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WO/2023/165831A1 |
The present disclosure is directed to a method for separating supercoiled plasmid DNA (pDNA) from a liquid sample, the method comprising the steps of: (a) adding a liquid sample comprising pDNA to a first chromatography material comprisi...
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WO/2023/167871A1 |
The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein o...
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WO/2023/166975A1 |
The present invention strengthens an α-helix structure involved in a bioactivity of a peptide. The present invention provides causing a reaction between a side chain of a tryptophan residue and a side chain of a cysteine residue provide...
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WO/2023/167238A1 |
[Problem] To establish a method for producing an Fc-containing molecule having a highly pure and uniform sugar chain structure while using as small amount of sugar chain donor molecules as possible, etc., said method allowing free select...
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WO/2023/167855A1 |
The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein o...
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WO/2023/165476A1 |
A targeting peptide specifically targeting Sortilin/SORT1 protein, and a targeting peptide-drug conjugate comprising the targeting peptide. The targeting peptide is a linear peptide or cyclic peptide with non-natural chemical modificatio...
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WO/2023/164769A1 |
A radiopharmaceutical 177Lu-DOTATATE compound, a composition comprising one or more ascorbate compounds with the substantial or complete absence of a gentisate compound, a single or multiple dosage kit, and a sealed container are provide...
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WO/2023/167857A1 |
The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein o...
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WO/2023/167863A1 |
The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein o...
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WO/2023/167340A1 |
The present invention relates to a chimeric peptide containing a first domain and a second domain, wherein the first domain contains (i) a peptide containing at least an amino acid sequence shown by any of ID SEQ NOS: 1-4, (ii) a peptide...
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WO/2023/160721A1 |
Provided in the present disclosure are IL-15 variants, IL-15/IL-15Rα-Fc fusion proteins comprising the IL-15 variants and IL-15/IL-15Rα fusion protein comprising the IL-15 variants the methods of producing the same and the uses thereof...
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WO/2023/164258A1 |
Provided herein are capillary electrophoresis methods for separating and detecting double-stranded ribonucleic acid (dsRNA) contaminants in samples of single-stranded ribonucleic acids (ssRNA) such as RNA therapies (e.g., mRNA vaccines).
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WO/2023/155318A1 |
Provided are a broad-spectrum anti-SARS-CoV-2 lipopeptide, a preparation method therefor, a virus membrane fusion inhibitor comprising the lipopeptide, and use of the lipopeptide in the preparation of a pharmaceutical composition for pre...
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WO/2023/158599A1 |
A method is disclosed for washing an amino acid that has been added to a solid phase resin during solid phase peptide synthesis (SPPS), comprising: adding a first quantity of wash solvent, wherein once the wash with the first quantity of...
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WO/2023/157457A1 |
Conventional protein-containing specimen pretreatment methods preceding analysis using LC-MS or electrophoresis are time-consuming, which is a limitation for various applications of the methods. Said methods also have problems such as sa...
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WO/2023/154822A2 |
Provided herein are embodiments relating to affinity chromatography purification and separation of contaminant species, including HCPs (Host Cell Proteins), from desired molecular and chemical species.
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WO/2023/154467A1 |
Provided herein are methods for preparing a protein composition having a reduced quantity of a recombinant cell byproduct which provides an undesirable color to a protein. The methods involve the use of absorbents or flocculants that cap...
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WO/2023/153878A1 |
Disclosed is a method of purifying factor XIII comprising (a) first salt precipitation, (b) heat treatment, and (c) second salt precipitation, in which factor XIII can be purified at high yield from a plasma sample or the like through a ...
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WO/2023/149512A1 |
The purpose of the present invention is to provide a protein deamidase agent having improved thermal stability. A guanidinium compound and polyamine can improve the thermal stability of a protein deamidase.
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WO/2023/150500A1 |
The present invention relates to peptide inhibitor of the interleukin-23 receptor (IL-23R) or salts, solvates or forms thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation disea...
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WO/2023/148172A1 |
The present invention relates to a method of purifying a target component from a full plasma sample. The present invention further relates to a method of removing one or more target components from a full plasma sample.
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WO/2023/143391A1 |
Provided are a low-endotoxin collagen comprising a low-endotoxin collagen solution and a low-endotoxin collagen freeze-dried product, and a preparation method therefor. The method comprises the steps of loading a sample, rebalancing, was...
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WO/2023/143525A1 |
B domain and Z domain mutants of a protein A, and an application thereof. Specifically, provided is an isolated polypeptide, which is selected from: (1) a polypeptide having a substitution mutation at one or more positions selected from ...
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WO/2023/143530A1 |
The present invention relates to a protein composition having a joint repair function. Preparation of the protein composition comprises the following steps: adding any one of or a combination of a nuclease or Benzonase nuclease of 20-35 ...
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WO/2023/142410A1 |
Provided are a talaromyces marneffei mannan protein and a use thereof in preparation of a talaromyces marneffei antibody test kit. The amino acid sequence of the mannan protein is as shown in SEQ ID NO. 1. The mannan protein can bind to ...
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WO/2023/143522A1 |
The present invention relates to a nerve repair protein composition. The preparation thereof comprises the following steps: adding 20 U/mL-35 U/mL of any one or a combination of nuclease or totipotent nuclease to a cell protein extract, ...
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WO/2023/026286A9 |
Methods and apparatus are disclosed for preparing plasma enriched with Interleukin Receptor 1 antagonist ("IL-IRa") using glass beads or polyacrylamide microbeads and recovering the plasma enriched in IL-IRa with a filter.
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WO/2023/137994A1 |
Disclosed in the present invention are a specific nanoantibody Nb3.27 against a colorectal cancer-associated Bacteroides fragilis toxin protein activator, and an application thereof. By means of in-depth research of enterotoxigenic Bacte...
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WO/2023/134773A1 |
One or more embodiments in the present specification relate to a purification method, the purification method comprising: mixing magnetic beads with a purification target substance; and transferring the magnetic beads and the purificatio...
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WO/2023/133913A1 |
Disclosed are a method for preparing a multifunctional pea peptide and the use thereof, which belong to the technical field of biomedicine. The method for preparing a multifunctional pea peptide comprises the following steps: S1, prepara...
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WO/2023/135187A1 |
The present invention relates to novel proteins that specifically bind to the ferritin. The novel proteins of the present invention are advanced and powerful tools because they allow precise purification methods of ferritin, for example ...
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WO/2023/136301A1 |
Provided is a method that prevents decreases in solubility in an organic solvent when elongating a peptide chain by a peptide coupling reaction and improves the reactivity of a peptide chain and the operability in a purification process....
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WO/2023/134443A1 |
The present invention relates to the technical field of biological filtering. Disclosed in the present invention are a filtering device and method for filtering and removing viruses from a protein-containing feed liquid. The filtering de...
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WO/2023/137062A1 |
Methods of purifying a heterodimeric protein (e.g., a bispecific antibody) from impurities through a series of chromatographic cycles are disclosed. In various embodiments, the pH of the elution buffer is increased with increasing cycles...
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WO/2023/130855A1 |
A process for preparing a high-yield collagen sponge. The process comprises: selecting collagen-rich animal tissues, and cutting same into slices or blocks to form tissue slices or tissue blocks; performing a pre-treatment, an enzyme rea...
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WO/2023/132963A1 |
The present disclosure provides an automated method for chemical treatment of cells in a mixing chamber, wherein the automatable method comprises providing cells, providing a chemical agent for treating cells, forming a liquid mixture co...
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WO/2023/132543A1 |
The present invention relates to a uracil-DNA glycosylase (UDG) derived from a photobacterium leiognathi strain, and use thereof. A novel UDG of the present invention is an enzyme isolated from low-temperature bacteria photobacterium lei...
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WO/2023/124207A1 |
The present application relates to the technical field of immunoglobulin separation and purification, and in particular, to an immunoglobulin-binding protein and an application thereof. The immunoglobulin-binding protein is obtained by s...
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WO/2023/125958A1 |
Provided are a recombinant Artemisia vulgaris pollen type I allergen (Art v1), a gene encoding same, and a method for expressing and purifying same. Art v1 obtained by means of the optimization of different gene sequences and the combina...
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WO/2023/129844A1 |
An analytical method for detecting presence of oxidizing substances by measuring degradation of peptides may include preparing a test preparation that includes a peptide and a sample. The peptide degrades in the presence of oxidizing sub...
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WO/2023/128507A1 |
The present invention provides a hexameric N-formyl peptide library and uses thereof, wherein the hexameric N-formyl peptide library is for discovering a formyl-peptide receptor activating active substance for the development of a therap...
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WO/2023/128981A1 |
The present invention relates to a method (100) for producing filtering biofilms produced with a modified bacterial major biofilm protein that can bind with a modified lectin protein exhibiting a high binding affinity to multiple mannose...
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WO/2023/129778A1 |
Polymer engineering is achieved by deploying a constitutively active dehydratase enzyme of RiPP biosynthesis to accept a substrate containing a non--amino acid monomer at a position flanking the reaction site.
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WO/2023/127331A1 |
One problem to be addressed by the present invention is to provide: a protecting group removing method capable of suppressing generation of double-hit bodies and diketopiperazine, easily scavenging a fulvene backbone-including compound t...
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WO/2023/123591A1 |
Disclosed are a method for purifying a GLP-1 analog and the use thereof. The purification method comprises: performing reversed-phase purification on a crude peptide solution, performing desalination using a mixed solution of water and a...
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WO/2023/130098A2 |
The present disclosure provides a detectable labeling reagent for coupling to a target biomolecule. The detectable labeling reagent may comprise a chemical handle configured to couple to the target biomolecule. The detectable labeling re...
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WO/2023/127752A1 |
A polypeptide that has a sequence having a sequence identity of 90% or more with respect to a sequence obtained by modifying one amino acid residue in the amino acid sequence represented by SEQ ID NO: 1, and that has a catalytic activity...
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WO/2023/125956A1 |
Provided are a recombinant artemisia annua pollen type I allergen (Art al), and gene coding and expression purification methods therefor. By combining different optimized gene sequences, different secretory signal peptides, expression ve...
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WO/2023/127869A1 |
The present invention pertains to a method for producing a N-monoalkyl amino acid or an ester thereof, or a peptide including the N-monoalkyl amino acid or an ester thereof, the method comprising an alkylating step for mixing, in the pre...
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WO/2023/126903A2 |
The present invention relates to a separation and quantification method of a non-ionic surfactant in a composition comprising polypeptide and non-ionic surfactant by using a zwitterionic hydrophilic interaction liquid chromatography (ZIC...
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