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Matches 1 - 50 out of 28,530

Document Document Title
WO/2018/069295A1
The present invention relates to a method of preparing a lysine side-chain modified peptide by solid phase peptide synthesis.  
WO/2018/071324A1
Pesticidal proteins exhibiting toxic activity against Lepidopteran pest species are disclosed, and include, but are not limited to, TIC4472, TIC4472PL, TIC1425, TIC2613, and TIC2613PL. DNA constructs are provided which contain a recombin...  
WO/2018/068347A1
Provided are recombinant plasmids containing the heterodimeric snake venom protein Agkisacutacin A chain gene and Agkisacutacin B chain gene, respectively, cell strains containing the recombinant plasmids, and a method for expressing the...  
WO/2018/066558A1
Disclosed is a method for purifying a recombinant protein from a recombinant cell in which a target recombinant protein is expressed within the cell as an insoluble body, said method characterized in that said recombinant cell is treated...  
WO/2018/065538A1
A preparation comprising peptides from natural allergens for use in the prevention of development of allergy.  
WO/2018/066595A1
A collagen composition in which the content of collagens each having a molecular weight of 90,000 or higher is 70% or higher on a solid basis with respect to the mass of the proteins, and which has a solubility in water (25°C) of 10% or...  
WO/2018/066914A1
The present invention relates to a tripeptide having fatty acids bonded thereto and a cosmetic composition comprising same and provides excellent skin anti-aging, wrinkle reduction, skin elasticity enhancement, and skin permeation effects.  
WO/2018/065972A1
Provided is a method of isolating a botulinum toxin type A macro complex from a botulinum toxin-containing solution, the method including performing anion exchange chromatography and cation exchange chromatography.  
WO/2018/063796A1
In various embodiments, ezetimibe-associated apoA-I mimetic peptide are provided that show improved synergistic activity between ezetimibe and the apoA-I peptide in vivo. In certain embodiments the peptide component is a trransgenic 6F a...  
WO/2018/058177A1
A method of preparing extracellularly assembled higher order antigen from a native lower order antigen the method comprising the following steps: (i) contacting lower order antigen with a solution comprising a reducing agent for a time a...  
WO/2018/063981A1
Methods and kits for purifying protein-nanoparticle conjugates are provided. In some embodiments, a multimodal medium having a size exclusion mode and a capture mode is used to purify the protein-nanoparticle conjugates.  
WO/2018/061509A1
Provided is a cyclic peptide having excellent antibody binding properties and improved chemical resistance. The cyclic peptide is represented by formula (I) below. (I) RN-Xg-[Xi-Xa-Xm-X1-X2-X3-Xn-Xb-Xj]k-Xh-RC. In formula (I), RN represe...  
WO/2018/056764A1
The present invention relates to a novel insulin analog, use thereof, and a method for preparing the same analog.  
WO/2018/057470A1
Methods for rapid solid phase peptide synthesis (SPPS) at elevated temperatures are provided. The methods of the invention shorten the time required for peptide synthesis significantly, while still providing crude peptide in good yield, ...  
WO/2018/053634A1
The disclosure concerns a class of hemoglobin based oxygen carriers (HBOCs) comprising a first hemoglobin protein cross-linked by a chemical reaction that is followed by a strain-promoted alkyne-azide cycloaddition (SPAAC) reaction or by...  
WO/2018/053797A1
A purification method for a primary treatment of a CHO cell culture medium is provided, comprising the following steps: 1) harvesting a CHO cell culture medium; 2) adding a flocculant, adjusting a pH value and stirring; and 3) clarifying...  
WO/2018/055584A1
Process for producing collagen particles, wherein there is provided: an electrochemical cell (1) with three electrodes, a membrane (8) at least partially covered by an electrically conductive metal layer and having a plurality of pores (...  
WO/2018/052041A1
Provided is an anti-core-fucosylated human immunoglobulin G (IgG) antibody or a fragment of the antibody, the antibody or the fragment of the antibody being characterized by binding to a human IgG that contains in the Fc region an N-link...  
WO/2018/052594A1
The present invention relates to chimeric antigen receptors (CARs) specific to Intercellular adhesion molecule-1 (ICAM-1) comprising I domain of the aL subunit of human lymphocyte function-associated antigen 1 (LFA-1 ). The invention par...  
WO/2018/053049A1
Provided herein are polynucleic acids and expression vectors for the expression and secretion of angiotensin peptide fragments (e.g., angiotensin-(1-7)) in probiotic bacteria. Provided herein are also probiotic compositions that enable e...  
WO/2018/052615A1
The present disclosure is directed to an engineered phospholipid or lysophospholipid (e.g., sphingosine 1-phosphate (S1P)) chaperone derived from an Apolipoprotein M (ApoM)-Fc fusion protein having an extended half life in vivo. The disc...  
WO/2018/051348A1
A method of purifying a recombinant antibody having the complementarity determining regions (CDRs) of denosumab, the method comprising subjecting a preparation comprising said antibody to a mixed mode chromatography on a Capto™ Adhere ...  
WO/2018/050849A1
Method for recovering a target protein from a feedstock comprising said target protein and at least one impurity compound selected from host cell proteins (HCP), DNA, RNA or other nucleic acid, the target protein being characterized by a...  
WO/2018/047856A1
The present invention addresses the problem of providing a fused protein capable of easily producing a protein structure having high uniformity, and providing a structural body formed by such a fused protein. This fused protein has a pro...  
WO/2018/046475A1
The present invention is within the field of protein engineering and purification. The invention relates to a target-binding polypeptide mutant of an IgG binding polypeptide, such as Protein A, Protein G, Protein L or Protein M, comprisi...  
WO/2018/048698A1
A process for separating aggregated proteins from monomeric proteins in a biological solution, the process including: providing at least one filter element having a contacting surface, wherein the filter element comprises filter media co...  
WO/2018/045587A1
A purification method for an anti-VEGF type monoclonal antibody comprises: first, carrying out capture by using a composite material chromatography to separate an antibody from most of components in a harvesting solution; and then, carry...  
WO/2018/047785A1
A collagen-like polypeptide having practically sufficient heat resistance can be stably produced by a process for producing a polypeptide by condensing (a) at least one peptide oligomer represented by any of formulae (1) to (3) H-(X-Y-Gl...  
WO/2018/047080A1
The present invention relates to a method of purifying a recombinant polypeptide from Host Cell Proteins (HCP), the method comprising: (a) applying a solution comprising the recombinant polypeptide and HCP to a superantigen chromatograph...  
WO/2018/049155A1
The present invention relates to compositions comprising polymeric nanoparticles and MCL-1 antagonistic peptides or polynucleotides encoding same. Also provided are methods for treating certain diseases, such as cancer, by administering ...  
WO/2018/047197A1
The invention pertains to the method for the site selective modification of peptides and proteins comprising of the activation of the single site (Nɛ-NH2) of peptides and proteins and the method comprising one of formylation; intercepti...  
WO/2018/047906A1
A cation exchange chromatography carrier which is provided with: a substrate; and a copolymer that is immobilized on the substrate and comprises one monomer unit which has at least a sulfonic acid group. This cation exchange chromatograp...  
WO/2018/041389A1
The present invention relates to a method for the purification of viruses or virus-like particles using a crosslinked cellulose hydrate membrane, and to a kit for the purification of viruses or virus-like particles and the use thereof.  
WO/2018/044130A1
The present invention is related to a method for producing a target protein having a particular site which has been modified, more specifically to a novel method for producing a target protein having a carbon-carbon bond-based site-speci...  
WO/2018/043629A1
The present invention relates to a novel polypeptide and to the use thereof, the polypeptide exhibiting an affinity to proteins that partially contain CH1-CL domains forming a non-natural three-dimensional structure, and being capable of...  
WO/2018/044356A1
An improvement in of deprotection in solid phase peptide synthesis is disclosed. The method includes the steps of adding the deprotection composition in high concentration and small volume to the mixture of the coupling solution, the gro...  
WO/2018/043631A1
The present invention establishes a process for producing a protein using a chemical synthesis method, in particular, using both an enzymatic polymerization method and a block copolymerization method. Provided are: a protein produced by ...  
WO/2018/043645A1
The purpose of the present invention is to provide a protein purification method which can reduce impurities significantly compared with conventional protein purification methods using activated carbon and can achieve a high collection r...  
WO/2018/045200A3
In various embodiments, the invention provides subtiligase variants that recognize an N- terminus of a protein or peptide substrate that is different than the N-terminus that is recognized by the corresponding wild-type subtiligase. Also...  
WO/2018/041985A1
Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV),...  
WO/2018/037742A1
The purpose of the present invention is to provide an adsorbent material having high dispersibility and reversibility. An adsorbent material characterized by comprising: a polymer material which has multiple functional groups capable of ...  
WO/2018/037244A1
A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorb...  
WO/2018/039163A1
The present invention is related a method of purifying a heterologous protein from an egg white. In some embodiments, the disclosure is directed to a method of purifying a heterologous protein from an egg white comprising the heterologou...  
WO/2018/037097A1
The present invention concerns a method for preparing a microorganism hydrolysate of which at least one amino acid and/or one amino acid precursor is labelled, comprising a step of obtaining a microorganism hydrolysate in solution in whi...  
WO/2018/035610A1
The present invention provides 18F-labeled amino acids or derivatives thereof having formula (I) and methods of making same, which can be suitable for PET imaging: (Formula (I)).  
WO/2018/035116A1
Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a tangential flow filtration (TFF) unit and a circuit system including a tangential flow virus filtration (TFVF) unit. Al...  
WO/2018/032521A1
The present invention provides a method for synthesizing liraglutide, comprising the steps of: obtaining a dipeptide fragment, a tripeptide fragment, a tetrapeptide fragment, and/or a pentapeptide fragment; obtaining Fmoc-Gly-resin; coup...  
WO/2018/033814A1
The present disclosure relates to the field of extraction of phycocyanin from an algal biomass. The process of the present disclosure relates to a simple yet efficient and rapid method to extract phycocyanin from the algal biomass which ...  
WO/2018/034901A1
Disclosed are methods of making elamipretide (MTP-131), a peptide compound with therapeutic potential for treating various mitochondrial myopathies. The synthesis of the peptide can be achieved via the use of N-carboxyanhydride-modified ...  
WO/2018/032843A1
A method for synthesizing a semaglutide. The method comprises: coupling, by referring to the peptide sequence and structure of a semaglutide, a dipeptide fragment or a tripeptide fragment with an amino acid with N-terminus Fmoc protectio...  

Matches 1 - 50 out of 28,530