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Matches 1 - 50 out of 907

Document Document Title
WO/2018/145578A1
Disclosed is a method for synthesizing astragaloside IV, comprising the following steps: protecting hydroxyl groups at the 3-position and 6-position of cycloastragenol using protecting groups R1; after protecting hydroxyl groups at the 1...  
WO/2018/029604A1
The present invention relates to C-3 novel triterpenone with C-17 reverse amide compounds of Formula (I); and pharmaceutically acceptable salts thereof, wherein ring Formula (II), R1, R2, R3, R4, R5, R6, R7, 'n' and 'm' are as defined in...  
WO/2018/029610A1
The present invention relates to C-3 novel triterpenone with C-17 N-amide compounds of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6 and 'X' are as defined in formula (I). The invention also r...  
WO/2018/029602A1
The present invention relates to C-3 novel triterpenone with C-28 heterocycle compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, W, ring X and ring Y are as defined in formula (I). The present invention ...  
WO/2018/025247A1
The present invention relates to C-3 novel triterpenone with C-28 diamide compounds of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6 and 'm' are as defined in formula (I). The present inventio...  
WO/2017/215677A2
Disclosed are a carbocisteine pharmaceutical composition and effects thereof for treating leukemia. The carbocisteine pharmaceutical composition provided in the present invention comprises carbocisteine and a naturally produced compound ...  
WO/2017/215677A3
A carbocisteine pharmaceutical composition and use thereof in preparing medications for treating leukemia. The carbocisteine pharmaceutical composition provided in the present invention comprises carbocisteine and a naturally produced co...  
WO/2017/021852A1
Method for the separation of at least one isoprenic constituent from the resin of a plant of guayule and/or of the guayule type comprising the steps of: a) providing a defatted resin of guayule and/or of the guayule type; b) subjecting t...  
WO/2016/173524A1
Disclosed in the present application are the compounds as shown in formulae I, II, III, IV or V, tautomers thereof, stereoisomers thereof or pharmaceutically acceptable salts thereof, and also disclosed is the use thereof in preparing dr...  
WO/2016/007535A1
This disclosure concerns compounds which are useful as HSP90/CDC37 antagonists and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the interaction of HSP90 and CDC37. This disclosur...  
WO/2014/167386A1
A process is disclosed wherein, using either 17a-(3-hydroxypropyl)-6p,7p;15p,16p- dimethylene-5p-androstane-3p,5,17p-triol (II) or 3β,5^ΐΙ^κ^-6β,7β;15β,16β- dimethylene-5β,17α-pregnane-21,17-carbolactone (III) as starting mater...  
WO/2014/128525A1
A process is described wherein, by employing 17a-(3-hydroxypropyl) -63,7β3;15β,16β-dimethylene-5β-androstane-3β,5,17β-tri ol (II) as starting product, in a single stage reaction there is obtained drospirenone, (I), whereby the reac...  
WO/2014/022772A1
In one aspect, the invention relates to methods for promoting muscle hypertrophy or decreasing adiposity by providing to an animal in need thereof an effective amount of a compound. This abstract is intended as a scanning tool for purpos...  
WO/2014/011085A1
The invention relates to the field of medicine. Described is an effective, low-toxicity agent in the form of the methyl 2-cyano-3,12-dioxo-18βН-olean-1(2),11(9)-dien-30-oate of formula (1): which exhibits antioxidant, anti-inflammatory...  
WO/2014/011085A8
The invention relates to the field of medicine. Described is an effective, low-toxicity agent in the form of the methyl 2-cyano-3,12-dioxo-18βН-olean-1(2),11(9)-dien-30-oate of formula (1): which exhibits antioxidant, anti-inflammatory...  
WO/2013/100811A1
The invention relates to the chemistry of natural and physiologically active substances and especially, to a process for obtaining an intermediate product in the synthesis of steroid hormones of the pregnane series. The process for obtai...  
WO/2013/091144A1
The present invention relates to a compound characterized by the following Formula I or a pharmaceutically acceptable salt thereof, wherein X, Y, and Z are as described herein. Compounds of the present invention are useful for the treatm...  
WO/2013/089594A1
The invention relates to the chemistry of natural and physiologically active substances and more particularly to a process for obtaining an intermediate product in the synthesis of steroid hormones of the pregnane series. The targeted...  
WO/2013/089595A1
The invention relates to the chemistry of natural and physiologically active substances and more particularly to a process for obtaining an intermediate product in the synthesis of steroid hormones of the pregnane series. The targeted ta...  
WO/2013/038316A1
The present invention relates to a method for preparation of betulinic acid from betulin. The method comprises oxidizing betulin to betulinic acid with a catalyst of formula (5), e.g. 2,2,6,6-tetramethylpiperidine 1 - oxyl (TEMPO), in th...  
WO/2013/038314A1
The invention relates a method for preparation of betulonic acid or betulinic acid from betulin wherein the method comprises a stage for oxidizing betulin to betulonic aldehyde and/or betulinic aldehyde with Pd(ll)-catalyst catalyzed oxi...  
WO/2013/038312A1
The present invention relates to a method for preparation of betulinic acid from betulin. The method comprises oxidizing betulin to betulinic and/or betulonic aldehyde with a ruthenium based catalyst catalyzed oxidation process in the pr...  
WO/2013/020245A1
Disclosed are a compound characterized by the following formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising said compound or a pharmaceutically acceptable salt thereof, wherein R3, L, and ...  
WO/2012/160250A3
The present invention provides an improved method for obtaining a bark extract by hydrolysis and acidification in the presence of water. The method comprises the steps of subjecting birch bark to hydrolysis; separating the undissolved ba...  
WO/2012/160250A2
The present invention provides an improved method for obtaining a bark extract by hydrolysis and acidification in the presence of water. The method comprises the steps of subjecting birch bark to hydrolysis; separating the undissolved ba...  
WO/2012/109752A1
The present invention includes novel compounds based on the tomatidine skeleton as well as composition comprising these compounds alone and in combination with known compounds, which exhibit antimicrobial activity against extracellular o...  
WO/2012/107513A1
The invention relates to processes for obtaining 6β,7β; 15β, 16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone, commonly known as Drospirenone, as well as to intermediate compounds of formula (II) useful in said process.  
WO/2012/023599A1
A process for producing a triterpene alcohol by carrying out the following steps (A)-(C) in this order: (A) hydrolyzing γ-oryzanol with an alkali; (B) mixing the resulting alkali hydrolysate with a low-polar organic solvent to extract t...  
WO/2012/016860A1
The invention relates to a process for the preparation of Drospirenone in high yields and purity starting from a compound of formula (2) wherein R is a hydroxyl protective group as defined in the claims, through a sequence of oxidation, ...  
WO/2011/113196A1
Preparation method of drospirenone is disclosed, which uses 3β,5-dihydroxy-6β,7β,15β,16β-dimethylene-5β-androster- 17, 20-epoxy as the starting material and comprises the following steps: oxidizing the hydroxyl group at position 3,...  
WO/2011/060634A1
23-hydroxy-betulinic acid derivatives, including 3-oxo-23-hydroxy-betulinic acid, 3-oxo-23-hydroxy-dihydrobetulinic acid and 23-hydroxy-dihydrobetulinic acid, their preparation methods and medical uses as antitumor and anti-HIV agents ar...  
WO/2010/146042A1
The invention relates to processes for obtaining steroids with a spirolactone group in position 17, particularly to industrially obtaining 6β,7β; 15β,16β-dimethylene-3-oxo-17α- pregn-4-ene-21,17-carbolactone, commonly known as Drosp...  
WO/2010/142705A1
The present invention relates to substituted steroid compounds having the formula (I) Wherein R1 is H or halogen; R2 is H, (1C-4C)alkyl, (1C-4C)acyl, glucuronyl or sulfamoyl; R3 is H or halogen; R4 is H, (1C-4C)alkyl, (2C-4C)alkenyl or (...  
WO/2010/133687A1
The present invention relates to a compound with the following formula (I), or to a pharmaceutically acceptable salt thereof, as well as to pharmaceutical compositions including same and to the use thereof as a drug, in particular for tr...  
WO/2010/134830A1
Formule (I) and (II). The present invention relates to the use of a new lupane derivative of general formula (I) or (II), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, for preventin...  
WO/2010/118023A1
Described herein are methods of making drospirenone. Also described are intermediate compounds that may be used to synthesis drospirenone.  
WO/2010/114305A3
The present invention relates to a PEGylated betulin derivative, and a cosmetic composition containing the same. The PEGylated betulin derivative of the present invention is water-soluble and has an excellent UV blocking effect, a white ...  
WO/2010/114305A2
The present invention relates to a PEGylated betulin derivative, and a cosmetic composition containing the same. The PEGylated betulin derivative of the present invention is water-soluble and has an excellent UV blocking effect, a white ...  
WO/2010/058795A1
Provided is an antioxidant which is highly safe, inhibits oxidation of biological components, in particular, lipids and is usable as a drug, a food or a drink, a food additive, an external skin preparation and so on. A compound selected...  
WO/2010/028487A1
The instant application is directed to bidesmosidic betulin and betulinic acid saponin derivatives of formula (I), and use thereof as antitumor agents. In particular, said compounds are effective in treating lung carcinomas, colorectal a...  
WO/2009/146811A1
The present invention relates to C-ring-substituted pregn-4-ene-21,17-carbolactones of the general formula I in which R6,7 is an α- or β-methylene and R9 is a hydrogen atom and R11 is a bromine, chlorine or fluorine atom or R9 and R11 ...  
WO/2009/111574A3
Described herein are bismethylene-17α carbolactone derivatives having progestational and/or antimineralocorticoid and/or aldosterone antagonistic activity. Also described herein are methods of preparing and using these novel compounds.  
WO/2009/100532A1
The invention relates to 17ß lupane derivatives of formula (I): wherein R1 and X are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the inventi...  
WO/2009/083268A2
The invention relates to 17-(1'-propenyl)-17-3'-oxidoestra-4-en-3-one derivatives with general chemical formula (1) wherein the radicals Z, R4, R6a, R6b, R7, R15, R16a, R16b and R18 have the designations given in claim 1, and to the solv...  
WO/2009/083267A3
The invention relates to steroid-17, 17-lactol-derivatives with the chemical formula (I) and the tautomer forms thereof with general chemical formula (Ia) wherein R4, R6a, R6b, R7, R15, R16a, R16b, R18, R22and Z have the designations giv...  
WO/2009/083268A3
The invention relates to 17-(1'-propenyl)-17-3'-oxidoestra-4-en-3-one derivatives with general chemical formula (1) wherein the radicals Z, R4, R6a, R6b, R7, R15, R16a, R16b and R18 have the designations given in claim 1, and to the solv...  
WO/2009/082819A8
The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, th...  
WO/2009/082818A1
The invention relates to 21 -keto triterpene compounds of formula (I): wherein R1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, th...  
WO/2009/083271A1
The invention relates to 15,16-methylene-17-(1 '-propenyl)-17-3'-oxidoestra-4-en-3-one derivatives with general chemical formula (I), wherein Z, R4, R6a, R6b, R7 and R18 have the designations given in claim 1, and to the solvates, hydrat...  
WO/2009/083267A2
The invention relates to steroid-17, 17-lactol-derivatives with the chemical formula (I) and the tautomer forms thereof with general chemical formula (Ia) wherein R4, R6a, R6b, R7, R15, R16a, R16b, R18, R22and Z have the designations giv...  

Matches 1 - 50 out of 907