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WO/2008/138200A1 |
The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in preventing and treating central nervous system disorders by inhibiting over-activation of NMDA and/...
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WO/2008/140345A1 |
The invention relates to biologically active agents, in particular to glycyrrhizic acid derivatives, and also to substances for inhibiting the reproduction of human immunodeficiency virus. Glycyrrhizic acid di- and/or trinicotinates of g...
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WO/2008/136838A1 |
The invention concerns novel synthetic triterpenoids, such as CDDO-EA and CDDO-TFEA, and their use for the treatment and prevention of diseases, such as MS.
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WO/2008/137599A2 |
Novel 2-alkoxyestradiol analogs, pharmaceutical compositions and methods of treatment of proliferative and angiogenesis associated conditions are disclosed.
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WO/2008/124922A1 |
Compounds having the structure, their salts or N-oxide derivatives: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, a...
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WO/2008/111497A1 |
Disclosed is a novel prophylactic or therapeutic agent for an ophthalmic disease associated with oxidative stress. A compound represented by the general formula (I) or a salt thereof has an excellent activity of inducing the phase-II enz...
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WO/2008/086759A2 |
The invention relates to a method of preparation and isolation of betulin diacetate from birch bark from paper mills and its optional processing to betulin, wherein the birch bark is ground, mixed with two- to twenty-fold excess volume o...
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WO/2008/083461A1 |
There is provided a method of producing a plant composition comprising dehydrosoyasaponin I (D-I), the method comprising the steps of extracting a plant flour with a solvent capable of extracting soyasaponins to produce an extract, and t...
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WO2007141383A9 |
The invention relates to compounds derived from betulin, and to the use thereof in plant pest control, particularly as antifeedants for butterfly larvae, beetles and snails. Further, the invention relates to novel betulin derivatives and...
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WO/2008/071169A2 |
The invention relates to a method for modifying non-specific inhibitors of 11 beta hydroxysteroid dehydrogenase (11 beta HSD) with a basic pentacyclic framework of the oleanan and ursan type, in order to be able to synthesize chemical co...
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WO/2008/070347A2 |
The present invention provides for novel compounds of formula I, II, III and IV, as described herein. The present invention also provides for novel methods of manufacturing compounds of formula I, II and III from compounds of formula IV,...
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WO/2008/054250A1 |
The invention relates to organic chemistry and medicine, in particular to virology. More specifically the invention relates to a novel chemical compound n'-{n-[3-oxo-lupen-28-oyl]-9-aminononanoyl} -3-amino-3-phenylpropeonic acid of formu...
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WO/2008/037226A2 |
The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water-insoluble terpenoid having a free carboxylic, hydroxy or amino functional group is der...
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WO2008000070B1 |
The present invention relates to novel derivatives of glycyrrhetimc acid of Formula (I),
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WO/2008/000068A1 |
The present invention relates to a new method of preparing 2-iodo triterpenoid and related compounds via the reaction of the corresponding 1 ene-3-ones in the presence of iodine and pyridine in an ether solvent. The method is particularl...
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WO/2007/147713A1 |
New aminoalkoxyimino derivatives at position 3 of substituted B- homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, ...
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WO/2007/141390A1 |
The invention relates to conipouns derived from betulin, and to the use thereof as antiviral agents in applications of pharmaceutical industry, particularly as agents against alphaviruses.
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WO/2007/141392A2 |
The invention relates to compositions of cosmetic and pharmaceutical industries comprising betulonic acid for humans and animals, and further, to the use of betulonic acid in compositions of cosmetic and pharmaceutical industries. The in...
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WO/2007/141391A1 |
The invention relates to betulin derivatives, and to the use thereof as agents against protozoa of the genus Leishmania and against leishmaniasis in applications of pharmaceutical industry.
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WO/2007/141389A1 |
The invention relates to compouns derived from betulin, and to the use thereof as antibacterial agents in pharmaceutical and cosmetic applications.
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WO/2007/105015A2 |
The present invention relates to novel derivatives of 18β-glycyrrhetinic acid and methods of synthesising the derivatives. Also included within the scope of the present invention are pharmaceutical compositions comprising the derivative...
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WO/2007/101873A2 |
The present invention relates to betulonic and betulinic acid derivatives and, in particular, to C-28 and C-3 derivatives. The present invention relates to betulonic acid esters, dihydro-betulonic acid esters, PAG-modified betulinic acid...
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WO/2007/099304A1 |
There is provided a compound having Formula (I): wherein G is a fluorocarbyl group, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group, capable of inh...
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WO/2007/098247A2 |
Substituted taraxastanes useful for treating viral infections, are provided herein. Thus, in a first aspect, the invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, wherein the variables Ri, R2, a...
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WO/2007/094497A1 |
Disclosed is an ameliorating or prophylactic agent for metabolic syndrome, which comprises, as an active ingredient, at least one triterpene selected from the group consisting of corosolic acid, a corosolic acid analogue and pharmaceutic...
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WO/2007/077203A2 |
The invention relates to triterpenequinone and triterpenephenol derivatives, their pharmaceutically acceptable 5 salts, prodrugs, solvates or stereoisomers as selective blocking agents of the choline kinase enzyme, pharmaceutical composi...
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WO/2007/060684A1 |
The present invention provides an improved process for the isolation of oleane compounds from the bark of Terminallia arjuna ( Roxb.). More particularly, the present invention relates to an improved process for the isolation of arjunic a...
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WO/2007/042542A1 |
The invention relates to a large-scale method for producing highly pure betulinic acid from ground plane tree bark, the betulinic acid representing 3ß-hydroxy-lup-20(29)-en-28-acid of formula
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WO/2007/006208A1 |
Medicinal composition containing ginseng secondary glycosides, its preparation method and application. The present composition contains mainly, as active ingredients, the ginsenoside with protopanoxadiol as aglucone (ginsenoside Rg3) and...
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WO/2006/134167A1 |
The invention provides for compounds having formula (1) wherein, R1 is O, (H,H), (H,OH), or NOR, with R being hydrogen, (C1-6) alkyl or (C1-6) acyl; R2 is hydrogen, methyl, ethyl, or ethenyl; R3 is hydrogen, methyl, ethyl, ethenyl, fluor...
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WO/2006/133395A2 |
The present invention provides for methods of selectively converting triterpen-3-ones to the corresponding triterpen-3-ols. The selectivity of the methods is at least about 80% of the beta-isomer, at the C-3 position. Specifically, the p...
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WO/2006/133314A2 |
The present invention provides for methods of selectively converting betulin to betulonic aldehyde. The present invention also provides for methods of selectively converting 3-substituted triterpen-28-ols to the corresponding 3-substitut...
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WO/2006/132033A1 |
In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphatized to produce a phosphatized triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation...
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WO/2006/105356A2 |
The present invention provides a method for preparing a compound of formula (I), the method comprising contacting a compound of formula (II) with an effective amount of a compound of formula (III) or (IV). The present invention also prov...
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WO/2006/105354A1 |
The present invention provides a process of preparing betulin-28-aldehyde from betulin. The process includes contacting betulin with a compound of formula (I), e.g., TEMPO (2,2,6,6-tetramethylpiperidine 1-oxyl) for a period of time effec...
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WO/2006/077801A1 |
A method for preparing a compound represented by the formula (II): (II), which comprises reacting a compound represented by the formula (I): (I), wherein each of R1 and R1' is independently a lower alkyl optionally having a substituent a...
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WO/2006/069466A1 |
The invention discloses series of triterpenoid PTP1B inhibitors of following formula (I), and the pharmacologic studies further suggests such compounds or their physiological acceptable salts have the activity of inhibiting PTP1B, thus t...
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WO/2006/069499A1 |
The present invention relates to a class of triterpenes type PTP1B inhibitors having structures as below. Pharmacological studies indicate that this class of compounds or the physiological acceptable salts thereof have inhibitory activit...
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WO/2006/031943A1 |
The present invention provides compounds and compositions useful for controlling bacterial biofilms as well as for controlling and/or preventing bacterial infections. The compounds of the invention are pentacyclic acid triterpenes. Metho...
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WO/2006/003012A1 |
The invention relates to novel 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula (I) wherein R2 represents a C1-C8 alkyl, a C1-C8 alkyloxy group or a halogen atom, R13 represents a hydrogen atom or a methyl group, and R17 r...
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WO/2006/002602A1 |
The invention provides the uses. of Xanthoceras sorbifolia. Especially, it provides extracted from husk or fruit-stems of Xanthoceras sorbifolia, the method for preparing the same and uses thereof. The compound is named as Xanthoceraside...
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WO/2005/105823A1 |
The invention relates to compounds of formula (I) and their salts, wherein R1 is straight- or branched-chain alkyl of l-4 carbon atoms or halogen-substituted straight- or branched-chain alkyl; wherein halogen is fluorine, chlorine, bormi...
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WO/2005/097819A1 |
The invention relates to D-homo-17-chloro-16(17)-en steroids of formula (I) having an androgenic activity, methods for the production thereof, pharmaceutical compositions containing said compounds, and the use thereof for producing medic...
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WO/2005/061528A2 |
This invention provides 19-nor-D-homosteroids, having a mixed androgenic/progestagenic profile, which are orally active, prevent trabecular bone mineral density (BMD) loss, and which lack liver toxicity, having a structure according to t...
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WO/2005/047304A2 |
The present invention provides a method for obtaining a natural product (e.g., betulin, lupeol and/or betulinic acid) from a plant extract (e.g., birch bark extract). The method employs a distillation with water and an organic solvent th...
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WO/2005/021573A1 |
The invention relates to &Dgr 15-D-homosteroids of general formula (I), methods for the production thereof, and pharmaceutical compositions containing said compounds. The inventive compounds of general formula (I) are provided with andro...
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WO/2005/002496A2 |
The invention relates to a method of obtaining taxosteroids and the precursors thereof from hydrindane bicyclic systems. According to the invention, the compounds have a tetracyclic system which combines the structural characteristics of...
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WO/2004/112815A1 |
A substance excelling in the efficacy of melanogenesis promotion and being effective in hair graying prevention and amelioration and in skin melanism; and a composition making effective use of the substance. In particular, such a substan...
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WO/2004/089357A2 |
The present invention provides for pharmaceutical compositions that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides for a cosmetic formulation that includes a triterpene...
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WO/2004/074309A1 |
The invention relates to D-homoestra-1, 3, 5 (10)-trien-3-yl 2-substituted sulfamates of general formula (I), wherein R3 is C1-C5 alkyl or a C1-C5 alkyloxy group and to the use thereof for producing a drug for curing tumoral diseases whi...
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