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JPS60502056A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS60237096A |
A novel process for the preparation of prednisone derivatives of the formula I wherein R1 is alkyl of 1 to 4 carbon atoms and R2 is selected from the group consisting of hydrogen and hydrocarbon of 1 to 8 carbon atoms comprising reacting...
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JPS6052160B2 |
1365469 D-homosteroids F HOFFMANNLA ROCHE & CO AG 29 March 1973 [29 March 1972] 15112/73 Headings C2U and C2C The invention comprises compounds of formula (wherein R6 is H, F, Cl or Me; R9 is H, F, Cl or Br; and R17 and R21 are each hydr...
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JPS6050799B2 |
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JPS60222495A |
A compound of the formulawherein St represents a corticosteroid moiety bonded to the carbonyl via the 21-hydroxy group of said corticosteroid; wherein Z is a bond or -O-; wherein n is an integer from 4 to 9; wherein Q is (1) Y-CH2COOH wh...
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JPS6044320B2 |
A series of novel steroidal 9,11 beta -dihalo-[16 alpha ,17-b]-1,4-dioxanes is disclosed herein. These compounds are useful as anti-inflammatory agents.
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JPS6044318B2 |
1512400 16,17-Naphthopregnenes E R SQUIBB & SONS Inc 13 Nov 1975 [25 Nov 1974] 46902/75 Heading C2U The invention comprises #4 and #1'4 steroids of formula wherein R 1 is Cl, F or OH; R1 1 is H; or R 1 and R1 1 together are oxo; R 2 is H...
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JPS60190792A |
PURPOSE: To obtain the titled compound usefuel as an anti-inflammatory agent in high yield, by reacting a reaction product of a specific carboxylate and a fluorine gas with a 11β-hydroxysteroid compound. CONSTITUTION: A carboxylate (e.g...
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JPS6043358B2 |
New 16-methyl-9 alpha -halo corticosteroid esters and ethers having high topical anti-inflammatory potency and low systemic activity and the manner in which they can be produced are described.
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JPS60188398A |
PURPOSE: To produce the titled fluorine-containing steroid compound useful as an anti-inflammatory agent, in high yield, by reacting an alkali metal salt of an organic acid with fluorine gas, reacting the product with Δ3.5-pregnadiene d...
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JPS6040440B2 |
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JPS6040439B2 |
17 alpha -butyryloxy-11 beta -hydroxy-21-propionyloxy-4-pregnen-3,20-dione, i.e., hydrocortisone 17-butyrate 21-propionate of the present invention is prepared by acylating hydrocortisone 17-butyrate with propionic acid anhydride or hali...
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JPS60158199A |
PURPOSE: In reacting pregnan 21-iodosteroid with phosphoric acid in the presence of a tertiary amine, to obtain the titled compound useful as an anti-inflammatory ointment in high yield, making ≥ a specific molar ratio of an amount of ...
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JPS60139697A |
Hydrocortisone and prednisolone derivatives of the general formula I in which ... is a single bond or a double bond, R is a 1-oxoalkyl radical with 2 to 6 carbon atoms, a benzoyl radical or an alkoxycarbonyl radical, are substances with ...
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JPS60116699A |
PURPOSE: A steroid is clathrated by allowing it to react with cyclic (1-2)-β-D- glucan to form the titled clathrate which can solubilize the steroid which is hard soluble in water without aid of toxic surface active agent, thus being us...
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JPS6019320B2 |
An improved process for isolating 3-hydroxy steroids and 3-keto steroids from mixtures thereof with lipids by dissolving the mixtures in an organic solvent, mixing the dissolved mixture with a metal salt to form insoluble adducts of the ...
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JPS6034990A |
17-haloethynyl steroids of the partial formula wherein R1 is hydrogen or methyl, R2 is alkyl of 1-4 carbon atoms, acyl of 1-7 carbon atoms, trimethylsilyl, 2-tetrahydropyranyl, or nitrate, X is bromine or iodine, and V is methylene, ethy...
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JPS6028927A |
PURPOSE: An external preparation for the skin having no side effect like hormone, mildness to the skin, and improved remedying effect on pimples, containing deoxycorticosterone as an active ingredient. CONSTITUTION: An external preparati...
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JPS604198B2 |
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JPS60994B2 |
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JPS604200A |
NEW MATERIAL:The compound of formula I (X is H or halogen; R1 is H, halogen or lower alkoxy; R2 is lower alkyl or cycloalkyl; R3 is methyl having α- or β-configuration or H; n is 1W4). EXAMPLE: 17α-( β-Carbomethoxy )propionyloxy-21-c...
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JPS59155761A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5933600B2 |
The invention relates to novel 11,11-alkylidene steroids of the estrane and (19-nor-)pregnane series having a double bond starting from carbon atom 5, the alkylidene group in 11-position having the formula R1 ANGLE C= , R2 wherein R1 and...
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JPS5926279B2 |
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JPS5922719B2 |
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JPS5922720B2 |
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JPS5955899A |
21-Hydroxycorticosteroid esters which can have good solution stability and are therefore suitable for formulation into aqueous compositions for injection or infusion, have the formula… St-O-CO-Y-(CH2)n-X-(CH2)m-NR1R2… wherein St is t...
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JPS5912680B2 |
Pregnanoic acid derivatives of the following formula in which the substituents are defined in Claim 1, are prepared. These compounds are obtained by oxidising a corresponding pregnane derivative which has an aldehyde group in position 21...
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JPS5910799B2 |
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JPS5942399A |
1502513 Steroid[16α,17-b] dioxanes E R SQUIBB & SONS Inc 13 May 1975 [8 Nov 1974] 20206/75 Heading C2U The invention comprises #4 steroids of Formula I and their #1,4, #4,6 and #1,4,6 analogues wherein A 1 is selected from (the valency ...
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JPS5942400A |
1502513 Steroid[16α,17-b] dioxanes E R SQUIBB & SONS Inc 13 May 1975 [8 Nov 1974] 20206/75 Heading C2U The invention comprises #4 steroids of Formula I and their #1,4, #4,6 and #1,4,6 analogues wherein A 1 is selected from (the valency ...
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JPS597200A |
NEW MATERIAL:A compound shown by the formula I (R is ethyl, propyl, or butyl). EXAMPLE: 6α-Methylpredonisolone 17α-butylate (11β, 12-dihydroxy-17α-butylyloxy- 6α-methylpregna-1,4-diene-3,20-dione). USE: Having high local antiphlogis...
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JPS591720B2 |
The invention relates to a new process for the preparation of 6 alpha -halo-3-keto- DELTA 1,4-pregnadiene-derivatives in two-steps-synthesis affording directly 6 alpha -halo-derivatives by reacting 3-keto-9 beta ,11 beta -oxido- DELTA 1,...
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JPS5855158B2 |
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JPS5855157B2 |
1504132 2 - Bromo - 6# - fluoro - pregnane compounds G PALLADINO 24 Feb 1975 [8 March 1974] 10443/74 Heading C2U Novel steroids have the formula wherein X is oxo, #-OH or #-Cl; Y is F or Cl but is not F when X is Cl; R1 is H or C 2-8 alk...
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JPS5855156B2 |
1504294 6#-Fluoro-pregnadienes G PALLADINO 24 Feb 1975 [5 March 1974] 9728/74 Heading C2U Novel steroids have the formula wherein R and R1 are each H or 2-8C alkanoyl; X is keto, #-OH or #-Cl; Y is F or Cl but is not F when X is Cl; Z is...
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JPS58208299A |
NEW MATERIAL:A compound of formula I (R is lower alkyl, aryl; R' is lower alkyl, alkenyl, aryl). EXAMPLE: 6α-Methylprednisolone 17,21-dibutyrate. USE: Anti-inflammatory steroid for external use. PREPARATION: 6α-Methylprednislone of for...
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JPS5850236B2 |
NEW MATERIAL:A combination of prostaglandin and D ring of steriod hormone bonded directly or via a binding agent. EXAMPLE:A combination of esteradiol and PGF2alpha of the formula [R is (CH2)n; n is 1 or 2; m is 0 or 1]. USE:Delivery prom...
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JPS58185518A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5844360B2 |
1365469 D-homosteroids F HOFFMANNLA ROCHE & CO AG 29 March 1973 [29 March 1972] 15112/73 Headings C2U and C2C The invention comprises compounds of formula (wherein R6 is H, F, Cl or Me; R9 is H, F, Cl or Br; and R17 and R21 are each hydr...
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JPS5842198B2 |
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JPS5842168B2 |
A composition for a topical preparation which comprises a steroid, crotamiton, propylene glycol and a carboxyvinyl polymer in an aqueous medium, said composition having been neutralized with an organic amine, and a process for producing ...
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JPS5839840B2 |
1368005 7-Carboxy steroids and related compounds G D SEARLE & CO 24 Aug 1972 [25 Aug 1971] 39401/72 Heading C2U Novel steroids have the formulµ wherein Z is H, alkali metal, alkaline earth metal/2, ammonium or alkyl; Z1 is H, alkali met...
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JPS5837320B2 |
1387911 Anti-inflammatory medicines SCHERING AG 23 Feb 1972 [4 Oct 1971 27 Jan 1972 (3)] 8299/72 Heading A5B [Also in Division C2] Anti-inflammatory compositions comprise steroids of the formula: (wherein X is H, halogen or CH 3 ; Y is H...
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JPS5834480B2 |
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JPS5830320B2 |
Steroids of the formula WHEREIN X is a hydrogen atom, a halogen atom or methyl; Y is a hydrogen atom or a halogen atom; Z is carbonyl, beta -acyloxymethylene or, when Y is a hydrogen atom, also methylene; R1 is a hydrogen atom or methyl;...
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JPS5830319B2 |
The invention relates to a process for the production of 16 alpha -methyl- DELTA 1,4,9(11)-pregnatrien-3,20-diones having the formula WHEREIN R is hydrogen or the acyl of a carboxylic acid having 1 to 18 carbon atoms, pharmacological pre...
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JPS5883699A |
The title complexes have 3-100 times the water-solubility of the uncomplexed steroids, e.g. spironolactone, nortestosterone, methyltestosterone, androst-4-ene- 3,17-dione, progesterone, Reichstein S, Reichstein S aceate, 16-methyl- Reich...
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JPS5879998A |
Novel dihalogenated steroids of the formula in which X represents methylene or an alpha -oriented methyl group together with a hydrogen atom and R represents an alkyl group having a maximum of 6 carbon atoms, and their 1,2-dehydro deriva...
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JPS5877898A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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