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JPS63190897A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS6338040B2 |
Novel 17-[(hydroxymethyl)formamido methylene]-steroids of the formula I wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with halogen or an oxygen or nitrogen function and ...
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JPS6337796B2 |
Novel 19-nor-steroids of the formula I' wherein R1 and R2 taken together form a cycloalkyl of 3 to 8 carbon atoms or are individually selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of...
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JPS6337797B2 |
A process for the preparation of the isomers of a compound of the formula (I> CMR20=CH-X-Z wherein M is lithium, sodium or potassium; R20 is fluorine, chlorine atom or NR alpha R beta in which R alpha and R beta are the same or different...
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JPS63132897A |
(C1-C4)alkyl prednisolone- or methylprednisolone-21-carbonate is rearranged using lithium di-(C1-C4)alkylcuprate.e
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JPS6310159B2 |
3-enol ethers of 11 beta -hydroxy- DELTA 4-pregnene-3-ones are prepared by reacting triethylorthoacetate with an 11 beta -hydroxy- DELTA 4-pregnene-3-one in a solvent which is at least 40% by weight or more ethanol and 60% by weight or l...
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JPS6261599B2 |
The invention refers to compounds having anti-inflammatory activity, characterized by the formula (I) in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents at the carbon ato...
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JPS6254438B2 |
The novel product, 9 alpha ,11 beta -dichloro-16 alpha -methyl-21-oxycarbonyldicyclohexylmethoxy- DELTA 1,4-pregnadiene-3,20-dione, having surprenant "in loco" anti-inflammatory activity without any systemic anti-inflammatory activity an...
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JPS62230726A |
PURPOSE: A remedy, constituted of a fat emulsion containing a steroid having immunosuppressive action, useful for treating autoimmune diseases, e.g. chronic rheumarthritis, systemic lupus erythematosus, etc., having improved activity sus...
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JPS62228021A |
Postsurgical adhesions are reduced or prevented by the topical administration to the site of surgical trauma of tissue a glucocorticoid, in small amounts continually over the critical wound healing period.
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JPS6247199B2 |
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JPS6245846B2 |
1479488 Inhalant compositions SCHERING AG 24 June 1974 [23 June 1973] 27902/74 Heading A5B Inhalant compositions suitable for treatment of allergic disorders of the respiratory tract comprise a corticoid of formula:- in which -B-A- repre...
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JPS6245878B2 |
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JPS6244560B2 |
This specification relates to the production of 9.alpha.-halo-11.beta.-hydroxy-corticosteroids, to intermediates used in the production of such steroids, and to the production of such intermediates themselves. The specification is partic...
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JPS6241680B2 |
New 16-methyl-9 alpha -halo corticosteroid esters and ethers having high topical anti-inflammatory potency and low systemic activity and the manner in which they can be produced are described.
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JPS6238359B2 |
Novel DELTA 4-pregnenes of the formula I wherein X1 is selected from the group consisting of =O and Y is selected from the group consisting of hydrogen and halogen, R1 is selected from the group consisting of hydrogen and acyl of an orga...
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JPS6234040B2 |
Corticoid-21-sulphopropionate derivs. of formula (I) and their salts with pharmaceutically-acceptable bases are new: (St = steroid residue of an antiinflammatory corticoid; esp. it has formula (X = H, Cl, F or CH3; Y = H, F or Cl; Z = ox...
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JPS6229438B2 |
Procedure for preparing new 2,2-dimethyl-19-nor-steroids of formula I: * (see formula I) * in which R1 represents a hydrogen atom, a hydroxyl group, an acyloxy group OCOR2, R2 representing a hydrocarbon radical containing from 1 to 17 ca...
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JPS62142197A |
This specification relates to the production of 9.alpha.-halo-11.beta.-hydroxy-corticosteroids, to intermediates used in the production of such steroids, and to the production of such intermediates themselves. The specification is partic...
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JPS6228157B2 |
New and useful steroids of the pregnane series and compositions therefor are disclosed of the formula: (I) wherein R1 is selected from the group consisting of H, F, OH, and OR2, and R2 is carbacyl of one to eighteen carbon atoms, which s...
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JPS6228158B2 |
This invention discloses a general process for the production of corticoids from androstenes. This invention provides an economically viable alternative synthesis of 17 alpha -hydroxyprogesterones and the corticoids.
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JPS6227075B2 |
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JPS6227076B2 |
1. A process for the preparation of a 17 alpha-(3-iodobenzoyloxy)-9 alpha-chloro-4-pregnene-3,20-dione or a D-homo homolog thereof of the formula I see diagramm : EP0001737,P9,F2 wherein n is 0 or 1 ; C1 ~-~-~- C2 represents a C-C single...
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JPS62123196A |
NEW MATERIAL:An inclusion compound of prednisolone with heptakis (2,6-di-O- methyl)-β-cyclodextrin. External appearance; white crystalline powder. solubility; greatly soluble in water. USE: Water-solubility of an adrenal cortex steroid ...
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JPS6222999B2 |
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JPS6222996B2 |
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JPS6220197B2 |
The novel compounds of the formula I, in which the substituents have the meaning indicated in Patent Claim 1, are prepared by esterifying a compound of the formula II with salicylic acid or acetylsalicylic acid. The novel compounds of th...
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JPS6214558B2 |
The present invention relates to pregnane derivatives of the formula wherein R1 and R3 are hydroxyl groups or readily cleavable etherified or esterified hydroxyl groups and R20 is hydroxymethyl or readily cleavable etherified or esterifi...
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JPS6214556B2 |
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JPS6214557B2 |
9 alpha ,21-Dihalo-11 beta ,17 alpha -dihydroxy-6 alpha -fluoro-16 alpha -methylpregna-1,4-diene -3,20-dione 17-esters of the formula in which X1 is chlorine or fluorine, X2 is bromine or chlorine, and Ac is an acyl group derived from a ...
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JPS6211000B2 |
The present invention relates to a novel process for the preparation of 11 beta -hydroxy-18-alkyl-estrane compounds by reacting an 11 beta -hydroxy-13-methyl-gonane compound with an excess of an acylhypoiodite to give an estrano-18,11 be...
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JPS61502960A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS6150960B2 |
1530975 9,11 - Dihalo - 16 - methyl steroids ROUSSEL UCLAF 2 March 1977 [2 March 1976] 08713/77 Heading C2U The invention comprises compounds of formula (wherein L is H or C 1-18 acyl, and either X is Cl or Br and Y is Cl, or X is Cl and...
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JPS6145970B2 |
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JPS6144844B2 |
Pharmaceutical compositions containing a corticosteroid and an ester of L-arginine with an aliphatic alcohol exhibit a synergistic effect in the protection against shock. The corticosteroid may be 6- alpha -methylprednisolone-21-hemisucc...
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JPS6131115B2 |
Steroid esters of the Formula I I wherein the A, B, C, and D rings can be substituted in the usual manner, R10 is hydrogen or methyl; R13 is alkyl of 1-3 carbon atoms; R17 is 17 alpha -alkynyl or alkadiinyl of up to 4 carbon atoms or 17 ...
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JPS6131116B2 |
The active compounds correspond to the general formula I in which R1 denotes an alkanoyl group or cycloalkanoyl group having 1 to 8 carbon atoms or a benzoyl group and X represents a fluorine atome, a chlorine atom or an alkanoyloxy grou...
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JPS6129960B2 |
Derivatives of 9-chloroprednisolone of the formula in which R1 is alkanoyl with 1 to 8 carbon atoms or benzoyl, and X is fluorine, chlorine, hydroxyl, alkanoyloxy with 1 to 8 carbon atoms or benzoyloxy, are prepared. These compounds are ...
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JPS6126554B2 |
Novel corticoids of formula I (I), wherein X is beta -hydroxymethylene, beta -fluoromethylene or carbonyl; Y is fluorine, chlorine, hydroxy, or acyloxy of 1-10 carbon atoms; and R1 is acyloxy of 1-10 carbon atoms, possess strong anti-inf...
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JPS6123799B2 |
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JPS61112095A |
The invention relates to new pregnene derivatives of the general formula (I), (I) wherein R1 stands for a C1-4 alkyl group; R2 stands for a hydrogen atom or a C2-4 alkanoyl group; R3 stands for a hydrogen atom, a hydroxyl group or a C2-4...
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JPS6118559B2 |
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JPS6116249B2 |
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JPS6172798A |
A process for preparing a 17 alpha -hydroxy-20-keto steroid comprises contacting a DELTA <1><6>-20-keto steroid with a silylating agent in the presence of a catalyst, and contacting the resultant DELTA <17(20)>-20-silyl ether steroid (so...
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JPS611438B2 |
There is disclosed 16 alpha-methyl-17 alpha-bromo-1,4-pregnadiene-21-ol-3,20-dione-type compounds of the formula where R is hydrogen or acyl; X is hydrogen, bromine, or fluorine; Y is hydrogen or oxygen; and Z is hydrogen or alpha - or b...
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JPS611080B2 |
1368005 7-Carboxy steroids and related compounds G D SEARLE & CO 24 Aug 1972 [25 Aug 1971] 39401/72 Heading C2U Novel steroids have the formulµ wherein Z is H, alkali metal, alkaline earth metal/2, ammonium or alkyl; Z1 is H, alkali met...
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JPS611033B2 |
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JPS611079B2 |
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JPS61356B2 |
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JPS611699A |
C16-unsaturated corticoids are readily transformed to the corresponding 16 alpha -methyl-17 alpha -hydroxy corticoids by use of a DELTA 17(20)-20-silyl ether.
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