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Matches 1 - 50 out of 1,933

Document Document Title
WO/2019/136487A2
Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.  
WO/2019/129308A1
Provided is a method for recycling steroid epoxy isomer. Reacting with a reactive metal such as lithium, sodium, and potassium in an diphenyl organic solvent so as to reduce and form conjugated double bonds; in an alkaline environment, k...  
WO/2019/129176A1
The present invention provides a sarsasapogenin derivative and a preparation method and application thereof. The derivative has a structure as shown in formula I, and the definition of each substituent is as described in the specificatio...  
WO/2019/126741A1
Provided herein are compounds of Formula (I-I): and pharmaceutically acceptable salts thereof; wherein p, R1, R3a, R2a, R11a, R11b, R6a, and R6b are defined herein. Also provided herein are pharmaceutical compositions comprising a compou...  
WO/2019/116070A1
The invention relates to compounds of formula (I), their method of synthesis as well as their use to treat neurodegenerative disorders.  
WO/2019/090405A1
The invention disclosed herein is intended for the pharmaceutical industry and the area of medicine for combating flu, and relates to any medicinal-product composition that is characterized by containing ciclesonide in the composition th...  
WO/2019/081586A1
The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to DCA and pharmaceutically acceptable salts thereof, the carbon atoms of...  
WO/2019/080571A1
The present invention provides a method for extracting toosendanin, comprising: first washing and drying melia azedarach bark or melia azedarach seeds, grinding, and performing extraction by using a cellulase and apectinase water solutio...  
WO/2019/055493A1
A method for treating a mitogen activated protein kinase kinase/extracellular signal-regulated kinase ("MEK")-induced or an MEK-related pathology in a mammal, comprising administering a pharmaceutical composition containing an effective ...  
WO/2019/021122A3
The present invention relates to novel Liver X Receptor (LXR) modulators, their use in diagnostic and therapy, more particularly in the treatment of diseases associated with LXR, such as cancer, inflammation, metabolic and autoimmune dis...  
WO/2019/023769A1
The present invention relates, most generally, to steroidal glycosides that can be used for treating skin disorders. Particularly, the invention relates to the use of certain steroidal glycosides, per se or in the form of aglycone, spiro...  
WO/2019/021122A2
The present invention relates to novel Liver X Receptor (LXR) modulators, their use in diagnostic and therapy, more particularly in the treatment of diseases associated with LXR, such as cancer, inflammation, metabolic and autoimmune dis...  
WO/2019/015914A1
The invention relates to a process for the preparation of obeticholic acid and derivatives thereof comprising: (a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate t...  
WO/2019/006534A1
Methods, uses, compositions and kits for treating steroid-resistant chronic rhinosinusitis (CRS), including refractory CRS, in a subject, or for improving or restoring the response to anti- inflammatory sinus treatment in a patient suffe...  
WO/2018/213077A1
Provided herein are compounds, compositions, conjugates and methods for the treatment of diseases, and/or conditions such as, but not limited to, proliferative diseases. In certain embodiments, compounds, compositions, and conjugates are...  
WO/2018/201516A1
A compound and an application thereof for treatment of cataract. The structural formula of the compound is as shown in formula I. The compound of formula I, a prodrug thereof, or a pharmaceutically acceptable salt thereof, can be used to...  
WO/2018/145162A1
The present invention relates to a new class of steroid saponins that have interesting biological activity. In particular the present invention relates to a class of steroid saponins in which the sugar moiety has been selectively functio...  
WO/2018/121770A1
An antidepressant steroid compound and a preparation method and an application thereof; the structure of said compound is shown in formula (I), and the definition of each substituent is as described in the description and claims. The com...  
WO/2018/089373A9
Described herein protein steroid conjugates whereby a glucocorticoid compound is conjugated to a binding agent which is preferably an antibody. These are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to c...  
WO/2018/089373A3
Described herein protein steroid conjugates whereby a glucocorticoid compound is conjugated to a binding agent which is preferably an antibody. These are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to c...  
WO/2018/033939A1
Disclosed herein is an improved process for the preparation of Budesonide using Perchloric acid catalyst in water as a major medium.  
WO/2017/211820A1
The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to novel intermediates useful for the preparation of DCA and pharmaceutic...  
WO/2017/210471A1
Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same, e.g., to treat autoimmune or inflammatory diseases.  
WO/2017/199036A1
The invention relates to a process for preparing a compound of general formula (la): wherein R2, Y, R4and R5are as defined herein, wherein the epoxidation is conducted using an oxidant and methyltrioxorhenium as a catalyst (MeReO3). The ...  
WO/2017/199033A1
The invention relates to compounds of general formula (I): wherein: R1,R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditio...  
WO/2017/199039A1
The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein. The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis...  
WO/2017/186135A1
Disclosed in the present invention are a compound and an application thereof for the treatment of cataracts. The structural formula of the compound is shown in formula I. The compound shown in formula I, a prodrug thereof, or a pharmaceu...  
WO/2017/139485A1
Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, which method comprises contacting the cancer cells with an apoptosis inducing ligand in conjunction with an effec...  
WO/2017/134087A1
Steroidic calixarene compounds according to formula (I): (I) wherein: ∙ R represents -(CH2)x-L-(CH2)y-Ster, wherein : ○ x and y are integers comprised between 0 and 2; ○ n is an integer comprised between 1 and 5; ○ L represents a...  
WO/2017/088080A1
The present invention relates to a method for obtaining and purifying saponins from plant extracts, which comprises extracting saponins and subsequently removing impurities by adding a salt selected from the group of alkaline earth metal...  
WO/2017/053868A8
Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions...  
WO/2017/053868A1
Disclosed herein are C4 modified oleanolic acid derivatives of the formula: Formula (X) or Formula (XII), as well as analogs thereof, wherein the variables are defined herein. In addition, disclosed herein are pharmaceutical compositions...  
WO/2017/028397A1
The present invention provides a method for extracting peroxyergosterol from wall-broken ganoderma lucidum spore powder. The method comprises the steps of preparation of peroxyergosterol crude extract, medium-pressure preparative chromat...  
WO/2017/021852A1
Method for the separation of at least one isoprenic constituent from the resin of a plant of guayule and/or of the guayule type comprising the steps of: a) providing a defatted resin of guayule and/or of the guayule type; b) subjecting t...  
WO/2016/173524A1
Disclosed in the present application are the compounds as shown in formulae I, II, III, IV or V, tautomers thereof, stereoisomers thereof or pharmaceutically acceptable salts thereof, and also disclosed is the use thereof in preparing dr...  
WO/2016/135749A1
This invention also relates to novel class of diosgenin acetate-Isoxazole and the synthesis of diosgenin acetate-Isoxazole starting from Diosgenin and its relatives with five (5) synthetic routes, acetylation (A), F-ring opening of diosg...  
WO/2016/079517A1
The invention relates to compounds of formula (I), wherein R1, R2, Y, R4 and R5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids.  
WO/2016/039359A1
The present invention relates to: a terpenoid derivative which is capable of activating a Keap1/Nrf2/ARE signaling pathway and has an excellent anti-inflammatory activity and an excellent cell-protecting activity; and a sustained-release...  
WO/2016/029888A1
The present invention provides amphiphilic compounds with tetradecahydrophenanthrene skeleton and their enantiomers, exhibiting neuroprotective effects, their use as medicaments for treating neuropsychiatric disorders associated with an ...  
WO/2015/198232A1
The present invention discloses fused triterpene compounds, represented by the compounds of Formula I (as described herein), processes for their preparation, pharmaceutical compositions comprising the said compounds, their use as retinoi...  
WO/2015/158163A1
The present invention relates to cyclopentanoperhydrophenanthrene framework compounds and a preparation method therefor. The compounds have certain biological activity, can also be used as an intermediate synthon for synthesizing some co...  
WO/2015/158216A1
Disclosed is the use of Kudinosides for the manufacture of treating pulmonary disease. And kits provided herein facilitate relieving the symptoms resulting from the pulmonary disease (e.g., asthma, chronic obstructive pulmonary disease (...  
WO/2015/095971A1
The present invention provides bacterial ATP synthase inhibitors such as a compound of formula (I): (Formula (I)) (A) in combination with an aminoglycoside antibiotic for preventing or treating a bacterial infection in a subject; or (B) ...  
WO/2015/089338A3
The present invention encompasses the recognition that reproducible and detectable changes in the level and or activity of Glucocorticoid Receptor (GR) are associated with incidence and/or risk of Castration Resistant Prostate Cancer (CR...  
WO/2015/081778A1
The present invention belongs to the field of organic synthesis, relates to a method for synthesizing a saponin, and in particular, to a method for constructing a glycosidic bond in a saponin, and comprises the following steps: directly ...  
WO/2015/075549A1
A Salacia composition described herein significantly reduces appetite, activates Hormone Sensitive Lipase, and manages a healthy lipid profile through inhibition of HMG-CoA Reductase enzyme. Salacia compositions described herein include ...  
WO/2015/075693A1
The invention relates to a process for the synthesis of (11 β,17α)-17-acetoxy-11 - inethyl-19-norpregn-4-en-3,20-dione of formula (I) using the compound of formula (II) as starting material as well as the intermediates of the process.  
WO/2015/077780A1
Provided herein are synthetic analogs of withanolide natural products of formula (I), wherein R1-R4 are as defined herein, and their pharmaceutical uses in treating neurodegenerative diseases.  
WO/2015/075693A8
The invention relates to a process for the synthesis of (11β,17α)-17-acetoxy-11 - methyl-19-norpregn-4-en-3,20-dione of formula (I) using the compound of formula (II) as starting material as well as the intermediates of the process.  
WO/2015/048316A1
The present invention relates to novel glucocorticoid compounds. The invention also relates to methods of using these compounds, the synthesis of these compounds, and to compositions and formulations comprising the glucocorticoid compoun...  

Matches 1 - 50 out of 1,933