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Matches 1 - 50 out of 3,719

Document Document Title
WO/2020/187298A1
The present invention relates to a method for preparing a chenodeoxycholic acid derivative. Particularly, disclosed is a method for carrying out one-pot reduction on a compound represented by formula (Ⅵ), i.e., 3α-hydroxyl-ethidene-7-...  
WO/2020/189734A1
Provided is a compound or salt thereof represented by formula (I) below [In formula (I), R1 represents –COOH or –CY1Y2OH (where, Y1 and Y2 each represent a hydrogen atom or a detectable marker), A1 represents a sugar or an aglycone, ...  
WO/2020/177240A1
The present application relates to the field of drug synthesis and specifically relates to chenodeoxycholic acid and a preparation method therefor. The preparation method for the chenodeoxycholic acid comprises the following steps: formi...  
WO/2020/176436A1
The present invention pertains to a composition for preparing a medicament for preventing and/or treating a virus infection, especially a hepatitis B virus infection and/or a herpes simplex virus, and uses thereof.  
WO/2020/172313A1
The invention provides compounds as allosteric modulators that are useful as sweet flavor enhancers. The present invention also includes ingestible compositions comprising the present compounds and methods of enhancing the sweet taste of...  
WO/2020/169643A1
The present invention relates to the diethylamine salt of 3a- tetrahydropyranyloxy-6a-ethyl-7a-hydroxy-53-cholanic acid (I), which is a new intermediate in the synthesis of obeticholic acid, to the use of said diethylamine salt in the sy...  
WO/2020/163201A1
The present application relates to methods of treating or preventing an intestinal inflammatory disease or condition (e.g., intestinal ischemia reperfusion injury) in a subject in need thereof, comprising administering a therapeutically ...  
WO/2020/119836A8
A process for preparing obeticholic acid, wherein the 7-keto-litocholic acid amide of formula (II), where R1, R2 are a C1-C6 n-alkyl, or together a C5-C6 cycle and the protecting group on the hydroxyl in position 3 is a carbamoyl with th...  
WO/2020/117945A8
The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), or an infl...  
WO/2020/136292A1
The present invention relates to compounds that can be defined as compounds derived from lithocholic acid and the metabolites thereof. For this reason, the compounds of the invention are named using the steroid numbering system. More par...  
WO/2020/125825A1
The present technical solution relates to compounds of general formula (I), wherein X is independently H or OH, while at least one X is OH, for use as a medicament, particularly in the treatment or prevention of cellular growth and regen...  
WO/2020/068004A3
A new lanostane triterpenoid (24E)-3β-acetoxy-15α-propionyloxylanosta-7,9( 11 ),24-trien-26-oic acid (GA003), is synthesized by acylation reaction of a naturally occurring fungal metabolite, (24E)-3β-acetoxy-15α-hydroxylanosta-7,9( 1...  
WO/2020/128514A1
2-Fluorinated bile acid compounds of general formula (I) wherein at least one of R1 and R2 represents F and the other is chosen 3 from H and F and wherein R3 is as defined herein; are of use in the treatment and prevention of neurodegene...  
WO/2020/131058A1
Disclosed is a method for enhancing the activity of telomerase using a composition containing ecdysterone. The invention also discloses the use of a composition containing ecdysterone and/or an extract containing ecdysterone, isolated fr...  
WO/2020/121140A1
The present invention relates to fractionation of crude tall oil, which originates from the Kraft process black liquor. In the method,according to the present invention, simulated moving bed (SMB) chromatography is used to efficiently se...  
WO/2020/119836A1
A process for preparing obeticholic acid, wherein the 7-keto-litocholic acid amide of formula (II), where R1, R2 are a C1-C6 n-alkyl, or together a C5-C6 cycle and the protecting group on the hydroxyl in position 3 is a carbamoyl with th...  
WO/2020/117945A1
The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), or an infl...  
WO/2020/104356A1
The present invention relates to 7-dehydrocholesterol-hemihydrate. It has been found that the formation of 7-dehydrocholesterol-hemihydrate offers an efficient method of increasing the storage stability of 7-dehydrocholesterol, respectiv...  
WO/2020/104353A1
The present invention relates to 7-dehydrocholesterol-hemimethanolate. It has been found that the formation of 7-dehydrocholesterol-hemimethanolate offers an efficient method of increasing the storage stability of 7-dehydrocholesterol, r...  
WO/2020/095888A1
Provided is a method for producing high-purity cholesterol which does not contain a substantial amount of desmosterol, said method comprising reacting cholesterol mixed with desmosterol with a halogenating reagent and water and then sepa...  
WO/2019/161211A3
Methods useful for reducing or preventing hepatic steatosis and NASH are provided herein. Such methods may comprise administering to a subject in need thereof an FXR agonist in combination with an amount of a branched amino acid in free ...  
WO/2019/228602A8
The invention relates to a process for recovering sterols and a fraction rich in fatty acids and resin acids from tall oil pitch, said process comprising a) saponifying the tall oil pitch with an alkali to hydrolyse esters included in th...  
WO/2020/076815A1
Steroid compounds are disclosed that have a formula represented by the following: (I) and wherein R1, R2, R3a, R3b, R4a, R4b, R5, R6a, R6b, R7, R8, and n are as described herein. The compounds may be prepared as pharmaceutical compositio...  
WO/2020/061317A1
The invention relates to sterol esters and methods for producing purified sterols that can be utilized in methods for producing a lipid nanoparticle.  
WO/2020/061332A1
The invention relates to compositions and methods for the preparation, manufacture, and therapeutic use of compositions comprising mRNA and a lipid nanoparticle comprising a compound of the invention and an ionizable lipid.  
WO/2020/045570A1
Provided are: a novel compound that forms a self-assembly; the self-assembly; production methods for the compound and the self-assembly; and pharmaceutical use of the compound and the self-assembly. The compound is represented by formula...  
WO/2020/039449A1
The present invention relates to an improved process for the preparation of Obeticholic acid and intermediates used in the process thereof. The invention also relates to a solid form of tertiary butylamine salt of Obeticholic acid and te...  
WO/2020/030737A1
The present invention relates to isolithocholic acid (3ß-hydroxy-5ß-cholan-24-oic acid, iso-LCA) and isoallolithocholic acid (3ß-hydroxy-5α-cholan-24-oic acid) and their deuterated analogs for preventing or treating Clostridium diffi...  
WO/2020/025942A1
Compounds of general formula (I): wherein R2a, R2b, R3a, R3b, R5, Y and R7 are as defined herein are selective agonists at the FXR receptor and are useful for the treatment or prevention of diseases and conditions including nonalcoholic ...  
WO/2020/020728A1
Disclosed are compounds of formula (I), wherein X, Y, Z are annular atoms comprised in a five-membered carbocyclic or heterocyclic ring, selected from the group consisting of CH, NH, N, O, S; saidcarbocyclic or heterocyclic ring being op...  
WO/2020/020306A1
The present invention relates to a crystal form of a compound of formula (I) and an application thereof in preparing a drug for treating an ophthalmic disease.  
WO/2020/003051A1
The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, form...  
WO/2019/211668A3
The present invention contemplates novel neurosteroid derivative compounds, such as derivatives of ganaxolone and allopregnanolone, having improved solubility and bioavailability. The novel neurosteroid derivative compounds are character...  
WO/2019/228602A1
The invention relates to a process for recovering sterols and a fraction rich in fatty acids and resin acids from tall oil pitch, said process comprising a) saponifying the tall oil pitch with an alkali to hydrolyse esters included in th...  
WO/2019/209850A1
Described herein is the chemical structure of neurosteroid derivative compounds, methods of synthesizing the derivatives, and their uses in treating disorders, including those of the central nervous system. These compounds are readily sy...  
WO/2019/197962A1
The present invention relates to the crystalline forms of (3α, 5β, 6α, 7α)-6-ethyl-3,7-dihydroxycholan-24-oic acid, commonly known as Obeticholic acid (1). Further, the present invention also provides process for the preparation of O...  
WO/2019/191637A1
Methods of preventing or retarding or reversing or abolishing the onset of Parkinson's and other neurodegenerative diseases are discussed.  
WO/2019/178980A1
A method for preparing gynostemma pentaphylla makino saponin LVI, XLVI, L, LI, Damulin A or Damulin B. In said method, Gynostemma cardiospermum Cogn.ex Oliv is used as a raw material to prepare a high content of target product by means o...  
WO/2019/183159A1
Provided are variants of saponins that are found in Quillaja saponaria (QS) Molina tree bark that are chemically modified to distinguish them from naturally occurring parent saponins. The modified saponins have increased adjunctive activ...  
WO/2019/170521A1
The present invention relates to a new intermediate for the synthesis of obeticholic acid, the compound of formula (I) or a geometric isomer thereof, a process for obtaining the same, as well as the use of said intermediate in the synthe...  
WO/2019/159020A1
Disclosed is a process for producing cholesterol from fish oil, including the following steps: (a) distilling fish oil in a vacuum distillation column to obtain a first residue and a first distillate, (b) distilling the first distillate ...  
WO/2019/155217A1
The invention relates to methods for disrupting cholesterol crystals and related methods for the prevention and/or treatment of disease.  
WO/2019/129249A1
The present invention relates to a novel use of a triterpenoid. In particular, the present invention provides a use of a compound of formula I, or an optical isomer thereof, or a racemate thereof, or a solvate thereof, or a pharmaceutica...  
WO/2019/126741A1
Provided herein are compounds of Formula (I-I): and pharmaceutically acceptable salts thereof; wherein p, R1, R3a, R2a, R11a, R11b, R6a, and R6b are defined herein. Also provided herein are pharmaceutical compositions comprising a compou...  
WO/2019/119832A1
Provided are a compound for treating metabolic diseases having the structure as shown in formula (I) or formula (II), or a racemate, stereoisomer, geometric isomer, tautomer, solvate, hydrate, metabolite, pharmaceutically acceptable salt...  
WO/2019/106865A1
Provided are: an acyl novel steryl glucoside; and a method for producing an acyl steryl glucoside by using labyrinthula as a raw material. This acyl steryl glucoside is represented by structural formula (I), structural formula (II), or s...  
WO/2019/047989A3
Crystalline form J-1 and J-2 of obeticholic acid, whereas crystalline form J-1 shows characteristic reflections in an X-ray powder record using CuKα radiation: 6.3; 9.4; 12.2; 14.4; 16.5 and 19.0 ± 0.2° 2-theta and crystalline form J-...  
WO/2019/108673A1
Cataract and presbyopia affect billions of people worldwide. Described herein are new compounds and methods of treating and preventing these diseases.  
WO/2019/097434A1
The aspects of the present disclosure relates to novel lanosterol derivatives and novel 25-hydroxycholesterol derivatives including their pharmaceutically acceptable salts as well as methods of treatment and pharmaceutical compositions a...  
WO/2019/085963A1
The present application belongs to the field of pharmaceutical chemistry, and relates to a method for preparing a cholic acid compound. Specifically, the present application provides a process for preparing a compound as shown in formula...  

Matches 1 - 50 out of 3,719