Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 5,273

Document Document Title
WO/2018/101826A1
The invention related to a biopolymer that is functionalized with a peptide, preferably a growth factor-binding peptide. The invention further relates to a device comprising a functionalized biopolymer, to methods for treatment of a tiss...  
WO/2018/092867A1
The present invention addresses the problem of: providing an IgG-binding peptide which can be used for the purification of an IgG and has excellent stability, e.g., alkali stability; and others. The present invention also addresses the p...  
WO/2018/092885A1
[Problem] To provide an anti-human MUC1 antibody Fab fragment, which is expected to be useful for the diagnosis and/or treatment of cancer, particularly the diagnosis and/or treatment of breast cancer or bladder cancer, and a diagnosis m...  
WO/2018/088509A1
The present invention provides a polypeptide and a malaria vaccine comprising said polypeptide, the polypeptide comprising any of the following amino acid sequences: (a) an amino acid sequence represented by SEQ ID NO. 4; (b) an amino ac...  
WO/2018/089465A1
Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mV. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to...  
WO/2018/089857A1
The present technology provides compositions and nanoemulsions useful in optoacoustic imaging. A composition of the present technology includes at least one contrast agent covalently linked to a targeting agent; where the at least one co...  
WO/2018/088507A1
The present invention provides a polypeptide and a malaria vaccine comprising said polypeptide, the polypeptide comprising any of the following amino acid sequences: (a) an amino acid sequence represented by SEQ ID NO. 4 or SEQ ID NO. 8;...  
WO/2018/061004A1
The present invention provides constructs comprising a plurality of peptides capable of targeting at least two different extracellular tumor antigens and a toxin, optionally connected to an organic scaffold. Use of such constructs in tre...  
WO/2018/052041A1
Provided is an anti-core-fucosylated human immunoglobulin G (IgG) antibody or a fragment of the antibody, the antibody or the fragment of the antibody being characterized by binding to a human IgG that contains in the Fc region an N-link...  
WO/2018/046129A1
The invention relates to methods for producing hydrogels for reversibly immobilising glycoproteins and/or cells on the hydrogel, involving lectins being coupled to the hydrogel, corresponding lectin-coupled hydrogels, the use thereof in ...  
WO/2018/047856A1
The present invention addresses the problem of providing a fused protein capable of easily producing a protein structure having high uniformity, and providing a structural body formed by such a fused protein. This fused protein has a pro...  
WO/2018/049182A3
The invention relates to systems and methods for effective production and use of microorganisms and/or the fermentation broth in which they are produced. Advantageously, the system is cost-effective, scalable, quick, versatile, efficacio...  
WO/2018/043645A1
The purpose of the present invention is to provide a protein purification method which can reduce impurities significantly compared with conventional protein purification methods using activated carbon and can achieve a high collection r...  
WO/2018/039400A1
Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune ce...  
WO/2018/036403A1
A novel oligosaccharide linker. The oligosaccharide linker is used to prepare an antibody-drug conjugate with site-specific linkage and an antibody-drug conjugate with two coupled drugs. The oligosaccharide linker comprises a biantennary...  
WO/2018/027329A1
of the Invention The present invention provides conjugates containing a (i) TGF-β antagonist, such as a TGF-β antagonist antibody, protein, peptide, or small molecule capable of inhibiting TGF-β signaling, bound to (ii) a bone-targeti...  
WO/2018/029347A1
1. Synthesis of bitter principle derivatives based on the denatonium structure according to formula (1). 2.1. The aim of the invention is to introduce couplable carboxylic acid functionalities into the denatonium structure by means of si...  
WO/2018/011266A1
The present invention relates to reagents comprising a substituted acyl borate or a substituted hydroxyl amine, to a method of synthesizing a carrier-linked prodrug using said reagents and to carrier-linked prodrugs obtainable by said me...  
WO/2018/008596A1
Provided is a solid phase support by which the recognition site of an antibody for detection can be oriented toward a measurement sample side so that the antibody can be immobilized in a measurement area. A solid phase support for protei...  
WO/2018/005556A1
Provided are methods of identifying peptide epitopes of an antigen recognized by the non-classical major histocompatibility complex (MHC) molecule designated MHC-E. In some embodiments, the antigen is a tumor antigen, autoimmune antigen ...  
WO/2017/219974A1
Provided in the present invention is a bispecific antibody comprising an antibody fragment combating MUC1VHH and an antibody fragment combating CD16VHH. The antibody fragment used in the present invention is a variable region sequence de...  
WO/2017/216323A2
The present invention relates to a method for managing the therapy of patients and patient (sub)populations (responder/non-responder) suffering from rheumatoid arthritis (RA) and to the use of suitable marker sequences, in particular in ...  
WO/2017/216323A3
The present invention relates to a method for managing the therapy of patients and patient (sub)populations (responder/non-responder) suffering from rheumatoid arthritis (RA) and to the use of suitable marker sequences, in particular in ...  
WO/2017/212838A1
Provided is a material-fixing substrate wherein copper does not have to be used as a catalyst since a cyclic alkyne is provided at a substrate-binding region where a covalent bond is formed to a surface of the substrate, and therefore, f...  
WO/2017/213107A1
A nanocapsule accumulation method includes: a step (C) for radiating laser light (L1) outside the wavelength region of localized surface plasmon resonance of gold nanoparticles (1) to an aqueous liquid (W) in which a plurality of nanocap...  
WO/2017/206713A1
A method for coupling magnetic particle with antibody molecules, comprising the following steps in sequence: balancing of magnetic particles, aldehyde modification and reduction of the magnetic particles, coupling of activated magnetic p...  
WO/2017/204325A1
[Problem] To provide: streptolysin O which has excellent properties including an antigenic activity and thermal stability; a method for producing the streptolysin O; and a use of the streptolysin O. [Solution] A polypeptide comprising su...  
WO/2017/201428A8
Provided are compositions and methods of making hydrogels, aerogels, films and composites directly from a microbial culture or complex mixture using curli nanofibers.  
WO/2017/201064A1
This disclosure provides, e.g., methods for coupling an entity to a solid substrate. The method can comprise treating the substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological poly...  
WO/2017/201428A1
Provided are compositions and methods of making hydrogels, aerogels, films and composites directly from a microbial culture or complex mixture using curli nanofibers.  
WO/2017/196954A1
Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I), including stereoisomers, salts and tautomers thereof, wherein R1, R2, R3, L1, L2, L3, L4, L5, M, m and n are as defined herein...  
WO/2017/195641A1
The purpose of the present invention is to provide an affinity separation matrix having extremely excellent binding capacity and binding efficiency with respect to a κ-chain variable region-containing peptide, a method for producing the...  
WO/2017/192801A1
The present invention generally relates to separation matrix comprising a lipoic acid (LA) compound or derivative thereof for use in a method for purifying and isolating a biotin-binding protein, including fusion proteins and complexes t...  
WO/2017/192743A1
Disclosed herein are methods, platform, antibodies, vaccines, constructs, and kits for generating a modified multispanning membrane polypeptide. In some instances, also disclosed herein are methods, platform, antibodies, vaccines, constr...  
WO/2017/190108A1
The invention provides novel targeted particles as contrast agents for use in molecular imaging of vulnerable plaque, and methods of preparation and application thereof.  
WO/2017/186669A1
The invention concerns novel streptavidin muteins and their use for determination, isolation or purification of proteins under denaturing conditons.In one embodiment such a mutein has an Cys residue at sequence position 127 of the wild-t...  
WO/2017/188346A1
[Problem] To provide a material for efficiently capturing and collecting specific cells, and a method for capturing and collecting cells by using said material. [Solution] Provided is a material which is used for capturing and collecting...  
WO/2017/180420A1
Provided herein are methods for determining the T cell receptor affinity and sequence of antigen-specific T cells using a micropipette adhesion assay and single cell paired TCRα/TCRβ sequencing. Further provided are methods for the tre...  
WO/2017/162801A1
The present invention relates to the preparing of solutions, in particular for performing analysis methods, in particular by spectrometry, especially for the production of standard solutions that are useful, for example, in the calibrati...  
WO/2017/165788A1
Disclosed are fluorescent markers that include a known number of copies of a fluorescently-labeled protein regularly interspersed along the length of the fluorescent marker. The fluorescent markers may be used to quantify fluorescently-l...  
WO/2017/156616A1
The application relates to liposomal nanovesicles comprising porphyrin-lipid conjugates within the liposomal lipid bilayer. Said porphyrin-lipid conjugate comprise porphyrins that are modified with a -CH(R1)-O-R2 group and that chelate a...  
WO/2017/157662A1
The invention relates to new membranes containing customised membrane transport proteins (such as TCDB-classified proteins) acting as pore-forming proteins (such as FhuA) or peptides acting as pores in the membrane. Preferably, these mem...  
WO/2017/150680A1
This method assists in the detection of Alzheimer's disease and involves determining the profile of signal peptides contained in a bodily fluid derived from a subject being examined, and comparing said determined signal peptide profile o...  
WO/2017/149002A1
The present invention relates to novel fusion proteins for capturing of cells. The invention features fusion proteins comprising a non-lg protein that is capable of binding a cell-surface target, at least one cleavage site for the releas...  
WO/2017/143406A1
The present disclosure relates to multi-specific molecules which are capable of simultaneously binding at least two different target antigens or epitopes. The molecules comprise at least one binding domain molecule (BDM) which binds to a...  
WO/2017/136708A1
A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.  
WO/2017/103914A1
The present invention provides protein-polymer conjugates, and methods for generating biocompatible scaffolds formed of hydrogels comprising the conjugates and use of the scaffolds for tissue regeneration. The present invention further p...  
WO/2017/094885A1
The present invention involves a ligand fluorescent sensor protein that specifically responds to ligands, leading to a change in fluorescence properties. The ligand fluorescent sensor protein includes a first fluorescent protein domain, ...  
WO/2017/094792A1
The present invention relates to a targeted shell for a drug delivery system. The purpose of the present invention is to provide a targeted shell for use in a drug delivery system. Utilizing the reactivity of a thiol and an alkyl halide,...  
WO/2017/088058A1
The present disclosure relates to peptide compounds and conjugate compounds, processes, methods and uses thereof for treating cancer and increasing cellular internalization of said peptide compounds. The peptide compounds are selected fr...  

Matches 1 - 50 out of 5,273