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WO/2012/059308 |
The present invention relates to a method for the purification of antibodies from a protein mixture produced in a bioreactor, at least comprising the steps of intermediate purification and polishing, wherein the intermediate and polishin...
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WO/2012/061400 |
The present invention relates to methods for removing free carbohydrate from a carbohydrate-protein conjugate composition using ion exchange membranes or monoliths. The present invention further relates to pharmaceutical compositions pro...
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WO/2012/055903 |
The present invention relates to a liquid (or solution)-phase manufacturing process for preparing the decapeptide Degareiix, its amino-protected precursor, and other useful intermediates. The invention further relates to polypeptides use...
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WO/2012/057529 |
The present invention provides a method for purifying a large amount of human granulocyte-colony stimulating factors (hG-CSFs) from a recombinant E. coli with high yield and purity. According to the method of the present invention, human...
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WO/2012/055986 |
The present invention relates to a method for capturing virus-like particles of interest from a mixture comprising the use of an expanded bed of adsorbent; suitably wherein said method comprises the steps of: (a) providing an expanded be...
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WO/2012/055509 |
The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C- PEP carrying a specific diketopiperazine (DKP) comprising ...
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WO/2012/054998 |
The present invention relates to a method for labelling somatostatin analogues with radionuclides, to a reagent for in vivo or in vitro diagnosis on the basis of somatostatin analogues labelled with radionuclides, to the diagnostic use t...
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WO/2012/055905 |
The present invention relates to a liquid (or solution)-phase manufacturing process for preparing the decapeptide Degarelix, its protected precursor, and other useful intermediates. The invention further relates to polypeptides useful in...
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WO/2012/057508 |
The present invention relates to a method for increasing chaperone activity by irradiating peroxiredoxin (Prx) proteins. More particularly, the present invention may be useful for preparing recombinant proteins imparting resistance again...
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WO/2012/054500 |
The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject. The compositions include at least one alkyl glycoside and at least one therapeutic agent, wherein the alky...
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WO/2012/054679 |
The present application relates to methods for purifying recombinant proteins, including antibodies and antibody fragments. Suitably, the methods utilize depth filtration to clarify the desired proteins from a solubilized mixture, and pr...
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WO/2012/049245 |
A method for purification of complement Factor H from a complement Factor H containing source such as blood or blood plasma, in particular a caprylate precipitate of a Factor H containing source, which is e.g. obtained by addition of cap...
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WO/2012/051405 |
The invention provides methods of preparing macrocycles including macrocycle stabilized peptides (MSPs). Macrocycles and MSPs are prepared according to nucleophilic capture of an iminoquinomethide type intermediate generated from a suita...
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WO/2012/048401 |
A soy protein product, which may be an isolate, produces transparent heat-stable solutions at low pH values and is useful for the fortification of soft drinks and sports drinks without precipitation of protein. The soy protein product is...
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WO/2012/048514 |
Provided is an assisted protein refolding method with ion exchange chromatographic medium, wherein the steps are as following: 1)using ion exchange chromatographic medium having the charge same as the protein, 2) pre-processing ion excha...
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WO/2012/048877 |
The present invention concerns a new dimedon derivative and a method for the purification of PNA and peptide oligomers.
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WO/2012/050822 |
Methods and associated compositions of matter (e.g., kits, cell lines, etc.) for screening compounds that bind to macrophase mannose receptor (MMR). Compounds identified by these methods and drug conjugates that includes these compounds ...
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WO/2012/045331 |
The present invention relates to a purification process of biomolecules, especially proteins and includes an aqueous two phase extraction and a membrane affinity adsorption of the waste stream of the aqueous two phase extraction
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WO/2012/047724 |
Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. ...
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WO/2012/045617 |
The present invention relates to a composition comprising a tryptophan-containing peptide and having a Trp/LNAA ratio of more than 0.1 for decreasing eating or appetite during or after stress.
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WO/2012/048331 |
The invention provides methods and apparatus for the selective isolation of phosphorylated and glycosylated proteins and their fragments. Metal cation is used to precipitate proteins or protein fragments containing phospho groups and/or ...
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WO/2012/041218 |
A process for purifying cyclic lipopeptide compounds or salts thereof comprises the steps of: (1) charging a crude compound of formula I onto a macroporous adsorption resin; (2) washing the macroporous adsorption resin using water, an or...
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WO/2012/040833 |
The invention provides a method of determining changes in a first set of residues r1 due to changes in a second set of residues r2 in a protein system comprising one or more proteins comprising n and r2. In exemplary embodiments, the met...
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WO/2012/041805 |
The present application relates to novel derivatives of monomethyl auristatin F which are substituted at the N-terminus with a carboxyalkyl group, to a method for producing said derivatives, to the use of said derivatives for treating an...
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WO/2012/043800 |
Disclosed is a method for producing a surfactin or a salt thereof, which comprises a step wherein a surfactin or a salt thereof is extracted by adding an organic solvent that contains a branched alkyl alcohol into a liquid culture medium...
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WO/2012/041801 |
The present invention relates to a method for isolating acyclohexapeptide and to a novel crystalline form of caspofungin diacetate thus obtained.
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WO/2012/040216 |
The invention provides methods and materials for using apatite chromatography supports to dissociate and remove contaminants that are complexed to biological products. The invention further provides materials and methods for dissociating...
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WO/2012/037771 |
The present invention provides an active peptide derived from scorpions, and derivatives, analogues, and active fragments thereof. The peptide is obtained from scorpions through extraction, separation, and purification, and has an amino ...
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WO/2012/040041 |
The present invention relates to compositions and methods for the chromatographic purification of antibodies, such as monoclonal antibodies, employing improved simulated moving bed separation strategies and, in certain embodiments, Raman...
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WO/2012/035115 |
The present invention relates to a raft deficient yeast expression system for the production of heterologous membrane proteins, preferably proteins that are naturally raft- associated, more preferably G-protein coupled receptors. This ce...
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WO/2012/036140 |
The present invention relates to an affinity carrier for refining or removing a protein or peptide having a kringle sequence, such as plasminogen; and to a method for removing or refining a protein or peptide having a kringle sequence by...
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WO/2012/036962 |
There are provided compounds and methods for amidating the C-terminus of a polypeptide. The method include reacting a polypeptide which includes a C-terminal thioester or C-terminal selenoester with any one of a defined set of auxiliary ...
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WO/2012/033653 |
Compositions relating to a combination of two types of separation matrix; and to variant host cells which contain at least one essential host protein that is fused to an affinity binding tag or has been mutated to replace at least two of...
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WO/2012/030512 |
A process for isolating a protein of interest from a sample includes the steps of providing a sample comprising the protein of interest; and subjecting the sample to chromatography in flow-through mode, wherein the sample is applied to a...
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WO/2012/029794 |
The present invention provides an aromatic compound containing a specific branch. This aromatic compound containing a specific branch is easily soluble in isopropyl acetate, which is excellent for separating liquids, and can be used for ...
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WO/2012/028753 |
The invention relates to a method for producing and purifying recombinant proteins in plants, by the production of transgenic plants that express the recombinant proteins fused with proteins associated with the starch granule by means of...
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WO/2012/028602 |
The present invention relates to a method of preparing a peptide comprising the amino acid sequence His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu- Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-
Lys-Ile-Thr-Asp (SE...
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WO/2012/028697 |
Provided is a novel set of tags for the rapid immobilization and/or purification of proteins or other biological or organic molecules. In particular, a system based on donor strand (Ds) complementation comprising a Ds-tag and a cognate l...
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WO/2012/030268 |
Foam fractionation is disclosed as a method for nucleoprotein capture and concentration from plant extracts without DNA or starch contamination. Plant nuclear proteins are first extracted by dilute acid or high-salt. Air is introduced as...
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WO/2012/031215 |
A structure activity relationship model is used for determining whether unknown chemical compounds are of a desired classification where the structure activity relationship model is based on a set of known chemical compounds having known...
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WO/2012/026887 |
The present invention generally relates to various peptides and particles, for example, for use in screening of particle- or bead-based peptide libraries. In one aspect, the present invention is generally directed to articles including p...
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WO/2012/023580 |
The purpose of the present invention is to provide a method for highly efficiently producing low immunogenic streptavidin having an antibody bonded thereto and being in an active state. Provided is a method for producing a conjugate cons...
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WO/2012/024224 |
A solid phase peptide synthesis method is disclosed. The method includes the steps of deprotecting an amino group in its protected form that is protected with a protecting group containing a Michael acceptor site composed of an α,β-uns...
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WO/2012/023579 |
The purpose of the present invention is to provide a process for producing streptavidin and a streptavidin variant having reduced immunogenicity, which can purify streptavidin and the streptavidin variant with high purity. The present in...
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WO/2012/024452 |
Modified relaxin polypeptides and their uses thereof are provided.
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WO/2012/024400 |
Proteins, including monoclonal antibodies, that have been retained on hydroxyapatite resins for purposes of protein separation, purification, or both, are eluted from the resins by a elution buffer that contains controlled amounts of cal...
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WO/2012/024400 |
Proteins, including monoclonal antibodies, that have been retained on hydroxyapatite resins for purposes of protein separation, purification, or both, are eluted from the resins by a elution buffer that contains controlled amounts of cal...
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WO/2012/022688 |
The invention relates to a method for inactivating proteases by multiple change of pH in the cell culture supernatant at the beginning of the operation of purifying biopharmaceuticals. First of all a pH of 3-5, and subsequently a pH of 7...
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WO/2012/020231 |
The invention discloses processes for preparing compounds comprising an α-amino acid motif. The compounds are useful in e.g. the chemical ligation of peptides.
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WO/2012/019423 |
The invention discloses an angiogenesis inhibitor, which has an amino acid sequence selected from SEQ ID NO: 1 or SEQ ID NO: 2, and a molecular weight of 25000-35000 daltons as determined by non-reducing SDS-PAGE. The invention further d...
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