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JP2014231526A |
To provide methods for preparing 17-alkynyl-7-hydroxy steroids and related compounds.The invention relates to processes for preparing 17-alkynyl-7-hydroxy-steroids, such as 17-Ethynyl-10R,13S-dimethyl 2,3,4,7,8R,9S,10,11,12,13,14S,15,16,...
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JP5626616B2 |
A process is described for the preparation of drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for preparing pharmaceutical compositions with contraceptive action; comprising...
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JP2014177633A |
To provide a process of treating an oil derived from a microorganism.A process of treating an oil is provided, the process comprising contacting the oil with a polar solvent to extract at least one compound that is soluble in the solvent...
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JP2014523903A |
this indication -- composition of aryl fluoride -- for example18It is related with a reagent and a method useful to the manufacture of a radioactive tracer in which the sign was carried out by F. The reagent and method of indicating in t...
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JP5558751B2 |
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JP2014009191A |
To provide a method of producing acylated sterol glycoside at high concentration.The method of producing acylated sterol glycoside includes: a first step extraction operation in which rice bran as an ingredient is subjected to a supercri...
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JP5282084B2 |
A process of making an aromatase inhibitor of formula (I) wherein each of R1, R2, R3, and R4, independently, is hydrogen, halogen, or C1-C6 alkyl, comprising reacting a compound of formula (II) with an acid in the presence of a suitable ...
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JP2013510826A |
This invention relates to a new process for preparing (11 ß, 16a)-9-fluoro-11 - hydroxy-16,17-[1 -methyl -ethyl idenebis(oxy)]-21 -[1 -oxo-[4- (nitrooxymethyl)benzoxy]]pregna-1,4-dien-3,20-dione, comprising the steps of (i) reaction of ...
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JP2013028808A |
To provide a process of treating a microbially derived oil.The process of treating an oil comprises contacting the oil with a polar solvent to extract at least one compound that is soluble in the solvent, and then separating the solvent ...
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JP5133937B2 |
A process for preparing an intermediate compound of formula (II) where X is as defined in the specification, R 1 is haloalkyl, alkyl, alkenyl, cycloalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl or arylalkyl; R 2 , R 3 , R 4 and R 5 are ...
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JP5075626B2 |
The invention provides a process for the preparation of 2-substituted-derivatives of estrone and estradiol comprising i) the preparation of a compound of general formula (II) by reacting a compound of general formula (I) in one or more s...
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JP4981668B2 |
The invention relates to a process for the preparation of 4-steroids of the formula R 1 and R 2 are independently selected from the group consisting of hydrogen, F, Cl, Br, I, C 1-6 -alkyl and C 1-6 -alkoxy, and R 4 is selected from the ...
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JP4971179B2 |
The invention relates to an industrial process for the preparation of 17-hydroxy-6β,7β;15β,16β-bismethylene-3-oxo-17α-pregn-4
-ene-21-carboxylic acid γ-lactone of formula (I), and to the key-intermediates for this process.
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JP4914113B2 |
To provide a method for producing sterols in simple operations without using a special apparatus, while preventing the formation of wastes. This method for producing the sterols from a tall pitch is characterized by comprising (I) a proc...
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JP4870787B2 |
To provide a method by which fucoxanthin and fucosterol can be produced in higher yield from brown alga. The method for producing the fucoxanthin and/or the fucosterol includes separating the fucoxanthin and/or the fucosterol from an ext...
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JP4827189B2 |
Process of oxidizing an alcohol in an amide solvent with use of a mixed reagent containing hydrogen peroxide and a tungsten catalyst.
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JP4796695B2 |
Processes for recovering phytosterols are described. The processes comprise: (a) providing a liquid mixture containing a phytosterol, methanol, and one or more additional compounds, wherein the methanol is present in an amount of from 25...
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JP4768181B2 |
The invention is directed to 11 beta -aryl-17,17-spirothiolane substituted steroid compounds of formula (I) exhibiting binding to the progestin receptor. Also disclosed are methods of using and process of making the compounds.
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JP2011162532A |
To provide a production method of brassinosteroid-like substances excellent in functions and effects improving with microdose, various vegetable physiological activity such as plant growth promotion, vessel bundle differentiation promoti...
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JP2011148821A |
To provide a novel method for preparing a cortisol conjugate.The method for preparing the cortisol conjugate includes reacting 3-cortisolcarboxymethyl oxime conjugated to bovine serum albumin (3-CMO-BSA) with sodium borohydride.
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JP4712689B2 |
A process for the sterilization of water insoluble solid medicinal substances is described. The process provides the sterilization of drug substances, which are suitable for pulmonary administration. In particular, the process is used in...
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JP4691028B2 |
A method for obtaining an extract containing the natural mixture of conjugated equine estrogens in which a mixture of conjugated estrogens obtained by solid-phase extraction from pregnant mares' urine is depleted in phenolic urine conten...
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JP4686650B2 |
This invention relates to novel glucocorticoid receptor agonists of formula (I): and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to t...
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JP2011513303A |
The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.
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JP4645997B2 |
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JP4642341B2 |
A process for the separation and recovery of minor components from vegetable oil such as palm oil. Esterified palm oil is subjected to molecular distillation giving a concentrate rich in minor components. The concentrate is then adsorbed...
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JP4629030B2 |
The invention relates to a process for preparing compounds of formula (I): in which R1, R2, R3, n and X are as defined in the description, and to the intermediate compounds for implementing this process.
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JP2011500740A |
11 beta -Fluoro-3-acetoxyestra-3,5-dien-17-one (I), is new. An independent claim is included for the preparation of (I). ACTIVITY : None given. MECHANISM OF ACTION : None given.
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JP4607758B2 |
A method to stereospecifically prepare a steroidal sapogenin or a derivative thereof by reducing a 3-keto,5β-H steroidal sapogenin with a hindered organoborane or an organo-aluminium hydride. A 3β-hydroxy,5β-H steroidal sapogenin or d...
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JP4490560B2 |
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JP4481831B2 |
An improved stereoselective process for the preparation of 6alpha-fluoropregnane derivatives of formula (I), comprising the reaction of 3-benzoyloxy Delta3,5-pregnane derivatives of formula (II), with an electrophilic fluorination agent ...
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JP4484865B2 |
The disclosed invention refers to a process for obtaining fatty acid alkyl esters, rosin acids and sterols from crude tall oil (CTO), which is characterized by the following steps: (a) reacting the free fatty acids present in the CTO wit...
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JP4474921B2 |
A process to produce 2,5-bis(trifluoromethyl)nitrobenzene in a high yield from an industrially easily available material by using a substance with which the reaction operation is simple and handling is easy, with a small number of steps ...
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JP4476480B2 |
A compound selected from the group consisting of a compound of the formulawherein the substituents are defined as set forth in the specification which compounds are useful for the treatment of osteoporosis.
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JP4456811B2 |
The invention relates to a process for the preparation of 16,17-[(cyclohexylmethylene)bis(oxy)]-11,21-dihydroxypregna-
1,4-diene-3,20-dione[11beta,16alpha(R)] and similar compounds, by reaction of an appropriate 16,17-ketal with cyclohex...
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JP4437923B2 |
A process for a preparation of Compound (V), a pharmaceutically acceptable salt or a solvate thereof, said process comprising the steps represented by the following formula: wherein R<1> and R<2> are each independently C1 - C8 alkyl
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JP4438308B2 |
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JP4414761B2 |
A method for obtaining an extract from a natural mixture of conjugated estrogens from the urine of pregnant mares (PMU) by solid-phase extraction on semipolar adsorption resins in which the resulting extract meets the pharmaceutical spec...
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JP2010503722A |
The present invention relates to crystalline ciclesonide methanol solvate Form C, processes for its preparation, its use in the synthesis of crystalline ciclesonide Form A and its use in medicine.
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JP4404710B2 |
An object of the present invention is to provide a process according to which 5-ene-3-one or 3,6-dione derivatives of sterols can be synthesized with a better yield, as well as a process for production of lipid metabolism improvers, food...
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JP2010501505A |
Methods of deoxofluorination of ketones for the production of geminal difluoride compounds on an industrial scale include the following steps: -Preparing an exhaust mixture consisting of ketones and dialkylaminosulfatrifluorides;-At leas...
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JP4393640B2 |
The present invention provides a method of obtaining highly pure phytosterols practically and efficiently from crude phytosterol compositions derived from vegetable fats and oils. That is, the present invention provides a method of sapon...
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JP4392066B2 |
The invention relates to a steroid compound having the formula (I) comprising a ring E, said ring sharing carbon atoms at position 16 and 17 with the five-membered ring D and being alpha with respect to said D-ring. In addition, the carb...
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JP4376319B2 |
Compounds of the formulaWhere the substituents are defined in the application.
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JP4361976B2 |
The invention relates to a method for the preparation of a mixture of sulfated estrogens containing delta(8,9)-dehydro estrone Ädelta(8,9)DHEÜ or derivatives thereof.
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JP4363846B2 |
A process for preparing an intermediate compound of formula (II) where X is as defined in the specification, R 1 is haloalkyl, alkyl, alkenyl, cycloalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl or arylalkyl; R 2 , R 3 , R 4 and R 5 are ...
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JP4331478B2 |
The invention relates to a process for the production of 4-(17alpha-methyl-substituted 3-oxoestra-4,9-dien-11beta-yl)benzaldehyde-(1E or 1Z)-oximes of general formula (I), in which R1 is a hydrogen atom, a C1-6-alkyl radical or a CnF2n+1...
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JP2009526068A |
The invention encompasses a crystalline form of ciclesonide characterized by an XRD pattern having peaks at about 1 1.0, 14.8, 15.7, 16.5, and 22.8 degrees two-theta ± 0.2 degrees two-theta, methods of its preparation and pharmaceutical...
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JP4297654B2 |
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JP4285773B2 |
Disclosed is a method to obtain an extract containing a natural mixture of conjugated oestrogens from mare's urine by solid-phase extraction of the mixture of conjugated oestrogens from pregnant mare's urine on non-ionic semipolar polyme...
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