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Matches 1 - 50 out of 29,516

Document Document Title
WO/2019/198833A1
The present invention is a liquid-phase peptide synthesis method that, in an Fmoc method utilizing a carrier (Tag), has the purpose of reducing processing time and cutting back on usage of poor solvents for solidification of a Tag-peptid...  
WO/2019/195878A1
Provided herein are methods for preparing a phosphorylated protein for phosphoproteomic analysis. Methods for preparing a phosphorylated protein for phosphopeptide analysis using mass spectrometry (MS) are described. Kits for preparing a...  
WO/2019/198834A1
The purpose of the present invention is to provide a method for producing leuprorelin that allows a crude product of high purity to be obtained in a shorter production period, as compared with conventional production methods. Provided is...  
WO/2019/199476A1
The invention relates to methods for preparing stable buffered and buffer-free protein compositions. The invention also relates to methods of purifying proteins from one or more impurities.  
WO/2019/200378A1
Antimicrobial compositions having bactericidal activity are described. Also described is a method of treating bacterial infections using compositions comprising antimicrobial peptides or variants thereof.  
WO/2019/197469A1
The present invention relates to a method for the synthesis of a polypeptide comprising a pre-determined amino acid sequence. The method according to the invention comprises coupling cycles of coupling an N-terminally protected amino aci...  
WO/2019/197466A1
The invention relates to a method for the cleavage of a solid phase-bound polypeptide from the solid phase, the method comprising contacting the solid phase, to which the polypeptide is bound, with a composition consisting essentially of...  
WO/2019/197292A1
The present invention relates to method for purifying proteins naturally occurring in mammalian milk from aqueous protein solution using water-soluble silicate. The silicates form an insoluble precipitate of a silicate-protein complex fr...  
WO/2019/197760A1
The invention relates to a method for purifying proteins comprising a purification step that uses centrifugal partition chromatography, referred to as CPC, from a microalgae extract dispersed in a mixture comprising an aqueous two-phase ...  
WO/2019/192877A1
A bind/elute chromatography method and compositions for low salt/low solution conductivity separation of target proteins from a mixture of aggregates and other impurities.  
WO/2019/193416A1
Sense codon reassignment to unnatural amino acids (uAAs) represents a powerful approach for introducing novel properties into polypeptides. The main obstacle to this approach is competition between the native isoacceptor tRNA(s) and orth...  
WO/2019/192493A1
Disclosed in the present invention are an antibody targeting LAG-3, a preparation method therefor and the use thereof. In particular, disclosed in the present invention is a novel monoclonal antibody targeting LAG-3. Also disclosed in th...  
WO/2019/193139A1
Disclosed is a process for the production of a membrane protein comprising the steps of: expressing a membrane protein in a host organism present in an aqueous medium, liberating the membrane protein from the host organism, adding a dete...  
WO/2019/192059A1
A functionalized high-density chromatographic substrate, a preparation method therefor, and an application thereof. The chromatographic substrate functionalization method employs a hydrophilic microsphere having a polyhydroxy structure o...  
WO/2019/189248A1
The present invention relates to a method for producing a protein formed body, the method comprising a step in which a protein solution containing a target protein, a void-forming material and a solvent is used to form a formed body of t...  
WO/2019/185628A1
The invention relates to a method of separating immunoglobulin variants, comprising the steps of: a) providing a column packedwith an Fc-binding affinity chromatography resin; b) loading a sample comprising at least two Fc-comprising imm...  
WO/2019/184089A1
Disclosed are a compound represented by formula II, a preparation method therefor and an application thereof. Using the compound represented by formula II to synthesize lanreotide has the following advantages: 1. during a reaction, a car...  
WO/2019/191005A1
The present invention in particular relates to a method of producing an immunogenic composition exhibiting reduced virucidal activity, as well as to the immunogenic composition and uses thereof, wherein the method in particular comprises...  
WO/2019/184366A1
Provided is a method for removing a recombinant human nerve growth factor precursor by using hydrophobic interaction chromatography characterized in that a washing step is added before elution, said washing step using a washing fluid red...  
WO/2019/190092A1
The present invention relates to a Bordetella pertussis-derived protein-obtaining method including an affinity chromatography process. The present invention increases the production yield of PT and FHA proteins by isolating PT and FHA pr...  
WO/2019/190531A1
The invention provides novel cosmetic films having crosslinked derivatized collagen and one or more cosmetic ingredients, and methods for their preparation and use for applying collagen one or more cosmetic agents to skin.  
WO/2019/185705A1
The present invention relates to IL-2 conjugates, a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such IL-2 conjugate or a pharmaceutically acceptable salt thereof and their uses.  
WO/2019/184370A1
The present invention provides a method for removing N-terminal truncated and abnormal variants in rhNGF, characterized by: 1) first, washing, by means of a cleaning liquid, a rhNGF raw material loaded onto a cation exchange material to ...  
WO/2019/187602A1
A purpose of the present invention is to provide: an immunoglobulin κ chain variable region-binding peptide that is capable of specifically binding to a protein containing immunoglobulin κ chain variable region and has a high chemical ...  
WO/2019/191133A1
Disclosed herein are methods of controlling, modulating, increasing, or improving protein yield in a sample mixture comprising a target protein and impurities comprising monitoring in real-time an ultraviolet (UV) signal of the sample mi...  
WO/2019/187377A1
This base material for a filler comprises a natural polymer immobilized on the surface of a porous organic polymer carrier, the porous organic polymer carrier has a crosslinking degree of 50-85 mol%, the exclusion limit molecular weight ...  
WO/2019/187534A1
The purpose of the present invention is to provide an industrially practicable method for producing reduced glutathione by reducing oxidized glutathione. The method for producing reduced glutathione according to the present invention is ...  
WO/2019/187603A1
A purpose of the present invention is to provide a peptide that has a high chemical stability to alkalis, etc. Another purpose of the present invention is to provide: a DNA encoding the aforesaid peptide; a vector containing the DNA; and...  
WO/2019/184368A1
Provided is a method for obtaining highly pure rhNGF from a CHO cell culture. Said method combines cation exchange chromatography and hydrophobic interaction chromatography, and is characterized in that a washing step is respectively add...  
WO/2019/185706A1
The present invention relates to a conjugate comprising a moiety of formula (I) or to conjugates of formula (I') and to pharmaceutical compositions comprising such conjugates.  
WO/2019/189064A1
In a method for producing a protein from animal cells, clogging of a column or filter closely packed in an airtight container makes continuous operation difficult. To solve this problem, provided is a module wherein: a slurry containing ...  
WO/2019/189802A1
The present invention relates to a method for producing a recombinant structural protein having a desired molecular weight, the method comprising: (A) a step of preparing a recombinant structural protein solution in which a recombinant s...  
WO/2019/187469A1
The purpose of the present invention is to provide a method for efficiently producing a long-chain peptide suitable even for industrial mass-synthesis. A method for producing the long-chain peptide according to the present invention is c...  
WO/2019/187468A1
The purpose of the present invention is to provide a method for producing a peptide by a liquid phase process wherein the epimerization of the peptide is suppressed and the isolation of an N-terminal deprotected amino acid or an N-termin...  
WO/2019/191416A1
In certain embodiments, the present invention provides a method of purifying a monomeric monoclonal antibody from a mixture which comprises the monomeric monoclonal antibody and one or more contaminants, comprising: a) subjecting the mix...  
WO/2019/184088A1
Disclosed are reaction carriers 1, 2 and 3 and a preparation method therefor and an application thereof. A reaction carrier 1/2/3 is used to synthesize angiotensin II, which can effectively increase the solubility of a full protective pe...  
WO/2019/185691A1
The present invention concerns a method for purifying a protein comprising in a continuous mode: one filtration step involving the use of at least one chelating agent, an exchanging step involving the use of at least one diafiltration me...  
WO/2019/183406A1
Methods for purifying multivalent antibody constructs, antibody constructs purified using the methods, and pharmaceutical compositions comprising the purified constructs, and methods of treatment of the purified constructs are presented.  
WO/2019/181910A1
Provided is a recombinant pro-activin A protein that has human activin A activity. Also provided is a novel method for producing human activin A. The present invention pertains to a recombinant pro-activin A protein containing the mature...  
WO/2019/183270A1
The present disclosure provides puromycin-based probes, as well as compositions and kits comprising the probes. The present disclosure provides methods of detecting an analyte, and imaging methods, using the probes.  
WO/2019/183265A1
The presently disclosed subject matter relates to peptides and flavor compositions that include at least one, two, three, four, five or more peptide compounds, and screening methods for identifying the same. The flavor compositions can b...  
WO/2019/183334A1
In various aspects, the present disclosure pertains to sorbents for isolating at least one target protein from a liquid sample, the sorbents comprising a solid support comprising attached at least one attached high affinity reagent with ...  
WO/2019/182433A1
The present invention relates to a method of refolding recombinant core streptavidin from inclusion bodies, characterised by the steps of: suspending inclusion bodies of the recombinant core streptavidin in a chaotropic agent solution ha...  
WO/2019/178587A1
The present invention provides a method of purifying a target molecule in a sample containing the target molecule, for example, an acidic target molecule, that utilizes a multimodal ligand.  
WO/2019/178489A1
The present disclosure relates to the use of host cell protein biomarkers to assess disulfide bond reduction in compositions comprising a protein of interest. In some embodiments, the disclosure relates to methods of predicting the occur...  
WO/2019/175412A2
Composite material comprising a support material and at least one polymeric layer, wherein the at least one polymeric layer is present in form of a polymeric mesh and is comprising at least one non-adsorbing/non-adsorptive polymer with r...  
WO/2019/175867A1
The present disclosure relates to solid phase synthesis of organic molecules and particularly to highly efficient methods for synthesizing polymers, such as peptides, nucleotides or saccharides, employing solid phase synthesis.  
WO/2019/173760A1
Provided herein are, inter alia, non-toxic, bioreactive unnatural amino acids and methods of using same.  
WO/2019/170635A1
The present invention relates to composite materials useful for purifying proteins obtained from biological feedstocks. The composite materials of the invention comprise a porous support having an average pore size of 5 to 500 nm, said p...  
WO/2019/169799A1
Disclosed are a biotinylated insulin antigen having a structure as represented by formula 1 and a biotinylation process thereof. The biotinylated insulin antigen of the present invention improves the coating efficiency of an insulin anti...  

Matches 1 - 50 out of 29,516