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WO/2024/060196A1 |
Provided are an RNA reaction type fluorescent probe (9), a preparation method therefor, and use thereof in tumor imaging and treatment. After the probe (9) is responded by an ALP enzyme, the fluorescence thereof is enhanced, and a photo-...
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WO/2024/062149A1 |
The present invention relates to compounds, especially to conjugates and derivatives of alternariol labelled at specific positions in the molecule, suitable for the production of antibodies with a high affinity for alternariol. Likewise,...
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WO/2024/060507A1 |
The present invention relates to the field of efficient utilization of biological resources. Disclosed is an aquatic protein pretreatment method. According to the method, an aquatic protein is pretreated by using a dense phase carbon dio...
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WO/2024/063469A1 |
The present invention is related to a method for purifying heparan-N-sulfatase from a heparan-N-sulfatase-containing solution including at least one impurity, the method comprising performing multi-mode chromatography (MMC) to obtain an ...
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WO/2024/064309A1 |
A method for selectively isolating lower immunogenic biomolecule-polymer conjugates from an initial source of biomolecule-polymer conjugate, the method comprising eluting the initial source of biomolecule-polymer conjugate through a hydr...
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WO/2024/061639A1 |
The present invention relates to a method for removing free polymers present in a solution containing a hydrophobic protein, wherein the method comprises: (a) contacting the solution containing the free polymers not bound to the hydropho...
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WO/2024/058924A1 |
A process for deprotecting a protected amino acid during solid phase peptide synthesis (SPPS) includes removing a protecting group of a protected amino acid in a reaction vessel with a deprotecting base present in the reaction vessel in ...
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WO/2024/058951A1 |
Provided herein are methods of determining the reduction susceptibility of a protein and methods of adjusting the culturing condition of the protein based on the reduction susceptibility.
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WO/2024/056626A1 |
The present invention relates to a method for separating a product of interest from impurities and an apparatus for performing the method. The method comprises the steps in the indicated order: (1) loading on a chromatography matrix a fi...
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WO/2024/059235A2 |
The disclosure provides methods of purifying a target protein, e.g., an antibody, from a host cell such as a mammalian cell using purification protocols incorporating harvest recovery operations comprising a continuous solids discharge d...
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WO/2024/057361A1 |
The present invention develops a method involving: solubilizing, without using a modifying agent, an insoluble protein included in an inclusion body, which is aggregate of a recombinant protein expressed in a microorganism; separating sa...
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WO/2024/017826A3 |
The present invention is directed to a novel process for purifying a recombinant polypeptide from a solution containing one or more impurities. The process may include a chromatography process which includes a wash buffer containing a sm...
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WO/2024/058110A1 |
This method for purifying an antibody comprises preparing a solution containing an antibody, and filtering the solution using a porous membrane containing regenerated cellulose to purify the antibody. This method for purifying an antibod...
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WO/2024/055988A1 |
Provided are an isolated polypeptide consisting of a mutant B domain of Protein A, an unnatural immunoglobulin binding protein containing the mutant B domain, a conjugate containing the mutant B domain or the unnatural immunoglobulin bin...
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WO/2024/051616A1 |
Provided is a polypeptide, which has: (I) an amino acid sequence set forth in any one of SEQ ID No. 1, SEQ ID No. 4, and SEQ ID No. 5; or (II), an amino acid sequence obtained by substitution, deletion, or addition of one or more amino a...
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WO/2024/054992A1 |
The present disclosure is directed to methods of separating a chelator from a mixture and measuring the concentration of the chelator in the mixture using a chromatography column. Such methods can be useful in adjusting the concentration...
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WO/2024/052938A1 |
The present invention relates to a process for the production and purification of recombinant, untagged, trimeric SARS-CoV-2 spike protein. The present invention discloses the process of production recombinant SARS-CoV-2 spike protein yi...
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WO/2024/044852A1 |
Described herein is a high-throughput method of synthesizing biofunctional microparticles. In aspects, the method comprises casting biofunctional microparticle precursors onto a microporous template to form microparticles, wherein the te...
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WO/2024/048050A1 |
According to the present disclosure, provided is a carrier peptide fragment having excellent cell membrane permeability. The disclosed carrier peptide fragment comprises an amino acid sequence represented by SEQ ID NO: 1, KKRTLRKSNRKKR, ...
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WO/2024/045430A1 |
The present invention relates to the technical field of biological functions of proteins, and specifically relates to a polypeptide, a fused polymer protein and the use thereof. The polypeptide is selected from: (1) a polypeptide that ha...
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WO/2024/046404A1 |
A recombinant botulinum toxin and a preparation method therefor. By designing and optimizing the heavy chain and light chain sequences of the recombinant botulinum toxin, adding and cleaving protein tags will not introduce amino acid res...
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WO/2024/046469A1 |
Provided is a cyclic peptide, which has a sequence of cyclo(X1X2X3X4X5X6), wherein X1 is asparagine; X2 is glycine or sarcosine; X3 is arginine; X4 is selected from a group consisting of threonine, tyrosine, and phenylalanine; X5 is lysi...
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WO/2024/040769A1 |
The present application provides a sericin protein peptide having a moisturizing function, a method for preparing same, and use thereof. According to a first aspect of the present application, a sericin protein peptide having a moisturiz...
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WO/2024/041535A1 |
The present disclosure relates to a nano-composition, a preparation method therefor, and use thereof. The nano-composition is formed by self-assembly of an oligopeptide containing a tryptophan dipeptide motif and cisplatin. The general f...
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WO/2024/040807A1 |
Disclosed are a cell membrane-based biological material for cross-species cell component delivery and a preparation method. The biological material is based on cell membrane coating, and cross-species cell components are delivered into s...
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WO/2024/041521A1 |
Disclosed are methods for constructing conjugates. An amine-containing component and a thiol-containing component, in comparable mole ratios, react with an ortho-phthalaldehyde in one step, to generate a conjugate bearing a substituted o...
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WO/2024/043282A1 |
The present invention provides a method for producing a modified protein, the method comprising a step for obtaining a modified protein by mechanochemically treating a mixture containing a protein and an acylation agent.
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WO/2024/041532A1 |
The present disclosure relates to a complex comprising a tetravalent platinum moiety and an oligopeptide as an axial ligand chemically linked to the platinum.
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WO/2024/038918A1 |
The present invention pertains to: an aptamer which contains an oligonucleotide (for example, an oligonucleotide containing a base sequence which has at least 90% of the sequence identity of the base sequence represented by SEQ ID NO 14 ...
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WO/2024/039859A1 |
A method of collecting fungal spores includes steps of producing fungal spores by fungal cells within a fungal culture; combining a hydrophobic liquid with the fungal culture; mixing the fungal culture after the step of combining the hyd...
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WO/2024/039920A1 |
Provided herein are methods and cell-free systems for production of a recombinant antibody in which the antibody is directed against a target protein that is natively expressed as an intracellular protein. Also provided herein are modifi...
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WO/2024/032081A1 |
The present invention provides a preparation method for semaglutide, and an intermediate. The preparation method comprises the steps of: (1) reacting compound SEM110 and compound SEM120 in a solvent under an alkaline condition to obtain ...
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WO/2024/032812A1 |
Disclosed are preparation and use of a high-activity and high-safety cardamine violifolia selenoprotein standard sample. The preparation method comprises: hydrolyzing cardamine violifolia powder with cellulase, carrying out enzymolysis, ...
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WO/2024/032485A1 |
The present invention relates to a non-phosphorylated and non-ubiquitinated CREPT protein and use thereof. Specifically, the present invention relates to a protein that is obtained by modifying CREPT or a homologous protein thereof. The ...
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WO/2024/032821A1 |
Provided is a new and highly toxic amyloid oligomer Aβo*3F. The Aβo*3F is specifically bound by a 3F antibody, is the most important toxic ingredient in a mixture of Aβ oligomers, and has a strong pathogenic effect. Further provided i...
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WO/2024/036284A1 |
The present disclosure provides methods, compositions and apparatus for generating probes having affinity for analytes of interest, such as polypeptides. Also provided are methods, compositions and apparatus for evaluating and characteri...
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WO/2024/036317A1 |
Provided herein are compositions, systems, methods, and kits for peptide analysis, including peptide sequencing. In some cases, the methods may be used for mapping post-translational modifications on peptides or proteins.
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WO/2024/031963A1 |
Disclosed are a chimeric compound for degrading cyclophilin A, a preparation method therefor, and use thereof. The structural formula of the chimeric compound is represented by formula I. The compound represented by formula I provided by...
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WO/2024/032881A1 |
The present invention relates to an improved method of producing products comprising a target protein (TP) capable of crystallising under salting-in conditions by crystallisation of the TP. The invention makes use of at least two differe...
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WO/2024/033534A1 |
The present invention relates to a method of fractionating a sample comprising proteins, polypeptides and/or peptides, said method comprising (a) performing a first change of physicochemical conditions of said sample, wherein said first ...
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WO/2022/150591A9 |
The present disclosure provides methods for determining the presence of at least one biomolecule in a sample. The present disclosure further provides methods for determining the presence of a coronavims antibody in a sample.
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WO/2024/031965A1 |
Disclosed are a PROTAC compound with cyclophilin A degradation activity, a preparation method therefor, and use thereof. The structural formula of the PROTAC compound is represented by formula (I). The compound represented by formula (I)...
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WO/2024/028350A1 |
The invention relates to a method for the preparation of peptides via solid-phase peptide synthesis and particularly to a method of deprotecting of an Fmoc protected amino acid building block linked to a resin R-AA-(AA)n-PF.
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WO/2024/028340A1 |
The present invention relates to the field of industrial fermentation and protein production. In particular, it relates to a method for producing a protein of interest in a fermentation medium comprising the following steps a) inoculatin...
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WO/2024/028088A1 |
The invention relates to a method for introducing a biological sample, to be concentrated, containing biological material into a centrifugal microfluidic cartridge (15) and subsequently analysing the biological sample by means of a centr...
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WO/2024/028498A1 |
The present invention pertains to a chromatography method for the purification and/or separation of target nanoparticles. Said method relies on a hydrophilic stationary phase that comprises rigid beads with throughpores, making these bea...
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WO/2024/028338A1 |
The present invention relates to the field of industrial fermentation and protein production. In particular, it relates to a method for producing a protein of interest in a fermentation medium comprising the following steps a) inoculatin...
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WO/2024/029556A1 |
[Solution] A filter 10 comprises: a base material 20 that is composed of porous polyurethane, in which a plurality of fine pores are formed; and an active group 28 that is fixed to a surface 26 of the base material 20 and is capable of f...
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WO/2024/030092A1 |
The present invention relates to protein-based nanoparticles, synthesis of these nanoparticles and their use in cancer therapy for improving the stabilization and cellular uptake of MS1 peptide that specifically binds to and inhibits Mcl...
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WO/2024/029394A1 |
The present invention provides a carrier which is for chromatography, which has a large dynamic binding capacity with respect to an antibody or a fragment thereof, and through which a protein ligand is unlikely to leak even when the carr...
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