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Matches 1 - 50 out of 29,333

Document Document Title
WO/2019/138957A1
The present invention provides an immobilization method which enables achieving excellent inactivation of excess formyl groups while ensuring firm immobilization of a ligand. This method is for immobilizing, on a formyl group-containing ...  
WO/2019/136560A1
The present application discloses biofunctional surfaces that have self-assembled monolayers of fluorine groups with "built-in" functional groups promote targeted cell and biomolecule binding to the surface while reducing non-specific bi...  
WO/2019/138783A1
A concentration device (100A) is for concentrating a solution containing biological substances, and comprises: a first chamber (5a) into which the solution is injected; a second chamber (5b) which is filled with a drawing agent (6); and ...  
WO/2019/137435A1
Provided in the present invention is a production process for an immunoglobulin for intravenous injection, which comprises isolating to obtain components I+II+III/II+III from healthy human plasma; then precipitating by means of octanoic ...  
WO/2019/138784A1
A concentration device (100A) is for concentrating a solution containing biological substances, and comprises: a first chamber (5a) into which the solution is injected; a second chamber (5b) which is filled with a drawing agent (6); a fi...  
WO/2019/138299A1
The present invention relates to an improved process for the preparation of Micafungin sodium of a Compound of Formula (I), by treating Micafungin or its base addition salt with longer chain fatty acid sodium salt.  
WO/2019/135233A1
Disclosed herein is a process of preparing a polypeptide copolymer by polymerizing a mixture comprising N-carboxyanhydrides of alanine, tyrosine, carboxylate-protected glutamate and an amine-protected lysine, to form a protected polypept...  
WO/2019/134052A1
A method for designing in-silico a (D)-polypeptide ligand that binds with a target is provided. The method includes providing a (L)-polypeptide ligand that binds with the target, the (L)-polypeptide ligand comprising one or more (L)-heli...  
WO/2019/083318A3
The present invention relates to a method for purification of immunoglobulins and, more particularly, to a method for purification of immunoglobulins, the method comprising anion exchange chromatography and cation exchange chromatography...  
WO/2019/127920A1
A liquid phase spherical carrier as represented by formula I, a preparation method therefor and use thereof. R is a functional group, preferably a group having hydroxyl, amino, carboxyl or halogen. The liquid phase synthesis carrier can ...  
WO/2019/129876A1
Processes for providing a PEGylated protein composition comprising mono-PEGylated protein and oligo-PEGylated protein, and processes for providing mono-PEGylated protein compositions with high yield and productivity are provided. The pro...  
WO/2019/132418A1
The present invention relates to a method for converting a buffer through two-stage diafiltration and, more specifically, to a method for diafiltering a solution containing a protein, a method for preparing a protein preparation by using...  
WO/2019/129848A1
The present application concerns a method for preparing an antibody or antibody fragment composition from raw milk from a non-human mammal expressing said antibody or antibody fragment in its milk, comprising the steps of a) precipitatio...  
WO/2019/127686A1
The present invention relates to a combined ligand, as well as a combined biomimetic chromatography medium, a preparation method therefor, and application thereof. Regarding the combined biomimetic chromatography medium, a hydrophilic po...  
WO/2019/129877A1
A process for providing a mono-PEGylated protein composition is provided. The process is particularly suitable for providing mono-PEGylated erythropoietin composition. The process comprises subjecting a mixture comprising non-PEGylated, ...  
WO/2019/121263A1
In order to separate carboxyterminal variants of Abeta peptides, gel electrophoresis is carried out in the presence of sodium lauroyl sarcosinate (sarkosyl). The sarkosyl can be provided in a concentration between 0.1% and 0.8% (w/v) in ...  
WO/2019/121296A1
A method for preparation of a separation matrix, comprising the steps of: a) providing a solid support and an alkali-stable ligand derived from an immunoglobulin- binding bacterial protein; b) reacting said alkali-stable ligand with said...  
WO/2019/121235A1
The present invention provides the method and means for an efficient isolation of membrane-bound proteins from biological samples, e.g. in samples from raw or processed plant material, preferably defatted plant seed meal such as canola m...  
WO/2019/122054A1
The present invention relates to methods for separating multispecific CrossMab antibodies from light chain mispaired variants thereof in a solution comprising CrossMab bispecific antibodies and mispaired antibody variants thereof by hydr...  
WO/2019/122234A1
The present invention relates to recombinant polypeptide therapeutics having an engineered O-linked amino acid (AA) glycosylation sequence (motif), which is covalently linked to O-glycan(s) (tag). Recombinant O-glycosylated polypeptides ...  
WO/2019/121846A1
A process for purifying a recombinant protein comprising the steps of: i) providing a solution comprising the recombinant protein; ii) adding an alkyl glycoside to the solution; and iii) purifying the recombinant protein. The addition of...  
WO/2019/121630A1
An essentially non-destructive method for extracting intracellular water-soluble molecules from unicellular microalgae, the method comprising: - a step of providing unicellular microalgae lacking a secondary cell wall or having a seconda...  
WO/2019/126554A1
Provided herein are methods relating to the purification of a polypeptide comprising an Fc region (e.g., an antibody) via protein A chromatography; methods relating to the use of a wash solution comprising a benzoate salt and/or benzyl a...  
WO/2019/123994A1
Provided is an alkyl diphenylmethane protection agent that does not solidify or insolubilize a compound, a functional group of which is protected thereby, while making separation and purification after reaction easy. An alkyl diphenylmet...  
WO/2019/120480A1
The present inventions relates to methods involving incubation of undissolved and/or insoluble GLP-1 peptide in solutions or suspensions comprising one or more organic solvents.  
WO/2019/120639A1
The present invention relates to methods and compounds for the solid phase synthesis of peptides carrying a substituent at an amino group of an amino acid side chain.  
WO/2019/083319A3
The present invention relates to a method for preparing a composition containing factor 8 (FVIII) capable of controlling the content of von Willebrand factor (vWF) and von Willebrand factor (vWF) and, more specifically, to a method for p...  
WO/2019/114123A1
Provided in the present invention is a GnRH polypeptide antigen and a preparation method therefor. Further provided is a method for using the GnRH polypeptide antigen to prepare castration vaccines for animals.  
WO/2019/117274A1
With regard to the present invention, it was discovered that a deprotection agent can be deactivated by a salt formed from a base and an acid having characteristics (i) and (ii), and as a result, excessive elongation of a peptide can be ...  
WO/2019/118378A1
Customized whole cell cancer vaccines can be produced from autologous (ex vivo or in situ) or allogeneic human or veterinary patient cell lines. Cells are transformed with S. pyogenes DNA that expresses an Emm protein on the cell surface...  
WO/2019/116357A1
This disclosure relates to a method for extracting keratin from animal hair, in particular from pigs hair, wherein the method comprises several steps, for example degreasing the animal hair with a solution of a degreaser and filtering th...  
WO/2019/118818A1
A fibronectin type III (FN3) domain-nanoparticle or direct conjugate complex containing a polynucleotide molecule, a toxin, polynucleotide molecule or other pharmaceutically active payload is obtained by panning an FN3 domain library wit...  
WO/2019/114159A1
A Camellia Oleifera meal polypeptide as well as a preparation method and an application thereof. The Camellia Oleifera meal polypeptide is prepared by taking Camellia Meiocarpa Hu. meal as raw materials, hydrolyzing the Camellia Meiocarp...  
WO/2019/079663A8
Provided herein, in some embodiments, are artificial secretion peptides capable of directing secretion from Lactobacillus for use, for example, in producing heterologous proteins, including therapeutic proteins.  
WO/2019/112027A1
An objective of the invention is to provide an antibody, a composition for use in detecting or capturing a polypeptide in a sample, and a method for detecting or capturing a polypeptide in sample. The disclosure provides an antibody, a c...  
WO/2019/109934A1
The present invention provides a salt of a phenylpropionamide derivative and a preparation method therefor. The present invention specifically provides an acetate, hydrochloride, phosphate, citrate, benzoate, or fumarate of 4-amino-1-((2...  
WO/2019/027168A9
The present invention relates to a method for obtaining a Bordetella pertussis-derived PRN protein, the method comprising a freezing and thawing process capable of effectively increasing an extracted level of PRN protein. In the present ...  
WO/2019/106193A1
The present invention relates to a peptide hormone with one or more O-glycans attached at specific amino acid residues as well as to formulations comprising the same.  
WO/2018/143648A9
Disclosed is a method for producing a soluble CRM197 protein at high yield by excessively expressing the protein in the cytoplasm of E. coli. The present invention provides a method for producing a recombinant CRM197 protein soluble in t...  
WO/2019/108797A1
This disclosure generally relates to novel processes for the preparation of drug linker compounds and compositions comprising such drug linker compounds. The presently disclosed methods for synthesizing Fmoc-Val-Cit-PABOH and related com...  
WO/2019/101939A1
The invention relates to a method for preparing peptides comprising the step of forming a peptide bond wherein the carboxyl group of a first amino acid or first peptide is activated and an amino group of the first activated amino acid or...  
WO/2019/103106A1
[Problem] To provide a technology with which an aggregated protein can be solubilized without using a strong modifying agent, and the aggregated protein can be consistently rewound (refolded) into a structure similar to the native struct...  
WO/2019/101940A1
The invention relates to a method for preparing peptides comprising the step of forming a peptide bond wherein at least one amino acid or peptide comprises a protecting group having a water-solubility enhancing group, and said forming of...  
WO/2019/099852A1
Provided are humanized antibodies that bind to the 2C7 epitope of Neisseria gonorrhoeae. Also provided are compositions and methods for treating Neisseria gonorrhoeae infection in a subject in need thereof.  
WO/2019/096777A1
The present invention relates to methods for purifying heterologous antibodies from caprine milk, such as goat milk. The present invention includes protein A based affinity chromatography to obtain purified transgenically expressed antib...  
WO/2019/095592A1
Provided is a liquid phase preparation method for Reltecimod, comprising the following steps: step 1), synthesizing three fully protected polypeptide fragments, i.e., R1-Ser(R4)-Pro-OH, R2-Met-Leu-Val-OH and R3-Ala-Tyr(R5)-Asp(R6)-OH; st...  
WO/2019/096234A1
As represented by formula I, a glycopeptide antibiotic compound having anti-drug-resistant bacteria activity or a pharmaceutically acceptable salt of same, a pharmaceutical preparation of same, a preparation method for same, and applicat...  
WO/2019/098945A1
The present invention relates to stapled relaxin-3 peptide agonists; to their functional analogues, derivatives, fragments, and/or their functional mimetics that comprise a chemical staple between at least two amino acid residues and exh...  
WO/2019/099481A1
Disclosed are deuterated analogs of SBT-20 and elamipretide (MTP-131). The compounds are useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.  
WO/2019/094326A1
The present invention provides compositions and methods for treating cancers with reduced or absent CDH1 using a RHOA dominant negative polypeptide or biologically active fragment thereof, and/or a nucleic acid encoding a RHOA dominant n...  

Matches 1 - 50 out of 29,333