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WO/2005/002496 |
The invention relates to a method of obtaining taxosteroids and the precursors thereof from hydrindane bicyclic systems. According to the invention, the compounds have a tetracyclic system which combines the structural characteristics of...
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WO/2005/000869 |
Novel pentacyclic steroids and pentacyclic D-homosteroids comprising: (i) the tetracyclic steroid ring system or tetracyclic D-homosteroid ring system, respectively; (ii) a C(3) substituent selected from the group consisting of (a) a hyd...
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WO/2004/075831 |
A novel method is provided to measure 11β-hydroxysteroid dehydrogenase activity in intact whole animal tissues in the presence of systemically or ex vivo administered inhibitors of the enzyme. Inhibitors of the type 1 isoform (11β -HSD...
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WO/2004/072092 |
The invention relates to novel derivatives of betulinic acid with increased activity for the treatment of carcinomas and HIV diseases, to a method for producing novel betulinic acid derivatives of this type and to their use as medicaments.
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WO/2004/055040 |
The present invention relates to a simple and new single pot process for the preparation of oryzanol from the oryzanol enriched saponifiable fraction of rice bran oil (RBO) soapstock.
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WO/2004/028455 |
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable sa...
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WO/2003/092578 |
The present invention relates to improved methods for synthesising cyproterone acetate (17&agr -Acetoxy-6-chloro-1&agr , 2&agr -methylene-4,6-pregnadiene-3,20-dione) from solasodine. The methods of the invention are shorter as those of t...
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WO/2003/080778 |
This invention relates to methods for treating distillates obtained during the process of deodorizing various oils. More particularly, this invention relates to methods for recovering fatty acids, tocopherols, and sterols from a distilla...
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WO/2003/066656 |
There is provided a crystalline complex comprising a compound of formula (I) in which the crystal lattice is stabilised by the presence of a guest molecule, characterised in that the crystalline complex is of space group P212121 having u...
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WO/2003/066032 |
There is provided a pharmaceutical aerosol formulation comprising (i) a compound of formula (I) or a solvate thereof as medicament, (ii) a liquified hydrofluoroalkane (HFA) gas as propellant; and characterised in that the compound of for...
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WO/2003/066026 |
There is provided according to the invention a pharmaceutical formulation comprising an aqueous carrier liquid having dissolved therein: (a) a glucocorticoid of formula (I), wherein R represents ethyl or a 5 membered heterocyclic aromati...
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WO/2003/066024 |
There is provided a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof.
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WO/2003/066036 |
According to one aspect of the invention, there is provided a pharmaceutical formulation for administration by inhalation comprising a compound of formula (I), or a solvate thereof, together with a long−acting β2−adrenoreceptor agon...
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WO/2003/066659 |
The invention relates to an improved method for obtaining highly pure, crystalline betulinic acid from a methanolic extract of ground plane bark and/or plane rind. The invention also relates to a highly pure, crystalline betulinic acid, ...
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WO/2003/062260 |
The invention provides novel compounds that are quaternary amine derivatives of betulin and other triterpenes. The compounds have antibacterial, antifungal, and surfactant properties.
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WO/2003/053993 |
The invention makes steroids available having formula (I) wherein R1 is O, (H,H), (H, OH), NOH, wherein OH is optionally etherified or esterified; R2 is hydrogen, or (C1-15)acyl; and the dotted lines indicate one or two optional bonds, f...
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WO/2003/020214 |
Disclosed are compounds that exhibit high transport across the intestinal wall of an animal. The compounds may optionally be linked to drugs that are poorly absorbed or poorly transported across the intestinal wall after oral administrat...
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WO/2002/094849 |
Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding &agr , β−unsaturated ketone using copper iodide and t−butyl hydroperoxide. A steroid compound containing the &agr , β−unsaturated ketone struc...
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WO/2002/092618 |
Disclosed is 17$g(a)-hydroxy-4-androstenh-3-one and the novel derivatives thereof of general formula (I), in addition to a method for the production thereof and medicaments containing said compounds are used to regulate spermatogenesis a...
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WO/2002/049622 |
The invention relates to a matrix transdermal system containing (21S)-21-hydroxy-21-methyl-14,17-ethano-19-norpregna-4,9,15-
triene-3,20-dione comprising a polyacrylate adhesive.
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WO/2002/048171 |
Disclosed are androgenic steroids of the (14$g(b), 17$g(a))-17-(hydroxymethyl) type. The invention relates to an improvement hereof, which is based on the presence of a $g(b)-oriented, annellated cyclopropyl group which includes carbon a...
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WO/2002/017895 |
Aldosterone receptor antagonists for the prevention and treatment of cognitive dysfunction are disclosed.
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WO/2002/015920 |
We describe methods and compositions for treating a patient suffering from a hyperproliferative disorder or photoageing. Our methods involve blocking the activity of a retinol binding protein receptor (RBPr) in cells of the patient, and/...
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WO/2002/009719 |
Antitumor agents comprising as the active ingredient a compound selected from among maslinic acid, erythrodiol, uvaol, betulinic acid, betulin, physiologically acceptable salts thereof and derivatives thereof.
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WO/2002/000682 |
The invention discloses a steroid compound having the formula (1), wherein dotted bonds represent optional double bonds; R¿6? is H, =CH¿2?, or -CH¿3?, or -CH¿2?-CH¿3?; R¿7? is H, C¿1-4?-alkyl, C¿2-5? alkenyl or C¿2-5?-alkynyl, w...
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WO/2001/049293 |
The present invention relates to a pharmaceutical composition that is lower toxicity and antiphlogistic as well as anti-exudation. The composition contains escin of general formula (I) and escin of general formula (II) as active componen...
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WO/2001/047945 |
The present invention provides a process for preparing the antiprogestational agent, 17$g(a)-acetoxy-11$g(b)-[4-N,N-(dimethylamino)phenyl]-21-met
hoxy-19-norpregna-4,9-diene-3,20-dione, intermediates useful in the process, and processes ...
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WO/2001/042274 |
The invention relates to novel 14,15-cyclopropanosteroids of the 19-norandrostane series having the general formula (I), preparation thereof and pharmaceutical compositions containing said compounds. Compounds of the formula (I) have an ...
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WO/2001/042275 |
The invention relates to novel unsaturated 14,15-cyclopropane-androstanes of the general formula (I), to their production and to pharmaceutical compositions containing these compounds. The compounds of formula (I) are progestational and/...
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WO/2001/040255 |
The disclosed invention relates to the unexpected finding of novel steroids which are characterized by a 14$g(b),15$g(b)-cyclopropane ring and a 17$g(a) hydroxymethyl group. These steroids according to the invention are found to have in ...
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WO/2001/015717 |
Medicinal compositions and preparations for administration comprising ginseng, which is useful as a cell protecting agent and a remedy for nerve trauma, its extract, ginseng components, metabolites thereof or salts thereof (for example, ...
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WO/2001/005805 |
The invention relates to novel C-19-halogen-substituted steroids of the androst-9(11)-ene series, i.e. 17$g(b)-hydroxy-19-halogen-androsta-4,9(11)-diene-3-one of general formula (I) and to methods for the production thereof. The inventio...
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WO/2000/068245 |
The present invention relates to pharmaceutically active 14$g(b)-H-sterols, to pharmaceutical compositions comprising them and to the use of these novel compounds for the preparation of medicaments. More particularly it has been found th...
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WO/2000/059922 |
The invention relates to novel equilenine derivatives of general formula (I) and methods for producing the same and medicaments containing said derivatives. The novel compounds are potent antioxidants and are used in the geriatric prophy...
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WO/2000/056757 |
The invention provides compositions comprising formula 1 steroids, e.g., 16alpha-bromo-3beta-hydroxy-5alpha-androstan-17-one hemihydrate and one or more excipients, typically wherein the composition comprises less than about 3% water. Th...
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WO/2000/047603 |
The invention relates to novel compounds as pharmaceutical agents which have in vitro a higher affinity to estrogen receptor preparations of the rat prostate than to estrogen receptor preparations of the rat uterus and which preferably h...
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WO/1999/067276 |
Disclosed are novel 14,15-cyclopropanosteroids of the 19-norandostane series, having general formula (I) and the pharmaceutically acceptable salts thereof. The invention also relates to a method for the production thereof and to pharmace...
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WO/1999/067275 |
Disclosed are novel unsaturated 14,15-cyclopropanoandrostanes of general formula (I) and the pharmaceutically acceptable salts thereof. The invention also relates to the production thereof and pharmaceutical preparations containing said ...
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WO/1999/058549 |
Certain novel sterol derivatives can be used for regulating the meiosis in oocytes and in male germ cells.
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WO/1999/051623 |
A medicine composition comprising, as an active component, an oleanane derivative represented by formula (1), wherein Me represents methyl, with respect to X, Y and Z; any of (1), (2), (3) and (4) is selected: (1) X and Z together repres...
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WO/1999/044616 |
A series of novel steroid derivatives are described. The steroid derivatives are antibacterial agents. The steroid derivatives also act to sensitize bacteria to other antibiotics including erythromicin and novobiocin.
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WO/1999/045025 |
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have formulae (I) or pharmaceutically acceptable salts thereof; where...
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WO/1999/034806 |
This invention provides novel compounds derived from a marine sponge, $i(Adocia sp.), that specifically modulate kinesin activity by targeting the kinesin motor domain and mimicking the activity of a microtubule. The compounds act as pot...
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WO/1999/028337 |
The invention relates to novel 15-methyl-cyclopropanosteroids of general formula (I), wherein R¿1? represents a hydrogen atom, an alkyl group, an acyl group, or a sulfamoyl group, R¿2? and R¿3? represent independently from each other ...
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WO/1999/002191 |
This invention provides methods and compositions for enhancing transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, th...
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WO/1998/055497 |
The present invention is directed to betulinol derivatives and betulinol-antibody conjugates having formulae (1), (2) and (3): HO-antibody-spacer-(A?2�)�n?, wherein A?1� is a moiety having formula (4); A?2� is a moiety having for...
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WO/1998/055499 |
The invention relates to 11$g(b)-aryl-substituted 14,17-ethano-oestratriens of general formula (I), in which R?1� is a hydrogen atom, a C�1?-C�12?-alkanoyl-, a benzoyl-, a straight-chain or branched C�1?-C�12?-alkyl-, a C�3?-...
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WO/1998/051294 |
A composition and method of preventing or inhibiting tumor growth, and of treating malignant cancers without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition.
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WO/1998/051293 |
A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, whi...
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WO/1998/042729 |
The invention relates to novel estratrienes of general formula (I) containing several sulfamoyoxy groups per molecule (m = 1-5). They are produced by reacting the appropriate steroid alcohols with sulfamoy or n-alkyl or alkanoylsulfamoyl...
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