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Matches 1 - 50 out of 5,482

Document Document Title
WO/2019/177056A1
This modified protein is characterized by: comprising a protein multimer having an amino acid sequence in which the α1 domain of HLA-G and the α3 domain of HLA-G are linked; and at least one amino acid residue in the amino acid sequenc...  
WO/2019/176860A1
This cell adhesive material is obtained by modifying a substrate surface by using a peptide group comprising a peptide that contains: 40% to 75%, inclusive, of one or more types of basic amino acid residues selected from the group consis...  
WO/2019/166594A1
The invention relates to a hydrogel useful for promoting neurotization, osteogenesis and angiogenesis.  
WO/2019/163919A1
Provided are: an Fc-binding protein having improved stability against acids compared to native-form human FcγRIIa; a production method for the protein; and an antibody-adsorbing agent using the protein. The problem is solved by: an Fc-b...  
WO/2019/161491A1
A device, interface complex, diagnostic system, kit or method for use in binding analyte of interest, wherein immobilizing is on an aluminum oxide surface. An interface molecule is immobilized on the aluminum oxide surface. Attached to t...  
WO/2019/162682A1
The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the mu...  
WO/2019/157597A1
A method of generating cells of the T cell lineage is provided comprising (a) culturing a sample comprising stem cells or progenitor cells with a Notch ligand conjugated to a suspension support and (b) isolating cells of the T cell linea...  
WO/2019/157362A1
Provided herein are in situ generated conformationally constrained peptide arrays, methods for synthesizing such arrays, and methods, systems and assays comprising the use of the synthesized constrained peptide arrays for characterizing ...  
WO/2019/136560A1
The present application discloses biofunctional surfaces that have self-assembled monolayers of fluorine groups with "built-in" functional groups promote targeted cell and biomolecule binding to the surface while reducing non-specific bi...  
WO/2019/088772A3
Provided in the present specification is an ETV2 transcription factor comprising: a polyamide including a DNA binding domain for an ETV2 gene; a nuclear localization signal peptide; and a nanoparticle.  
WO/2019/126308A1
Methods and apparatus for improving expressed human milk (EHM0 shelf-life as well as maintaining or improving EHM taste and smell comprising the utilization of specific lipase inhibitors and antibodies.  
WO/2019/115525A1
The present invention refers to a rigid material composition containing a luminescent protein immobilized therein, a process for preparing it, as well as to a hybrid light emitting-diode comprising a light-emitting diode and a color down...  
WO/2019/118831A1
This invention relates to anti-cannabidiol antibodies and methods of using these antibodies for the detection and quantification of bioactive cannabidiol.  
WO/2019/109822A1
Provided is a type of rhizobium, with the classified nomenclature of Bradyrhizobium sp.KTMS 0001 or Bradyrhizobium sp.KTMS 0002, and the deposit number of CCTCC No: M2017580 or CCTCC No: M2017581. Also provided are a bacterial preparatio...  
WO/2019/103151A1
[Problem] The purpose of the present invention is to provide a novel intracellular delivery means for delivering a nucleic acid to within a cell and thereby causing a desired function to be exhibited more efficiently, namely, for deliver...  
WO/2019/093280A1
The present invention relates to a bundle of highly oriented collagen fibers which has a major-axis-direction length of 1 m or larger.  
WO/2019/092742A1
The present disclosure discloses a process for immobilizing polypeptides on a surface, said method comprising: (a) coating a surface with a molecule to capture biotin tagged polypeptide to obtain a coated surface; and (b) contacting at l...  
WO/2019/084661A1
A method for making metal nanorods comprises combining a source of metal cations with at least one surfactant to form a mixture, wherein the metal cations are reduced and the metal nanorods are produced. Metal nanorods produced by the me...  
WO/2019/083048A1
The present invention relates to an Fc-binding protein exhibiting improved alkaline resistance, a method for producing said protein, an antibody adsorbent obtained by immobilizing said protein on a carrier, and a method for separating an...  
WO/2019/084456A1
Provided herein, in some aspects, are delivery vehicles comprising a glycosphingolipid and an agent to be delivered attached to the glycosphingolipid. In some embodiments, the glycosphingolipid comprises an oligosaccharide and a short ch...  
WO/2019/074523A1
The present disclosure is drawn to a biological fluid, including water, from 0.05 wt% to 3 wt% protein having an acidic isoelectric point (pl) less than about 6.5, and from 0.5 wt% to 20 wt% ionic protein stabilizer system. The ionic pro...  
WO/2019/073992A1
The present invention provides an antibody-modified filter capable of specifically adsorbing or removing a target substance, and a material used in the filter. An antibody-binding surface-modified substrate that includes a substrate-bind...  
WO/2019/028281A3
The present invention provides methods for guiding preservation of human neurons or human nerves during surgery by administering a fluorescently-labeled peptide that specifically binds to the human neurons or human nerves. The invention ...  
WO/2019/068022A1
The present disclosure provides a flow-through electroporation device configured for use as a stand-alone module or as one module in an automated multi-module processing system.  
WO/2019/064297A1
The present invention provides cytotoxic peptides, analogs thereof and fragments thereof, conjugates of said peptides, analogs or fragments as well as compositions comprising same. In addition, uses of these compounds and compositions in...  
WO/2019/054198A1
The present disclosure provides an antibody binding to an intranuclear protein of influenza virus and use of the same. The present disclosure provides an antibody which recognizes a peptide comprising the 205th-231st amino sequence in SE...  
WO/2019/052405A1
Disclosed are a maleimide group-modified angiogenesis inhibitor HM-1 and the use thereof, which fall within the technical field of polypeptide drugs. The selection of a suitable maleimide group to modify the N-terminus of the angiogenesi...  
WO/2019/050283A1
The present invention relates to: a composition comprising cell fate regulatory factor-supported porous silica particles; and a method for regulating cell fate, comprising a step of treating various cells with the same. The present inven...  
WO/2019/046699A1
The invention includes a bioelectronic interface comprising a self-assembling unit, wherein the self-assembling unit comprises a variant GPCR fusion protein bound to an S-layer fusion protein. The invention also encompasses a biosensor o...  
WO/2019/040973A1
A method for the synthesis of a cyclic ornithine-proline-D-cyclohexylalanine-tryptophan- arginine pentapeptide of Formula A; wherein R1 and R2 are, independently, -H, or -C(O)R3 where R3 is -Ch2Ph, - CH2CH2Ph, -CH=CHPh, -C(NHAC)CH2Ph; th...  
WO/2019/041013A1
Disclosed is a hybrid protein that consists of the fusion of: a protein from the TRIM21 family (or only the C-terminal domain PRYSPRY thereof) fused to the enzymes peroxidase, alkaline phosphatase or luciferase (for enzymatic detection) ...  
WO/2019/039777A1
The present invention relates to a porous silica carrier for stabilizing proteins and enzymes, and a production method and use thereof. A silica carrier according to the present invention is harmless to the human body, is based on silica...  
WO/2019/039602A1
Provided is a carrier for affinity chromatography having high immunoglobulin purification efficiency. This protein contains two or more domains linked together by a linker. The domains have affinity to immunoglobulins. The linker is a pe...  
WO/2019/036631A1
The present invention provide novel immunofiber compositions for protein or peptide purification and simple and cost-efficient methods and systems using these compositions. In some embodiments, the immunofibers comprise a customized Z-33...  
WO/2019/032921A1
This application generally relates to the field of methods, systems and compositions for addressing diseases associated with apoptotic cell death, including autoimmune diseases and inflammatory diseases, and more particularly to such met...  
WO/2019/028168A1
Materials and methods for generating protein-polymer conjugates on solid supports are provided herein. The methods can include, for example, reversibly immobilizing a protein on a solid support, modifying the protein by adding polymer su...  
WO/2019/018836A1
Infusion therapy for primary or metastatic tumors includes infusion of fluids that are into supplying blood vessels at concentration and flow rates that kill tumor cells or but don't kill normal cells. The infused fluids can be known tox...  
WO/2019/013148A1
A liganded substrate having at least part of the surface thereof covered by a polymer (P1) containing a structural unit represented by formula (1a) and (1b), a raw material of said liganded substrate, and a production method thereof are ...  
WO/2019/013332A1
A method for inhibiting nonspecific binding to binding proteins that bind to the surface molecules of exosomes and eukaryotic cell membranes is provided which involves immobilizing said binding proteins on a carrier in the presence of ge...  
WO/2018/227261A1
The present invention relates to a method for producing an inorganic nanostructured complex (CFI-1), a protein-associated nanostructured complex (MRB-CFI-1) and antitumour use. The main use is in treating urinary bladder cancer, both in ...  
WO/2018/219108A1
Provided herein are engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. Also provided are polynucleotides encoding engineered polypeptides, host cells ca...  
WO/2018/215503A1
A recombinant protein comprising a functional polypeptide and, linked to the N-terminus of said functional polypeptide, an N-terminal spacerhaving a length such that the number of amino acid residues between a signal peptide cleaving sit...  
WO/2018/213331A1
Methods and compositions are provided for diagnosing of autosomal-dominant polycystic kidney disease (ADPKD), chronic kidney diseases, kidney dysfunction, and preeclampsia in a subject, preferably in a urine sample of a human subject. Th...  
WO/2018/207906A1
The present invention relates to: a protein-peptide fusion body in which a peptide having a function to be adsorbed onto the surface of a substrate is provided on the N-terminal side or the C-terminal side of a protein capable of recogni...  
WO/2018/194134A1
[Problem] To provide: a stabilized anti-periostin antibody-immobilized carrier; a stabilized periostin measurement reagent; and a method for stabilizing an anti-periostin antibody in a carrier having the antibody immobilized thereon. [So...  
WO/2018/193039A1
The present invention relates to a vaccine composition V comprising a peptidic entity A comprising one or more sequence motifs A1 of the sequence RR-X1a-X1b-L (SEQ ID NO: 23) wherein X1a is a hydrophobic amino acid moiety and X1b is a pe...  
WO/2018/190357A1
A purpose of the present invention is to provide a highly sensitive and less expensive lectin-immobilized base material (for example, a lectin plate), said lectin-immobilized base material having stable qualities and being able to be suf...  
WO/2018/180204A1
The purpose of the present invention is to provide: a novel modified protein G which is capable of binding to immunoglobulin and shows a high chemical stability against an alkali solution; an affinity separation matrix comprising the mod...  
WO/2018/180205A1
The purpose of the present invention is to provide: a novel affinity dissociation matrix which has bindability to an immunoglobulin and has excellent chemical stability toward an alkaline solution; and a method for producing an immunoglo...  
WO/2018/151811A3
The invention provides a methods of a disease or disorder in a subject by inducing a TGF alpha immune response. The TGF-alpha immune response is induced using a TGF-alpha polypeptide or biologically active fragment, a vaccine, a genetic ...  

Matches 1 - 50 out of 5,482