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JP3984310B2 |
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JP3968114B2 |
To provide a new steroid compound useful as an anti-estrogenic agent. The compound has a structure of formula (III). The invention further relates to a pharmaceutical composition containing the compound or its pharmaceutically permissibl...
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JP3958101B2 |
To improve Corey-Kim oxidation of an alcohol. The reagent for oxidation reaction of an alcohol comprises a compound represented by the formula: P-X1-SR (I) (wherein P is a polymer residue; X1 is a spacer; R is H or CH3). The reagent redu...
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JP2007161684A |
To provide a triterpene compound having an excellent melamine production-inhibiting effect, and to provide an external preparation used for the skins and containing the compound as an active ingredient.This triterpene compound is represe...
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JP2007143413A |
To provide a method for eliminating unfavorable smell-causing components and bitter taste components which a quillai extract contains, and a method for producing quillai extract from which the unfavorable smell-causing components and the...
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JP2007515455A |
The invention provides 19-nor-D-homosteroids, having a mixed androgenic/progestagenic profile, which are orally active, prevent trabecular bone mineral density (BMD) loss, and which lack liver toxicity, having a structure according to th...
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JP2007506761A |
The present invention relates to novel synthetic derivatives of triterpenes and the use of such derivatives as pharmaceuticals. The present invention is directed to novel compounds of Formula I: or pharmaceutically acceptable salt or est...
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JP2007502801A |
The invention relates to Delta15-D-homosteroids of general formula (I) process for their production and pharmaceutical compositions that contain these compounds. The compounds of general formula I according to the invention have androgen...
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JP2007022923A |
To provide a hair follicle apoptosis inhibitor having prevention of fallen hair caused by hair follicle apoptosis and growth promotion effect of healthy hair thereby, and a hair cosmetic composition in which the hair follicle apoptosis i...
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JP2006327965A |
To provide a skin care preparation capable of being suitably applied to inflammation such as allergic inflammation and atopic dermatitis, of which the control is difficult for an ordinary anti-inflammatory, such as indomethacin or predni...
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JP3828953B2 |
To obtain an inhibitor of a lipase, having high safety and high inhibiting activities against the lipase and capable of preventing a food from deteriorating by blending at least one of a compound of triterpenes and its derivative, etc., ...
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JP2006522051A |
A process for producing an extract of ivy leaves using an extracting agent, with the extract comprising alpha-hederin. In this process, a quantity of dried ivy leaves is first of all comminuted, then fermented by adding water and subsequ...
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JP2006520756A |
Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid sequences containing a mutation in the Gag p25 pr...
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JP3820349B2 |
A sulphamate compound suitable for use as an inhibitor of oestrone sulphatese (E.C.3.1.6.2) is described. The compound is a polycyclic compound comprising at least two ring components, wherein the polycyclic compound comprises at least o...
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JP3810827B2 |
PURPOSE: To easily obtain at low cost in an industrially advantageous way a tea leaf saponin useful for the food area, medicines, quasi-drugs etc., by subjecting the hot water extraction residues of tea leaves to extraction with a hydrou...
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JP3802034B2 |
To obtain a cosmetic composition highly stimulating collagen synthesis. Betulic acid is used in production of therapeutic agents for wrinkles of the skin, slackening of the skin, phlegmon and actinic diseases. The betulic acid is used in...
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JP2006169236A |
To provide a new diabetes-therapeutic agent having both properties of a biguanide-based medicine and a nateglinide-based medicine and reduced in adverse effects less than those of the medicines.The new diabetes-therapeutic agent is a gly...
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JP2006515859A |
New triterpenoid derivatives with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) were synthesized. Among them, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile (CNDDO), 1-(2-cyano-3...
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JP3783200B2 |
To obtain a composition having a vascularizing action. This vascularizing agent is characterized by formulating friedelin and/or an extract obtained from one or more plants selected from plants containing the friedelin.
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JP2006512330A |
The invention relates to a composition containing total triterpenoid sapogenins extracted from bamboo, the preparation method and use thereof. These total triterpenoid sapogenins are extracted from many parts of bamboo such as bamboo sha...
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JP3754762B2 |
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JP3746075B2 |
Gonadal and D-homo gonadal steroid derivatives of formula (I) and their salts are new. A double bond may be present between atoms 9 and 11, 8 and 9, 8 and 14, 14 and 15, 6 and 7 or 7 and 8; between atoms 8 and 9 and 14 and 15 or between ...
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JP2006504706A |
The present invention describes the use of pomolic acid, its derivatives and pharmaceutical preparations derived from them as anti-neoplasic agents in the treatment of multidrug resistant tumors. In relation to other drugs that present a...
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JP2006504704A |
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable sa...
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JP3727353B2 |
A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (I) or a salt thereof: wherein R<1> represen...
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JPWO2004009521A1 |
The present invention comprises a compound selected from the group consisting of soyasaponins compounds, soyasapogenins compounds, glycyrrhizins and salts thereof as an active ingredient, and is a therapeutic agent for a disease requirin...
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JP2005532296A |
An improved method is provided for treating disease states characterized by the existence of pathogenic cell populations. In accordance with the improved method, cell-targeted ligand-immunogen or ligand-hapten complexes are administered ...
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JP2005527613A |
Composition for halting the metastasis of cancer cells comprising rubidum ursolate. The rubidium ursolate is formed from a mixture of rubidium and ursolic acid obtained from the bark of the Virburnum plant.
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JPWO2003057224A1 |
The present invention contains, as an active ingredient, a compound selected from the group consisting of maslinic acid, erythrodiol, uvaol, bethulin, physiologically acceptable salts thereof and derivatives thereof, which have an apopto...
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JP3684370B2 |
Disclosed herein are modified saponins or fractions thereof obtainable by modification of a crude Quillaja saponaria extract or by modification of purified saponins obtainable from a crude Quillaja saponaria extract useful in pharmaceuti...
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JP2005519913A |
The invention provides novel compounds that are quaternary amine derivatives of betulin and other triterpenes. The compounds have antibacterial, antifungal, and surfactant properties.
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JP2005170918A |
To provide a skin care preparation for external use effectively improving rustle, dryness and roughness of the skin without having an association with type IV allergy reaction.This skin care preparation improves the turnover function of ...
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JPWO2003070263A1 |
The present invention provides a licorice hydrophobic extract having excellent powder properties, which is useful for foods, food additives, nutritionally functional foods, foods for specified health uses, dietary supplements, beverages,...
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JP2005517020A |
The invention relates to an improved method for obtaining highly pure, crystalline betulinic acid from a methanolic extract of ground plane bark and/or plane rind. The invention also relates to a highly pure, crystalline betulinic acid, ...
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JP2005137201A |
To provide a method for producing soyasapogenol B, by which the soyasapogenol B useful as a medicine or a raw material for medicines can newly be produced from sophoradiol (12-oleanene-3,22-diol).This method for producing soyasapogenol B...
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JP2005139114A |
To provide a diabetes treatment/prophylactic agent etc. which is effective for treating and preventing diabetes, does not induce hypoglycemia, is safely used as a therapeutic agent and for therapy, exerts an efficacy higher than those of...
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JP2005126370A |
To provide a method for retrieving momordicin by extracting it in high purity from Momordica charantia.The method comprises the following procedure: Momordica charantia is subjected to extraction with ethanol to form a Momordica charanti...
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JP3643491B2 |
To obtain a photoresist composition suitable for lithography process using a KrF (248 mm) or ArF (193 nm) light source. This photoresist composition contains a copolymer obtained by polymerizing a compound of the formula (R1 is hydrogen,...
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JP2005029570A |
To provide a method for inexpensively producing corosolic acid in high yield, in an industrial scale.The method for production of corosolic acid comprises a step starting from ursolic acid which exists in comparatively large amount in pl...
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JPWO2003029391A1 |
The present invention comprises extracting and treating olive plants and / or by-products obtained in the olive oil production process with an organic solvent or a hydrous organic solvent, such as oleanolic acid, maslinic acid, physiolog...
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JPWO2003028475A1 |
The present invention comprises one or more selected from the group consisting of pentacyclic triterpenes and their physiologically acceptable salts having an excellent melanin production inhibitory effect, or derivatives thereof. Regard...
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JP2004307397A |
To provide a standard substance capable of accurately and easily assaying a lipid hydroperoxide, and to provide such a stable lipid hydroperoxide capable of increasing its level in vivo when orally administered, thus usable in treating o...
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JP2004529107A |
The present invention discloses the use of ERSS-selective ligands for production of medicaments for regulating fertility without additional use of a progestin. ERSS-agonists are used for treatment of infertility and ERSS-antagonists for ...
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JP2004262868A |
To provide oleanane-based triterpene derivative having anti-inflammatory action.The present invention provides an oleanane-based triterpene derivative represented by general formula (I) to (III) or its pharmaceutically acceptable salt, a...
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JP2004528308A |
The invention provides use of an agent which lowers levels of 11beta-HSD1 in the manufacture of a composition for the promotion of an atheroprotective lipid profile.
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JP2004528360A |
The invention relates to the use of lipooxigenase inhibitors for treating acne, particularly inflammatory acne. The inventive lipooxigenase inhibitor can be used alone or in combination with other lipooxigenase inhibitors or anti-acne ac...
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JP3561063B2 |
To provide a new composition containing betulinic acid at a specific concentration and effective for highly stimulating the collagen synthesis. This composition contains ≥6 μM, preferably 6 μM to 50 mM of betulinic acid expressed by ...
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JP2004526779A |
The invention relates to an extract from the pods of lupin seeds containing lupeol, more particularly an extract wherein the content thereof by weight is greater than 30%, preferably greater than 50%, even more advantageously 70-100% The...
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JP2004525127A |
The invention relates to novel compounds having Vanilloid Receptor (VR1) antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders.
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JP2004215562A |
To obtain an orally administrable material, hardly causing hypoglycemia after administration and applicable to the therapy and prophylaxis of diabetes or elevation of blood glucose level.The additive for food and drink contains a compoun...
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