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Matches 1 - 50 out of 563

Document Document Title
WO/2018/147345A1
Provided is a method by which a compound, which is useful as an intermediate and in which an oxo group is introduced specifically at the 15-position of a steroid skeleton, can be produced at a high yield without involving a complex proce...  
WO/2018/134278A1
The present invention refers to a new process for the synthesis of (9β,10α)-pregn-4-ene-3,20-dione, commonly known as retroprogesterone, having the formula (1) shown below.  
WO/2018/025083A1
The described invention relates to small molecule therapeutic compounds capable of reducing the incidence of intracerebral hemorrhage and brain microhemorrhages identified using zebrafish and mouse models of intracerebral hemorrhage and ...  
WO/2018/019301A1
Provided is a compound represented by formula I, or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, polycrystalline material, or precursor thereof, and a manufacturing method and pharmaceutical applicatio...  
WO/2017/205964A1
Estrane-based and androstane-based aminosteroid derivatives are described herein. More specifically, the following piperazinyl-steroid compounds of Formula I, Formula II, Formula III, and Formula IV are described. The compounds display c...  
WO/2017/195804A1
Provided is a crystalline polymorph A of 15β-hydroxy-osaterone acetate having improved stabilities (storage stability, pulverization stability, and absorption property). Diffraction peaks characteristic of this crystalline polymorph A o...  
WO/2017/186135A1
Disclosed in the present invention are a compound and an application thereof for the treatment of cataracts. The structural formula of the compound is shown in formula I. The compound shown in formula I, a prodrug thereof, or a pharmaceu...  
WO/2017/190034A1
The present invention provides a compound having the structure: formula (I), for use in combinatoin with an anti-tuberculosis drug for treating a subject infected with M. tuberculosis.  
WO/2017/159922A1
The present invention relates to a composition for preventing hair loss and, more specifically, to a compound having a structure in which finasteride and a peptide are linked through a covalent bond and a pharmaceutical composition or a ...  
WO/2017/001439A1
Novel homo-aza-steroidal esters with alkylating bis(2-chloroethyl)aminophenoxy propanoic acid and substituted derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of can...  
WO/2016/181312A1
The present technology provides polycyclic epoxides of Formula I, compositions comprising such expoxides and methods of using such epoxides. In particular, these compounds are useful for inhibiting cancer cell proliferation and tumor ang...  
WO/2016/084790A1
The present invention provides a compound represented by general formula (I) which has excellent retinoic acid receptor-related orphan receptor γt inhibitory activity and IL-17 production inhibitory activity, or a pharmaceutically accep...  
WO/2015/188611A1
A limonin extraction method, comprising the following steps: step one, raw material digesting or juicing: directly soaking raw material in water or using a presser to directly juice the raw material to obtain the extract; step two, addin...  
WO/2015/085447A1
Disclosed in the present invention are triptolide-nucleic acid aptamer derivatives, and a preparation method and use thereof. The structure of the triptolide-nucleic acid aptamer derivatives is as shown by formula I, wherein the definiti...  
WO/2015/070713A1
The present invention relates to the field of medicinal chemistry, and in particular relates to limonin oxime ether derivatives (I) and (II), and the preparation method and the medicinal thereof. The pharmacological experiments show that...  
WO/2015/013453A1
The invention provides methods and compositions for use of desmopressin in combination with a 5-alpha reductase inhibitor. The methods and compositions are useful in the treatment of nocturia and other urinary frequency disorders.  
WO/2014/059314A1
This document relates to compounds and compositions useful for treating cancers, such as brain and nervous system cancers.  
WO/2014/056401A1
Disclosed are a double-bond substituted tripterygium wilfordii lactone derivative as represented by formula (I), or pharmaceutically acceptable salt or hydrate thereof, or optical isomer thereof, wherein R1=OH, R2=H, or R1=H, R2=OH. Also...  
WO/2013/106975A1
The present invention provides extraction of brassinolide analogs from plants and applications thereof, comprising applications in promoting plant growth, resisting low temperature, and resisting and high salt. In addition, the present i...  
WO/2012/116664A1
The invention relates to a method for stimulating the natural defence and the induction of resistance to diseases in plants, by means of the simultaneous activation of genes related to the pathway of salicylic acid, to the pathway of jas...  
WO/2012/083112A2
Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula (Z), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), or (XVII). Also described herein are pharmaceutical compositions that include at least one compound...  
WO/2012/083112A3
Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula (Z), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), or (XVII). Also described herein are pharmaceutical compositions that include at least one compound...  
WO/2012/035553A1
Provided is a process for preparing androstenone derivatives, specifically 3-oxo-4-aza-5α-androstene-17β-carboxylic acid of Formula I, a key intermediate for dutasteride.  
WO/2011/088160A3
Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat a...  
WO/2011/054929A3
The invention relates to a method for producing triptolide from a suspension cell culture of Tripterygium sp., to a triptolide-enriched extract obtainable by means of extraction from the culture medium of an in vitro culture of dediffere...  
WO/2011/054929A2
The invention relates to a method for producing triptolide from a suspension cell culture of Tripterygium sp., to a triptolide-enriched extract obtainable by means of extraction from the culture medium of an in vitro culture of dediffere...  
WO/2011/054182A1
Sodium transhinone IIA sulfonate hydrate and preparation method and use thereof are disclosed. The molecular formula of said sodium transhinone IIA sulfonate hydrate is C19H17NaO6 . nH2O, wherein n is 0.5-4.0. The storage stability of th...  
WO/2011/010682A1
Disclosed is a sterol derivative, which has an effect of promoting the proliferation of nerve stem cells, or a pharmaceutically acceptable salt of the same. Specifically disclosed is a sterol derivative represented by general formula (I)...  
WO/2011/004242A3
The present invention provides an improved process for the preparation of Dutasteride (I) which comprises: (i) reacting 4-aza-5α-androst-l -en-3-one-17β-carboxylic acid (VII), Formula VII with sulfonic acid anhydride (RSO2)2O in presen...  
WO/2010/112079A1
The present invention relates to a process of separation of 4-aza-androst-1-ene-17-oic acid from 4-aza-androstan-17-oic acid, which brings to 4-aza-androst-1-ene-17-oic containing less than 0.05% w/w of 4-aza-androstan-17-oic acid, with ...  
WO/2009/136629A1
Disclosed is a method for the screening of a compound having an activity to selectively modulate an androgen receptor. The method comprises the steps of: contacting a substance to be tested with a prostate cancer cell and measuring the ...  
WO/2009/124460A1
The invention discloses Tripterygium wilfordii diterpene lactone derivatives represented by formula (1), their optical isomers and pharmaceutically acceptable salts and hydrates. The invention also provides pharmaceutical compositions an...  
WO/2009/096445A1
Disclosed are a neural stem cell propagation accelerator which contains a compound produced by Penicillium sp. strain CND1007 (FERM BP-10917) or a pharmacologically acceptable salt thereof, a novel compound produced by Penicillium sp. st...  
WO/2009/083258A2
The present invention relates to a synthetic process for manufacturing Dutasteride comprising the mixed anhydride formation, subsequent reaction with 2,5- bis(trifluoromethyl)phenylamine in the presence of an appropriate Lewis catalyst a...  
WO/2009/083258A3
The present invention relates to a synthetic process for manufacturing Dutasteride comprising the mixed anhydride formation, subsequent reaction with 2,5- bis(trifluoromethyl)phenylamine in the presence of an appropriate Lewis catalyst a...  
WO/2009/059806A3
The invention is related to the area of new 6-Oxa-8α-steroid estrogen analogues and the synthesis of these new biological active steroid estrogen analogues, namely, to the preparation of 6-oxa-8α-steroid estrogens and their use as estr...  
WO/2009/059806A2
The invention is related to the area of new 6-Oxa-8α-steroid estrogen analogues and the synthesis of these new biological active steroid estrogen analogues, namely, to the preparation of 6-oxa-8α-steroid estrogens and their use as estr...  
WO/2009/024103A2
The present invention relates to natural brassinosteroids of general formula (I), wherein R is CH2 or O-CH2 group, R2 is hydrogen or hydroxyl, R3 is hydroxyl, R24 is alkyl or alkenyl, which are selected from the group consisting of methy...  
WO/2009/024103A3
The present invention relates to natural brassinosteroids of general formula (I), wherein R is CH2 or O-CH2 group, R2 is hydrogen or hydroxyl, R3 is hydroxyl, R24 is alkyl or alkenyl, which are selected from the group consisting of methy...  
WO/2008/125069A3
This invention deals with a method of increasing the yield of photosynthetic assimilation of carbon dioxide in plants by means of application of agents that increase the carboxylase activity of the enzyme ribulose 1,5-bisphosphate carbox...  
WO/2008/125069A2
This invention deals with a method of increasing the yield of photosynthetic assimilation of carbon dioxide in plants by means of application of agents that increase the carboxylase activity of the enzyme ribulose 1,5-bisphosphate carbox...  
WO/2007/098388A2
The present invention is directed to novel 7-oxa-estra-4,9-diene-3,17-dione derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by at least one progesterone or glu...  
WO/2007/098388A3
The present invention is directed to novel 7-oxa-estra-4,9-diene-3,17-dione derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by at least one progesterone or glu...  
WO/2007/067490A1
Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficie...  
WO/2006/121655A1
The present invention relates to synthetic processes useful in the preparation of fluorinated 4-azasteroid derivatives of formula I that modulate androgen receptors and have application in the treatment of conditions caused by androgen d...  
WO/2006/044453A1
The present invention relates to compounds of Formula (I): wherein R1, R2, R3, and R8 are defined herein, useful as P13K inhibitors.  
WO/2006/002966A1
The invention relates to a process for the preparation of 4-steroids of the formula (I), R1 and R2 are independently selected from the group consisting of hydrogen, F, Cl, Br, I, C1-6-alkyl and C1-6-alkoxy, and R4 is selected from the gr...  
WO/2005/110958A1
Disclosed is a method for oxidizing an alcohol in an amide solvent using a mixed reagent containing hydrogen peroxide and a tungsten catalyst.  
WO/2005/105091A1
Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficie...  
WO/2005/075497A1
Process for the preparation of 17ß-substituted-3-oxo-4-aza-5&agr -androstane derivatives, which are useful intermediates for the synthesis of 3-oxo-4-aza-5&agr -androst-1-ene derivatives including finasteride, is provided.  

Matches 1 - 50 out of 563