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Patent Searching and Data


Matches 1 - 50 out of 28,677

Document Document Title
WO/2018/130000A1
Disclosed in the present invention are a self-assembled serially-connected cell-penetrating peptide nano-particulate antibacterial agent capable of penetrating the blood brain barrier, a preparation method therefor, and uses thereof. The...  
WO/2018/126525A1
Provided is a method for preparing a hexapeptide, said method comprising the following steps: (1) synthesizing Fmoc-Arg(pbf)-2-Chlorotrityl Chloride Resin; (2) synthesizing Fmoc-Glu(OtBu)-Glu(OtBu)-Met-Gln(Trt)-Arg(pbf)-Arg(pbf)-2-Ch lor...  
WO/2018/129328A1
Compositions and methods for optically-verified, sequence-controlled polymer synthesis are described.  
WO/2018/126524A1
The present invention provides a method for purifying areginine essence, comprising: (1) resolving: resolving an areginine essence coarse product to be purified in acetic acid-sodium acetate solution, and filtering same to obtain a filtr...  
WO/2018/129043A1
Compositions, kits and methods for diagnosing and treating an increased risk of preterm birth (PTB) involves a composition comprising at least one reagent capable of detecting, binding, specifically complexing with, or measuring the leve...  
WO/2018/123953A1
The present invention relates to a method for recovering a protein of interest from a mixture that contains the protein of interest and a material that is different from the protein of interest. This method for recovering a protein compr...  
WO/2018/122875A1
The present invention relates to a novel process for preparation of peptides having amino acid chain length in the range of 2-40 comprises the steps: i) attaching an end-blocked amino acid with an ionic liquid based solid support in pres...  
WO/2018/120277A1
A pharmaceutical composition comprising F1 and F3 polypeptides, and an application thereof in treating an HPV infection. The pharmaceutical composition is prepared into various conventional dosage forms, such as an emulsion and ointment,...  
WO/2018/122874A1
The present invention relates to an ionic liquid based support of Formula-I: wherein: X+ is a heteroatom containing cationic part; W is a halogen containing polymeric solid support; n is an integer in the range of 2 to 8; Y is a hydropho...  
WO/2018/121640A1
Provided are an optimized Der f2 gene, a recombinant Der f2 protein encoded thereby, a vector comprising said gene, and a Pichia pastoris strain. Also provided are an expression method, a purification method, and an application of the re...  
WO/2018/117186A1
The present invention relates to a crystals of glutathione trisulfide dihydrate and a method for producing the same. According to the present invention, for example, by concentrating a solution in which glutathione trisulfide is dissolve...  
WO/2018/117143A1
Provided is a chromatographic method for collecting blood coagulation factor VII and/or activated blood coagulation factor VII from a plasma-derived fraction with high yield. According to the method of the present application, it becomes...  
WO/2018/118902A1
An enzyme-responsive peptide and a method off using such enzyme-responsive peptide are disclosed. An enzyme-responsive peptide, the peptide comprising an amino acid having an α-amino group, an α-carboxylic acid group and a ε-amine gro...  
WO/2018/116269A1
The present invention provides a process of increasing protein recovery and quality of the protein of interest by pre-treatment of the depth filter. The present invention relates to a process of increasing recovery of Etanercept by pre-t...  
WO/2018/108839A1
Compositions and methods are provided for producing materials having increased immunoglobulin binding capacities, the materials including full-length or truncated forms of protein A, protein G, protein A/G, protein L and other immunoglob...  
WO/2018/108896A1
Disclosed is a process for the purification of lipopolypeptide antibiotics from culture broths which comprises: a) removal of the mycelium from the broth; b) anion-exchange chromatography of the solution resulting from stage a), eluting ...  
WO/2018/111010A1
The present invention relates to an antibody specifically bound to a hemocoagulation factor VIII or an antigen binding fragment thereof, and a use thereof. More specifically, the present invention relates to: an antibody which is specifi...  
WO/2018/107247A1
The invention relates to the treatment of stroke and related diseases, to fibrin clot formation and related thrombin activity, and to preparation of compounds, in particular, peptides and polypeptides for inhibiting, or for modifying the...  
WO/2018/107079A1
The present disclosure involves optimized methods for production of hiologically active proteins termed optimally manufactured stradomers. The present disclosure further provides compositions and methods useful in the treatment of diseas...  
WO/2018/102889A1
A construct comprising: (i) an optionally derivatized glycopeptide antibiotic; (ii) a nanoparticle; and (iii) a first linker connecting (i) and (ii) is provided. The construct may further comprise a second linker located between the firs...  
WO/2018/106112A1
The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.  
WO/2018/103064A1
A synthetic peptide that targets cancer stem cells is provided. The peptide consists of the amino acid sequence of anyone of SEQ ID NO: 1 to SEQ ID NO: 15. Also provided is a composition comprising said synthetic peptide with a therapeut...  
WO/2018/104922A1
The present invention relates to the efficient solid-phase synthesis of liraglutide represented by Formula-I. The present invention relates to an efficient process for the preparation of liraglutide by sequential coupling employing solid...  
WO/2018/103758A1
Provided are a high-titer polymyxin E2 sodium methanesulfonate, preparation method and use thereof in preparing a medicament for treating gram-negative bacterial infection.  
WO/2018/105982A1
The present invention relates to a method for purifying a recombinant protein from recombinant E. coli at high yield and purity without using an additional activation process and including variants and to a method for purifying a recombi...  
WO/2018/102890A1
A visualization construct comprising: (i) an optionally derivatized glycopeptide antibiotic; (ii) a visualization component; and (iii) a first linker connecting (i) and (ii) is provided. The visualization component may be a fluorescent c...  
WO/2018/105198A1
Provided is a mixed mode affinity chromatography carrier which has an excellent antibody adsorption capacity, and excellent impurity removal capability and drug resistance. The mixed mode affinity chromatography carrier comprises a subst...  
WO/2018/101358A1
Provided is a protein composition comprising a dried product of a dispersion where a protein is dispersed in a solution of a stabilizer, wherein the stabilizer comprises at least one member selected from the group consisting of a catecho...  
WO/2018/102411A1
Some embodiments described herein relate to a method that includes separating an analyte- containing sample via electrophoresis in a capillary. The capillary is loaded with a chemiluminescence agent, such as luminol, that is configured t...  
WO/2018/100560A1
The present invention concerns Au and Cu-based mononuclear coordination compounds, drug formulations thereof, the relating synthesis and encapsulation method in macromolecules or supramolecular aggregates or nanostructures, as well as th...  
WO/2018/100561A1
The present invention relates to mononuclear coordination compounds of Au and Cu, pharmaceutical formulations based thereof, the relative method of synthesis and encapsulation of the compounds in macromolecules, supramolecular aggregates...  
WO/2018/100562A1
The present invention relates to mononuclear and dinuclear coordination compounds of Ru and Ga, pharmaceutical formulations based thereof, the relative method of synthesis and encapsulation of the compounds in macromolecules, supramolecu...  
WO/2018/097603A2
The present invention provides a MERS-CoV S immunogenic composition comprising at least one polypeptide selected from a group consisting of SEQ ID NOs: 2, 4, 6 and 8, and a method for preparing the same. The immunogenic composition prepa...  
WO/2018/091544A1
The invention provides conjugates, comprising an organ or tissue targeting moiety linked to a biologically active moiety or linked to a diagnostic moiety. Such a biologically active or diagnostic moiety can be, for example, an oligonucle...  
WO/2018/093049A1
The present invention relates to a method for removing factor XI (FXI) when purifying plasma proteins and, more particularly, to a method for removing FXI with a cation exchange resin made of a ceramic material after concentration with d...  
WO/2018/092867A1
The present invention addresses the problem of: providing an IgG-binding peptide which can be used for the purification of an IgG and has excellent stability, e.g., alkali stability; and others. The present invention also addresses the p...  
WO/2018/094213A1
Microfluidic devices and nanobiosensors comprising a magnetic nanoparticle attached to a reporter molecule via a release unit for microfluidic-based detection of a target analyte in a biological sample. The nanobiosensor can be magnetica...  
WO/2018/091339A1
Method for the synthesis of a molecular lasso structure consisting of a cyclic moiety and of a linear moiety, wherein the linear moiety is covalently attached to the cyclic moiety and with its free end is partially threaded through the o...  
WO/2018/092691A1
One embodiment of the present invention provides a method for purifying an antibody, which comprises separation of an antibody and an HCP from each other by bringing a solution that contains the antibody and the HCP into contact with a c...  
WO/2018/094269A1
Embodiments described herein relate generally to plant extract compositions and methods to isolate fatty acid esters derived from crosslinked polyesters. Particular embodiments are directed to methods of preparing compositions of fatty a...  
WO/2018/087232A1
The present invention relates to peptides binding target compounds including other peptides with high specificity and affinity.  
WO/2018/088962A1
The present invention relates to the methods of solid-phase peptide synthesis or recombinant production of ginsentide or ginsentide-like peptides or salts thereof. Further provided are uses of the ginsentide or ginsentide-like peptides o...  
WO/2018/087278A1
The present invention provides a novel process for desalting protein solutions using micropore anion and cation exchange resins. In addition, a continuous process for desalting biopharmaceutical solutions was developed. Devices for use i...  
WO/2018/082759A1
The present invention in its broadest aspect relates to a method for reducing glycoalkaloid content and turbidity of an aqueous phase comprising compounds selected from two or more of PA, PI, PPO, LipO, pectin, lipid, glycoalkaloid and p...  
WO/2018/083692A1
The present invention discloses a system and method for modulating protein expression in targeted microorganisms. The system comprises: (a) a plasma discharge source for discharging plasma to said microorganisms, said plasma comprising a...  
WO/2018/085375A1
Provided herein are methods for iodinating biomolecules, including proteins and peptides. The methods can be used to successfully and efficiently iodinate biomolecules under relatively mild reaction conditions. As a consequence, the meth...  
WO/2018/075716A1
Disclosed herein is a method for validation of continuous viral clearance comprising the steps of providing a probe to be validated, spiking the probe in a valid manner, performing viral clearance, sampling the spiked probe and analyzing...  
WO/2018/074579A1
The purpose of the present invention is to develop a new technique for improving secretory production of a heteroprotein by Corynebacterium, and to provide a secretory production method for a heteroprotein. A Corynebacterium, having the ...  
WO/2018/075818A1
The invention relates to the formulation of pharmaceutical compositions of etanercept. The invention also relates to methods of removing buffer and of formulating pharmaceutical compositions of etanercept.  
WO/2018/073717A1
The present disclosure relates to a bio-manufacturing process that enables continuous production of a therapeutic protein with reduced heterogeneity. The bio-manufacturing process disclosed herein utilizes a multi column chromatography s...  

Matches 1 - 50 out of 28,677