Steroids

Matches 301 - 350 out of 929	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2000/039249A1	UME EXTRACT HAVING MEDICINAL EFFECTS AND COMPOSITIONS CONTAINING THE SAME Ume ($i(Prunus mume) SIEB. et Zucc.) leaf, stem, nucleus and flower are extracted 5 times by volume as much methanol. The obtained extract has an antioxidative effect, an inhibitory effect on gastric mucosa damage, an aldose reductase in...
WO/2000/026174A2	PROCESS FOR PREPARING NATURAL PRODUCT DERIVATIVES FROM PLANTS IN A SINGLE STEP A process is disclosed, for preparing a derivative of a targeted natural product from plants. The targeted natural product is extracted from the desired part of the plant and the targeted natural product is transformed into the desired d...
WO/2000/026229A1	2-SUBSTITUTED-D-HOMOOXASTEROID DERIVATIVES Oxasteroid derivatives represented by general formula (a) which have excellent effects of inhibiting the polymerization of tubulin, inhibiting neovascularization and/or stabilizing p53 protein Zn formula (a) one of A and B represents C=O...
WO/2000/024762A1	BETULINIC ACID AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF NEUROECTODERMAL TUMORS The present invention is, generally, directed to the use of betulinic acid and derivatives thereof for the treatment of neuroectodermal tumors. The present invention is based on the discovery that betulinic acid and its deriatives are po...
WO/2000/009075A2	CHEMICALLY MODIFIED SAPONINS AND THE USE THEREOF AS ADJUVANTS The present invention is directed to novel bidesmosidic saponin derivatives comprising a triterpene aglycone core substituted at positions 3 and 28 with a monosaccharide or an oligosaccharide which can be the same or different, and havin...
WO/2000/003748A2	COMPOSITIONS WHICH CONTAIN TRITERPENES FOR REGULATING HAIR GROWTH The present invention relates to compositions containing i) from about 0.0001 % to about 99.9 % of certain compounds selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane tri...
WO/2000/003749A2	METHOD FOR REGULATING HAIR GROWTH A method for regulating the growth and loss of hair via the use of compositions containing a compound selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane triterpenes, deriv...
WO/1999/067272A1	A COMPOUND, WF002, PRODUCTION THEREOF AND USE THEREOF The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprisin...
WO/1999/065478A1	THERAPEUTIC COMPOSITIONS AND METHODS OF USE Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
WO/1999/053933A1	PROCESS FOR RECOVERY AND PURIFICATION OF SAPONINS AND SAPOGENINS FROM QUINOA ($i(CHENOPODIUM QUINOA)) The invention relates to a process for commercial extraction of saponins from quinoa, and optionally for the formation of corresponding sapogenins. The saponin extraction process comprises contacting a saponin-containing part of a quinoa...
WO/1999/051623A1	DEPRESSANT FOR PRODUCTION OF TGF-$g(b) A medicine composition comprising, as an active component, an oleanane derivative represented by formula (1), wherein Me represents methyl, with respect to X, Y and Z; any of (1), (2), (3) and (4) is selected: (1) X and Z together repres...
WO/1999/046279A2	INHIBITORS OF TYPE 5 AND TYPE 3 17$g(b)-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE Novel methods of medical treatment and/or inhibition of development of diseases are disclosed for diseases that are sensitive to androgenic or estrogenic activity. The treatments utilize inhibitors of type 5 and/or type 3 17$g(b)-hydroxy...
WO/1999/045025A1	ACYLATED BETULIN AND DIHYDROBETULIN DERIVATIVES, PREPARATION THEREOF AND USE THEREOF Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have formulae (I) or pharmaceutically acceptable salts thereof; where...
WO/1999/027935A1	STEROID 3-O-SULPHAMATE DERIVATIVES AS INHIBITORS OF OESTRONE SULPHATASE A sulphamate compound suitable for use as an inhibitor of oestrone sulphatase (E.C.3.1.6.2) is described. The compound is a polycyclic compound comprising at least two ring components, wherein the polycyclic compound comprises at least o...
WO1998052573A9	TRITERPENE SAPONIN ANALOGS HAVING ADJUVANT AND IMMUNOSTIMULATORY ACTIVITY The present invention is directed to novel chemical compounds in which a lipophilic moiety such as a lipid, fatty acid, polyethylene glycol or terpene is covalently attached to a non-acylated or desacylated triterpene saponin via a carbo...
WO/1998/058946A1	TRITERPENE DERIVATIVES AND MEDICINAL COMPOSITION Oleanane derivatives represented by general formula (I) or pharmacologically acceptable salts thereof; and a medicinal composition containing any of these as the active ingredient, wherein Me represents methyl; X, Y, and Z are any of the...
WO/1998/051294A2	METHOD AND COMPOSITION FOR TREATING CANCERS A composition and method of preventing or inhibiting tumor growth, and of treating malignant cancers without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition.
WO/1998/051293A1	USE OF BETULINIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF MELANOMA A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, whi...
WO/1998/043936A2	IMPROVED METHODS OF MANUFACTURING BETULINIC ACID Improved methods of manufacturing betulinic acid from betulin are disclosed. The methods provide the $g(b)-isomer of betulinic acid in high purity and high yield.
WO/1998/042729A2	STEROID SULFAMATES, METHOD FOR THE PRODUCTION AND USE THEREOF The invention relates to novel estratrienes of general formula (I) containing several sulfamoyoxy groups per molecule (m = 1-5). They are produced by reacting the appropriate steroid alcohols with sulfamoy or n-alkyl or alkanoylsulfamoyl...
WO/1998/040077A1	ANTI-ANGIOGENIC AGENTS The application discloses methods of treating mammalian diseases characterized by undesirable angiogenesis by administering compounds including those having general formula (1) wherein A is a fused tropone having general formula (I), (II...
WO/1998/037899A1	LIVER PROTECTION OR TREATMENT AGENTS COMPRISING ASIATIC ACID DERIVATIVES AS THE ACTIVE COMPONENT The present invention relates to liver protection or treatment agents, which comprise asiatic acid derivatives having formula (1) or pharmaceutically acceptable salts or esters thereof, as the active component.
WO/1998/023278A1	MEDICINES FOR TREATING DEMENTIA OR COGNITIVE DISORDER, WHICH COMPRISES ASIATIC ACID DERIVATIVES The present invention relates to medicines for treating dementia and cognitive disorder, which comprises asiatic acid derivatives. More specifically, the present invention relates to a use of asiatic acid derivatives represented by formu...
WO/1998/001126A2	METHOD OF MANUFACTURING A STEROL ESTER MIXTURE Process for the manufacture of a mixture of fatty acid esters comprising the steps of: (a) hydrolysing a sterol ester or a mixture of sterol esters such that a mixture is obtained comprising phenolic acids and/or fatty acids, and free st...
WO/1998/000093A1	PHOTOAGING INHIBITOR AND SKIN-CARE PREPARATION A photoaging inhibitor that is highly safe and excellent in the photoaging inhibitory effect and comprises a triterpenoid derivative and one or more salts thereof, the derivative being ursolic, oleanolic or betulic acid wherein the hydro...
WO/1997/031014A1	TRITERPENE DERIVATIVES AND REMEDIES FOR LIVER DISEASES Triterpene derivatives efficacious in the treatment of liver diseases. The remedies contain as the active ingredient triterpene derivatives represented by general formula (I) or salts thereof: wherein R1 represents hydroxy, arylmethyloxy...
WO/1997/027314A1	PROCESS FOR PRODUCING OLEANOLIC ACID ANALOGS BY CULTURING HAIRY ROOT A process for producing oleanolic acid analogs which comprises inducing and culturing hairy roots originating in a plant capable of forming oleanolic acid analogs (such as myricerol, 27-hydroxy-caffeoylmyricerol, myricerone or 27-hydroxy...
WO/1997/003088A1	TRITERPENE DERIVATIVES AND REMEDY FOR LIVER DISEASES A remedy for liver diseases which comprises a triterpene derivative represented by following general formula (I) or a pharmaceutically acceptable salt thereof wherein R1 represents hydroxy, alkoxy, alkylcarbonyloxy or aralkyloxy; R2 repr...
WO/1996/039033A1	BETULINIC ACID DERIVATIVES AND USES THEREFOR Some betulinic acid and dihydrobetulinic acid acyl derivatives according to the present invention have been found to have potent anti-HIV activity. Introducing a C2-C20 substituted or unsubstituted acyl group at the C3-hydroxy group of b...
WO/1996/038161A1	DRUG DELIVERY ENHANCEMENT VIA MODIFIED SAPONINS Disclosed herein are modified saponins or fractions thereof obtainable by modification of a crude Quillaja saponaria extract or by modification of purified saponins obtainable from a crude Quillaja saponaria extract useful in pharmaceuti...
WO/1996/029068A2	USE OF BETULINIC ACID AND ITS DERIVATIVES FOR INHIBITING MALIGNANT MELANOMA GROWTH AND A METHOD OF MONITORING THIS A composition and method of inhibiting tumor growth and treating malignant melanoma without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically app...
WO/1996/017819A1	ASIATIC ACID DERIVATIVES, ITS MANUFACTURING METHOD AND DERMATOLOGICAL AGENT CONTAINING IT The object of the present invention is to provide asiatic acid derivatives (I), its pharmaceutically acceptable salts or esters. Asiatic acid, its trisaccharide asiaticoside and madecassic acid, extracted from Centella asiatica have been...
WO/1996/011711A1	SAPONIN PREPARATIONS AND USE THEREOF IN ISCOMS A preparation of saponins of Quillaja saponaria, comprises fractions of Quil A having good adjuvant activity, low haemolytic activity and good ability to form immunostimulatory complexes (iscoms).
WO/1996/001618A1	DERMATOLOGIC PREPARATION A dermatologic preparation comprising at least either an escinol represented by general formula (1) or a salt thereof and having an excellent skin-lightening effect and a high safety in virtue of characteristic effects of the escinol, wh...
WO/1996/000236A1	TRITERPENE DERIVATIVE AND MEDICINAL COMPOSITION Hederagenin derivatives represented by general formula (1) and pharmaceutically acceptable salts thereof, and a medicinal composition containing the same as the active ingredient and being efficacious in treating nephritis, wherein R1 re...
WO/1995/009179A1	COMPOUNDS WITH ADJUVANT ACTIVITY The present invention relates to a plant cell extract with adjuvant activity obtainable by extracting fresh plant material consisting of substantially living cells, originating from saponin producing plants of the genera Quillaja, Sapona...
WO/1995/004535A1	ESTROGENIC COMPOUNDS AS ANTI-MITOTIC AGENTS The application discloses methods of making medicaments for treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural ...
WO/1995/002606A1	HAEMOLYTIC SAPONIN EXTRACTION AND PURIFICATION METHOD A saponoside mixture is immersed in an absolute ethanol bath at a temperature of 40-60 �C; a first rapid hot filtering step is performed in the bath at 40-60 �C to separate the polar and non-polar impurities from the dissolved saponi...
WO/1994/024145A1	DERIVATIVES OF TRITERPENOID ACIDS AND USES THEREOF Triterpenoid acid derivatives are described that exhibit dual pharmacophobic activities, specifically selectin ligand and leukotriene biosynthetic inhibitory activities, and have significant applications for the treatment or prevention o...
WO/1994/014833A2	SUBSTITUTED 6-AZAANDROSTENONES The present invention relates to certain substituted 17beta-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), wherein R1 and R2 i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R1 and R2 i...
WO/1994/009026A1	NEW BIOACTIVE TRITERPENOIDS AND SECO-TRITERPENOIDS The new triterpenoids of general formulae (I), (II), (III) and (IV) where R1 represents a dialkyl, trialkyl, triphenyl, diphenylalkyl, alkyldiphenyl, dialkylphenyl, haloalkyl, halophenylalkyl, allylalkyl or alkylaminoalkyl group and R2 r...
WO/1994/005152A1	DERIVATIVES OF TRITERPENOID ACIDS AS INHIBITORS OF CELL-ADHESION MOLECULES ELAM-1 (E-SELECTIN) AND LECAM-1 (L-SELECTIN) Triterpenoid acid derivatives have been found to have structures similar to natural ligands to the extent that these derivatives bind to natural selectin receptors including endothelial leukocyte adhesion molecule-1 (ELAM-1) and leukocyt...
WO/1994/001118A1	METHODS FOR ENHANCING DRUG DELIVERY WITH MODIFIED SAPONINS Methods for enhancing the transport of pharmacologically active substances across mucous membranes of an animal by administration of pharmaceutical compositions comprising modified saponins or fractions thereof obtainable by modification...
WO/1994/000125A1	17-ALKYLKETONE STEROIDS USEFUL AS 5-alpha-REDUCTASE INHIBITORS Invented are 17alpha and 17beta-alkylketone-3-carboxy aromatic A ring analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-alpha-re...
WO/1993/022333A1	17$g(a) AND 17$g(b)-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID Invented are 17$g(a) and 17$g(b)-substituted acyl-3-carboxy aromatic A ring analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-$g...
WO/1993/013124A1	INHIBITORS OF 5-ALPHA-TESTOSTERONE REDUCTASE The present invention relates to certain substituted 17$g(b)-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), especially those of formula (IG) wherein R?1¿ and R?1¿ are: i) independently hydrogen or lower alkyl and the bon...
WO/1993/010142A1	NEW LUPANE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM New lupane derivatives having the general formula (I) wherein R is (A) wherein R' and R", similar or different, are H or alkyl, X is a bond, carbamyl or aminocarbonyl optionally substituted, Y is a bond or phenylen, R° and R°°, simila...
WO/1993/009129A1	TRITERPENE COMPOUND HAVING ANTIINFLAMMATORY ACTIVITY A method of antiinflammatory, and more particulaly antiarthritic, treatment of a human or animal patient comprises administering to the patient an effective amount of a compound of general formula (II) in substantially pure form, wherein...
WO/1992/017185A1	TARGETED DRUG DELIVERY VIA MIXED PHOSPHATE DERIVATIVES The invention provides compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein [D] is the residue of a drug having a reactive functional group, said functional group being attached, directly or through a bridg...
WO/1992/012991A1	TRITERPENE DERIVATIVE A triterpene derivative represented by general formula (I), which has an antiendotheline activity and is useful for preventing and treating the diseases of the cardiovascular system, and a pharmaceutical composition thereof. In formula (...

Matches 301 - 350 out of 929	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >