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Matches 1 - 50 out of 5,719

Document Document Title
WO/2020/189766A1
The purpose of the present invention is to provide a polypeptide-modified liposome which has excellent antibody binding capacity. In each immunoglobulin binding domain (sequence number 1-4) configuring a protein A, at least 3 amino aci...  
WO/2020/047185A9
The present invention includes a composition and method of allosterically potentiating the activity of neurolysin comprising contacting the neurolysin with an amount of a histidine-containing dipeptide that is an allosteric that increase...  
WO/2020/181393A1
Various embodiments are described herein for the fabrication enzyme degradable hydrogels useful as payload delivery systems. More particularly, embodiments disclosed herein relate to enzyme-degradable hydrogel systems comprising a crossl...  
WO/2020/172218A1
The subject invention provides a composition comprising an enomomer which comprises a) a carrier molecule, and b) at least one aptamer, wherein the carrier molecule is an antibody, an antigen-binding moiety, a serum protein, an intracell...  
WO/2020/172590A1
The present invention relates generally to methods of generating a biomimetic cell wall (BCW) on a target surface, compositions comprising the BCW, and methods of use of the compositions, including biomedical applications of the BCW coat...  
WO/2020/158691A1
An objective of the present invention is to provide a variant of a hepatocyte growth factor or active fragment thereof capable of lowering liver tropism and selectively expressing bioactivity in target disease tissue other than liver tis...  
WO/2020/158690A1
The purpose of the present invention is to provide a polyethylene glycol-modified form of a hepatocyte growth factor or an active fragment thereof wherein the effect of extending in vivo half life period of polyethylene glycol modificati...  
WO/2020/158835A1
The problem addressed by the present invention is to provide a reagent kit, a measurement kit, and a measurement method for measurement of serum amyloid A that promote dissociation of serum amyloid A from HDL and make it possible to meas...  
WO/2020/153253A1
Provided are porous zirconia particles having high specificity for immobilizing a specific protein. The porous zirconia particles are used for immobilizing protein. In a pore size distribution measured by a BET method, the fine pore diam...  
WO/2020/125743A1
Provided is a human interleukin-2 (IL-2) variant having one or more amino acid mutations or a derivative thereof. The IL-2 variant or derivative thereof has increased stability compared to wild-type IL-2 and improved properties as an imm...  
WO/2020/114358A1
Provided are a specifically binding CD19 antibody or an antigen binding fragment thereof, wherein the antibody binds to a CD19 protein having 3.5μg/mL or lower IC50, and the uses the antibody or the antigen binding fragment thereof in p...  
WO/2020/111028A1
A method in which gold particles are coated with protein, the method being characterized by using either of the following buffering solutions. 1) A buffering solution that has a final salt concentration, excluding MgCl2 and DTT, of great...  
WO/2020/110982A1
The inventors of the present invention found that patients in an at-risk mental state (ARMS) have significantly increased biopyrrin and cortisol, and significantly decreased immunoglobulin κ free light chain (κFLC) and immunoglobulin ...  
WO/2020/109833A1
The present invention relates to a method for immobilizing a peptide, in particular a CD31-mimetic peptide on a substrate surface, in particular a stent surface, allowing a strong anchoring of said peptide onto a polydopamine polymer fun...  
WO/2020/111029A1
A method in which a solution that includes an amphipathic molecule and protein is used to coat gold particles.  
WO/2020/081716A3
The present invention includes a polypeptide for use in a three dimensional (3D) culture system for the growth of cells comprising one or more repeats of a sequence n1-(X1X2GXP)-n2 (SEQ ID NO: 8), wherein X1 and X2 are any amino acids ex...  
WO/2020/105700A1
The present invention provides a technique for improving the sensitivity in an immunological measurement of tau protein. More specifically, the present invention provides: an antibody conjugate comprising at least two anti-tau protein an...  
WO/2020/104440A1
The disclosed technology relates to a method of immobilising a protein on a substrate. The disclosed technology further relates to the substrate comprising the immobilised protein, the use of the substrate in a wound dressing, and the us...  
WO/2020/102609A1
The invention provides compositions and methods for the cytoplasmic delivery of antibodies and other proteins. Specifically, provided herein are compositions having an anionic polypeptide and a cationic transfection agent for facilitatin...  
WO/2020/095985A1
Provided is a method for producing a peptide-nucleic acid complex that contains a peptide and nucleic acid encoding the peptide. The method comprises a step of preparing a nucleic acid containing a first coding sequence that encodes a pe...  
WO/2020/096020A1
The purpose of the present invention is to provide a method for producing a peptide that interacts with a lipid bilayer, and a lipid-bilayer-penetrating peptide obtained through the method. Provided is a lipid-bilayer-penetrating peptide...  
WO/2020/027585A3
The present invention relates to a polypeptide delivery composition, which comprises porous artificial chaperone particles having an average pore diameter of 1-100 nm, so as to make polypeptides become stapled, thereby fixedly changing t...  
WO/2020/082145A1
The present invention relates to polypeptides that have immunogenic activity, which can be used alone or together, having high discriminatory capacity for screening the hepatitis C virus (HCV). The polypeptides according to the invention...  
WO/2020/079979A1
The present invention provides a polymer replica of a target molecule, the polymer replica being capable of accurately inheriting surface information possessed by the target molecule in a molecular imprinting technique. A polymer replica...  
WO/2020/075670A1
The purpose of the present invention is to provide a solid-phase support on which an IgG-binding peptide is immobilized, the peptide being usable for IgG purification, having resistance to repeated washing with an alkaline solution after...  
WO/2020/067418A1
The present invention addresses the problem of providing a method for producing adeno-associated viral capsid protein useful as an antigen for the production of anti-AAV antibodies. The present invention provides a method for producing a...  
WO/2020/061036A1
In some embodiments, methods of detecting an association between a query protein and a target moiety are described. In some embodiments, compositions are described. In some embodiments, kits are described.  
WO/2019/084456A9
Provided herein, in some aspects, are delivery vehicles comprising a glycosphingolipid and an agent to be delivered attached to the glycosphingolipid. In some embodiments, the glycosphingolipid comprises an oligosaccharide and a short ch...  
WO/2020/051331A1
The present invention is directed to methods of screening populations of transgenic cells for cells that produce a protein of interest. The methods comprise culturing transgenic cells in culture conditions that include at least one non-n...  
WO/2020/050205A1
The present invention addresses the problem of providing a gel formation kit that enables regeneration of hyaline cartilage, a gel formed using the gel formation kit, and a gel production method using the gel formation kit. The present i...  
WO/2020/047185A1
The present invention includes a composition and method of allosterically potentiating the activity of neurolysin comprising contacting the neurolysin with an amount of a histidine-containing dipeptide that is an allosteric that increase...  
WO/2020/045477A1
A method for purifying a polypeptide is provided by which undesired polypeptides can be efficiently removed. The method is for purifying a desired polypeptide by subjecting a sample containing the desired polypeptide and undesired polype...  
WO/2020/041876A1
T cells, notably CD8 T cells, are known to be essential players in tumor eradication as the presence of tumor-infiltrating lymphocytes (TILs) in several cancers positively correlates with a good prognosis. To eliminate tumor cells, CD8 T...  
WO/2020/047320A1
Disclosed herein include methods, compositions, and kits suitable for use in detecting the activation level of a signal transducer. In some embodiments, there are provided synthetic protein circuits wherein recruitment of synthetic prote...  
WO/2020/040307A1
Provided is an affinity carrier having improved alkali resistance. This immunoglobulin-binding protein contains a mutant polypeptide chain. This affinity carrier includes a solid-phase carrier to which the immunoglobulin-binding protein ...  
WO/2020/035716A1
The subject matter of the invention is a method for conjugation of free thiol group(s) containing biomolecules, leading to the biomolecular complex formation, comprising a reaction to connect biomolecules using a gold-donor agent in whic...  
WO/2020/036118A1
The present invention addresses the problem of providing a fucose-binding protein which is improved in the productivity when expressed in a host such as Escherichia coli, the binding affinity for a fucose-containing sugar chain such as a...  
WO/2020/032179A1
In order to make it possible to supply differentiated T cells steadily, the present invention provides: a method for the production or expansion culture of a CD3-positive cell in which CD3, which serves as a T cell marker, is expressed o...  
WO/2020/027237A1
The purpose of the present invention is to provide a method for producing, at a low cost, a peptide having specific binding capability that can be used for target molecule purification. Specifically, this peptide fusion protein includes ...  
WO/2020/027585A2
The present invention relates to a polypeptide delivery composition, which comprises porous artificial chaperone particles having an average pore diameter of 1-100 nm, so as to make polypeptides become stapled, thereby fixedly changing t...  
WO/2020/022475A1
A protein that recognizes the drug moiety of an antibody-drug conjugate in which a drug represented by the formula is linked to an antibody via a linker; a method for measuring the concentration of the antibody-drug conjugate in the plas...  
WO/2020/018540A1
An immunogen includes an antigenic EGFRvIII peptide linked to a Qβ bacteriophage virus-like particle (VLP) carrier. The antigenic EGFRvIII peptide has at least 53%, at least 61%, at least 69%, at least 76%, at least 84%, or at least 92%...  
WO/2020/018936A1
The present invention provides systems and methods for concentrating and recovering phosphate from samples. The method comprises using immobilized PBP for binding phosphate and a desorption solution having a pH of 11 or greater to recove...  
WO/2020/004671A1
The present invention addresses the problem of providing a separating agent which does not significantly reduce the dynamic binding capacity (DBC) to a target substance even when CIP treatment is continuously carried out under an alkalin...  
WO/2020/006312A1
Disclosed are compositions and methods for treating cancers characterized by the presence of solid tumors, which simultaneously target a plurality of targets on cancer cells using single CAR T construct.  
WO/2020/004668A1
[Problem] To provide a separating agent with enhanced dynamic binding capacity (DBC) with respect to a target substance. [Solution] Said problem is solved by a separating agent comprising a carrier and a protein, wherein the protein is a...  
WO/2019/244961A1
Provided is an affinity carrier using a mutant VHH antibody. The affinity carrier comprises a solid phase carrier and an immunoglobulin-binding protein bound to the solid phase carrier, wherein the immunoglobulin-binding protein contains...  
WO/2019/241249A1
Clonally derived barcoded cell populations and methods of generating the same, as well as methods of use thereof, e.g., to evaluate heterogeneity of a starting population of cells.  
WO/2019/238074A1
Provided are an LAG-3 antibody having high affinity and high biological activity, and an application thereof. In particular, provided is a new anti-LAG-3 monoclonal antibody. The antibody is capable of binding to an LAG-3 antigen with hi...  
WO/2019/237101A1
Peptide compounds derived from cathepsin G (CG), neutrophil elastase (NE), and cationic antimicrobial protein of 37 kDa (CAP37), and methods of their use in inhibiting and/or reversing polymerization of amyloid β peptide into oligomers ...  

Matches 1 - 50 out of 5,719