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Matches 1 - 50 out of 28,826

Document Document Title
WO/2018/187499A1
Disclosed herein are stable peptide antagonists based on the consensus yc-subunit binding site to inhibit the activity of yc-cytokines. Such peptide antagonists are capable of inhibiting the activity of multiple yc-cytokine family member...  
WO/2018/185048A1
Disclosed is a method for recovering a desired fermentation product from a fermentation broth where the desired product has precipitated during the fermentation.  
WO/2018/187610A1
In certain embodiments a device is provided for electrorotation flow. In certain embodiments the device comprises a microfluidic channel comprising a plurality of electrodes disposed to provide dielectrophoretic (DEP) forces that are per...  
WO/2018/187333A1
Provided herein are novel methods and matrices for the purification an antibody from a starting material using a mimetope. The method comprises contacting an immunoaffinity chromatography matrix, comprising a solid support and a mimetope...  
WO/2018/187303A1
Polypeptides which comprises a plurality of luminescent metal binding sites and constructs comprising the polypeptides and bound luminescent metals are provided. When the constructs are exposed to suitable wavelengths of energy, the boun...  
WO/2018/180204A1
The purpose of the present invention is to provide: a novel modified protein G which is capable of binding to immunoglobulin and shows a high chemical stability against an alkali solution; an affinity separation matrix comprising the mod...  
WO/2018/181274A1
The purpose of the present invention is to provide an efficient nucleic acid collection method capable of concentrating, from a nucleic acid-containing sample, a nucleic acid, in a state of being usable for a genetic amplification reacti...  
WO/2018/178397A1
The invention relates to the synthesis of amphiphilic amino acid derivatives, in particular to a method for the N-alkylation of an unprotected amino acid or the N-terminus of an oligopeptide substrate, comprising reacting said unprotecte...  
WO/2018/181679A1
The present invention addresses the problem of providing a novel peptide solid-phase synthesis method for synthesizing a peptide in a large quantity. The present invention also addresses the problem of providing a novel peptide solid-pha...  
WO/2018/177369A1
A method for preparing an antibody-drug conjugate (ADC). In particular, the method mainly utilizes a combination of antibody biomolecules and an ion exchange carrier through electrostatic interaction to realize solid phase preparation of...  
WO/2018/178991A1
A method is disclosed that exploits the combined features of carbohydrate binding modules (CBM) and nanocrystalline cellulose (CNC) for 'fishing out' specific agents of interest (AOI), such as proteins, which are optionally present or pr...  
WO/2018/178375A1
The invention provides a method and a kit for combined virus inactivation and capture/purification of a feed containing a protein of interest. The method comprises the steps of: contacting a feed comprising a protein of interest with neg...  
WO/2018/180205A1
The purpose of the present invention is to provide: a novel affinity dissociation matrix which has bindability to an immunoglobulin and has excellent chemical stability toward an alkaline solution; and a method for producing an immunoglo...  
WO/2018/172708A1
A method for preparing a liquid extract rich in phycocyanin from cyanobacteria or microalgae containing phycocyanin in solution, comprising a step of carrying out the cellular lysis of an aqueous suspension of said fresh cyanobacteria or...  
WO/2018/174831A1
This invention relates to a process for producing a compound of Formula I, comprising : 1 ) performing a stereoselective metathesis reaction on a compound of Formula II so as to form an intramolecular alkenyl chain, and 2) cleaving S fro...  
WO/2018/174307A1
The present invention relates to a method for separating and purifying a mussel adhesive protein, comprising the steps of: (1) crushing cells containing a mussel adhesive protein; (2) centrifuging the crushed cells to obtain an insoluble...  
WO/2018/175534A1
This disclosure provides a natriuretic peptide derivative of Formula (I), and to compositions including a natriuretic peptide derivative of Formula (I), (fatty acyl)z-(B)x-(G)y-NP (I), wherein: z is 1, x is an integer from 2 to 4 and y i...  
WO/2018/174826A1
This invention relates to a method for producing an alkenyl 1 -aminocyclopropane-1 -carboxylic acid of Formula I wherein R1 is a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B ...  
WO/2018/174078A1
The present invention addresses the problem of providing a novel cyclic peptide compound excellent in cell membrane permeability, a method for producing the same, a composition for screening use, and a method for selecting a cyclic pepti...  
WO/2018/165766A1
A method for the purification of albumin from plasma is described. The method comprises (a) contacting the plasma with sodium caprylate (NaCP) at an amount dependent on total protein concentration and the ratio of NaCP to total protein i...  
WO/2018/170098A1
Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, f...  
WO/2018/169953A1
Antibodies that include a sulfatase motif-containing tag in a constant region of an immunoglobulin (Ig) heavy chain polypeptide are disclosed. The sulfatase motif can be converted by a formylglycine-generating enzyme (FGE) to produce a f...  
WO/2018/166146A1
A liquid phase synthesis method for oxytocin having mild reaction conditions. The method synthesizes three oxytocin fragments: a fragment 1: Boc-Cys(Acm)-Tyr(tBu)-OH, a fragment 2: H-Ile-Gln(Trt)-Asn(Trt)-Cys(Acm)-Pro-OMe, and a fragment...  
WO/2018/169061A1
The present invention addresses the problem of providing a method for efficiently separating megakaryocytes from platelets produced from the megakaryocytes, and of providing an instrument for efficiently separating megakaryocytes from pl...  
WO/2018/170488A1
The present disclosure relates generally to methods of producing, processing, or purifying antibodies. The present disclosure also relates to methods of producing, processing, or purifying a target antibody from cell cultures to remove h...  
WO/2018/165159A1
Provided herein, in one aspect, is a composition for in vitro transcription and translation, comprising: a treated cell lysate derived from one or more organisms such as bacteria, archaea, plant or animal; a plurality of supplements for ...  
WO/2018/161858A1
Provided are methods of isolating virus particles and producing virus vaccine composition comprising subject a biological sample to an anion exchange chromatography and a hydroxyapatite chromatography. Also provided are rabies virus vacc...  
WO/2018/164195A1
Disclosed is a method for producing a purified protein, comprising: a step for raising pH of an acidic aqueous protein solution containing a target protein, impurities, acidic compound, and water for dissolving the foregoing, thereby pre...  
WO/2018/162557A2
The present invention relates to method for purifying proteins using silicates.  
WO/2018/161976A8
Disclosed in the present invention are a tetrapeptide propylene oxide derivative or a pharmaceutically acceptable salt thereof, as well as a preparation method therefor, and the use thereof. The structure of the tetrapeptide propylene ox...  
WO/2018/162754A1
The present invention relates to a method for isolating Glu-plasminogen, said method comprising the anion exchange chromatography of blood plasma or a plasma fraction comprising Glu-plasminogen. Furthermore, the present invention relates...  
WO/2018/161976A1
Disclosed in the present invention are a tetrapeptide propylene oxide derivative or a pharmaceutically acceptable salt thereof, as well as a preparation method therefor, and the use thereof. The structure of the tetrapeptide propylene ox...  
WO/2018/162501A1
There is disclosed a relatively simple method to increase the performance of surface localised multi-valent affinity ligands whose target's isoelectric pH differs significantly from the ligand's optimal target-binding pH. This situation ...  
WO/2018/163947A1
Disclosed are: a fusion protein containing an R1-EN and a protein fused to a C-terminus or an N-terminus of said R1-EN or a protein having said R1-EN in a loop; a protein crystal production method including a step for crystallizing said ...  
WO/2018/157866A1
Provided is a method for localizing and modifying a target amino acid group on a macromolecular compound. The described localization and modification method contains a method for filtering a target amino acid group, which uses a molecule...  
WO/2018/159842A1
The purpose of the present invention is to provide a method for culturing darbepoetin-producing cells and thereby producing a darbepoetin composition, wherein the method increases the total amount of the darbepoetin composition produced ...  
WO/2018/159089A1
Provided are: an economically superior protein crystallization method that can efficiently identify conditions for crystallization using a small amount of a protein; and a crystallization device used in this method. According to the pres...  
WO/2018/159721A1
[Problem] To provide a method for producing an amino-acid polymer more easily and efficiently than conventional production methods for amino-acid polymers. [Solution] Provided is a method for producing an amino-acid polymer from thioacid...  
WO/2018/159615A1
The invention provides methods of purifying and/or producing a protein. In some embodiments, a method of the present invention comprises the step of eluting a protein from a Protein L matrix by lowering a conductivity. In some embodiment...  
WO/2018/153772A1
A separation matrix comprising porous particles to which antibody-binding protein ligands have been covalently immobilized, wherein the density of said ligands is above 5 mg/ml, the volume-weighted median diameter of said porous particle...  
WO/2018/155764A1
The present invention relates to an airtight apparatus for separating and purifying an extract, comprising: a chamber cartridge having a plurality of chambers for receiving samples and magnetic beads for separation of biological material...  
WO/2018/157150A1
Described are a genetically modified microorganism and corresponding methods and products. The genetically modified microorganism may include a first gene that encodes an acyl transferase and a second gene that encodes a peptide or prote...  
WO/2018/151855A1
What is described herein relates to the use of a dense membrane module as pathogen barrier as well as the use of at least one dense membrane module and/or at least one nanoporous membrane module in a method for the continuous, processing...  
WO/2018/149809A1
The invention describes a method of purifying alpha-lactalbumin from whey with a single chromatographic step. The method involves adjusting the pH of the whey and loading the whey onto a cation exchanger for a prolonged period of time/vo...  
WO/2018/151811A3
The invention provides a methods of a disease or disorder in a subject by inducing a TGF alpha immune response. The TGF-alpha immune response is induced using a TGF-alpha polypeptide or biologically active fragment, a vaccine, a genetic ...  
WO/2018/150973A1
The present invention addresses the problem of providing an Fc-binding protein having an improved antibody separation ability. The present invention also addresses the problem of providing a high-accuracy antibody separation method using...  
WO/2018/151743A1
The disclosure relates to chromatography ligands, e.g., chromatography ligands comprising at least two binding units and at least one spacer domain, wherein each binding unit comprises one or two immunoglobulin binding domains.  
WO/2018/147393A1
The present invention pertains to a separating agent for human insulin purification with which human insulin can be recovered at a high yield, in the case where human insulin is to be isolated from a solution, said solution containing hu...  
WO/2018/146283A1
The invention concerns an improved process for the preparation of the dodecapeptide NX210 of SEQ ID NO: 1 in which the formation of side products is minimized.  
WO/2018/143648A2
Disclosed is a method for producing a soluble CRM197 protein at high yield by excessively expressing the protein in the cytoplasm of E. coli. The present invention provides a method for producing a recombinant CRM197 protein soluble in t...  

Matches 1 - 50 out of 28,826