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Matches 1 - 50 out of 28,991

Document Document Title
WO/2019/009317A1
Provided are: a novel compound usable as an organic tag which has a high stability under acidic conditions in peptide synthesis, etc.; and a method for highly efficiently producing a peptide wherein the compound is used as an organic tag.  
WO/2019/009388A1
The purpose of the present invention is to provide: an anti-human CEACAM5 antibody Fab fragment which is expected as useful in diagnosing cancer, in particular, colon cancer, breast cancer, lung cancer, thyroid cancer or cancer metastasi...  
WO/2019/003180A1
Disclosed herein are underlying aspects, including optimized media and growth conditions, for the enhanced secretion of a self-assembling extracellular self assembling native protein from a Yarrowia lipolytica strain through liquid cultu...  
WO/2019/001778A1
A method of continuous separation of a plasmid from a process feed in an apparatus with at least three chromatography columns packed with separation matrix particles, wherein while one chromatography column is loaded with the process fee...  
WO/2018/235958A1
The purpose of the present invention is to provide a method for purifying protein which does not use polar solvents such as dimethyl sulfoxide (DMSO), a method for producing a protein solution, and a method for producing a protein moulde...  
WO/2018/237159A1
A wash buffer comprising a surfactant for use in affinity and cation exchange chromatography to purify proteins of interest from protein aggregates and to remove and/or inactivate viruses. When used during affinity or cation exchange chr...  
WO/2018/237178A1
In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclos...  
WO/2018/232422A1
Aspects described herein relate to improved methods for infusing food and beverage compositions with lipophilic active agents. More particularly, aspects described herein relate to improved methods for infusing food and beverage composit...  
WO/2018/227664A1
Provided is a method for purifying a Nostoc sphaeroides Kutzing phycoerythrin, the method comprising: (1) selecting an anion exchange column for being passed through; (2) formulating a PB buffer solution, i.e., buffer A, and a PB-NaCl bu...  
WO/2018/227665A1
Provided is a method for purifying a Nostoc sphaeroides Kutzing phycocyanin, the method comprising the following steps: (1) selecting an anion exchange column for being passed through ; (2) formulating a Tris-HCl buffer solution, i.e., b...  
WO/2018/227285A1
Methods are provided for extracting and purifying maternal antibodies from breastmilk, followed by further processing to facilitate oral ingestion. The methods may be used on breastmilk from any mammal, including humans, for consumption ...  
WO/2018/225851A1
A method for producing a peptide containing an N-substituted amino acid or an N-substituted amino acid analogue according to the present invention includes the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino aci...  
WO/2018/225864A1
The present inventors found that, in screening a cyclic peptide compound capable of specifically binding to a target molecule, the hitting rate of a cyclic peptide compound capable of specifically binding to the target molecule can be im...  
WO/2018/224387A1
A method for purification of a target in a solution includes providing a target in a solution, the solution comprising one or more contaminants, providing a polymer conjugate in the solution, wherein the polymer conjugate is configured t...  
WO/2018/222773A2
The measurement of Factor Xa (FXa) enzymatic activity using novel fluorogenic peptide substrates that have a C-terminus cleavable fluorophore and optionally the ability to attach to a solid support. Fluorogenic measurements increase sens...  
WO/2018/220396A1
A process for the extraction of collagen from collagen-containing matter, wherein the process comprises; incubating the collagen-containing matter in an acidic solution to form an incubant, then diafiltrating the incubant to substantiall...  
WO/2018/222550A1
Filter elements (20, 100) for perfusion systems and methods are provided. A filter element sheet includes a microporous membrane (63, 112) having a mean pore size of at least about 0.65µm and a feed spacer (25, 120) comprising woven fib...  
WO/2018/222972A1
The present invention relates to a method and/or device for improving the separation behaviors and performance of aqueous two-phase system (ATPS) for the isolation and/or concentration of one or more target analytes from a sample. In one...  
WO/2018/221745A1
The present invention addresses the problem of providing a method for efficiently extracting a target protein contained in a biological sample such serum or plasma and enabling highly accurate analysis. Provided is a method for removing ...  
WO/2018/222137A1
There is provided a method of processing shell waste for recovering components comprised in shell of shellfish, the method comprising: mixing the shell waste with a denaturing agent or water at a pre-determined temperature for a pre-dete...  
WO/2018/215959A1
The present invention is directed to a method for extracting recombinant proteins from bacteria by Ph shock.  
WO/2018/214463A1
A compound represented by formula I or a stereoisomer, tautomer, oxynitride, hydrate, solvate, metabolite, or pharmaceutically acceptable salt or prodrug of the compound represented by formula I.  
WO/2018/215503A1
A recombinant protein comprising a functional polypeptide and, linked to the N-terminus of said functional polypeptide, an N-terminal spacerhaving a length such that the number of amino acid residues between a signal peptide cleaving sit...  
WO/2018/213922A1
A process for the linear synthesis of a gram-positive class II bacteriocin or a variant thereof is disclosed herein. The process comprises the stepwise addition of selected amino acids to a solid support; pseudoproline positioning and re...  
WO/2018/213935A1
Surfaces contactable by a bulk liquid for use in particle isolation are described. The surfaces comprise a plurality of ribs spaced apart to capillarily retain a portion of the bulk liquid and particles of interest therebetween. Collecti...  
WO/2018/216628A1
Provided is a protein stabilizer for stably storing a protein such as an enzyme, an antibody, an enzyme-labeled antibody or the like in a solution, said protein being to be used in a biochemical measurement. Also provided is a protein st...  
WO/2018/215539A1
The present invention pertains to the use of a nitrogen-doped porous carbon material for the enrichment of phosphorylated peptides and/or proteins. The advantage of using a carbon-derived material is that it provides high surface area, h...  
WO/2018/218093A1
The present invention provides a bioconjugation method and compounds for use therein. The bioconjugation method comprises the step of conjugating a biological molecule containing a first unsaturated functional group with a payload compri...  
WO/2018/216376A1
[Problem] To provide a processing device that can efficiently carry out microwave irradiation. [Solution] A processing device is provided with: a vessel 101 that is constituted of a material having microwave reflectivity, has a first end...  
WO/2018/210336A1
A GLYX-13 preparation method and an intermediate compound thereof. According to the provided method, Fmoc-O-tert-butyl-L-threonine, Fmoc-L-proline, N-carboxybenzyl-L-threonine amide, and proline benzyl ester hydrochloride are used as sta...  
WO/2018/213537A1
A label for an antibody or protein is described that is both site-selective and unusually stable in vivo. The label has a general formula given by Formula (I) wherein R1 is a metal chelator, a fluorophore or a click-chemistry synthon.  
WO/2018/210794A1
The invention relates to a process for the manufacturing and purification of recombinant enzyme products, in particular of food enzyme products and the use thereof. The invention particularly relates to a process for the processing of en...  
WO/2018/212658A1
The invention relates to a subtilisin BPN' variant or homologue thereof, comprising the following mutations compared to subtilisin BPN' represented by SEQUENCE ID NO: 2 or a homologue sequence thereof: - a deletion of the amino acids cor...  
WO/2018/211529A1
The present invention relates to a novel cloning, expression and refolding process for preparing antibody fragments. More particularly, the present invention relates to a cloning, expression and refolding platform for preparing recombina...  
WO/2018/212556A1
The present disclosure relates to a method for separating and purifying an antibody or an antibody fragment thereof in high purity using affinity chromatography, and specifically, to a method for separating the antibody and antibody frag...  
WO/2018/207932A1
Provided is a device capable of diagnosing cancer specifically and with high sensitivity. This cancer diagnosis device (1) is provided with: extracellular vesicle capturing portions (16 to 18) in which an immobilization carrier in which ...  
WO/2018/205401A1
Provided is a preparation method for plecanatide, comprising the following steps: 1) sequentially couple Fmoc-AA-OH on a solid-phase synthetic resin; 2) remove a StBu protecting group on Cys; 3) remove a Cys oxidation ring of the StBu pr...  
WO/2018/205402A1
The present invention provides a preparation method for ularitide, comprising the following steps: 1) sequentially coupling Fmoc-AA-OH on a solid-phase synthetic resin; 2) removing the resin with a lysis buffer; and 3) reacting an interm...  
WO/2018/208099A2
The present invention relates to a recombinant vector carrying cellulose binding domain 3 and a method for isolating a protein of interest, using the recombinant vector. The protein isolating method of the present invention can easily is...  
WO/2018/208447A1
Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and...  
WO/2018/208099A3
The present invention relates to a recombinant vector carrying cellulose binding domain 3 and a method for isolating a protein of interest, using the recombinant vector. The protein isolating method of the present invention can easily is...  
WO/2018/208448A1
Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and...  
WO/2018/203541A1
The present invention is characterized by providing a treatment method for recovering and purifying polypeptides having immunoglobulin binding activity using a genetically modified organism, wherein, rather than relying on differences in...  
WO/2018/200430A1
The present disclosure discloses methods for purifying antibodies providing an air overlay or headspace to single-use storage bags containing the antibody during purification. In specific embodiments, the application relates to purificat...  
WO/2018/197421A1
A continuous flow reactor, a method of performing a continuous flow reaction, and a method of controlling a moveable wall of a reaction chamber of a continuous flow reactor. The reactor comprising: an inlet; an outlet; and a reaction cha...  
WO/2018/201050A1
Flavin mono-oxygenase (FMO) enzymes, as well as expression cassettes and host cells for expressing such enzymes, and methods for using such FMO enzymes are described herein. The flavin mono-oxygenase enzymes are useful for generating pep...  
WO/2018/200921A1
The invention pertains to cancer treatment or prevention field. Particularly, the invention provides peptide fragments from SLIT2 protein and their applications in inhibition of cancer growth, invasion and metastasis.  
WO/2018/201020A1
Non-naturally occurring polypeptides are disclosed that include (a) 3-3 secondary structure elements, wherein each secondary structure element is either an α-helix (H domain) of between 10-20 amino acid residues in length or a β-strand...  
WO/2018/200279A1
A surface-confined aqueous reversible addition−fragmentation chain transfer (SCARAFT) polymerization method was developed to coat capillaries for use in capillary zone electrophoresis (CZE). This coating produced an electroosmotic an o...  
WO/2018/197218A1
The present invention relates to a device and method for sample preparation and collection. More closely the invention relates to a device to isolate DNA, RNA and proteins or other biomolecules in one single step from the same undivided ...  

Matches 1 - 50 out of 28,991