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Matches 1 - 50 out of 28,342

Document Document Title
WO/2018/012669A1
The present invention relates to a mesitylene-cored amphiphile, a method of preparing the same and a method of extraction, solubilization, stabilization, crystallization or analysis of a membrane protein using the same. When a mesitylene...  
WO/2018/010476A1
Provided are a glycopeptides based derivative represented by the general formula (I) and a pharmaceutically acceptable salt thereof. R1 is H, 2-alkylamine-ethyl group, a substituted benzyl group, a substituted phenylpropionyl group or a ...  
WO/2018/010475A1
A glycopeptide derivative represented by the general formula (I) and a pharmaceutically acceptable salt thereof, R1 is H, 2-alkylamine-ethyl, a substituted benzyl group, a substituted phenylpropionyl group, or a linear acyl group contain...  
WO/2018/013000A1
A plant for soy protein isolate production is being claimed wherein water consumption in the production process is significantly reduced (by a factor of 2.5) and liquid waste is nonexistent, which allows, moreover, to cut protein loss...  
WO/2018/009006A1
The present invention relates to a mutated immunoglobulin-binding protein having increased alkaline tolerance and, more specifically, to an immunoglobulin-binding protein in which, with respect to the A-domain of Staphylococcal protein A...  
WO/2018/008030A1
A method for producing a water-soluble protein concentrate from plant biomass is disclosed, comprising: obtaining plant matter from said plant biomass; drying said plant matter; grinding said dry plant matter; de-chlorophyllizing said gr...  
WO/2018/006269A1
Disclosed are an acridine-marker conjugate and a preparation method thereof, and a chemiluminescence immunoassay kit. The acridine-marker conjugate comprises an acridine substituent, a connecting vector, a bifunctional crosslinking agent...  
WO/2018/008596A1
Provided is a solid phase support by which the recognition site of an antibody for detection can be oriented toward a measurement sample side so that the antibody can be immobilized in a measurement area. A solid phase support for protei...  
WO/2018/006268A1
Disclosed are an acridine-marker conjugate, preparation method thereof, and a chemiluminescence kit. The acridine-marker conjugate comprises an acridine substituent, a polyamino acid, and a protein to be marked, connected in that order. ...  
WO/2018/007930A1
The invention relates to an improved method for a 5+3+2 solution phase syntheses of Icatibant acetate (1) comprising coupling of suitably protected peptide fragments which on deprotection followed by treatment with acetic acid provide Ic...  
WO/2018/008441A1
The present invention provides a production method for a metal-encapsulated cage-like protein, the method comprising a step for introducing a metallic element into a cage-like protein in the presence of polysaccharides to produce a metal...  
WO/2018/003909A1
The present invention provides a protein aggregation inhibitor which can be used for inhibiting the aggregation of a protein, said protein comprising a terminal-sulfanyl-group-containing sulfobetaine polymer having a repeating unit deriv...  
WO/2018/001273A1
Provided are a peptide or a salt thereof, and a preparation method therefor. The peptide may be selected from VVYP, AVLP, IGFP, LLIIVP and STAP. The preparation method comprises steps as follows: using a resin as a starting material, lin...  
WO/2017/219078A1
The present invention relates to the discovery of the importance of the vicinal cysteine residues located in von Willebrand factor (VWF) domain A2. Thus the invention discloses modified VWF wherein: (a) the vicinal cysteine residues of V...  
WO/2017/222300A1
The present invention relates to a method for producing an allergenic component-free purified bee venom, and an allergenic component-free purified bee venom produced thereby, the method enabling the production of an allergenic component-...  
WO/2017/222330A1
The present application provides a single-chain blood coagulation factor VIII including a B region which is partially deleted to contain at least four glycosylation sites, but not a heavy chain, a light-chain, and a region to be cleaved ...  
WO/2017/219952A1
The present invention provides a preparation method for an antifreeze protein of soybean. The method comprises the steps of: transforming plasmids containing the expression sequence of the antifreeze protein to expressed escherichia coli...  
WO/2017/219034A2
The present disclosure provides methods for manufacturing a fXa derivative protein at large scale leading to high yield of highly pure protein product. The method may include adding a detergent to a sample that contains a polynucleotide ...  
WO/2017/217930A1
This application describes compositions, kits, and methods for removing contaminants from a protein preparation, for example a cell culture harvest comprising a recombinant protein. The methods described herein can enhance the performanc...  
WO/2017/218830A1
This disclosure provides a high quality protein composition and the processes of making the same. The compositions prepared by filtration according to the instant disclosure may contain higher percentage of branched chain amino acids (BC...  
WO/2017/215312A1
A method using gingko nut shells for the preparation of calcium-chelating peptide comprises the following steps: (1) placing the gingko nut shells in an aqueous solution of NaOH, agitating same and, after settling, removing the supernata...  
WO/2017/218977A2
The present invention provides methods of purifying multispecific antibodies. The methods comprise the sequential steps of performing a capture chromatography, a first mixed mode chromatography and a second mixed mode chromatography. In ...  
WO/2017/218977A3
The present invention provides methods of purifying multispecific antibodies. The methods comprise the sequential steps of performing a capture chromatography, a first mixed mode chromatography and a second mixed mode chromatography. In ...  
WO/2017/211985A1
The invention relates to oligomeric macrocycles and to uses thereof as receptors for recognition of protein post-translational modifications (PTM) or specific motifs in proteins.  
WO/2017/214130A1
The disclosure provides a method of producing recombinant alkaline phosphatase comprising: (i) culturing an alkaline phosphatase in a recombinant cell culture; (ii) obtaining a preparation of recombinant alkaline phosphatase from the cel...  
WO/2017/214249A3
Disclosed are granulocyte-macrophage colony stimulating factor (GM-CSF) variants, polynucleotides encoding the GM-CSF variants, and methods of making and using the GM-CSF variants for the treatment of immune-related disorders, such as in...  
WO/2017/211775A1
The present invention relates in a first aspect to a method for the purification of biological macromolecular complexes. Typically, no chromatography steps are applied. That is, the present invention relates to a method for the purificat...  
WO/2017/211272A1
The present invention provides a phenyl propanamide derivative as represented by formula (I), a manufacturing method of the derivative, application of the derivative as a κ-opioid receptor (KOR) agonist, and application of the derivativ...  
WO/2017/212390A1
The invention relates to an improved method for 4+4 solution phase synthesis of Lanreotide acetate (1) comprising coupling of two suitably protected tetrapeptide fragments which on deprotection, oxidation, followed by treatment with acet...  
WO/2017/209587A1
The present invention relates to a method for the low-temperature acid extraction and purification of soluble type I native marine collagen from fresh or frozen sardine scales (sardina pilchardus), characterised in that it comprises the ...  
WO/2017/209471A1
A peptide of the present invention has a modified affinity binding to IgG by substitution of an amino acid at a certain position in an amino acid sequence with a different amino acid, and thus can find useful applications in IgG immobili...  
WO/2017/207223A1
The invention provides a process for preparing a protein-polysaccharide conjugated product comprising: (a) preparing a mixture comprising pea protein, polysaccharide, and an appropriate polar solvent; wherein: the weight ratio between po...  
WO/2017/204160A1
The purpose of the invention is to provide a method with which it is possible to produce surfactin well from culture broth, even using a general-purpose extraction solvent, and produce surfactin efficiently. The method for producing surf...  
WO/2017/200376A1
The invention relates to protein chemistry and protein analysis, more specifically to means and methods for the site-specific labeling of polypeptides. Provided is a method for the site-specific labelling of a polypeptide, comprising pro...  
WO/2017/200109A1
[Problem] To provide a technique with which it is possible to selectively introduce a disulfide bond into two free thiol groups positioned within the molecule of an organic compound such as a peptide by a simple process in a short time a...  
WO/2017/201061A1
Provided herein are filtration-based purification methods for amyloid fibers, such as curli fibers, directly from microbial culture, and their fabrication into free-standing thin films. Additionally, methods for recycling amyloid fibers ...  
WO/2017/201061A8
Provided herein are filtration-based purification methods for amyloid fibers, such as curli fibers, directly from microbial culture, and their fabrication into free-standing thin films. Additionally, methods for recycling amyloid fibers ...  
WO/2017/201105A1
Disclosed herein are methods for the isolation and purification of a botulinum neurotoxin (BoNT) protein, or a polypeptide comprising a receptor binding domain of BoNT, from a solution. The method comprises contacting the solution contai...  
WO/2017/195638A1
The purpose of the present invention is to provide a method capable of favorably refining an antibody or an antibody fragment that contains a κ-chain variable region, while producing a sharp elution peak without damaging the antibody or...  
WO/2017/195641A1
The purpose of the present invention is to provide an affinity separation matrix having extremely excellent binding capacity and binding efficiency with respect to a κ-chain variable region-containing peptide, a method for producing the...  
WO/2017/195780A1
Provided is a method for restoring the three-dimensional structure of an abnormalized protein. A method for restoring the three-dimensional structure of an abnormalized protein to a normal structure by bringing a functional mineral water...  
WO/2017/196963A1
Computational methods for classifying and predicting protein side chain conformations utilizing a data driven scoring function are disclosed. According to some embodiments, the methods may include obtaining structure data representing a ...  
WO/2017/190254A1
An apparatus and method for magnetic separation are provided. The apparatus and method can be used to separate magnetically linked targets from unlinked targets in a suspension. The apparatus has a two-dimensional magnetic array that inc...  
WO/2017/191748A1
The purpose of the invention is to provide a novel modified protein L (PpL) that presents bindability to the κ chain of immunoglobulins and has excellent chemical stability to alkali solutions, an affinity separation matrix having the m...  
WO/2017/191747A1
The purpose of the present invention is to provide a method for efficiently producing a protein including a κ chain variable region using a specific κ chain variable region-binding peptide having high alkali tolerance as a ligand, and ...  
WO/2017/192460A1
This disclosure relates to isotopically modified amino acids and their pharmaceutical or nutritional uses in stabilizing pharmaceutical protein-based formulations, proteins with long life span, and preventing or treating disease such as ...  
WO/2017/189925A1
The present invention provides methods of preparing a peptide having an N-terminal histidine, and compositions comprising a plurality of peptides prepared by the methods. The methods disclosed herein reduce racemization of the N-terminal...  
WO/2017/186855A1
The present invention provides means and methods for functionalizing a polypeptide of interest at its C-terminus with an amino acid derivative.  
WO/2017/189860A1
Methodology was developed for transformation of methionine residues into homocysteine derivatives. Methionine residues can undergo alkylation reactions at low pH to yield sulfonium ions, which can then be selectively demethylated to give...  
WO/2017/186654A1
The present invention relates to the use of sulfocysteine and derivatives thereof as cell culture additives to reduce the trisulfide levels in proteins produced in cell culture.  

Matches 1 - 50 out of 28,342