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JPS52144664A |
PURPOSE: Steroid derivatives I (R1 and R2 are 2-4C acyl which may be substituted by lower alkoxy), e.g. dexamethasone-17, 21-dipropionate.
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JPS52128364A |
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JPS52113954A |
1527061 Compositions containing clindamycin and a steroid UPJOHN CO 10 March 1977 [19 March 1976] 10067/77 Addition to 1403962 Heading A5B An anti-inflammatory composition contains 6α, 9α - difluoro - 11#, 17α, 21 - trihydroxy- 16# - ...
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JPS52111553A |
This invention relates to novel 17 alpha -esters of gestogens having an antitumour activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and method of tre...
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JPS5293759A |
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JPS5228795B1 |
1280570 6-Methylene-steroids UPJOHN CO 21 Oct 1970 [19 Nov 1969] 50031/70 Headings C2C and C2U 3-Keto-#4-6-methylene steroids are prepared by the following processes wherein R and R4 are each C 1-12 alkyl or hydrogyalkyl, C 3-8 cycloalky...
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JPS5289662A |
Novel 6 alpha ,9 alpha ,21-trihalogeno-11 beta -hydroxy-16 alpha or 16 beta -methyl-17 alpha -propionyloxy-pregn-4-ene-3,20-dione compounds of the formula (I) in which X represents chlorine or flourine, R represents the group -CH2CH-, -C...
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JPS5227158B1 |
1,146,711. Hydrolysis of steroidal acetals and ketals. SYNTEX CORP. 27 May, 1966 [2 May, 1965; 1 June, 1965], No. 23798/66. Headings C2C and C2U. Steroid cyclic acetals and ketals are hydrolysed to the corresponding free diols by treatme...
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JPS5285159A |
Pregnanes and androstanes are described which essentially possess a 3.alpha.-hydroxy group, a S.alpha.-hydrogen atom or a 4,5- or 5,6-double bond, a 17.alpha.-hydrogen atom and an 11.beta.-aminoester group. Other optional substituents or...
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JPS5285160A |
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JPS5283729A |
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JPS5283445A |
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JPS5224014B2 |
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JPS5224013B1 |
1,202,521. 9α - Unsubstituted - 11# - chloro - 19 - nor - steroids. GLAXO LABORATORIES Ltd. 8 Aug., 1967 [29 July, 1966; 18 May, 1967], Nos. 34275/66 and 23066/67. Heading C2U. [Also in Division A5] Novel 9α - unsubstituted 11# - chlor...
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JPS5273852A |
2,9 alpha -Dichloro-6 alpha -fluoro-16 alpha -methyl-11 beta ,17,21-trihydroxy- pregna-1,4-diene-3,20-dione compounds of the formula (I) (R1, R2 = OR where R = H, acid residue) have antiinflammatory effects. They are prepared by reacting...
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JPS5216112B1 |
1280569 6-Aminomethyl steroids UPJOHN CO 21 Oct 1970 [19 Nov 1969] 50030/70 Headings C2C and C2U Novel 6-aminomethyl steroids having in rings A and B the structure (wherein R1 and R2 are each C 1-12 alkyl, C 1-12 hydroxyalkyl, C 3-8 cycl...
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JPS5212777B2 |
1375357 Corticoid 21-sulphobenzoate ROUSSEL UCLAF 21 May 1973 [19 May 1972] 24013/73 Heading C2U The invention comprises 6α-methylprednisolone 21-(m-sulphobenzoate) and its alkali metal salts. The salts are prepared from the correspondi...
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JPS5233663A |
Novel 2,2-dimethyl steroids of the formula I wherein R is selected from the group consisting of hydrogen, -OH and R1 is selected from the group consisting of hydrogen and hydrocarbon of 1 to 17 carbon atoms Z is selected from the group c...
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JPS528308B1 |
1,271,159. Dimeric steroid carbonates. FARBWERKE HOECHST A.G. 5 May, 1969 [3 May, 1968], No. 22798/69. Heading C2U. The invention comprises compounds of formula wherein Q and Q 1 are each H or together represent an additional 1,2-bond or...
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JPS5223063A |
The Specification describes a synthetic route for the preparation of a 9,11-dehydro-3-oxygenated 17 alpha -hydroxy-20-ketopregnane which comprises the steps (i) electrophilically fluorinating a saturated 9,11-unsubstituted 3-oxygenated-1...
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JPS5214761A |
Novel 11,12-unsaturated 9 alpha -fluorosteroids, especially those of the androstane and pregnane series, with the following constitution in rings B and C it being possible for all the substituents customary in the known pharmacological a...
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JPS5210485A |
A method is disclosed for improving the activity of oxireductase enzymes, the improvement consisting in that an enzyme and a previously functionalized coenzyme are embedded in a filamentary structure, the coenzyme having previously been ...
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JPS52253A |
The present invention relates to 2-chloro-6 beta -fluoro-pregna-1,4-diene-3,20-diones having good anti-inflammatory activity, to processes for their preparation and pharmaceutical compositions thereof.
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JPS5141634B1 |
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JPS51125059A |
17 alpha ,21-Diesters of 17 alpha ,21-dihydroxysteroids of the pregnane series corresponding to the formula I in which the symbols X, Y, R<1> and R<2> have the meaning stated in Claim 1 are prepared by reacting a compound which has the g...
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JPS5140135B1 |
1317184 Injectable anaesthetics GLAXO LABORATORIES Ltd 11 June 1970 [20 June 1969] 31371/69 Heading A5B [Also in Division C2] Anaesthetic compositions suitable for use by parenteral administration comprise an aqueous solution containing ...
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JPS51110551A |
Novel retinoic acid esters of anti-inflammatory steroids of the pregnane series are described and their use in the treatment and control of acne vulgaris via the topical or intralesional route. A preferred mode of the invention comprises...
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JPS5129152B1 |
1,273,955. Dexamethasone 17-valerate. INSTITUTO LUSO FARMACO D'ITALIA S.r.L. 19 April, 1971 [14 March, 1970], No. 23992/71. Heading C2U. The novel title compound, alternatively named 9α-fluoro-11#,21-dihydroxy-16α-methyl-17α-valeroylo...
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JPS5125232B1 |
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JPS5125023B1 |
1292785 Esters of dexamethasone and betamethasone ISF SpA 19 April 1971 [17 Oct 1970] 22811/71 Heading C2U Novel steroids of the formula (wherein R 1 is a saturated or unsaturated hydrocarbon group of 8-14 carbon atoms and n is 3, 4, 5, ...
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JPS5163166A |
Corticoids of the formula wherein X is beta -hydroxymethylene or carbonyl, and 21-esters thereof with physiologically acceptable acids possess topical anti-inflammatory activity with relatively little systemic activity.
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JPS5111624B2 |
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JPS5134142A |
A novel group of 18,18-difluorosteroids of the general formula (I) wherein St, R1 and R2 have the meanings given hereinafter is produced by a chemically novel process characterized in that a corresponding 18-oxo compound is treated with ...
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JPS5111754A |
1462686 Steroid 9,11-epoxides OMNI RESEARCH Inc 13 Feb 1974 [21 Feb 1973] 53278/75 Divided out of 1462685 Heading C2U The invention comprises compounds I, VIIa, VIIb and 14 infra wherein "Ac" is acyl except in compound I where it is acet...
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JPS512460B1 |
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JPS514102A |
Saturated organic compounds containing a hydrogen atom bound to a tertiary carbon atom may be electrophilically fluorinated by reaction with an electrophilic fluorinating agent such as molecular fluorine or trifluoromethyl hypofluorite u...
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JPS5038103B1 |
1330563 1#,2# - Methylene - 9#,10α - steroids PHILIPS GLOEILAMPENFABRIEKEN NV 19 April 1971 [4 March 1970] 22847/71 Heading C2U [Also in Division A5] The invention comprises compounds of formula wherein X is H and Y is free or esterifie...
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JPS5037664B1 |
The invention relates to novel 16-methylene-17 alpha -acyloxy (or etherified hydroxy)-9 beta , 10 alpha -steroid compounds of the pregnane series which have an exceptionally high endocrinological activity, such as a very strong progestat...
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JPS5037663B1 |
21-Fluoro-steroids of the partial formula (I): (where R is H and R1 and R2 are H or hydrocarbyl or R1, R2 is a double bond) are prepd. in good yields by reacting steroids of partial formula (II) (where Z is H or an esterified carboxyl gp...
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JPS50142557A |
The invention relates to novel 16-methylene-17 alpha -acyloxy (or etherified hydroxy)-9 beta , 10 alpha -steroid compounds of the pregnane series which have an exceptionally high endocrinological activity, such as a very strong progestat...
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JPS5034555B1 |
The invention comprises a 10b -n-propyl steroid of the general formula in which A represents the oxygen atom of a keto group and B and C together represent a double bond and D represents a hydrogen atom or A either re...
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JPS5028955B1 |
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JPS5028953B1 |
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JPS5028954B1 |
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JPS5025472B1 |
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JPS50105660A |
1330563 1#,2# - Methylene - 9#,10α - steroids PHILIPS GLOEILAMPENFABRIEKEN NV 19 April 1971 [4 March 1970] 22847/71 Heading C2U [Also in Division A5] The invention comprises compounds of formula wherein X is H and Y is free or esterifie...
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JPS50105662A |
1330563 1#,2# - Methylene - 9#,10α - steroids PHILIPS GLOEILAMPENFABRIEKEN NV 19 April 1971 [4 March 1970] 22847/71 Heading C2U [Also in Division A5] The invention comprises compounds of formula wherein X is H and Y is free or esterifie...
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JPS50105653A |
The invention relates to novel 16-methylene-17 alpha -acyloxy (or etherified hydroxy)-9 beta , 10 alpha -steroid compounds of the pregnane series which have an exceptionally high endocrinological activity, such as a very strong progestat...
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JPS50105661A |
1330563 1#,2# - Methylene - 9#,10α - steroids PHILIPS GLOEILAMPENFABRIEKEN NV 19 April 1971 [4 March 1970] 22847/71 Heading C2U [Also in Division A5] The invention comprises compounds of formula wherein X is H and Y is free or esterifie...
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JPS50105659A |
The invention relates to novel 16-methylene-17 alpha -acyloxy (or etherified hydroxy)-9 beta , 10 alpha -steroid compounds of the pregnane series which have an exceptionally high endocrinological activity, such as a very strong progestat...
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