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JP03275698 |
NEW MATERIAL:22α-Hydroxy-3-oxo-glycyrrhizic acid shown by the formula. USE: 3α-Hydroxysteroid dehydrogenase inhibitor useful as an antiinflammatory drug. PREPARATION: Licorice root of crude drug or root of Glycyrrhizae Radix, a raw pla...
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JP03218393 |
NEW MATERIAL: A compound of formula I {X is -CH2CH2- or a bridge of formula II; R1 is H, 1-15C acyl, benzoyl, 1-15C alkyl, 3-9C cycloalkyl or alkylcycloalkyl; R2 is formula III or IV [R3 and R4 are each H or (fluorinated) 1-8C alkyl]}. E...
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JP03209394 |
NEW MATERIAL: A compound of the formula (R contains at least one saccharide group; R1 H, lower alkyl). USE: A sweeting agent. Useful for chocolate, candy, cake, chewing gum, imitation meat product, protein of vegetable source, soy sauce,...
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JP02275895 |
NEW MATERIAL: A compd. represented by formula I [wherein R1' is a (substd.) thienyl, furyl, a cycloalkyl or a (substd.) phenyl, R2 is methyl or ethyl, R3' is H, a (substd.) alkyl, an alkenyl or a (protected) acetyl, R4' is H, OH or a (su...
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JP02243698 |
PURPOSE: To provide the subject compsn. for treating uterine cancer containing a diluent or a carrier and a specific (substd.) estrogen nucleus as a part of a molecular structure and a therapeutically effective amt. of a sexual steroid a...
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JP02209888 |
NEW MATERIAL: A compd. represented by formula I [wherein X1 is II or an acyl, R is groups represented by formulae II-IV (X2 is H or an acyl and Y is an alkyl or aryl)]. USE: A compd. useful for synthesizing a hydroxylated derivs. of vita...
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JP02209887 |
NEW MATERIAL: Compounds of formula I [N is steroid nucleus selected from formula II-formula IV (X1 is H, acyl). USE: Useful for synthesis of hydroxylated derivatives of vitamin D2. PROCESS: PTAD-Diene-protected-22 aldehyde of formula V, ...
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JP02209864 |
NEW MATERIAL: Compounds of formula I (X1, X2 are H, an acyl; Y is an alkyl, aryl). USE: Useful for synthesis of hydroxylated derivative, of vitamin D2. PROCESS: Steroid aldehyde of formula II is condensed with sulfone A to obtain a hydro...
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JP02209863 |
NEW MATERIAL: Compounds of formula I [X1 is H, an acyl; R is formula II- formula IV (X2 is H, an acyl; Y is an alkyl, aryl; when Y is methyl, both X1 and X2 are not H)]. USE: Useful for synthesis of hydroxylated derivative of vitamin D2....
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JP02209862 |
NEW MATERIAL: Compounds of formula I [X1 is H, an acyl; R is formula II- formula IV (X2 is H, an acyl; Y is an alkyl, aryl)]. USE: Useful for synthesis of hydroxylated, derivatives, of vitamin D2. PROCESS: A starting substance of aldehyd...
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JP02149598 |
PURPOSE: To solubilize γ-orizanol without using ethyl alcohol by dissolving a monoester-containing sucrose fatty ester in purified water, mixing a melt composed of a polyoxyethylene hardened castol oil and γ-orizanol therewith and fusi...
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JP02149597 |
PURPOSE: To enable stabilization of the subject compound in storage at low temperatures and uniform solubilization thereof by dissolution thereof into a mixture composed of a polyoxyethylene hardened castor oil, a monoester- containing s...
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JP02036192 |
NEW MATERIAL: Compounds of formula I [wherein R is -COOX (X is H or a 1-8C alkyl) or CH2OH]. EXAMPLE: Methyl 3β-hydroxy-chola-5,23t-diene-24-carboxylate. USE: Prevention and a remedy of hypercholesterolemia, an HMG-COA reductase inhibit...
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JP02032022 |
PURPOSE: To obtain a cerebral function activator, containing a steroid compound or salts thereof and having arousal action on the brain, especially cerebral epistatic center in cerebral limbic systems and activating function of volitiona...
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JP02028194 |
NEW MATERIAL: Compd. of formula I [wherein W is formulas II or III (wherein R1 is H, hydroxy or acyloxy; R2 and R3 are each hydroxy or acyloxy; when R2 is acyloxy, R1 and R3 are each different from hydroxy]. EXAMPLE: (20S)-20-methylpregn...
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JP01160996 |
NEW MATERIAL:The compound of formula I [R1 is H, lower alkyl(carbonyl) or pyranyl; R2 and R3 are halogen or hydroxy; X is H or hydroxy]. EXAMPLE: 3β-Acetoxy-24,25-dibromo-cycloartan-7-one. USE: A synthetic intermediate for glycinoeclepi...
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JP63159395 |
PURPOSE: To industrially and advantageously obtain the titled compound useful as a synthetic intermediate for vitamin Ds, brassinolides which are plant growth regulators and ecdysone derivatives which are insect molting hormones, by appl...
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JP63145231 |
PURPOSE: To obtain a cerebral function activation agent useful for the remedy of cerebral diseases and activation of cerebral function, especially activation of cognition, by using a steroid compound or its salt as a component. CONSTITUT...
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JP63104948 |
PURPOSE: To enable effective concentration and purification of constituent cycloartenol ferulic acid ester, etc., of oryzanol, at high concentration, by subjecting oryzanol to multi-stage recrystallization, etc., using a specific easily ...
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JP63104996 |
PURPOSE: To obtain a steroidal compound useful as a synthetic intermediate for plant growth regulators and brassinolide analogs in good yield by ready operation, by reacting a stigmasterol as a raw material under specific condition. CONS...
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JP63104995 |
PURPOSE: To industrially obtain the titled compound useful as an intermediate for synthesizing brassinolide analogs which are plant growth regulators in high yield, by heating a specific compound in the presence of a salt of a sulfonic a...
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JP63083096 |
PURPOSE: To obtain the titled compound useful as a raw material for plant growth regulator, etc., in high yield, without using Jones reagent, by oxidizing a specific sterol with an N-halocarboxylic acid amide in a halogenated hydrocarbon...
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JP63072698 |
NEW MATERIAL:1,2α-Methylene-6,7α-difluoromethylene-17α-(3'-hy
droxy-propyl) androst-4-en-17β-ol-3-one. USE: A production intermediate for 1,2α-methylene-6,7α-difluoro-methylene-20- sprirox-4-en-3-one (MDS) useful as a remedy for hy...
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JP63054394 |
NEW MATERIAL:A compound expressed by formula I (R2 is H, OH or trifluoroacetoxy when R1 is methyl; R2 and R3 together form π bond; R1 and R2 together form methylene; R3 is H; R4 and R5 are H or R4 and R5 together form π bond; R6 is H o...
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JP63014796 |
PURPOSE: To separate and purify the titled compound useful as a remedy for autonomic imbalance, menopausal disorders, etc., by crystallizing substance containing cycloartenol ferulate, using a specific mixed solvent and then a specific s...
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JP63014797 |
PURPOSE: To economically obtain the titled compound useful for hyperlipemia, antipsychotic agent, etc., in high purity and good yield, by purifying a starting material such as crude or purified oryzanol using specific crystallization ope...
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JP63014798 |
NEW MATERIAL:A compound of formula I [formula II is formula IIIWV (R4 is 1W4C alkyl or benbyl; R5 is 1W4C alkyl, 1W4C alkoxy 1W2C alkyl or tetrahydropyranyl); R1 is 1W3C alkyl; R2 is H or 1W2C alkyl; R3 is H, acetyl, propionyl, benzyl, b...
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JP62277326 |
PURPOSE: To provide a medicine containing cycloartenol ferulic acid ester as an active component, useful for ameliorating amnesia and cerebral function disorder caused by injury at the head or neck, having low side effect and administrab...
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JP62135488 |
NEW MATERIAL:The compound of the formula. USE: A solublizer for substances which are poor in solubility in water such as steroids. PREPARATION: Tubers of shell, Bolbostemma paniculatum (Maxim.) Franquest, a Chinses medicine called tu-bei...
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JP62099396 |
PURPOSE: A specific 6-ketosteroid is iosmerized by using hydrobromic acid as a catalyst and heating them in a solvent to give the title compound which is used as a synthetic intermediate of brassinolides in high yield. CONSTITUTION: A 6-...
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JP62048694 |
NEW MATERIAL:A compound expressed by formula I (X is H or, together with Y, forms methylene; Y is H, alkanoylthio or aroylthio when X is H; the broken lines at C1-C2 and C6-C7 are, as necessary, double bond). EXAMPLE: 17-Hydroxy-15β, 16...
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JP62012792 |
PURPOSE: To isolate a pure saponin mixture containing a novel saponin useful for preventing and treating arteriosclerosis, by concentrating an extract solution of Astragali Radix with a lower alcohol and treating the resultant extract by...
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JP61275295 |
PURPOSE: To obtain steroid (MDS) useful for remedying hyperandrogeninosis such as a pimple, etc., in high yield by reacting 1,2α-methylene-20-spirox-4,6- dien-3-one with a specific alkali metal acetate. CONSTITUTION: 1,2α-Methylene-20-...
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JP61251698 |
NEW MATERIAL:A steroid of formula I (X is hydroxyl; Y is H: or X and Y forms oxo; R' is H, acyl, silyl, alkoxycarbonyl, benzyl or incorporate each other to form alkylidene or carbonyl; configurations in 22-, 23-positions are 22R, 23R or ...
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JP61243099 |
NEW MATERIAL:An α-1W4C alkyl cinnamate having one or two substituent groups of triterpene alcohol on the benzene nucleus, or a benzoic acid ester or cinnamic acid ester having two substituent groups comprising 1W4C alkoxy group and nitr...
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JP61243022 |
NEW MATERIAL:An α-1W4C alkylcinnamic ester having a monosubstiuent and disubstiuent groups of triterpene alcohol linked to the benzene nucleus or cinnamic ester of benzoic ester having disubstituent groups of 1W4C alkoxy and NO2, 1W4C a...
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JP61194022 |
PURPOSE: To obtain the titled coprecipitation product having high absorbability, improved solubility of cycloartenol ferulic acid ester which is a component of γ-oryzanol, and increased remedying effect to autonomic imbalance, by adding...
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JP61040298 |
PURPOSE: To provide the titled complex having increased rate of dissolution in water and absorbability through digestive tracts, and having antiarteriosclerotic and gonadotropic activities, etc., by clathrating a cycloartenol ferulic aci...
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JP60258119 |
PURPOSE: The titled remedy, containing specific three kinds of organic esters of triterpene alcohol, capable of reducing the total cholesterol, total phospholipid and triglyceride content in blood serum and increasing the content of high...
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JP60258198 |
NEW MATERIAL:Triterpene alcohol organic acid ester where esters of feluric, saturated monobasic and dibasic acids are excluded. EXAMPLE: Cycloartenol 3,4-dihydroxycinnamate ester. USE: Antihyperlipemic: it is stable, and low in toxicity....
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JP60248611 |
PURPOSE: An arteriosclerotic agent that contains, as an active ingredient, cycloartenol ferulate, thus showing good activity of reducing lipids and further causing no problem on safety (hepatic disorder) on long period administration. CO...
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JP60222496 |
NEW MATERIAL:A compound shown by the formula I (X is hydroxy, Y is alkali metallic salt of carboxyethyl, or X and Y together with neighboring carbon atom form lactone ring shown by the formula II). EXAMPLE: 17-Hydroxy-6β-,7β-methylene-...
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JP60181098 |
PURPOSE: To produce the titled compound useful as a raw material of phyto- hormone, etc., by preparing a 1-sterol mixture from a mixture containing brassicasterol, and subjecting the sterol mixture to inverted-phase partition column chro...
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JP60139685 |
PURPOSE: To obtain the titled compund which is a plant growth promoting substance in high yield in short steps, by mesylating the hydroxyl group of an easily available brassicasterol, reacting the resultant reaction product with sodium a...
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JP60130598 |
PURPOSE: 24-Methylenecycloartanol (ferulate ester) is solely or together with nonvolatile liquid, fluidized, then brought into contact with a solid catalyst such as acidic clay under vacuum to achieve industrially advantageous production...
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JP60105695 |
PURPOSE: To solubilize oryzanol useful for treating diseases derived from autonomic imbalance and antioxidants for processed food, etc. without using a surfactant, by reacting a specific amide based compound such as urea or nicotinic aci...
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JP59181300 |
PURPOSE: To obtain the titled compound having a substituent group and useful as a plant growth promoting agent, etc., stereoselectively and economically in an industrial scale, by reacting a specific brassinosteroid having protected hydr...
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JP59139400 |
NEW MATERIAL:A compound of formula I (X is H, halogen, hydroxyl; Y is H, lower alkyl, halogen, alkylthio; X and Y may incorporate to form a ring; Z1 is hydroxyl; Z2 is carboxyethyl alkali metal salt; Z1 and Z2 may incorporate together wi...
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JP59073600 |
PURPOSE: An ovulatory inducing agent, containing 24-methylenecycloartanol as a main constituent, and useful as a remedy for amenorrhea, dysmenorrhea, ovulatory disorder, menstrual cycle abnormality, etc. CONSTITUTION: An ovulatory induci...
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JP59036623 |
PURPOSE: The titled pharmaceutical, containing a 9,19-cyclolanostane derivative isolated as a component of Astragali Radix as an active constituent, capable of stimulating a host to promote the production of interferon, and useful as an ...
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