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Patent Searching and Data


Matches 151 - 200 out of 1,332

Document Document Title
WO/1999/032127A1
Compositions of angiostatic agents for treating GLC1A glaucoma and methods for their use are disclosed.  
WO1998020151A9
Disclosed is a method for the production of an adrenocorticoid steroid represented by general formula (I), wherein R1 and R3 may be H, alkyl, substituted alkyl, silyl, acyl, acyloxy or carbamoyl (and wherein R1 need not be the same as R3...  
WO/1999/028336A1
16$g(a),17$g(a)-Dialkylated steroids are prepared by reacting a 16$g(a)-alkyl-17(20)-enyl-20-silyl ether with an alkylating agent and an enol silyl ether cleaving agent in a suitable solvent.  
WO/1999/025359A1
The invention provides a process for the sterilization of a powdered form of a glucocorticosteroid, sterile glucocorticosteroids, sterile formulations containing glucocorticosteroids and use thereof in the treatment of an allergic and/or...  
WO1999001467A3
There are described therapeutically active compounds or salts or solvates thereof, hydrolysable in human or animal blood to compounds with reduced therapeutic activity. There is also described a method of identifying a compound capable o...  
WO/1999/003503A1
Methods for treating ocular neovascularization using photodynamic therapy in combination with an angiostatic steroid are disclosed.  
WO/1999/001467A2
There are described therapeutically active compounds or salts or solvates thereof, hydrolysable in human or animal blood to compounds with reduced therapeutic activity. There is also described a method of identifying a compound capable o...  
WO1998036733A3  
WO/1998/050042A1
This invention provides a method of providing progestational therapy to a mammal in need thereof which comprises administering a progestationally effective amount of a pharmaceutically acceptable salt of 5$g(a)-pregnan-3$g(b)-ol-20-one 3...  
WO/1998/036733A2
A cholinergic agent and/or a calcium channel blocker is administered locally to the anus for the treatment of benign anal disorders, in particular anal fissures and haemorrhoids. The agents induce a reduction in the mean and resting pres...  
WO/1998/035701A1
The invention provides a method of targeting a drug to areas of hypoxic and/or ischemic tissue within the body in which the desired drug species is linked to a non-cytotoxic bioreductive carrier. Also provided by the invention are novel ...  
WO/1998/032718A1
The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and...  
WO/1998/031352A1
A dry powder composition comprising one or more potent pharmaceutically active substances and a carrier substance, all of which are in finely divided form, wherein the formulation has a poured bulk density of from 0.28 to 0.38 g/ml is us...  
WO/1998/020151A1
Disclosed is a method for the production of an adrenocorticoid steroid represented by general formula (I), wherein R�1? and R�3? may be H, alkyl, substituted alkyl, silyl, acyl, acyloxy or carbamoyl (and wherein R�1? need not be th...  
WO/1997/041145A1
A compound having general formula (I) in which R1 is a member selected from the group consisting of -OCH3, -SCH3, -N(CH3)2, -NHCH3, -CHO, -COCH3 and -CHOHCH3; R2 is a member selected from the group consisting of halogen, alkyl, acyl, hyd...  
WO/1997/039018A1
The invention discloses products with formula (I) in which: either R1 stands for halogen, hydroxyl, (C1-C8) alkyloxy or (C1-C12) acyloxy, and R2 represents halogen or hydrogen; or R1 and R2 together form a double bond, Z is selected from...  
WO/1997/034871A1
Disclosed are (i) compounds of a steroid, a 'beta'-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous prod...  
WO/1997/027210A1
The invention relates to compounds of formula (I), in which R1, R2, R3, R4, R5, R6, n and X are as defined in the specification, and to pharmaceutical compositions containing them. These compounds are excellent progestogens which are dev...  
WO/1997/022616A1
Disclosed is a process for producing the epoxy steroid (1.0) wherein R1 is selected from H, -OH, or C1, and R2 is selected from hydrogen or lower alkyl. The process comprises reacting the triene of Formula (2.0) with a brominating or chl...  
WO1996040043A3  
WO/1996/040043A2
The invention relates to 3'alpha'-hydroxy, 17-(un)substituted derivatives of the androstane series and 3'alpha'-hydroxy, 21-substituted derivatives of the pregnane series. These derivatives are capable of acting at a recently identified ...  
WO/1996/040727A1
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor-pregnane steroid, or a pharmaceutical composition containing a vomerophe...  
WO/1996/034846A1
Compounds of 1,3-propane diol linked structure (I), when for use in therapy, where R1 is an acyl or fatty alcohol group derived from a C12-30 preferably C16-30 fatty acid desirably with two or more cis or trans double bonds, and R2 is hy...  
WO/1996/034855A1
Compounds of structure (I), and when for use in therapy: where R1 is an acyl group derived from a C16-30 fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3 series EFA or conjugated linoleic acid, or colu...  
WO/1996/034858A1
Niacin as a compound, per se or for use in therapy, of structure (I), where B is -C(=O)- (nicotinic acid) or -CH2-O- (niacin alcohol), the "link" C which is optional is a diol or hydroxy carboxylic acid or dicarboxylic acid residue, and ...  
WO/1996/022303A1
The present invention relates to a range of therapeutic compounds conjugated to one to three acyl groups derived from fatty acids. The therapeutic compounds are selected from the following group: 1) the corticosterone family of drugs; 2)...  
WO/1996/016076A1
Methods, compositions, and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.  
WO/1996/003421A1
6'alpha'-Hydroxy-21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidiny l]-1-piperazinyl]-16'alpha'-methylpregna-1,4,9(11)-triene-3, 20-dione, 6'beta'-hydroxy-21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl ]-1-piperazinyl]-16'alpha'-methylpregna-1,4,...  
WO/1995/032989A1
Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selectively forms 'DELTA'9,11 steroids from either 11-'alpha...  
WO/1995/029186A1
The present invention relates to methods and compositions for the transformation of cells. In particular, compositions and methods are disclosed which include combinations of the nucleic acid of interest and polyhydroxylated or polyglyco...  
WO/1995/021617A1
Methods, compositions, and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.  
WO/1995/020567A1
A codrug composition of at least two drug compounds covalently linked to one another via a labile bond to form a single codrug composition, and methods of use of the codrug for the treatment of various medical conditions. The codrug may ...  
WO/1995/004535A1
The application discloses methods of making medicaments for treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural ...  
WO/1994/027608A1
Methods and compositions for interacting with the GABAA receptor complex to induce sleep in humans using certain 5 3alpha-hydroxy-5-reduced steroid derivatives.  
WO/1994/026769A1
Novel anti-inflammatory compounds, compositions of these compounds and use of such compounds to treat inflammed ocular tissue are described. The compounds are derivatives and analogues of known steroid compounds (e.g., dexamethasone) and...  
WO/1994/016710A1
The present invention relates to a topical composition comprising ketoconazole, an acetonide glucocorticosteroid and a dermatologically acceptable carrier, characterized by a pH above 2.5 and below 6, and a method of preparing said compo...  
WO/1994/014834A1
Steroids of formula (I) where -_-_-_-_ is independently at each of the 1,2-, 4,5- and 6,7-positions, a single or double bond; R1 is a straight- or branched-chain C1-4 alkyl or C2-4 alkenyl; R2 is hydrogen or methyl; R3 is C1-7 alkyl, phe...  
WO/1994/013690A1
Steroids of formula (I) where --- is a single or double bond; R1 is hydrogen or fluorine; and R2 is propyl or trans-prop-1-enyl, and racemic mixtures and diastereoisomers thereof, processes for their preparation, pharmaceutical compositi...  
WO/1994/011386A1
Invented are 17alpha and 17beta-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-alpha-red...  
WO/1994/011004A1
Invented are 17alpha and 17beta-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-alpha-red...  
WO/1994/006434A1
A method and compound having hydrocortisone and tretinoin is disclosed for the treatment of hair loss. The method also includes identifying any underlying conditions causing hair loss, treating the underlying conditions if possible, admi...  
WO/1994/000125A1
Invented are 17alpha and 17beta-alkylketone-3-carboxy aromatic A ring analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-alpha-re...  
WO1993015103A3  
WO/1993/022333A1
Invented are 17$g(a) and 17$g(b)-substituted acyl-3-carboxy aromatic A ring analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-$g...  
WO/1993/018053A1
This invention provides a simplified method for converting pregnan-3,20-dione compounds to 3alpha-hydroxy,3beta-substituted-pregnanes. By selective use of reagents the unprotected dione is converted chemoselectively and diastereoselectiv...  
WO1993010141A3  
WO/1993/015103A2
Novel steroids having a 9alpha-hydroxy or a 9alpha-carbonate substituent can be prepared from 9alpha-hydroxyandrostenedione and can be utilized in the synthesis of commercially valuable corticosteroids such as betamethasone. The 9alpha-c...  
WO/1993/013123A1
Compounds of formula (I), wherein R17 and R'17 are such that: either R17 and R'17 together form ketone, hydrazono, oxime or methylene, or R17 is hydroxyl, hydroxymethyl or acyloxy and R'17 is hydrogen, alkyl or optionally substitued alke...  
WO/1993/010141A2
Angiostatic steroids for use in controlling neovascularization and ocular hypertension are disclosed. Pharmaceutical compositions of the angiostatic steroids and methods for their use in treating neovascularization and ocular hypertensio...  
WO/1993/003732A1
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid recept...  

Matches 151 - 200 out of 1,332