anhydride of cholic acid through the suspension of cholic acid in acetone or in aqueous acetone in presence of a base, and subsequent reaction with ...
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WO/2010/126953A1 |
New chemical entities which comprise corticosteroids and phosphorylated β- agonists for use in therapy and compositions comprising and processes for preparing the same are provided.
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WO/2010/123545A2 |
Compounds of Structural Formula I or pharmaceutically acceptable salts thereof, are effective inhibitors of angiogenesis:
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WO/2010/118025A1 |
Described herein are compounds which exhibit progesterone antagonistic effects and methods of treating cancer using such compounds.
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WO/2010/118023A1 |
Described herein are methods of making drospirenone. Also described are intermediate compounds that may be used to synthesis drospirenone.
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WO/2010/106383A1 |
The present invention relates to novel crystalline Form A of 17α-acetoxy-21-methoxy- l lβ-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-
dione, (also known as CDB-4124) and methods for the preparation of it in excellent purity.
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WO/2010/102673A1 |
The present invention relates to new cardiotonic Steroid Compounds of Formula (I) or (II) wherein X1, X2, X3, L, R1, R2, R3, R4, and R5 have the same meaning as that defined in the Claims. The invention also relates to the use of said Co...
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WO/2010/092381A1 |
A process for the preparation of cholyl-L-lysine comprising the steps of:- (a) reacting N-ε-CBZ-cholyl-L-lysine with a hydrogen source in the presence of a catalyst in a solvent comprising one or more alkanols; (b) removing the catalyst...
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WO/2010/071772A2 |
The present invention relates to methods for synthesizing preferred membrane-binding elements, preferably cholesterylamine derivatives, including 3-amino-5-cholestene (3-cholesterylamine) and related 3-halides through i-steroid and retro...
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WO/2010/059853A1 |
The invention relates to compounds of Formula A: (A) or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory ...
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WO/2010/043506A1 |
Method for preparing 2-alkoxy and 2-aryloxyestrogen compounds, and the intermediate compounds prepared during the use of this method, which intermediate compounds are useful intermediates in the preparation of certain physiologically act...
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WO/2010/015529A1 |
The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof. The compounds are useful in the treatment of illnesses wherein the known steroid, parent or precursor steroid, is g...
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WO/2010/015875A1 |
The present invention concerns a process for the preparation of lanosta-8-ene compounds having lanosta-8-ene-7-one or lanosta-8-ene-7-ol compounds as starting material.
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WO/2010/012904A2 |
The present invention relates to novel chemical compounds, in particular cholest-4-en-3-one oxime derivatives, and to the use thereof as medicaments, especially as cytoprotective medicaments, in particular as neuroprotective, cardioprote...
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WO/2010/012567A1 |
The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of usi...
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WO/2009/144738A1 |
Novel benzoic acid hydrazones of 5α-androstan-3, 17-dione have been prepared on the basis of steroidal tigogenin of the plant Yucca gloriosa. The hvdrazones of the General Formula (I), General Formula (II) and General Formula (III) as s...
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WO/2009/146218A2 |
This invention provides novel compounds comprising the following anti-inflammatory pharmacore Formula (I): wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprisin...
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WO/2009/122435A2 |
The present invention relates to preparation and biological evaluation of 3-acetoxy-17- acetamido-16-formyl-androst-5,17-diene (4) and 3-acetoxy2'-chloro-5-androsteno [17,16- b]pyridine (5) as gastric proton pump inhibitor and their comp...
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WO/2009/083268A2 |
The invention relates to 17-(1'-propenyl)-17-3'-oxidoestra-4-en-3-one derivatives with general chemical formula (1) wherein the radicals Z, R4, R6a, R6b, R7, R15, R16a, R16b and R18 have the designations given in claim 1, and to the solv...
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WO/2009/082818A1 |
The invention relates to 21 -keto triterpene compounds of formula (I): wherein R1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, th...
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WO/2009/082819A1 |
The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, th...
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WO/2009/053439A2 |
The invention relates to the technical field of anti-inflammatory compounds, specifically those of a steroid nature, in particular to a new amorphous form of a nitrooxy derivative of a corticosteroid, its pharmaceutical formulations and ...
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WO/2009/054725A2 |
The invention provides means and methods for alleviating one or more symptom(s) of Duchenne Muscular Dystrophy and/or Becker Muscular Dystrophy. Therapies using compounds for providing patients with functional muscle proteins are combine...
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WO/2009/050483A1 |
This invention relates to cationic lipids. More particularly the invention relates to biodegradable cationic lipids having a plurality of cationic headgroups and one or more lipophilic tail groups. The lipids are of utility in various ap...
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WO/2009/047101A1 |
New aminooxime derivatives at position 3 of 2-and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as he...
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WO/2009/047006A2 |
An amphoteric liposome comprising neutral lipids wherein said neutral lipids are selected from the group comprising cholesterol or mixtures of cholesterol and at least one neutral or zwitterionic lipid and wherein K (neutral) of said mix...
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WO/2009/033505A1 |
The present invention relates to new cardiotonic steroids and their use in the treatment of cancer, in particular to compounds of Formula (I), stereoisomers, tautomers, racemates, prodrugs, metabolites, or a pharmaceutically acceptable s...
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WO/2009/027994A2 |
The present invention relates to steroidal esters of 17-oximino -5-androsten-3-ol,of compound of general formula (A) wherein R is selected form a group consisting of arylalkyl, aryl, substituted aryl. The ester derivatives are synthesize...
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WO/2009/027108A1 |
The present invention relates to a new process for preparing estrogen-antagonistic 11 β-fluoro-17α-alkylestra-1,3,5(10)-triene-3,17-diols of the general formula (I) having a 7α-(ξ-alkylamino-ω-perfluoroalkyl)alkyl side chain and to ...
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WO/2009/024022A1 |
Fatty acid bile acid conjugates of formula I, pharmaceutically acceptable salts, their preparation methods, pharmaceutical compositions containing the same, and the uses of the fatty acid bile acid conjugates or their pharmaceutically ac...
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WO/2009/001148A2 |
The present invention relates to a process for the synthesis of the known 17-acetoxy-11-β-[4-(dimethylamino)-phenyl]-21-methoxy-19-no
rpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-etandiyl-bis(oxy)]-oest...
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WO/2008/155141A2 |
A facultative cationic sterol derivate, said sterol derivate has a pka value of between 3.5 and 8 and the general formula Cation-Spacer 2-Y-Spacer 1-X-Sterol wherein X and Y are linking groups and wherein at least on of X and Y is -NH(C=...
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WO/2008/151745A1 |
The 17ß-cyano-18a-homo-19-nor-androst-4-ene derivatives of the present invention have gestagenic activity. They have the general chemical formula (1), in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO...
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WO/2008/151746A2 |
The 17ß-cyano-19-nor-androst-4-ene derivatives of the present invention have gestagenic activity. They have the general chemical formula (1), in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, where...
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WO/2008/152112A2 |
The 17ß-cyano-19-androst-4-ene derivatives of the present invention have gestagenic activity. They have the general chemical formula (1), in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, wherein R...
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WO/2008/134668A2 |
Disclosed herein are heat-labile prodrugs, their preparation and uses.
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WO/2008/128844A1 |
The present invention relates to a novel method for preparing tauroursodeoxycholic acid which comprises a step of selective precipitation of the impurities present in the suspension obtained from the reaction of an aqueous solution of so...
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WO/2008/124878A1 |
The present invention relates to non-steroidal compounds useful in the treatment of inflammatory conditions and pharmaceutical compositions comprising them. A representative example of these compounds is formula (III).
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WO/2008/124922A1 |
Compounds having the structure, their salts or N-oxide derivatives: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, a...
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WO/2008/109936A1 |
The present invention provides a compound of Formula I, pharmaceutical compositions and methods of use thereof.
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WO/2008/099414A1 |
The present invention provides a novel series of cationic, lipid-based, 17α-substituted-estradiol derivatives. The present invention further provides a process for the preparation of a novel series of 17α-substituted-estradiol derivati...
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WO/2008/095806A1 |
The invention relates to nitrooxyderivative of corticosteroids of generalformula (I) and pharmaceutically acceptable salts or stereoisomers thereof wherein R is the corticosteroid residue of formula (II): wherein: R1 is OH, R2-CH3, or R1...
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WO/2008/095809A1 |
The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof wherein R is the corticosteroid residue of formula (II): The compounds are useful in the...
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WO/2008/095808A1 |
The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof wherein R is a corticosteroid residue selected from: The compounds are useful in the tre...
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