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JP4067123B2 |
The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting m...
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JP2008056679A |
To provide a new anti-malignancy polypeptide.Compounds and compositions for eliciting or enhancing immune reactivity to HER-2/neu protein are provided. The compounds include polypeptides and nucleic acid molecules encoding such peptides....
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JP2008056669A |
To obtain an inhibitor against meningococcal infection based on a nonimmune base.The compound can bind to the heptad repeat sequence(s) HR1 and/or HR2 of the NadA adhesin on the surface of a meningococcus, thereby inhibiting the ability ...
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JPWO2005095331A1 |
General formula (I): XYZ (I) [In the formula, X is H2N- or HS-; Y is -A1-, -A1-OA2-,-(CH2CH2O)n-A1-,-(CH2CH2O)n-A1-OA2-, -A1-NH-C (= O) -A2-, -A1-C (= O) -NH-A2-, -A1-(CH2CH2O)n-NH-C (= O) -A2-, -A1-(CH2CH2O)n-C (= O) -NH-A2-Etc .; and Z...
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JP2008504225A |
This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired...
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JP2008024642A |
To provide a new means capable of bonding a cell membrane permeating peptide to a protein in use (in cell introduction).A cell membrane permeating peptide derivative is synthesized by using a compound having the formula(4), a metal is co...
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JP2008500009A |
The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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JP2007534297A |
The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled recepto...
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JP2007529487A |
A process for covalently binding a tagged protein to a polymer particle comprising: contacting a tagged protein with a chelating agent-polymer particle conjugate wherein said tag comprises at least two histidine residues and at least two...
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JP2007526316A |
This invention relates to compositions and methods for treatment of vascular conditions. The invention provides arginine polymers and arginine homopolymers for the treatment and/or prevention of glaucoma, pulmonary hypertension, asthma, ...
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JP3976048B2 |
A sulfenyl compound represented by the general formula: R-S-X (I)(wherein R represents an organic group having at least one constituent element labeled with an isotope, and X represents a leaving group); a labeling reagent comprising it;...
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JP2007525410A |
The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibod...
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JP2007525641A |
The invention provides methods for identification and determination of target-specific sites in peptides and proteins, including a method for determining the primary sequence of a secondary structure within a known parent polypeptide tha...
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JP2007217330A |
To provide a new peptide having FRET (Fluorescent Resonance Energy Transfer) activity and its uses. The peptide having FRET activity comprises a specific amino acid sequence, where, in the molecule, one end is bonded with an energy donor...
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JP2007217376A |
To provide a self-assembly peptide gel having a variety of mechanical characteristics and a novel method for controlling the mechanical characteristics of the gel. A composition comprising a conjugate (A) comprising a compound (a) bonded...
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JP2007204403A |
To provide a highly productive refolding method of a protein by which the highly pure protein can be obtained in mass without requiring large dilution of the protein while keeping the refolding effect higher than that of the conventional...
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JP2007198952A |
To provide a method capable of analyzing easily structure of a protein by mass spectrometric analysis, in mass spectrometry using the protein with a modified group coupled via a thioether group, that is one kind of a protein with lipid s...
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JP3953511B2 |
Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed...
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JP2007519765A |
A conjugate comprising a magnetic polymer particle bound to a carboxymethylated aspartate chelating ligand, optionally chelating a metal ion.
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JP2007148991A |
To predict a disorder area of polypeptide with sufficient reliability.The biological information processor 100 for predicting the disorder area of polypeptide is provided. The biological information processor 100 has: a prediction object...
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JP2007143564A |
To provide a method for increasing the concentration of a nucleic acid encoding gene products having desired activities.The method increases the concentration of the nucleic acid by (a) forming an aqueous microcapsules comprising an aque...
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JP3930559B2 |
A medicinal composition containing a sialic acid derivative as the active ingredient and usable as an antiviral agent, diarrhea remedy, antiulcer agent, antiinflammatory agent, antiallergic agent and bifidus growth accelerator. A process...
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JP3909084B2 |
A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau proteine. The tau protein can be obtained from a brain homogenate, itself isolated fr...
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JP3899760B2 |
To provide a polyamino acid composition excellent in moisture- absorbent and dissipating properties and moreover having swelling properties, which composition can impart a hand (touch) close to that of natural materials to a synthetic re...
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JP2007504279A |
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, certain species of bacteria, including in particular bacteria in which a RAP-type and/or TRAP-type molecule...
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JP2007503810A |
The present disclosure relates to the field of cellular tumorigenesis and cancer biology. More specifically, the present disclosure relates to tumorigenesis and cancer in estrogen-responsive cell types, including cell types such as testi...
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JP2007501948A |
This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, e.g., immunologic, hematologic, vascular, or infectious diseases or conditions, by determining levels of complement pathway c...
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JP2007501866A |
Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastr...
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JP2007006701A |
To provide a new VOPT [ventroptin (a BMP-4 neutralizing factor protein)] binding to BMP-4 belonging to a BMP (bone morphogenetic protein) and inhibiting actions of the BMP-4 and a gene DNA encoding the VOPT and to provide a method, etc.,...
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JP3863965B2 |
To obtain the subject new peptide comprising a yolk low-molecular peptide obtained by hydrolyzing a yolk insoluble protein with a protease and useful for an oral intubation liquid diet, sports drink and a food for nutrient supply as a su...
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JP2006527703A |
Preparation containing synthetic peptide combinations for application to humans or animals, wherein the peptide combinations originate from the partial hydrolysis of tissues from the human organism, wherein the peptide combinations are o...
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JP2006527182A |
A conjugate includes at least one target-seeking unit, which specifically binds to receptors on the surface of endothelial cells, and at least one effector unit which is coupled to the unit by a linker. The effector unit exhibits at leas...
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JP2006526408A |
The invention provides for a polyvalent protein complex (PPC) comprising two polypeptide chains generally arranged laterally to one another. Each polypeptide chain typically comprises 3 or 4 “v-regions”, which comprise amino acid seq...
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JP2006306882A |
To provide a new nucleotide analog exhibiting an antitumor/antineoplastic activity, an antimicrobial activity of a wide spectrum and other desired activities.The invention provides a compound of formula: B-Z-PO(-L1)-L2 wherein -Z- is exe...
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JP2006524183A |
The present invention relates to new peptides for targeting to vascular endothelial growth factor receptor 2, VEGFR-2. The invention further relates to their use in therapeutically effective treatment as well as for diagnostic imaging te...
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JP2006290898A |
To provide a compound of formula I, wherein L1 and L2 are each independently an amino acid or polypeptide residue bound to the phosphorus atom of the compound through an amidate bond, or an oxyester, a thioester, a substituted or un-subs...
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JP3829186B2 |
To provide a method for predicting a site of a polypeptide to be cut by external energy, a method for identifying a peptide fragment acquired by cutting the polypeptide by the external energy, and a method for acquiring a desired peptide...
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JP2006256985A |
To provide a protein inhibiting in vivo calcium salt crystallization and having the activity of promoting such calcium salts in the enteric canal, to provide a method for producing the protein, besides, to provide a calcium salt crystall...
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JP2006520912A |
It is to provide a method and a kit for detecting the prognosis of cancer at high accuracy in a simple and rapid manner at low cost. The method is specifically a method for detecting the prognosis of cancer, at least including a step of ...
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JP2006519004A |
The present invention discloses open reading frame (ORFs) in human genome encoding for novel mucin-like polypeptides, and reagents related thereto including variants, mutants and fragments of said polypeptides, as well as ligands and ant...
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JP3803293B2 |
A method is provided of producing an immunogenic complex comprising a heat shock protein (hsp) coupled to a heterologous antigenic polypeptide, which method comprises: (a) expressing the antigenic polypeptide in a cell which cell has bee...
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JP3800245B2 |
A functional molecule can be introduced extremely rapidly and with superior cost performance by using a method for producing a functional PNA oligomer that comprises synthesizing a PNA oligomer by reacting a PNA monomer unit having a pro...
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JP2002516882A5 |
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JP2006516948A |
The composite containing the レソピ TRON which carried out the covalent bond to polypeptide and the above-mentioned polypeptide. The delivery method of the レソピ TRON to a patient including medicating a patient with the composite ...
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JP2006516947A |
A pharmaceutical composition comprising a polypeptide and an activator bound to said polypeptide.
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JP2006182779A |
To provide a nucleotide analog compound having antiviral activity.A compound represented by formula Ib, its stereoisomer and salt have antiviral activity (wherein, X1 indicates O or S; # indicates a carbon having optical activity; B indi...
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JP2006158400A |
To provide a PNA oligomeric derivative compound having various functions.Disclosed is a PNA monomer having adenine, guanine, cytosine or thymine, or PNA oligomeric derivative compounds directly linked or indirectly linked through a linke...
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JP2006149401A |
To provide a new polypeptide and a nucleic acid encoding the polypeptide.The PRO474 polypeptide comprising a specific sequence, the vector and host cell containing a nucleic acid sequence encoding the polypeptide, the chimera polypeptide...
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JPWO2004063216A1 |
The present invention is a conjugate of a substrate peptide of an enzyme secreted from mammal cells including lipids and humans and a water-soluble polymer, which can be used as a colloidal carrier of a tissue-specific drug delivery syst...
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JP2006137774A |
To provide new polypeptides and nucleic acid molecules encoding polypeptides in relation to identification and isolation of new DNAs and recombinant production of these proteins encoded by the DNAs.The invention relates to PRO531 polypep...
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