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Matches 1 - 50 out of 1,187

Document Document Title
WO/2020/180661A1
This disclosure relates to extracts from chestnut plants and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the leaves of a Castanea plant. In certain embodiments, the disclosur...  
WO/2020/165742A1
The present invention relates to novel triterpenone derivatives of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. The invention also relates to novel triterpenone deri...  
WO/2020/165741A1
The present invention relates to novel triterpene derivatives of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and ring are as defined herein. The invention also relates to novel triterpene derivativ...  
WO/2020/163642A1
The present invention provides a compound of formula (I) or a salt thereof: (F ormula (I)) wherein X, L, V, R1, R2, R3 and R4, are as defined herein. The claimed compounds inhibit the enzyme 11-hydroxysteroid dehydrogenase type 2 (11-HSD...  
WO/2020/161221A1
The present invention relates to a method for the production of a (poly)hydroxylated pentacyclic triterpene composition including a 3-O-p-coumaroyl ester of tormentic acid from a plant suspension cell culture, to a pharmaceutical composi...  
WO/2020/143640A1
The present invention relates to a steroid compound, and a use thereof and a preparation method therefor. It is expected that such compound can effectively treat mental and neurological diseases, and has good active efficacy, pharmacokin...  
WO/2020/121161A1
The present invention relates to the mesylate (CH3SO2) salt of the following compound (I).  
WO/2020/096486A1
The invention relates to the field of medicine and to the chemical and pharmaceutical industry, and concerns agents for treating cancer. 3-O-sulfamate-16,16-dimethyl-D-homoequilenin is proposed as an anti-cancer agent in monotherapy and ...  
WO/2020/068689A1
Described herein are terpinoid derivatives as NRF2 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of inflammatory diseases.  
WO/2020/006510A1
The present invention concerns novel pharmaceutically active triterpene amine derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicament...  
WO/2019/207460A1
The present invention relates to compound of Formula I or a pharmaceutically acceptable salt thereof (Formula I) wherein R1 is Formula (AA) or Formula (BB) where the squiggly line indicates the point of attachment to the rest of the mole...  
WO/2019/186342A1
The present invention discloses certain ionic liquid salts of 4-(((3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((R) -2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1- hydroxyethyl)-1-isopropyl-5a,5b,8,8,1 1 a-pentamethyl-2- oxo-3,3a,4,5,5a,...  
WO/2019/191637A1
Methods of preventing or retarding or reversing or abolishing the onset of Parkinson's and other neurodegenerative diseases are discussed.  
WO/2019/126761A1
Provided herein is a compound of Formula (I-I) or a pharmaceutically acceptable salt thereof, wherein t, R7, R3, R9, R6a, R6b, R11a, R11b, R15a, R15b, R16a, R16b, R17a, R17b, R18a, R18b, R19a, R19b, R5a, R5b, R8 and R13 are defined herei...  
WO/2019/079160A1
The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and ...  
WO/2019/060051A1
The present invention provides a compound of formula (I) or a salt thereof: (I) wherein X, L, V, R1, R2, R3 and R4, are as defined herein. These compounds are inhibitors of 11-hydroxysteroid dehydrogenase type 2 (11-HSD-2) and are used t...  
WO/2019/052560A1
Disclosed are a pentacyclic triterpene compound as shown in general formula (I) and a preparation method therefor. The compound has an effective antagonistic effect on FXR receptors.  
WO/2019/054379A1
The present invention pertains to a compound represented by formula (I) or a salt thereof. [In formula (I), ring C is a hydrocarbon ring, etc.; the hydrocarbon ring, etc., has a substituent group selected from the group consisting of hyd...  
WO/2018/237135A3
Disclosed is a novel process for the isolation of bioactive compounds from Terminalia arjuna. More specifically, the invention discloses a process for isolation and enrichment of bioactive compounds Arjunic acid, Arjunolic acid, Arjungen...  
WO/2019/018940A1
Natural sweetener compositions are disclosed, which generally include steviol glycosides extracted from a Stevia rebaudiana plant and an amino acid component consisting of free glycine. The natural sweetener compositions may optionally f...  
WO/2019/014412A1
Disclosed are crystalline polymorphs of Bardoxolone methyl, and pharmaceutical compositions thereof.  
WO/2018/113285A1
Disclosed is a method for preparing sodium aescinate, relating to the technical field of plant extraction. The method comprises: semen aesculi is taken and subjected to alcohol extraction, the resulting extracting solution is subjected t...  
WO/2018/103766A1
Disclosed is a compound as shown in formula I. Also disclosed are a synthesis method for the compound, and uses of the compound in the preparation of anti-cancer and anti-inflammatory drugs and a drug which treats hepatitis C.  
WO/2018/063010A9
The invention relates to a novel lupeol derivative, which is the ester of 4-picolinic acid (isonicotinic acid) and 20(29)-lupen-3.beta.-ol (lupeol), having structural Formula (1). The novel lupeol derivative is a result of modification o...  
WO/2018/088439A1
Provided are: a compound represented by formula (I); a retinoid metabolic pathway inhibitor comprising the same; an agent for increasing the ratio of memory T cells; a prophylactic and/or therapeutic agent for cancer or an infectious dis...  
WO/2018/073551A1
The present invention relates to a chemical composition characterized in that it comprises: - the molecule A or a physiologically acceptable salt thereof, and/or: - the molecule B or a physiologically acceptable salt thereof, said molecu...  
WO/2018/069086A1
Triterpenoid derivatives and compositions comprising said triterpenoids derivatives of Formula (I) are described, wherein R=-C(O)NHOH. Said triterpenoids and compositions show capacity to bind PHD2, stabilize HIF-1α and HIF-2α proteins...  
WO/2017/053868A8
Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions...  
WO/2018/063010A1
The invention relates to a novel lupeol derivative, which is the ester of 4-picolinic acid (isonicotinic acid) and 20(29)-lupen-3.beta.-ol (lupeol), having structural Formula (1). The novel lupeol derivative is a result of modification o...  
WO/2017/215678A3
Provided is a cefaclor pharmaceutical composition. The cefaclor pharmaceutical composition comprises cefaclor and a naturally produced compound (I) having a new structure and isolated from dry roots and stems of Acorus tatarinowii. When ...  
WO/2017/220050A3
Disclosed are an azithromycin pharmaceutical composition and a medical use thereof for cough relief. The azithromycin pharmaceutical composition contains azithromycin and a natural product compound (I) separated from dried rhizoma arisae...  
WO/2018/025462A1
Provided is a method for economically and easily producing soya saponins without crushing seeds or plant bodies or treating with an organic solvent. The method for producing soya saponins comprises: incubating or growing a legume plant b...  
WO/2018/006804A1
Provided are an application of a compound represented by formula I as a ligand of an orphan nuclear receptor Nur77, and an application for preventing or treating a disease related to the orphan nuclear receptor Nur77.  
WO/2018/006801A1
The present application relates to an orphan nuclear receptor Nur77 ligand and an application thereof. The application specifically relates to a compound represented by formula I and application of the compound as the orphan nuclear rece...  
WO/2018/002849A1
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoid compounds that possess unique antiviral activity are provided as HIV maturation inhibitor...  
WO/2017/220050A2
Disclosed are an azithromycin pharmaceutical composition and a medical use thereof for cough relief. The azithromycin pharmaceutical composition contains azithromycin and a natural product compound (I) separated from dried rhizoma arisae...  
WO/2017/215678A2
Disclosed are a cefaclor pharmaceutical composition and effects thereof for protecting acute lung injuries. The cefaclor pharmaceutical composition provided in the present invention comprises cefaclor and a naturally produced compound (I...  
WO/2017/210636A1
The disclosure relates to compositions, methods, and kits comprising glycyrrhetinic acid derivatives for selectively eradicating cancer cells (e.g., leukemic cells) in a population or subject, and related methods of treating cancer (e.g....  
WO/2017/185273A1
A method for preparing saikoside from bupleurum longiradiatum, comprising: washing bupleurum longiradiatum, picking out impurities from the bupleurum longiradiatum, air-curing the bupleurum longiradiatum, and grinding the bupleurum longi...  
WO/2017/177326A1
The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to ta...  
WO/2016/178092A8
Formula (I) The invention relates to C-3 novel triterpenone with C-28 reverse amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated dise...  
WO/2017/150723A1
Algae that generates a sterol and a sterol production method that uses the algae. According to the present invention, a sterol is produced by culturing algae, such as strain AJ7867 (FERM BP-22304) and strains derived therefrom, that has ...  
WO/2017/134596A1
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhib...  
WO/2017/128981A1
Provided are a compound (LQC-C) with a structure as shown by formula (I) and a preparation method thereof and a use thereof in preparing anti-tumour drugs. The compound has a significant activity in inhibiting the growth of tumour cell l...  
WO/2017/125870A1
The present invention relates to compounds characterized by having a structure according to the following Formula I: (I) or a pharmaceutically acceptable salt thereof. Compounds of the present invention are useful for the treatment or pr...  
WO/2017/088080A1
The present invention relates to a method for obtaining and purifying saponins from plant extracts, which comprises extracting saponins and subsequently removing impurities by adding a salt selected from the group of alkaline earth metal...  
WO/2017/083795A1
Disclosed are methods and compositions for treating alcohol dependence by administration to a patient of an inhibitor of 11β-hydroxysteroid dehydrogenases (11β-HSD) to modulate glucocorticoid effects. One such compound is the 11β-HSD ...  
WO/2017/076332A1
The present invention relates to a pentacyclic triterpenoid compound providing an acetyl-CoA carboxylase 1 (ACC1) protein regulating effect and uses of the compound. The compound of the present invention can be applied directly to ACC1 p...  
WO/2017/070615A1
Described herein, inter alia, are compositions and methods for treating or preventing obesity and using the same.  
WO/2017/064628A1
The present invention relates to C-3 novel triterpenone with C-28 urea derivatives of formula (I); or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable hydrates, tautomers, stereoisomers...  

Matches 1 - 50 out of 1,187