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Matches 1 - 50 out of 628

Document Document Title
WO/2018/225851A1
A method for producing a peptide containing an N-substituted amino acid or an N-substituted amino acid analogue according to the present invention includes the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino aci...  
WO/2018/214463A1
A compound represented by formula I or a stereoisomer, tautomer, oxynitride, hydrate, solvate, metabolite, or pharmaceutically acceptable salt or prodrug of the compound represented by formula I.  
WO/2018/187173A1
The present invention relates generally to novel depsipeptides, to methods for the preparation of the novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides...  
WO/2018/166899A1
Provided are processes for the production of PF1022A derivative compounds, including incubating a microorganism strain capable of producing such compounds in a culture medium to produce a resulting culture, said culture medium containing...  
WO/2018/151839A1
The present invention is directed to antimicrobial agents and compositions including the same. The antimicrobial agent can include a polypeptide or a peptidomimetic of the polypeptide. The polypeptide can have a net positive charge of at...  
WO/2018/106545A1
This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomyces fungicidicus. In particular, the present disclosure describes the genetic manipulation of regulat...  
WO/2018/103905A1
The present invention is drawn to modified Streptomyces fungicidicus isolates, to compositions comprising these isolates, and methods of using such isolates and compositions to biologically synthesize enduracidin (enramycin). In addition...  
WO/2018/093920A1
The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy1, Cy2, R1, R2, R3, R4, Ra and Rb is inverted compared with the natural...  
WO/2018/081898A1
CD47+ disease cells such as cancer cells are treated using a combination of CD47 blockade drug and a histone deacetylase (HDAC) inhibitor. The anti-cancer effect of one drug enhances the anti-cancer effect of the other. Specific combinat...  
WO/2018/045313A1
In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical...  
WO/2018/045245A1
Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.  
WO/2018/031521A1
In general, the invention relates to AbA derivatives that are useful for treating infection. These novel compounds are shown to be effective in treating various fungal infections. The invention also provides pharmaceutically acceptable c...  
WO/2017/201278A1
The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a...  
WO/2017/166812A1
Disclosed is a Rakicidin compound, Rakicidin B1. Also disclosed are applications of Rakicidins A, B, and B1 in preparing drugs for treating anaerobic infections.  
WO/2017/142040A1
A cyclic depsipeptide compound represented by general formula (I) or (II), or a salt thereof. (In formulas (I) and (II), A1, A2, and A3 each independently represent an amino acid structure represented by any of formulas (A-1) to (A-3), A...  
WO/2017/125933A1
The present invention provides nanoparticle conjugates incorporating the self- assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanosphe...  
WO/2017/116702A1
The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals, including humans. The compounds and compositions may be used fo...  
WO/2017/100645A3
The invention provides compounds that are inhibitors of bacterial RNA polymerase. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention ha...  
WO/2017/096304A1
Provided are SLC45A2 peptides that bind to MHC I (HLA-A2) on melanoma cells or other antigen-presenting cells and are recognized by T-cell receptors on T cells. The SLC45 A2 peptides may be therapeutically used to treat a cancer, such as...  
WO/2017/068596A1
The present invention is relates to an improved process for the preparation (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(1-methylethyl)- 2-oxa-12,13-dithia-5,8,20,23-tetraazabi-cyclo[8.7.6]tricos-1 6-ene-3,6,9,19,22-pentone of formula I.  
WO/2017/058114A1
The present invention relates to a method of forming a peptide of Formula (I) (P1-Xaa1-Xaa2-P2) by ligating a first peptide of Formula (II) (P1-Xaa1-X-R, wherein X is O or S) to a second peptide of Formula (II I) (Xaa1-Xaa2-P2) by enzyma...  
WO/2016/187534A1
The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasi...  
WO/2016/172795A1
The present invention concerns a method for the prevention and/or treatment of an activation-induced deaminase (AID)-associated disease in a subject in need thereof, said method comprising administering an effective amount of an uracil-D...  
WO/2016/144259A1
The present invention relates to ultrashort depsipeptides which are capable of self-assembling into hydrogels. One preferred embodiment is of Ac-ILVaGK-NH2, where a represents lactic acid. The invention also relates to the use of these d...  
WO/2016/141230A1
Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.  
WO/2016/134110A1
The invention relates, in part, to compounds, compositions, and methods useful to treat cancer in cells and subjects. In some aspects the invention includes compounds and methods that increase chemo-sensitivity and/or reduce chemo-resi s...  
WO/2016/114340A1
The purpose of the present invention is to provide a UV protective agent that is safe and has exceptional dispersibility of titanium oxide particles and zinc oxide particles even when the amount of surfactant compounded is decreased. The...  
WO/2016/111574A1
The present invention relates to a novel cyclic depsipeptide-based compound, a method for preparing same, and an antibacterial pharmaceutical composition containing same as an active ingredient, the novel cyclic depsipeptide-based compou...  
WO/2016/102434A1
The present invention relates to methods for displaying cyclic peptides on the surface of bacteriophage particles and collections thereof.  
WO/2015/183897A1
Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.  
WO/2015/155676A1
The invention relates to process for the chemical manufacture of depsipeptides of the formula (I) employing an aldehyde acetal intermediate, (Formula I) wherein the symbols have the meaning defined in the description, to new intermediate...  
WO/2015/136548A3
The present invention describes a process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin. The process of the invention includes fewer purification steps and provides romidepsin having purity...  
WO/2015/136548A4
The present invention describes a process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin. The process of the invention includes fewer purification steps and provides romidepsin having purity...  
WO/2015/131254A1
The present invention relates to a modified inhibin alpha protein, to antigenic fragments of same and to a fusion protein comprising same, as well as to an antigenic composition comprising a modified inhibin alpha and/or an antigenic fra...  
WO/2015/131355A1
A compound of formula I is an intermediate in a method for preparing a natural product histone deacetylase inhibitor Thailandepsin B. The method comprises the following steps: 1) adding an elemental iodine into a mixed solvent of dichlor...  
WO/2015/120548A1
Genetically encoded, photocleavable proteins are derived from a fluorescent protein. Upon illumination, the proteins photocleave and spontaneously dissociate into two or more fragments or release one end of an internal loop.  
WO/2015/093558A1
 Provided are a compound represented by formula (1) or a stereoisomer thereof as a novel cyclic depsipeptide derivative, and a pest control agent which includes the novel depsipeptide derivative.  
WO/2015/075747A1
The present invention relates to cell penetrating peptide for delivery of biomolecules into an eukaryotic cell. The present invention specifically relates to a peptide based drug delivery system for delivering nucleic acids and/or protei...  
WO/2015/031871A1
In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical...  
WO/2014/170295A1
Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and A take various meanings, pharmaceutical compositions containing them and their use in medicine, particularly as agents able to potentiate the effect of antifungal drugs.  
WO/2014/167310A1
The invention relates to novel self-assembling peptide complexes comprising a charged peptide and a polysaccharide, methods of producing them and uses therefor. The novel self-assembling peptide complexes of the present invention have pa...  
WO/2014/167071A1
The present invention relates to compounds and methods for inhibition of binding of ICAM-4 to platelet integrin αIIbβ3. The present invention also relates to a screening method and to a kit to detect or monitor in vitro the effect of a...  
WO/2014/107814A1
The present application discloses metallophores that complex soluble gold and generate solid gold forms, including gold nanoparticles. In an embodiment, the metallophores are microbial metabolites isolated from organisms that are resista...  
WO/2014/089053A1
The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptid...  
WO/2014/057419A2
The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I employing an aldehyde acetal intermediate Formula (I), wherein the symbols have the meaning defined in the description, to new in...  
WO/2014/057418A3
The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula (I), wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as wel...  
WO/2014/057419A3
The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I employing an aldehyde acetal intermediate Formula (I), wherein the symbols have the meaning defined in the description, to new in...  
WO/2014/057418A2
The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula (I), wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as wel...  
WO/2013/187480A1
An aim of the present invention is to provide a novel cyclic depsipeptide derivative and a pest control agent comprising the same. According to the present invention, a compound represented by formula (1) or a stereoisomer thereof, a pes...  
WO/2013/168075A1
This invention relates to an isolated compound of Formula (1) or derivatives or pharmaceutically acceptable salts thereof. The invention also includes all isomeric and tautomeric forms of the compound of Formula (1) or the derivatives th...  

Matches 1 - 50 out of 628