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Matches 1 - 50 out of 5,410

Document Document Title
WO/2019/074523A1
The present disclosure is drawn to a biological fluid, including water, from 0.05 wt% to 3 wt% protein having an acidic isoelectric point (pl) less than about 6.5, and from 0.5 wt% to 20 wt% ionic protein stabilizer system. The ionic pro...  
WO/2019/073992A1
The present invention provides an antibody-modified filter capable of specifically adsorbing or removing a target substance, and a material used in the filter. An antibody-binding surface-modified substrate that includes a substrate-bind...  
WO/2019/028281A3
The present invention provides methods for guiding preservation of human neurons or human nerves during surgery by administering a fluorescently-labeled peptide that specifically binds to the human neurons or human nerves. The invention ...  
WO/2019/068022A1
The present disclosure provides a flow-through electroporation device configured for use as a stand-alone module or as one module in an automated multi-module processing system.  
WO/2019/064297A1
The present invention provides cytotoxic peptides, analogs thereof and fragments thereof, conjugates of said peptides, analogs or fragments as well as compositions comprising same. In addition, uses of these compounds and compositions in...  
WO/2019/054198A1
The present disclosure provides an antibody binding to an intranuclear protein of influenza virus and use of the same. The present disclosure provides an antibody which recognizes a peptide comprising the 205th-231st amino sequence in SE...  
WO/2019/052405A1
Disclosed are a maleimide group-modified angiogenesis inhibitor HM-1 and the use thereof, which fall within the technical field of polypeptide drugs. The selection of a suitable maleimide group to modify the N-terminus of the angiogenesi...  
WO/2019/050283A1
The present invention relates to: a composition comprising cell fate regulatory factor-supported porous silica particles; and a method for regulating cell fate, comprising a step of treating various cells with the same. The present inven...  
WO/2019/046699A1
The invention includes a bioelectronic interface comprising a self-assembling unit, wherein the self-assembling unit comprises a variant GPCR fusion protein bound to an S-layer fusion protein. The invention also encompasses a biosensor o...  
WO/2019/040973A1
A method for the synthesis of a cyclic ornithine-proline-D-cyclohexylalanine-tryptophan- arginine pentapeptide of Formula A; wherein R1 and R2 are, independently, -H, or -C(O)R3 where R3 is -Ch2Ph, - CH2CH2Ph, -CH=CHPh, -C(NHAC)CH2Ph; th...  
WO/2019/041013A1
Disclosed is a hybrid protein that consists of the fusion of: a protein from the TRIM21 family (or only the C-terminal domain PRYSPRY thereof) fused to the enzymes peroxidase, alkaline phosphatase or luciferase (for enzymatic detection) ...  
WO/2019/039777A1
The present invention relates to a porous silica carrier for stabilizing proteins and enzymes, and a production method and use thereof. A silica carrier according to the present invention is harmless to the human body, is based on silica...  
WO/2019/039602A1
Provided is a carrier for affinity chromatography having high immunoglobulin purification efficiency. This protein contains two or more domains linked together by a linker. The domains have affinity to immunoglobulins. The linker is a pe...  
WO/2019/036631A1
The present invention provide novel immunofiber compositions for protein or peptide purification and simple and cost-efficient methods and systems using these compositions. In some embodiments, the immunofibers comprise a customized Z-33...  
WO/2019/032921A1
This application generally relates to the field of methods, systems and compositions for addressing diseases associated with apoptotic cell death, including autoimmune diseases and inflammatory diseases, and more particularly to such met...  
WO/2019/028168A1
Materials and methods for generating protein-polymer conjugates on solid supports are provided herein. The methods can include, for example, reversibly immobilizing a protein on a solid support, modifying the protein by adding polymer su...  
WO/2019/018836A1
Infusion therapy for primary or metastatic tumors includes infusion of fluids that are into supplying blood vessels at concentration and flow rates that kill tumor cells or but don't kill normal cells. The infused fluids can be known tox...  
WO/2019/013148A1
A liganded substrate having at least part of the surface thereof covered by a polymer (P1) containing a structural unit represented by formula (1a) and (1b), a raw material of said liganded substrate, and a production method thereof are ...  
WO/2019/013332A1
A method for inhibiting nonspecific binding to binding proteins that bind to the surface molecules of exosomes and eukaryotic cell membranes is provided which involves immobilizing said binding proteins on a carrier in the presence of ge...  
WO/2018/227261A1
The present invention relates to a method for producing an inorganic nanostructured complex (CFI-1), a protein-associated nanostructured complex (MRB-CFI-1) and antitumour use. The main use is in treating urinary bladder cancer, both in ...  
WO/2018/219108A1
Provided herein are engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. Also provided are polynucleotides encoding engineered polypeptides, host cells ca...  
WO/2018/215503A1
A recombinant protein comprising a functional polypeptide and, linked to the N-terminus of said functional polypeptide, an N-terminal spacerhaving a length such that the number of amino acid residues between a signal peptide cleaving sit...  
WO/2018/213331A1
Methods and compositions are provided for diagnosing of autosomal-dominant polycystic kidney disease (ADPKD), chronic kidney diseases, kidney dysfunction, and preeclampsia in a subject, preferably in a urine sample of a human subject. Th...  
WO/2018/207906A1
The present invention relates to: a protein-peptide fusion body in which a peptide having a function to be adsorbed onto the surface of a substrate is provided on the N-terminal side or the C-terminal side of a protein capable of recogni...  
WO/2018/194134A1
[Problem] To provide: a stabilized anti-periostin antibody-immobilized carrier; a stabilized periostin measurement reagent; and a method for stabilizing an anti-periostin antibody in a carrier having the antibody immobilized thereon. [So...  
WO/2018/193039A1
The present invention relates to a vaccine composition V comprising a peptidic entity A comprising one or more sequence motifs A1 of the sequence RR-X1a-X1b-L (SEQ ID NO: 23) wherein X1a is a hydrophobic amino acid moiety and X1b is a pe...  
WO/2018/190357A1
A purpose of the present invention is to provide a highly sensitive and less expensive lectin-immobilized base material (for example, a lectin plate), said lectin-immobilized base material having stable qualities and being able to be suf...  
WO/2018/180204A1
The purpose of the present invention is to provide: a novel modified protein G which is capable of binding to immunoglobulin and shows a high chemical stability against an alkali solution; an affinity separation matrix comprising the mod...  
WO/2018/180205A1
The purpose of the present invention is to provide: a novel affinity dissociation matrix which has bindability to an immunoglobulin and has excellent chemical stability toward an alkaline solution; and a method for producing an immunoglo...  
WO/2018/170571A1
The present patent application discloses recombinant or synthetic T. gondii antigens that can be used for diagnosing acute and chronic toxoplasmosis. Combinations for detecting IgG anti-T. gondii antibodies and IgM anti-T. gondii antibod...  
WO/2018/166527A1
Provided are a multispecific antibody targeting the HER2 extracellular domain II and an antigen on an immune effector cell, and a conjugate of the antibody and a nanoparticle, wherein the conjugate can further comprise a binding portion ...  
WO/2018/157866A1
Provided is a method for localizing and modifying a target amino acid group on a macromolecular compound. The described localization and modification method contains a method for filtering a target amino acid group, which uses a molecule...  
WO/2018/151811A3
The invention provides a methods of a disease or disorder in a subject by inducing a TGF alpha immune response. The TGF-alpha immune response is induced using a TGF-alpha polypeptide or biologically active fragment, a vaccine, a genetic ...  
WO/2018/148801A1
The present disclosure generally relates to nanoparticles adsorbed with gliadin molecules. In addition, the present disclosure relates to methods of preparing the nanoparticles adsorbed with gliadin molecules and methods of using said na...  
WO/2018/141349A1
The present invention relates to methods for the specific separation of target cells from a biological sample, comprising specific binding of the target cells to phase- change hydrogel compositions and separation of respective cell-hydro...  
WO/2018/141071A1
The present invention relates to products and method of preparing and using surface modified polymeric material having siliceous particles deposited thereon. The method and article are disclosed wherein a plastic substrate is provided wi...  
WO/2018/144438A1
The present invention provides a method of producing a polysaccharide - protein conjugate with capsular polysaccharide from Streptococcus pneumoniae serotype 19F conjugated to a carrier protein. The method includes a prolonged incubation...  
WO/2018/139665A1
Provided is a use for a peptide in surface-treating a medical device or medical material to be used in contact with blood, with which it is possible to obtain a medical device or medical material that can achieve highly efficient vascula...  
WO/2018/140974A1
Disclosed herein are methods, reagents, and pharmaceutical compositions for modulating immune effector cell activation that does not requirean antigen-specific antibody. The IgG Fc region is shown herein to contain both a domain that bin...  
WO/2018/137609A1
The present invention provides a multispecific antibody conjugate (i.e., a bispecific antibody conjugate), and a related composition, therapeutic method and use thereof. The antibody conjugate comprises a multispecific antibody coupled o...  
WO/2018/132572A1
R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii)...  
WO/2018/114878A1
Herein is reported a method for the enzymatic preparation/production of an antibody with a modified glycosylation in the Fc-region comprises the steps of incubating an antibody that has a glycosylation in the Fc-region with one or more e...  
WO/2018/109663A1
The present invention relates, in general, to polypeptides capable of transmigrating the blood-brain barrier, and uses thereof. More specifically, the present invention relates to polypeptides derived by site-directed mutagenesis of an e...  
WO/2018/101826A1
The invention related to a biopolymer that is functionalized with a peptide, preferably a growth factor-binding peptide. The invention further relates to a device comprising a functionalized biopolymer, to methods for treatment of a tiss...  
WO/2018/092867A1
The present invention addresses the problem of: providing an IgG-binding peptide which can be used for the purification of an IgG and has excellent stability, e.g., alkali stability; and others. The present invention also addresses the p...  
WO/2018/092885A1
[Problem] To provide an anti-human MUC1 antibody Fab fragment, which is expected to be useful for the diagnosis and/or treatment of cancer, particularly the diagnosis and/or treatment of breast cancer or bladder cancer, and a diagnosis m...  
WO/2018/088509A1
The present invention provides a polypeptide and a malaria vaccine comprising said polypeptide, the polypeptide comprising any of the following amino acid sequences: (a) an amino acid sequence represented by SEQ ID NO. 4; (b) an amino ac...  
WO/2018/089465A1
Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to...  
WO/2018/089857A1
The present technology provides compositions and nanoemulsions useful in optoacoustic imaging. A composition of the present technology includes at least one contrast agent covalently linked to a targeting agent; where the at least one co...  
WO/2018/088507A1
The present invention provides a polypeptide and a malaria vaccine comprising said polypeptide, the polypeptide comprising any of the following amino acid sequences: (a) an amino acid sequence represented by SEQ ID NO. 4 or SEQ ID NO. 8;...  

Matches 1 - 50 out of 5,410