Steroids

Matches 251 - 300 out of 965	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
JP7096864B2	3,3-Disubstituted 19-norpregnane compound and its use Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I):where R1, R2, R3, R3', R4, R6a, R6a, R11a, and R11bare as defined herein. Compounds of the present invention are contemplated useful for the preven...
JP2022519711A	Bioengineering optimization of microorganisms for 1,2-dehydrogenation of steroids The present invention relates to genetically modified bacteria, and in particular to their industrial application in 1,2-dehydrogenation of steroids.
JP2022517767A	Traceless linker and its protein-conjugate Provided herein are compounds, compounds containing traceless linkers, their protein conjugates, and their compositions. It is also associated with inflammatory diseases and autoimmune disorders, including administration of trace-free li...
JP2021535183A	C19 Skeletons and Steroids and Their Use and Manufacturing Methods The present disclosure describes sterically defined polycyclic (eg, tetracyclic) compounds containing a quaternary center in one or more ring fusions, synthetic methods for preparing such compounds, and methods thereof. With respect to m...
JP2021088582A	GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF To provide glucocorticoid receptor agonist immunoconjugates, and methods of making the same, and methods of using the same e.g., to treat autoimmune or inflammatory diseases.The present disclosure provides a compound having the following...
JP2021512909A	Steroidal derivative modulator, its manufacturing method and application The present invention relates to a steroidal derivative modulator, a method for producing the same, and an application thereof. The present invention particularly relates to a compound represented by the general formula (I), a method for...
JP6852118B2	Neuroactive 19-alkoxy-17-substitute steroids, their prodrugs and treatments using them The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorde...
JP2020180161A	19-NOR NEUROACTIVE STEROIDS AND USE METHODS THEREOF To provide 19-nor neuroactive steroids and use methods thereof.The invention is based, in part, on the desire to provide novel 19-nor (i.e., C19 desmethyl) compounds, e.g., related to progesterone, deoxycorticosterone, and their metaboli...
JP6781148B2	Hydroxysteroid compounds, their intermediates, their preparation methods, compositions and uses The present invention relates to novel steroidal compounds of formula (I), process for preparation of the same and composition comprising these compounds.
JP2020500198A	Skeletal muscle hypertrophy inducer The present invention relates to a skeletal muscle hypertrophy inducer and its use in promoting skeletal muscle regeneration, preventing skeletal muscle atrophy, or treating or preventing a disease or injury that causes skeletal muscle t...
JP6621217B2	Compounds and their use to improve muscle quality Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using ...
JP6542127B2	Neuroactive 19-alkoxy-17-substitute steroids, their prodrugs and treatments using them The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorde...
JP2019068741A	METHOD FOR PRODUCING STEROL To provide algae that produce sterol, and a method for producing sterol using the same.Algae such as AJ7867 strain (FERM P-22304) and a strain derived therefrom, having a sterol production ability, are cultured. From bodies of the result...
JP6503057B2	17α, 21-diester of cortexolone for use in tumor treatment The present invention provides cortexolone 17.alpha.-valerate for use in therapy, in particular for use as an antitumor active ingredient for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dyspl...
JP2019048851A	MODIFIED DRUGS FOR USE IN LIPOSOMAL NANOPARTICLES To provide modified drugs for use in liposomal nanoparticles.Provided herein is a drug derivative suitable for loading into liposomal nanoparticle (LN) carriers. In some preferred aspects, the derivative comprises a drug with low water s...
JP2018203666A	ANTIGENS FOR ISOLATING ANTI-CORTISOL ANTIBODIES AND ANTIBODY PRODUCING METHODS To obtain anti-cortisol antibodies having high reaction specificity, in particular, antibodies capable of distinguishing cortisol and corticosterone having a similar structure.An anti-cortisol antibody of which cross-reactivity to cortic...
JP2017526741A	Diazepan derivatives and their use The present disclosure provides a compound represented by the formula (I) and a pharmaceutical composition thereof. The compounds of formula (I) have been found to bind bromodomain and / or bromodomain-containing proteins (eg, bromo and ...
JP6194335B2	The method and constituent using an immunomodulatory property compound for treating and managing cancer and other diseases Methods of treating, preventing and/or managing cancer as well as diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory com...
JP2017132817A	METHODS AND COMPOSITIONS USING IMMUNOMODULATORY COMPOUNDS FOR TREATMENT AND MANAGEMENT OF CANCERS AND OTHER DISEASES To provide methods of treating and preventing certain types of cancer, including primary and metastatic cancer, as well as cancers that are refractory or resistant to conventional chemotherapy.A pharmaceutical for treating or preventing ...
JP6174645B2	Enzymatic means for obtaining the 17alpha-monoester of col Texolone and/or its 9, and 11- Dehydro derivative The present invention refers to new crystalline forms of cortexolone 17α-propionate and their pharmaceutical use.
JP2017105827A	C-HALOGEN BOND FORMATION To provide methods of halogenating a carbon-containing compound having an sp3 C-H bond.Methods of halogenating a carbon-containing compound having an sp3 C-H bond are provided. Methods of fluorinating a carbon-containing compound compris...
JP6108944B2	Enzymatic means for obtaining the 17alpha-monoester of col Texolone and/or its 9, and 11- Dehydro derivative The present invention refers to new crystalline forms of cortexolone 17α-propionate and their pharmaceutical use.
JP2016540001A	Polymorphic forms of steroid-like compounds, their production methods and their uses The present invention provides various solid forms of a particular steroid-like compound, as well as methods of producing the same and uses thereof. In one aspect, the crystalline form of the steroid-like compound, its production method ...
JP2016180004A	NOVEL 19-NORSTEROIDS FOR TREATING PROGESTERONE DEPENDENT CONDITIONS AND USE METHODS THEREOF To provide novel 19-norsteroids for treating progesterone dependent conditions and use methods thereof.The subject matter of the invention relates to the field of treatment of hormone dependent diseases. Disclosed herein are novel compos...
JP2016526011A	Nanoparticles for combination therapy Nanoparticles containing chemotherapeutic agents and anti-inflammatory agents are particularly cytotoxic to prostate cancer cells. The disclosure describes, among other things, a nanoparticle (NP) platform capable of delivering a combina...
JP2016519111A	IL4 which carried out conjugate to the antibody to an extra-cellular-matrix ingredient Conjugate including interleukin 4 (IL4) and a specific association member is indicated. Preferably, it combines with the extra-cellular-matrix ingredient relevant to new organism multiplication and/or a blood vessel rebirth, and the spec...
JP2016510753A	Antibiotic conjugate bound to steroid drug To describe a novel single drug entity formed by binding of an antibiotic to a steroid drug via a linker. Upon topical application to the eye, the conjugate undergoes enzymatic cleavage and / or hydrolysis cleavage to release the individ...
JP2016505038A	A novel compound of 11β-hydroxysteroids for use in mitochondrial biosynthesis and diseases associated with mitochondrial dysfunction or deficiency The present invention is a novel compound and composition of 11β-hydroxysteroids, as well as pharmaceuticals for preventing or reversing mitochondrial damage in human or animal subjects, for treating or preventing diseases associated wi...
JP5839770B2	Methods and compositions with immunomodulatory compounds for the treatment and management of cancer and other diseases Methods of treating, preventing and/or managing cancer as well as diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory com...
JP5830005B2	Methods and compositions with immunomodulatory compounds for the treatment and management of cancer and other diseases Methods of treating, preventing and/or managing cancer as well as diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory com...
JP5646992B2	Enzymatic method for obtaining 17α-monoester of cortexolone and / or 9,11-dehydro derivative thereof The present invention refers to new crystalline forms of cortexolone 17α-propionate and their pharmaceutical use.
JP5631203B2	How to get a steroid phosphate compound A process for obtaining 21-disodium phosphate pregnane derivative compounds of formula (I), wherein X=R=H or X=F and R=alpha-CH3 or X=F and R=beta-CH3: comprises spray drying a solution comprising compound of formula (I).
JP2014528485A	3,3-Disubstituted 19-norpregnane compound and its use The 3,3-disubstituted 19-nor-steroid compounds according to formulas (I) and (III) are provided herein: R1, R2, R3, R3', R4, R6a, R6a in the formulas. , R11a and R11b are as defined herein. The compounds of the present invention are inte...
JP5473029B2	Heat sterilization of glucocorticosteroids The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing-effective time...
JP2014508784A	Inhibitors of 17β-HSD1, 17β-HSD3, and 17β-HSD10 The present application discloses 17β hydroxy steroid dehydrogenase (17β HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17β HSD1 inhibitors include estradiol ...
JP5417562B2	17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadiendione as antiprogesterone agents The invention provides 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienediones as antiprogestational agents.
JP5413836B2	Tagging Reagents and Methods for Hydroxylated Compounds In various aspects, the present teachings provide labeling reagents and sets of labeling reagents for the relative quantitation, absolute quantitation, or both, of hydroxylated compounds including, but not limited to, hydroxylated ring c...
JP2014500316A	New 19-norsteroids and how to use them to treat progesterone-dependent conditions The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. New compounds and methods for treating these conditions are disclosed. Embodiments of the instant invention disclose meth...
JP5260537B2	Progesterone receptor antagonist The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
JP5250174B2	7 How to prepare α-methylsteroid The invention relates to a process for the preparation of 7α-methyl hydroxy steroids of the formula I wherein R1 is hydrogen, methyl or C≡CH; R2 is (CH2)nOH, wherein n is 0, 1 or 2; by a copper mediated 1,6-conjugate addition of a Gri...
JP5232083B2	New fatty acid derivative The properties of biologically active compounds, for example drugs and agrochemicals, which contain in their molecular structure one or more functional groups selected from alcohol, ether, phenyl, amino, amido, thiol, carboxylic acid and...
JP2013126999A	METHOD AND COMPOSITION FOR TREATMENT AND MANAGEMENT OF CANCER AND OTHER DISEASES BY USING IMMUNOMODULATORY COMPOUND To provide a method for treatment and prevention of specific type cancers, such as primary and metastatic cancers, and cancers unresponsive or resistant to conventional chemotherapy.There is disclosed a medicine for treatment or preventi...
JP5216589B2	Nitrooxy derivatives of steroids The invention relates to new steroids nitrooxyderivatives, to topical pharmaceutical formulations thereof, and their use for treating skin or mucosal membrane diseases or disorders. These new steroids nitrooxyderivatives have an improved...
JP5207432B2	Anti-solvent coagulation process The present invention relates to a antisolvent solidification process wherein a liquid medium comprising at least one organic or inorganic compound which is to be solidified is forced through a membrane into one or more antisolvents, or ...
JP5203472B2	Re-epithelialized pharmaceutical composition containing xanthan gum The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle. Said use and composition speed up an...
JP2013510826A	(11β, 16α) -9-Fluoro-11-Hydroxy-16,17-[1-Methyl-ethylidene bis (oxy)]-21-[1-oxo- [4- (nitrooxymethyl) benzoxy]] Pregna- Methods for preparing 1,4-diene-3,20-dione This invention relates to a new process for preparing (11 ß, 16a)-9-fluoro-11 - hydroxy-16,17-[1 -methyl -ethyl idenebis(oxy)]-21 -[1 -oxo-[4- (nitrooxymethyl)benzoxy]]pregna-1,4-dien-3,20-dione, comprising the steps of (i) reaction of ...
JP5162080B2	Mastitis treatment A pharmaceutical composition for intramammary administration to a nonhuman mammal comprising an antibacterial agent and prednisolone, wherein the composition comprises at least 20 mg of prednisolone, and its use for the treatment of clin...
JP5116469B2	Heat sterilization of glucocorticosteroids The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing-effective time...
JP5113832B2	Process for the preparation of steroid derivatives by reduction of oxosteroid compounds or by oxidation of hydroxysteroid compounds with hydroxysteroid dehydrogenase A process for the enantioselective reduction of compounds having a steroid structure (ABCD) including one or several heteroatoms, one or several double bonds and/or aromatic components in the ring structure and having at least one oxo gr...
JP2012528140A	New glucocorticoid receptor agonist This invention relates to novel glucocorticoid receptor agonists of formula (I): and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to t...

Matches 251 - 300 out of 965	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >