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JP2000229998A |
To obtain a new polypeptide compound (salt) having antifungal activity, useful for preventing and treating a Pneumocystis carinii infection, etc. This compound is shown by the formula I [R1 is H, an alkyl, a lower alkoxyalkyl, carboxyl o...
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JP2000154198A |
To provide a method for synthesizing a cyclic depsipeptide in a solid phase in a high yield in a simple reaction operation.This method for synthesizing a cyclic depsipeptide in a solid phase comprises condensing the carboxyl group of a c...
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JP2985091B2 |
A new cytostatic depsipeptide, designated "dolastatin 15", was isolated from the Indian Ocean shell-like mollusk Dolabella auricularia. Dolastatin 15 inhibited growth of the PS leukemia with ED50 0.0024 mu g/mL. Pharmaceutical preparatio...
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JPH11511142A |
The present invention relates to the use of didepsipeptides of the general formula (I) and their salts in which the radicals have the meaning given in the description, and to new didepsipeptides and processes for their preparation.
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JPH11255798A |
To produce the subject new substances comprising antitumor substances BE-66408s produced by a microorganism belonging to the genus Actinoplanes, capable of manifesting strong proliferation suppressing effects on murine and human tumorous...
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JPH11246594A |
To obtain a new bicyclic peptide consisting of a specific bicyclic depsipeptide, having activities for promoting the production of apolipoprotein E, useful as therapeutic agent of nerve injury, especially the therapeutic agent of dementi...
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JP2929555B2 |
PCT No. PCT/SE90/00797 Sec. 371 Date Jun. 11, 1992 Sec. 102(e) Date Jun. 11, 1992 PCT Filed Dec. 3, 1990 PCT Pub. No. WO91/09052 PCT Pub. Date Jun. 27, 1991.The invention relates to, novel peptide derivatives with the formula: R1-A1-A2-A...
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JP2919965B2 |
Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives.
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JPH11171897A |
To obtain the subject new peptide comprising a cyclic depsipeptide having a specific amino acid sequence, having strong cardiotonic effect, antiarrhythmic action and vasodilation action, free from adverse effect of arrhythmia, etc., and ...
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JPH11505208A |
PCT No. PCT/JP96/00774 Sec. 371 Date Sep. 29, 1997 Sec. 102(e) Date Sep. 29, 1997 PCT Filed Mar. 26, 1996 PCT Pub. No. WO96/30399 PCT Pub. Date Oct. 3, 1996New peptide compounds of the formula: wherein R1 is alkyl or aralkyl, R2 is amino...
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JPH11103886A |
To obtain a new antibiotic, vinylamycin, having antibacterial activities against gram stain positive bacteria and their multiple medicine-resistant bacteria (including methicillin-resistant bacteria). An antibiotic, vinylamycin, having a...
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JP2854141B2 |
Compounds of the formula I or pharmaceutically acceptable salts thereof wherein R1, R2, X1, X2, X3, X4, X5, X6, X7, and X8, are as set forth herein are described. These compounds are useful as agents in the treatment of fungal infections.
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JPH10511341A |
PCT No. PCT/EP95/03926 Sec. 371 Date Apr. 10, 1997 Sec. 102(e) Date Apr. 10, 1997 PCT Filed Oct. 5, 1995 PCT Pub. No. WO96/11945 PCT Pub. Date Apr. 25, 1996The present invention relates to a process for the aromatic sulfonylation, sulfen...
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JP2775573B2 |
PURPOSE: To obtain a new compound, composed of a peptide having a specific molecular structure, capable of manifesting high surface activity, having high biodegradability and useful as a strong detergent, for tertiary recovery of petrole...
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JPH10120590A |
To obtain an external agent capable of inhibiting the growth of an endobiotic pathogenic organism or killing the organism, potentiating an anti- inflammatory action and extremely less in side effect by adding a specific peptide to an ext...
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JPH10109999A |
To obtain a new cyclic peptide having a cyclic depsipeptide skeleton, and useful as an active ingredient for cardiotonic medicines having a strong cardiotonic action and an antiarrhythmic action and not causing side effects such as tachy...
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JPH10503511A |
Purified form of streptogramines, characterised in that it contains at least one component from group B streptogramines of general formula (I), wherein R1 is Me or Et, R2 is H or OH, and R3 is substituted benzyl of general formula (III),...
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JP2661367B2 |
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JPH09227594A |
To obtain a new compound consisting of a cyclic peptide compound having a specific amino acid sequence, high in an antibacterial activity and useful as an antibacterial agent, etc., by culturing a microorganism belonging to the genus Str...
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JP2647490B2 |
The invention concerns the aglycons of factors A1, A2, A3, A'1, A'2, A'3 of antibiotic A/16686 of following structure formula I their respective tetrahydroderivatives and mixtures thereof. The aglycons are produced by selective hydrolysi...
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JP2639737B2 |
Novel R106 compounds represented by the following general formula (I): wherein: A1 is Phe, o-FPhe, m-FPhe, or Tyr; A2 is MePhe, o-FMePhe, m-FMePhe, MeTyr, Sar, MeSer, or beta -oxoMePhe; A3 is Pro, 4Hyp, or SPro; A4 is allo-Ile or Nle; A5...
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JP2641256B2 |
Cyclic peptolides having the structure of a cyclosporin in which one amide linkage is replaced by an ester linkage are obtained by fermentation of fungal strains of the genus Cylindrotrichum Bonorden, or by cyclisation of a hydroxy-undec...
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JP2559208B2 |
PURPOSE: To obtain the subject copolymer which is improved in strength, rate of reabsorption and fusion processability by polymerizing a specific optically active 3-substututed-2,5-morpholinedione and a cyclic lactone in the presence of ...
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JP2507573B2 |
The invention concerns tetrahydroderivatives of factors A1, A2, A3, A min 1, A min 2, A min 3 of antibiotic A/16686 of formula I and mixtures thereof. The tetrahydroderivatives are produced by hydrogenation of the above mentioned factors...
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JPH08504165A |
Use of compounds of general formula (I), wherein R1 and R2 are methyl or hydrogen, R3 is: cyclohexyl, cyclohexenyl, or phenyl substituted in the para position, R4 is hydrogen, carboxy alkoxycarbonyl, optionally mono- or plurisubstituted,...
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JPH0826067B2 |
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JPH0826068B2 |
NEW MATERIAL:A peptide derivative (salt) expressed by formula I {A is Arg or Lys; Q<1> is H or pGlu; Q<2> is Gly-OH or OH; W is formula II [Y<1> is H or CO-T (T is formula III (R<1> is 2-7C alkylcarbonyl, 7-10C arylcarbonyl, etc.), etc.;...
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JPH0826071B2 |
Novel R106 compounds represented by the following general Formula (I): wherein: A1 is Phe, o-FPhe, m-FPhe, or Tyr; A2 is MePhe, o-FMePhe, m-FMePhe, MeTyr, Sar, MeSer, or beta -oxoMePhe; A3 is Pro, 4Hyp, or SPro; A4 is allo-Ile or Nle; A5...
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JPH0859691A |
To obtain the subject new compounds obtained by culturing a microorganism belonging to the genus Pseudomonas and producing caledothricins and collecting the products from the cultured material, having a wide antimicrobial spectrum, and u...
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JPH07103237B2 |
Novel, semi-crystalline depsipeptide polymers and copolymers particularly suitable for use in fabricating bioabsorbable medical implant devices such as sutures or clips and obtained through ring-opening polymerization of certain 3-substi...
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JPH07278188A |
PURPOSE: To obtain a new GE3 compound having excellent antibacterial and antineoplastic activity, thus useful as an antibacterial or antineoplastic agent, by culturing microbes belonging to Streptomyces and having ability to produce GE3 ...
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JPH0791315B2 |
The invention relates to depsipeptidic compounds related to antibiotic A/16696 complex of formula I Said compounds are named antibiotic A/16686 factors A'1, A'2 and A'3, respectively and are produced by fermentation of the microorganism ...
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JPH07242643A |
PURPOSE: To obtain a new compound which is a pure emetic toxin originated from Bacillus cereus known as a pathogenic microorganism causative of food poisoning. CONSTITUTION: This new microbial toxin is the compound of formula. It can be ...
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JPH07188286A |
PURPOSE: To obtain a new depsipeptide useful as a cardiotonic agent, etc., without any side effects such as arrhythmia. CONSTITUTION: This compound is expressed by the formula and has the following physical properties: appearance: colorl...
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JPH07138290A |
PURPOSE: To obtain a cardiotonic agent, available from a culture prepared culturing a sporogenous imperfect fungus which belongs to the genus Trichothecium and capable of producing a cyclic depsipeptide, having strong cardiotonic actions...
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JPH07109299A |
PURPOSE: To obtain the novel compound having strong suppressing actions on infection with human acquired immunodeficiency virus (HIV) and expected application to the treatment of patients infected with the HIV or prevention of the onset ...
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JPH07501316A |
Compounds wherein therapeutic peptides, including HIV protease inhibitors, are covalently linked to phospholipids, glycerides or other membrane-targeting and membrane-anchoring species, and their pharmaceutically acceptable salts, togeth...
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JPH06509324A |
PCT No. PCT/EP92/01304 Sec. 371 Date Dec. 16, 1993 Sec. 102(e) Date Dec. 16, 1993 PCT Filed Jun. 17, 1992 PCT Pub. No. WO93/00362 PCT Pub. Date Jan. 7, 1993.Antitumor peptides of the formula I where R1, R2, R3, R4 and R5 have the meaning...
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JPH06239892A |
PURPOSE: To obtain the subject compounds, cyclic depsipeptides separated from the culture fluid of Didymostilbe sp. RF-2091 strain, inhibiting the enzyme induced due to high-level cholesterol diet, useful as e.g. a medicine for treating ...
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JPH06211687A |
PURPOSE: To obtain the subject suppressor for cytomegaloviruses, having hardly any side effect and capable of preventing and treating infection in the infancy or the transplantation of organs, opportunistic infectious diseases, etc., wit...
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JPH06502407A |
A platelet aggregation inhibitor useful as an antithrombotic is provided which consists of a synthetic cyclic pentapeptide containing the tripeptide sequence Lys-Gly-Asp and a thioether linkage in the cycle. A prefered platelet aggregati...
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JPH06500782A |
Novel compounds of the general composition I, Lactate (1), Glycine (1), Valine (1), Isoleucine (1), pipecolic acid (1), Aspanic acid (1), Tyrosine (1), wherein each amino acid residue independently may occur in L- or D- form, and wherein...
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JPH05276962A |
PURPOSE: To efficiently produce antibiotic R106-I useful as a therapeutic agent fat mycosis. CONSTITUTION: The objective producing method of antibiotic R106-I by a fermentation method is characterized by culturing a microbial strain havi...
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JPH0561280B2 |
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JPH03170499A |
NEW MATERIAL: A cell growth inhibitor named dolastatin 14, expressed by the formula. USE: An agent for treating neoplasm diseases. PROCESS: For example, by solvent-extracting the Indian Ocean shell-less mollusk Dolabella auricularia by u...
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JPH0341475B2 |
An antitumor antibacterial complex having a quinoline nucleas referred to as BBM-928 is described which is produced by microbiological fermentation under controlled conditions using a species of actinomycetes. The bioactive components of...
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JPH0341157B2 |
An antitumor antibacterial complex having a quinoline nucleas referred to as BBM-928 is described which is produced by microbiological fermentation under controlled conditions using a species of actinomycetes. The bioactive components of...
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JPH0329080B2 |
A novel water-soluble peptide designated herein as Bu-2517 is produced by fermentation of Empedobacter sp. strain G393-B445 (ATCC 31962). The antibiotic exists in a cyclic depsipeptide structure and contains the amino acids D-serine, D-p...
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JPH02311423A |
PURPOSE: To obtain a medicine useful for curing or controlling a neoplastic disease by containing dolastatin 13 isolated from an integumentless mollusk from the Indian Ocean or its dehydrogenated material. CONSTITUTION: This medicine use...
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JPH02134399A |
NEW MATERIAL: A compd. containing 9 or more α-amino acid residues wherein the peptide backbone is connected by a peptide bond and represented by the formula [wherein R1 and R2 are each H or methyl; R3 is cyclohexyl or cyclohexenyl; R4 i...
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