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Matches 1 - 50 out of 5,319

Document Document Title
WO/2018/166527A1
Provided are a multispecific antibody targeting the HER2 extracellular domain II and an antigen on an immune effector cell, and a conjugate of the antibody and a nanoparticle, wherein the conjugate can further comprise a binding portion ...  
WO/2018/157866A1
Provided is a method for localizing and modifying a target amino acid group on a macromolecular compound. The described localization and modification method contains a method for filtering a target amino acid group, which uses a molecule...  
WO/2018/148801A1
The present disclosure generally relates to nanoparticles adsorbed with gliadin molecules. In addition, the present disclosure relates to methods of preparing the nanoparticles adsorbed with gliadin molecules and methods of using said na...  
WO/2018/141349A1
The present invention relates to methods for the specific separation of target cells from a biological sample, comprising specific binding of the target cells to phase- change hydrogel compositions and separation of respective cell-hydro...  
WO/2018/141071A1
The present invention relates to products and method of preparing and using surface modified polymeric material having siliceous particles deposited thereon. The method and article are disclosed wherein a plastic substrate is provided wi...  
WO/2018/144438A1
The present invention provides a method of producing a polysaccharide - protein conjugate with capsular polysaccharide from Streptococcus pneumoniae serotype 19F conjugated to a carrier protein. The method includes a prolonged incubation...  
WO/2018/139665A1
Provided is a use for a peptide in surface-treating a medical device or medical material to be used in contact with blood, with which it is possible to obtain a medical device or medical material that can achieve highly efficient vascula...  
WO/2018/140974A1
Disclosed herein are methods, reagents, and pharmaceutical compositions for modulating immune effector cell activation that does not requirean antigen-specific antibody. The IgG Fc region is shown herein to contain both a domain that bin...  
WO/2018/137609A1
The present invention provides a multispecific antibody conjugate (i.e., a bispecific antibody conjugate), and a related composition, therapeutic method and use thereof. The antibody conjugate comprises a multispecific antibody coupled o...  
WO/2018/132572A1
R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii)...  
WO/2018/114878A1
Herein is reported a method for the enzymatic preparation/production of an antibody with a modified glycosylation in the Fc-region comprises the steps of incubating an antibody that has a glycosylation in the Fc-region with one or more e...  
WO/2018/109663A1
The present invention relates, in general, to polypeptides capable of transmigrating the blood-brain barrier, and uses thereof. More specifically, the present invention relates to polypeptides derived by site-directed mutagenesis of an e...  
WO/2018/101826A1
The invention related to a biopolymer that is functionalized with a peptide, preferably a growth factor-binding peptide. The invention further relates to a device comprising a functionalized biopolymer, to methods for treatment of a tiss...  
WO/2018/092867A1
The present invention addresses the problem of: providing an IgG-binding peptide which can be used for the purification of an IgG and has excellent stability, e.g., alkali stability; and others. The present invention also addresses the p...  
WO/2018/092885A1
[Problem] To provide an anti-human MUC1 antibody Fab fragment, which is expected to be useful for the diagnosis and/or treatment of cancer, particularly the diagnosis and/or treatment of breast cancer or bladder cancer, and a diagnosis m...  
WO/2018/088509A1
The present invention provides a polypeptide and a malaria vaccine comprising said polypeptide, the polypeptide comprising any of the following amino acid sequences: (a) an amino acid sequence represented by SEQ ID NO. 4; (b) an amino ac...  
WO/2018/089465A1
Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to...  
WO/2018/089857A1
The present technology provides compositions and nanoemulsions useful in optoacoustic imaging. A composition of the present technology includes at least one contrast agent covalently linked to a targeting agent; where the at least one co...  
WO/2018/088507A1
The present invention provides a polypeptide and a malaria vaccine comprising said polypeptide, the polypeptide comprising any of the following amino acid sequences: (a) an amino acid sequence represented by SEQ ID NO. 4 or SEQ ID NO. 8;...  
WO/2018/061004A1
The present invention provides constructs comprising a plurality of peptides capable of targeting at least two different extracellular tumor antigens and a toxin, optionally connected to an organic scaffold. Use of such constructs in tre...  
WO/2018/052041A1
Provided is an anti-core-fucosylated human immunoglobulin G (IgG) antibody or a fragment of the antibody, the antibody or the fragment of the antibody being characterized by binding to a human IgG that contains in the Fc region an N-link...  
WO/2018/046129A1
The invention relates to methods for producing hydrogels for reversibly immobilising glycoproteins and/or cells on the hydrogel, involving lectins being coupled to the hydrogel, corresponding lectin-coupled hydrogels, the use thereof in ...  
WO/2018/047856A1
The present invention addresses the problem of providing a fused protein capable of easily producing a protein structure having high uniformity, and providing a structural body formed by such a fused protein. This fused protein has a pro...  
WO/2018/049182A3
The invention relates to systems and methods for effective production and use of microorganisms and/or the fermentation broth in which they are produced. Advantageously, the system is cost-effective, scalable, quick, versatile, efficacio...  
WO/2018/043645A1
The purpose of the present invention is to provide a protein purification method which can reduce impurities significantly compared with conventional protein purification methods using activated carbon and can achieve a high collection r...  
WO/2018/039400A1
Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune ce...  
WO/2018/036403A1
A novel oligosaccharide linker. The oligosaccharide linker is used to prepare an antibody-drug conjugate with site-specific linkage and an antibody-drug conjugate with two coupled drugs. The oligosaccharide linker comprises a biantennary...  
WO/2018/027329A1
of the Invention The present invention provides conjugates containing a (i) TGF-β antagonist, such as a TGF-β antagonist antibody, protein, peptide, or small molecule capable of inhibiting TGF-β signaling, bound to (ii) a bone-targeti...  
WO/2018/029347A1
1. Synthesis of bitter principle derivatives based on the denatonium structure according to formula (1). 2.1. The aim of the invention is to introduce couplable carboxylic acid functionalities into the denatonium structure by means of si...  
WO/2018/011266A1
The present invention relates to reagents comprising a substituted acyl borate or a substituted hydroxyl amine, to a method of synthesizing a carrier-linked prodrug using said reagents and to carrier-linked prodrugs obtainable by said me...  
WO/2018/008596A1
Provided is a solid phase support by which the recognition site of an antibody for detection can be oriented toward a measurement sample side so that the antibody can be immobilized in a measurement area. A solid phase support for protei...  
WO/2018/005556A1
Provided are methods of identifying peptide epitopes of an antigen recognized by the non-classical major histocompatibility complex (MHC) molecule designated MHC-E. In some embodiments, the antigen is a tumor antigen, autoimmune antigen ...  
WO/2017/219974A1
Provided in the present invention is a bispecific antibody comprising an antibody fragment combating MUC1VHH and an antibody fragment combating CD16VHH. The antibody fragment used in the present invention is a variable region sequence de...  
WO/2017/216323A2
The present invention relates to a method for managing the therapy of patients and patient (sub)populations (responder/non-responder) suffering from rheumatoid arthritis (RA) and to the use of suitable marker sequences, in particular in ...  
WO/2017/216323A3
The present invention relates to a method for managing the therapy of patients and patient (sub)populations (responder/non-responder) suffering from rheumatoid arthritis (RA) and to the use of suitable marker sequences, in particular in ...  
WO/2017/212838A1
Provided is a material-fixing substrate wherein copper does not have to be used as a catalyst since a cyclic alkyne is provided at a substrate-binding region where a covalent bond is formed to a surface of the substrate, and therefore, f...  
WO/2017/213107A1
A nanocapsule accumulation method includes: a step (C) for radiating laser light (L1) outside the wavelength region of localized surface plasmon resonance of gold nanoparticles (1) to an aqueous liquid (W) in which a plurality of nanocap...  
WO/2017/206713A1
A method for coupling magnetic particle with antibody molecules, comprising the following steps in sequence: balancing of magnetic particles, aldehyde modification and reduction of the magnetic particles, coupling of activated magnetic p...  
WO/2017/204325A1
[Problem] To provide: streptolysin O which has excellent properties including an antigenic activity and thermal stability; a method for producing the streptolysin O; and a use of the streptolysin O. [Solution] A polypeptide comprising su...  
WO/2017/201428A8
Provided are compositions and methods of making hydrogels, aerogels, films and composites directly from a microbial culture or complex mixture using curli nanofibers.  
WO/2017/201064A1
This disclosure provides, e.g., methods for coupling an entity to a solid substrate. The method can comprise treating the substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological poly...  
WO/2017/201428A1
Provided are compositions and methods of making hydrogels, aerogels, films and composites directly from a microbial culture or complex mixture using curli nanofibers.  
WO/2017/196954A1
Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I), including stereoisomers, salts and tautomers thereof, wherein R1, R2, R3, L1, L2, L3, L4, L5, M, m and n are as defined herein...  
WO/2017/195641A1
The purpose of the present invention is to provide an affinity separation matrix having extremely excellent binding capacity and binding efficiency with respect to a κ-chain variable region-containing peptide, a method for producing the...  
WO/2017/192801A1
The present invention generally relates to separation matrix comprising a lipoic acid (LA) compound or derivative thereof for use in a method for purifying and isolating a biotin-binding protein, including fusion proteins and complexes t...  
WO/2017/192743A1
Disclosed herein are methods, platform, antibodies, vaccines, constructs, and kits for generating a modified multispanning membrane polypeptide. In some instances, also disclosed herein are methods, platform, antibodies, vaccines, constr...  
WO/2017/190108A1
The invention provides novel targeted particles as contrast agents for use in molecular imaging of vulnerable plaque, and methods of preparation and application thereof.  
WO/2017/186669A1
The invention concerns novel streptavidin muteins and their use for determination, isolation or purification of proteins under denaturing conditons.In one embodiment such a mutein has an Cys residue at sequence position 127 of the wild-t...  
WO/2017/188346A1
[Problem] To provide a material for efficiently capturing and collecting specific cells, and a method for capturing and collecting cells by using said material. [Solution] Provided is a material which is used for capturing and collecting...  
WO/2017/180420A1
Provided herein are methods for determining the T cell receptor affinity and sequence of antigen-specific T cells using a micropipette adhesion assay and single cell paired TCRα/TCRβ sequencing. Further provided are methods for the tre...  

Matches 1 - 50 out of 5,319