Steroids

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Document	Document Title
WO/1985/005361A1	17abeta-HYDROXY-7alpha-METHYL-D-HOMO-19-NORANDROST-4,16-DIENE-3-ONE AND THE 17-ESTERS THEREOF: METHODS OF PREPARATION AND USES Novel compounds having the general formula (I), wherein: R1 is hydrogen or an acyl substitutent of formula -(C=O)-R2, wherein: R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkylene, haloalkyl, aryl, haloaryl or arylalkylene. T...
WO/1985/000818A1	23,23-DIFLUORO-25-HYDROXY-VITAMIN D3 AND PROCESS FOR PREPARING SAME New derivative of vitamin D, 23,23-difluoro-25-hydroxycholecalciferol, a method for preparing said compound and various new intermediates utilized in such process. The compound is characterized by vitamin D-like activity as evidenced by ...
WO/1984/002270A1	MICROFINE PARTICLES HAVING TARGET-SEEKING PROPERTIES Target-seeking microfine particles wherein estradiol-3N-bis-(2-chloroethyl)-carbamate 17beta-phosphate of formula (I) is bound to the reactive site of a carrier particle having at least one functional group selected from the group consis...
WO/1983/004256A1	METHOD FOR PREPARING 26,26,26,27,27,27-HEXAFLUORO-1alpha,25-DIHYDROXYCHOLESTEROL The method permits the use of cholenic acid or an ester of cholenic acid as the starting material and the preparation of a compound which can be readily converted into a highly active derivative of vitamin D, 26,26,26,27,27,27-hexafluoro...
WO/1983/003099A1	3-KETO-DELTA 4,9-19-NORSTEROIDS The invention relates to products having the general formula I, wherein R1 is thienyl or phenyl optionally substituted, furyl, cycloalkyl, naphtyl, phenyl-phenyl, alkyl or alkenyl; R2 is methyl or ethyl; R3 is H, OH, alkyl, alkenyl, opti...
WO/1981/002344A1	IMMUNOASSAY PRODUCTS AND METHODS An immunoassay method utilizes antigen tagged, enzyme encapsulating liposomes which are immunospecifically ruptured in the presence of cognate antibody and active complement. A homogeneous phase reaction occurs with the antibody and comp...
WO/1981/000410A1	CYTOTOXIC NUCLEOSIDE-CORTICOSTEROID PHOSPHODIESTERS Nucleotides of nucleosides or bases having known cytotoxic activity are reacted with steroids, preferably corticosteroids, to form corresponding cytotoxic nucleoside-corticosteroid phosphodiester analogues of the formula: (FORMULA) where...
JP2022075974A	C17, C20 AND C21 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE To provide C17, C20 and C21 substituted neuroactive steroids and their methods of use.Described herein are neuroactive steroids or pharmaceutically acceptable salts thereof. Such compounds are expected, in certain embodiments, to behave ...
JP7049313B2	C17, C20, and C21 replacement neurostimulatory steroids and how to use them Described herein are neuroactive steroids or a pharmaceutically acceptable salt thereof. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a comp...
JP6893173B2	Compositions and Methods for Treating CNS Disorders Described herein are neuroactive steroids of the Formula (II):or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6and------are as defined herein. Such compounds are envisioned, in certain emb...
JP6800748B2	Lipid-based platinum compounds and nanoparticles The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corres...
JP6779318B2	Anti-metastatic 2H-selenopheno [3,2-h] chromene, their synthesis, and how to use the drug The present invention relates to a novel cancer metastasis preventing and curing selenopheno[h]chromene derivatives, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment and/or prev...
JP2019068741A	METHOD FOR PRODUCING STEROL To provide algae that produce sterol, and a method for producing sterol using the same.Algae such as AJ7867 strain (FERM P-22304) and a strain derived therefrom, having a sterol production ability, are cultured. From bodies of the result...
JP2018199670A	OXYSTEROL-THERAPEUTIC AGENT DERIVATIVE FOR BONE HEALING To provide an oxysterol-therapeutic agent derivatives or OXY133-therapeutic agent derivative compounds and methods of synthesizing the same for use in promoting osteogenesis, osteoinduction and/or osteoconduction.A method of making a der...
JP2017535570A	Bile acid analogs as FXR / TGR5 agonists and how to use them The present invention relates to compounds of formula (IA) and formula (IB) for treating TGR5-mediated diseases or conditions and pharmaceutically acceptable salts thereof (in formula, R).1, R2, R3, R4, R5, R6, R7, R8, R9And m are as def...
JP6222057B2	A chemicals amplification resist material and a pattern formation method A chemically amplified resist composition comprising a base polymer, an acid generator, and a basic compound which is a cholanoate having an acid labile group-protected amino group has a high contrast of alkaline dissolution rate before ...
JP5883381B2	Lipophilic polynucleotide conjugate Disclosed are lipophilic polynucleotide conjugates including polynucleotide-cholesterol conjugates and methods of delivering therapeutic polynucleotides to a mammalian cell or patient in need of treatment using said conjugates. The discl...
JP5642126B2	Materials for self-assembling pattern formation and pattern forming method To provide a material for forming a self-organization pattern that can make a nanometer order fine pattern in which etching resistance is high.Provided is a compound in which a silsesquioxane skeleton having a group selected from a group...
JP5250174B2	7 How to prepare α-methylsteroid The invention relates to a process for the preparation of 7α-methyl hydroxy steroids of the formula I wherein R1 is hydrogen, methyl or C≡CH; R2 is (CH2)nOH, wherein n is 0, 1 or 2; by a copper mediated 1,6-conjugate addition of a Gri...
JP4932995B2	Improved phosphorylation method and compounds produced by this method The present invention is directed to improved processes for phosphorylation and compounds produced by the improved processes. The improved process for phosphorylating complex alcohols comprises the following steps: (a) forming an intimat...
JP4851946B2	Lipid-derived bisphosphonic acid Bis-phosphonic acids (I), containing a lipid residue, and their physiologically acceptable derivatives, particularly salts and trimethylsilyl compounds, are new. Bis-phosphonic acids of formula (I), containing a lipid residue, and their ...
JP4746319B2	Lipid-like phosphate triester The present invention relates to novel phosphoric triesters which comprise apolar lipid structures.
JP4712689B2	Sterilization of beclomethasone drug particles for lung delivery A process for the sterilization of water insoluble solid medicinal substances is described. The process provides the sterilization of drug substances, which are suitable for pulmonary administration. In particular, the process is used in...
JP4611019B2	A novel glucocorticoid receptor conjugate for the treatment of metabolic disorders This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering ...
JP4541166B2	Methods and compositions for inducing sleep Methods and compositions for interacting with the GABAA receptor complex to induce sleep in humans using certain 5 3 alpha -hydroxy-5-reduced steroid derivatives.
JP2010509355A	Guggling Lipid Methods and Compositions The present invention relates to the methods for preparing synthetic guggulphospholipids, their fatty acid analogues and other bioactive molecules. The present invention relates to E-guggulsterone and Z-guggulsterone or mixture of E- and...
JP4398517B2	New 3'-denatured oligonucleotide derivative 3'-Derivatised oligonucleotide analogues of formula (I) and (II) and their salts are new: R<1>-(A<1>)n'-(B<1>)m'-(A<2>)n-(B<2>)m-B<3> (I); R<1>-(A<1>)n'-(B<1>)m'-(A<2>)n-A<3> (II); A<1> and A<2> = gps. of formula (i); B<1> and B<2> = gps...
JP2009543823A	Sulfonylaminocarbonyl derivative of bile acid amide for use as an immunomodulator 4-(3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phena nthren-17-yl)-pentanoic acid amides wherein the nitrogen of the amide group is substituted by a sulfonylaminocarbonyl-(C1-4)-alkyl group; and the use of such compounds as pharm...
JP4338306B2	Use of steroid saponins for the prevention or treatment of dementia, and novel steroid saponin compounds The invention relates to the steroidal saponin compounds for the propylaxis or treatment dementia, the new steroidal saponin compounds and the pharmaceutical composition containing the same.
JP4281976B2	Its use in the detection of heterocyclic compounds and nucleic acids The invention concerns compounds of the general formula (I) in which the residues R1 to R7 have the meanings given in the application as well as methods for their preparation. The compounds are in particular suitable as substrates for RN...
JP4260886B2	21-Substituted progesterone derivative as a novel anti-progesterone A compound having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —CHO, —COCH3 and —CHOHCH3; R2 is a member selected from the group consisting of halogen, ...
JP4187437B2	Intermediates for the synthesis of vitamin D and steroid derivatives and methods for their production A compound having the structure: wherein n is an integer from 1-5; each of R1 and R2 independently is optionally substituted C1-C6 alkyl; each of W and X is independently hydrogen or C1-C6 alkyl; Y is O, S or NR3 where R3 is hydrogen, C1...
JP4116080B2	7α- (5-methylaminopentyl) -estratriene, its production method, a pharmaceutical preparation containing this 7α- (5-methylaminopentyl) -estratrian, and its use for producing a drug. This invention describes the new 7alpha-(5-methylaminopentyl)-estratrienes of general formula Iin whichR2 stands for a hydrogen or fluorine atom,R17 stands for a hydrogen atom, a methyl or ethinyl group,n stands for 2, 3 or 4, andx stand...
JP4097697B2	Heterocyclic dioxetane substance, its manufacturing method and its use PCT No. PCT/EP96/04506 Sec. 371 Date Apr. 20, 1998 Sec. 102(e) Date Apr. 20, 1998 PCT Filed Oct. 17, 1996 PCT Pub. No. WO97/14696 PCT Pub. Date Apr. 24, 1997Compounds of the general formula Ia and Ib are described in which R1 and R2 are ...
JP4066272B2	Androstanes and pregnanes for allosteric regulation of GABA receptors Methods, compositions and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
JP2007326871A	VITAMIN D COMPOUND To provide new vitamin D compounds having selective biological properties and good accessibility from an easily available or accessible starting substance. The invention provides vitamin D compounds expressed by formula I (R1, R2, R3, A,...
JP2007536194A	Immunomodulatory phosphonate conjugate The present invention includes not only phosphorus-substituted compounds having immunomodulatory activity, compositions containing such compounds, and therapeutic methods, which include the step of administering such compounds, but also ...
JP4010579B2	Vitamin D compounds and methods for producing these compounds The invention relates to a vitamin D compound of the general formula wherein R1 is a hydrogen atom or a hydroxy group, R2 is a hydrogen atom or a substituent selected from the group consisting of (C1-C3)alkyl, phenyl and trifluoromethyl,...
JP4008024B2	Compounds for interacting with the GABAA receptor complex Methods and compositions for interacting with the GABAA receptor complex to induce sleep in humans using certain 5 3 alpha -hydroxy-5-reduced steroid derivatives.
JP3987105B2	Regulation of meiosis The present invention relates to certain sterol derivatives for use as medicaments.
JP3983796B2	3α-Hydroxy-3β-Substitution-Pregnane Production Method This invention provides a simplified method for converting pregnan-3,20-dione compounds to 3 alpha -hydroxy,3 beta -substituted-pregnanes. By selective use of reagents the unprotected dione is converted chemoselectively and diastereosele...
JP3947508B2	PLATINUM CONTAINING COMPOUND, METHOD FOR SYNTHESIZING THE SAME AND APPLICATION OF THE SAME To provide a diagnosis kit containing a compound containing Pt, usable for detection of virus, microbes, parasites, abnormality of genes, an expression of genes. The Pt containing compound used for nucleic acid probe marking for hybridiz...
JP2007506675A	New fusidic acid derivative Fusidic acid derivatives substituted at C-24 may be used in therapy for the treatment of infections.
JP2007063296A	MEDICINAL COMPOSITION FOR TREATING HUMAN PROSTATIC ADENOCARCINOMA To provide a medicinal composition useful for treating human prostatic adenocarcinoma.The medicinal composition for treating human prostatic adenocarcinoma comprises a 5-α-reductase inhibiting compound of 17β-(N-t-butylcarboxamide)-5-�...
JP3886545B2	LABELLING OF HORMONE WITH RHENIUM AND TECTNETIUM PURPOSE: To obtain a new organic metal complex which is peculiar ligand for estrogen receptor, and usuful for imaging agents and treatment of hormone- dependent cancer. CONSTITUTION: The organic metal estrogen chain of formula [A is a 1-...
JP3845482B2	ISOMERIZATION OF EQUILIN To isomerize an equilin into a delta (8,9)-dehydroestrone easily convertible to a component of a composite estrogen composition for hormone exchange therapy, etc., by treating an equilin with ethylenediamine Li salt or Li amide. An equil...
JP2006519248A	How to make tibolone Disclosed is a process for the synthesis of 17²-hydroxy-7±-methyl- 19-nor-17±-pregn-5(10)-ene-20-yne-3-one (tibolone, 11) and intermediates useful for the synthesis thereof: (11).
JP3814292B2	Estra-1,3,5 (10) -triene derivatives, methods for producing them, and pharmaceutical compositions containing these compounds. 3-Sulphamoyloxy-oestra-1,3,5(10)-triene derivs. of formula (I) are new. R = NR1R2; R1, R2 = H or 1-5C alkyl; or NR1R2 = 4-6C polymethyleneimino or morpholino; R3 = H or 1-5C alkyl; R4 = H, opt. esterified OH, 1-5C haloalkyl or 1-5C alkox...
JP2006151994A	PREPARATION METHOD OF 3ALPHA-HYDROXY-3BETA-SUBSTITUTED-PREGNANE To provide a simple method for converting a pregnane-3,20-dione compound into a 3α-hydroxy-3β-substituted-pregnane.An unprotected dione is chemoselectively and stereoselelctively converted into a 3(R)-pregnane-3-spiro-2'-oxiran-20-one ...
JP3786855B2	STEROID SULFATASE INHIBITOR To obtain a new compound capable of inhibiting the steroid sulfatase activity in vitro and in vivo, a pharmaceutical composition effective in treatment of estrogen-dependent tumors and a pharmaceutical composition effective in treatment ...

Matches 251 - 300 out of 667	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 >