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WO/2023/274091A1 |
A recombinant reteplase gene optimized by a rice codon, a related vector, a method for preparing a genetically engineered rice seed, and a method for separating and purifying recombinant reteplase. Genetically engineered rice is processe...
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WO/2023/274298A1 |
A quantum dot modified protein vaccine and a preparation method therefor and an application thereof, relating to the field of nanomaterials and biomedicines. Raw materials of the quantum dot modified protein vaccine comprise quantum dot ...
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WO/2023/277186A1 |
Provided is a means that makes it possible to simultaneously and accurately analyze a target peptide, a component derived from a carrier for liquid phase peptide synthesis, and the like.　Provided is a method for simultaneously analyzin...
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WO/2023/274809A1 |
The present invention relates to a method of separating bispecific antibodies or bispecific antibody fragments. The method comprises the steps of a) providing a feed comprising bispecific antibodies or bispecific antibody fragments; b) c...
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WO/2023/272386A1 |
Novel peptides and their uses are provided. In particular, the peptides are useful for modulating glucose uptake. The peptides are also useful for regulating glucose levels and/or treating diabetes in a subject.
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WO/2023/278683A1 |
A fusion peptide comprising a GLP1 variant, and at least one adiponectin agonist peptide which is chemically attached to the GLP1 variant via by a spacer. The GLP1 variant portion can include one or more substitutions relative to the nat...
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WO/2023/275410A1 |
The invention is directed to a method of making a target peptide comprising reacting a mixed anhydride compound of Formula (I) with a second moiety which is an amino acid or peptide, wherein Formula (I) has the following structure: Formu...
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WO/2023/278802A1 |
Provided herein are formulations configured for the oral delivery of a nucleic acid, such as a non-coding RNA. The formulations provided for herein comprise a plurality of cationic lipids used to encapsulate the nucleic acid within a mic...
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WO/2023/277485A1 |
The present invention provides a method for preparing a micrococcin-based carboxylic acid compound and a micrococcin-based carboxylic acid compound prepared thereby, and the method for preparing a micrococcin-based carboxylic acid compou...
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WO/2023/275306A1 |
The present invention relates to a method for identifying peptides that specifically bind to a target molecule. The method may be used to identify both ribosomal and non-ribosomal peptides. With the method of the invention, peptides for ...
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WO/2022/268353A1 |
The present invention concerns a potato protein composition comprising: patatin; and optionally insoluble fibers from potato and/or other potato proteins, wherein the protein, preferably the potato protein, has an aqueous solubility at p...
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WO/2022/268993A1 |
The disclosure relates to a novel method for selection and identification of specific polypeptide binding agents for a target of interest. More specifically, the selection method involves capturing the target of interest on a surface usi...
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WO/2022/268556A1 |
The present invention relates to a method for purifying a feed comprising a concentration of a target product in a chromatography system (10) having a first adsorption purifying unit (13). The first adsorption purifying unit has a capaci...
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WO/2022/266927A1 |
Disclosed are a liraglutide variant, a preparation method therefor, and an application thereof. The twelfth amino acid Ser of the liraglutide variant is allosterically regulated to a D-type amino acid. The biological activity of the lira...
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WO/2022/261741A1 |
Disclosed herein are hydrogels useful for restoring a biological activity of a denatured polypeptide, solubizing one or more protein aggregates, and/or stabilizing a polypeptide, and methods of using the same, wherein the hydrogel compri...
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WO/2022/265335A1 |
Low-molecular-weight sericin according to the present invention can enhance absorption efficiency when applied to the skin and, especially, has excellent antioxidant and tyrosinase inhibitory effects, and thus can fundamentally inhibit t...
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WO/2022/266507A1 |
A column is disclosed for removal of sTNF-R2 from a body fluid. The column has a compartment, an inlet coupled to the compartment and configured to receive the body fluid, and a substrate disposed within the compartment. A capture ligand...
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WO/2022/266056A1 |
Processes are provided that yield high molecular weight collagen without enzymatic or chemical treatment, preserving triple helical content of native collagen. Processing conditions and energy input on animal tissue supply streams can be...
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WO/2022/265115A1 |
A method of producing a polypeptide compound, wherein a peptide compound represented by formula (P) is obtained by inducing an amide formation reaction between an amino-protected lactam compound represented by formula (R1) and an amino a...
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WO/2022/257831A1 |
Disclosed are polypeptide compounds using PD-1 receptors as targets. The polypeptide compounds comprise a compound 1, a compound 2, a compound 3, a compound 4 and a compound 5. The amino acid sequences of the compounds 1-5 are as shown i...
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WO/2022/260091A1 |
In this synthetic adsorbent, the maximum value of a differential pore volume (mL/g) determined under pressure conditions from 0.5 psia to 30.0 psia as measured by the following method exceeds 0.05 mL/g.
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WO/2022/261127A1 |
Provided herein are fusion proteins engineered from a dysferlin C2 domain sequence linked to a sequence of a homologous fusion partner, vector constructs with cDNA encoding the fusion proteins and viral vectors with the vector constructs...
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WO/2022/255195A1 |
The present invention provides a method for inexpensively and efficiently synthesizing polypeptide compounds comprising various amino acids. The method involves (i) inducing an amide formation reaction between the carboxyl group on the r...
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WO/2022/256383A1 |
Microchip Capillary Electrophoresis (MCE) assays and reagents to assess purity and to identify impurities in protein drug product samples are provided. Methods for analyzing analytes in a protein drug sample are provided.
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WO/2022/252619A1 |
A fermentation and enzymolysis preparation method for small peptides from a leaf-shaped fish and the use thereof. The preparation process comprises: crushing, degreasing and hydrolyzing a leaf-shaped fish to obtain a hydrolysate; carryin...
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WO/2022/255893A1 |
Provided are methods of diagnosis and differentiation of and between PD and DLB tissue samples.
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WO/2022/253175A1 |
A synthetic polymeric porous medium with a core-shell (s) hierarchical layer structure and has an essentially homogeneous porous structure from inside to outside of the medium, whose core and shell (s) are covalently modified with distin...
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WO/2022/255289A1 |
The present invention relates to a method for producing a glycopeptide, the method including a step for modifying an Fc region of an avian antibody, and a step for lysing the modified Fc region using a proteolytic enzyme, and the glycope...
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WO/2022/251357A1 |
Methods for reducing cleavage of a protein comprising a formylglycine (fGly) amino acid is provided. Such methods can involve protecting the protein from exposure to visible light having a wavelength of 500 nm or lower. Also provided her...
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WO/2022/250036A1 |
[Problem] To provide a method for separating and purifying a minute useful substance. [Solution] A method for separating and purifying a minute useful substance involves filtering a liquid containing the minute useful substance by means ...
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WO/2022/248587A1 |
The invention relates to a novel amino acid having a tetrazine moiety and peptide or protein comprising the novel amino acid compounds. The invention also relates to a method of producing peptide or proteins comprising a tetrazine moiety...
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WO/2022/251194A1 |
Disclosed herein are methods of determining load volumes for capture chromatography in system and methods for continuous manufacture of a biological product.
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WO/2022/247927A1 |
The present invention relates to an indicator molecule for the toxigenicity of aflatoxigenic fungi and the use thereof. The amino acid sequence of the indicator molecule ABFT-YJFZ01 for the toxigenicity of the aflatoxigenic fungi is as r...
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WO/2022/250035A1 |
[Problem] To provide an isolation and purification method for isolating and purifying extracellular vesicles. [Solution] An isolation and purification method of extracellular vesicles, said method being for obtaining a concentrated solut...
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WO/2022/245306A1 |
The present invention relates to the field of antibody purification in biotechnological production. In particular, the present invention provides an improved method for purifying an antibody from a harvested cell culture fluid comprising...
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WO/2022/243320A1 |
Disclosed is a method for producing a biomolecule by a cell cultured in vitro, the method comprising the steps of: (a) propagating the cell in a cell culture, wherein the cell is transformed with a vector, wherein the vector comprises (i...
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WO/2022/245924A1 |
Phenylalanine ammonia-lyase (PAL) variants with a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL for therapeutic uses, including the treatment of adolescent subjects having PKU.
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WO/2022/246086A1 |
Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high...
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WO/2022/242033A1 |
Provided in the present invention are a genetically engineered bacterium for producing porcine myoglobin, and methods for fermenting and purifying same. According to the present invention, the gene of the porcine myoglobin is integrated ...
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WO/2022/246342A1 |
The disclosure relates to systems and methods for improving the manufacturing of silk solutions and powders containing silk fibroin obtained from silkworm cocoons. The solutions and powders can be used to improve the post-harvest preserv...
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WO/2022/242339A1 |
The present invention provides an oligopeptide, a preparation method therefor, and an application thereof. The amino acid sequence of the oligopeptide is Phe-Pro-Gln-Tyr-Leu-Gln-Tyr-Pro-Tyr, and the IC50 of the oligopeptide to an angiote...
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WO/2022/134395A9 |
Disclosed are a novel BH3 mimetic peptide analog inhibiting PTP1B activity and an application thereof. The structural formula (I) of the novel BH3 mimetic peptide analog is as shown below. The mimetic peptide compound is derived from the...
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WO/2022/242993A1 |
The present invention relates to a method for preparing a library of peptides or an isolated peptide comprising (a) releasing one or more linear dithiol peptides carrying a sulfhydryl group in the N-terminal region of the one or more pep...
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WO/2022/245150A1 |
The present invention provides a method for preparing a macrocosine compound, and a pharmaceutical composition for the treatment and prevention of infection of a specific strain comprising a macrocosine compound, a solvate thereof, a hyd...
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WO/2022/242386A1 |
A bifunctional bean-derived polypeptide having antihypertensive activity and antioxidant activity, and a preparation method therefor. The method comprises: firstly, extracting a bean-derived protein isolate from beans by using an alkali-...
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WO/2022/242464A1 |
A novel CRISPR-associated transposase derived from pseudoalteromonas translucida KMM 520, wherein 16 PAMs can be identified and cargo genes can be inserted into 8 sites at a time with an efficiency of 100%, higher than a CRISPR-associate...
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WO/2022/238174A1 |
The present invention relates to purification of a tripeptide of formula (I). By using said method, the tripeptide of formula (I) is obtained in a very pure form and due to this effect the purified tripeptide can be used in a variety of ...
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WO/2022/241310A1 |
Provided is a modified B-type natriuretic peptide (BNP) comprising a covalently attached polymer comprising amino acids, where the polymer inhibits degradation and/or elimination of the BNP in a subject, and where the modified BNP retain...
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WO/2022/237510A1 |
The present invention relates to a molecular peptide mutant, and an amino acid sequence as shown in SEQ ID NO: 1. By means of the invention, SpyCatcher is designed and modified on the basis of not affecting the formation of isopeptide bo...
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WO/2022/238319A1 |
The present invention relates to protein purification, primarily in the chromatographic field. More closely, the invention relates to affinity chromatography using a split intein system comprising a C-intein tag and N-intein ligand, wher...
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