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Matches 201 - 250 out of 1,561

Document Document Title
WO/2005/097421A9  
WO/2009/108340A3
Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, insulin resistance, lipodystrophy and hypothalamic amenorrhea, anorexia-related infertility, among other diseases and conditions...  
WO/2009/108695A3
The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a ra...  
WO/2009/117473A3
A structure includes a substrate and a first plurality of bilayers on the substrate. The first plurality of bilayers includes a first layer including an antimicrobial peptide having a charge, and a second layer including a poly electroly...  
WO/2009/158704A2
The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, i...  
WO/2009/149554A1
The bioassay guided isolation and characterization of a novel antimicrobial peptide called myxinidin from an acidic extract of the epidermal mucus of hagfish (Myxine glutinosa L.) is disclosed. Detection of myxinidin in the extract of ex...  
WO/2009/151591A2
Disclosed herein are methods and compositions for generation of Bak- and/or Bax-deficient cell lines using engineered nucleases.  
WO/2009/149339A2
The present invention relates to novel polypeptides that activate p53, and the polynucleotides encoding these p53 activator peptides. The present invention also relates to pharmaceutical compositions comprising the p53 activator peptides...  
WO/2009/108812A3
The present invention relates to methods using cleaning compositions for the reduction of nucleic acid contamination. More particularly, the present invention relates to cationic compositions that bind to, and can remove, extraneous nucl...  
WO/2009/140833A1
A collagen peptide having immunoenhancing activity from Cyanea nozakii and the preparation method thereof are provided. The collagen peptide comprises 80-90 wt.% protein and 10-20 wt.% sugar, whose average molecular weight is ranged from...  
WO/2008/147536A8
This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Uspl4 (human), an...  
WO/2009/133408A2
A composition comprises a biological molecule that is susceptible to aggregation, dimerisation or hydrolysis, wherein the ionic strength is less than 40 mM.  
WO/2007/131218A8
A novel class of embryo derived peptides are described (Preimplantation factor) that were generated synthetically and were tested on peripheral blood immune cells and shown to block activated but not basal immunity, inhibiting cell proli...  
WO/2009/131052A1
Disclosed is a method for improving the filtering properties of a defatted soymilk peptide. Also disclosed is a defatted soymilk peptide having improved filtering properties. The filtering properties of a defatted soymilk peptide can be ...  
WO/2009/127130A1
Provided are an Achyranthes bidentata polypeptide and production methods and uses thereof. The Achyranthes bidentata polypeptide is prepared by adding ammonium sulfate into Achyranthes bidentata water solution, centrifuging the solution,...  
WO/2009/089066A3
The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma i...  
WO/2009/118375A2
Peptide aldehydes or ketone derivatives are particularly efficient for stabilizing subtilisin-type proteases in aqueous compositions such as liquid detergents, including peptide compounds with OH-substituted phenylalanine aldehyde as the...  
WO/2007/126415A3
The invention features methods for identifying compounds that inhibit cell death, and methods for identifying compounds that promote cell death, by blocking or accelerating, respectively, the translocation of the catalytic domain of toxi...  
WO/2009/108252A2
Provided is a method for stimulating in an individual an immune response against M. catarrhalis. The method is performed by administering to an individual a composition that contains at least one isolated M. catarrhalis protein in an amo...  
WO/2009/108812A2
The present invention relates to methods using cleaning compositions for the reduction of nucleic acid contamination. More particularly, the present invention relates to cationic compositions that bind to, and can remove, extraneous nucl...  
WO/2008/140834A3
This invention provides novel antimicrobial peptides that are effective to inhibit growth and/or proliferation of various gram positive bacteria. In particular, the peptides are effective against Streptococcus mutans a common oral pathog...  
WO/2009/075881A3
Methods, compounds, compositions, kits and articles of manufacture comprising one or more gap junction modulating agents for treatment of wounds that do not heal at expected rates, including chronic wounds, delayed healing wounds, incomp...  
WO/2009/089066A2
The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma i...  
WO/2009/079693A1
The present invention relates generally to the field of medicaments in the form of therapeutic molecules including inflammatory modulators and their design and selection. More specifically, the present invention relates to a target site ...  
WO/2009/054873A9
The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RAN...  
WO/2009/075881A2
Methods, compounds, compositions, kits and articles of manufacture comprising one or more gap junction modulating agents for treatment of wounds that do not heal at expected rates, including chronic wounds, delayed healing wounds, incomp...  
WO/2009/075788A1
Synthetic amino acids containing one or more non-fouling groups or moieties are described herein. In one embodiment, the amino acid has the following chemical formula: (I), where L is a linker group and Z is a non-fouling group including...  
WO/2009/076581A1
The present invention provides biomarkers for Alzheimer's disease, as well as methods of using the biomarkers to diagnose Alzheimer's disease, monitor the progression of Alzheimer's disease, monitor the treatment of Alzheimer's disease, ...  
WO/2002/099058A3
Human KCNMA genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that mod...  
WO/2009/070786A2
This invention encompasses compositions and methods for treating and imaging vulnerable plaque and other inflamed regions in a subject.  
WO/2007/008732A3
The invention provides compositions and methods for interfering with Nogo-receptor mediated signaling and mediating axonal growth. The invention also provides methods for treating central nervous system diseases, disorders or injuries.  
WO/2006/126188A3
The present invention provides novel uses for CXCR4 antagonists, including specifically peptides of the T-140 family, in the treatment of skin burns and other injuries. The invention further provides methods for increasing epithelializat...  
WO/2009/046129A3
We have discovered that the activated phosphorylated form of focal adhesion kinase (hereafter "FAKp") strengthens the microvascular endothelial cell (EC) junctions that form a barrier in pulmonary endothelia, and the increased barrier he...  
WO/2009/059379A1
The present invention provides antimicrobial peptides and analogs thereof that are cytostatic or cytotoxic toward at least one gram-negative bacterium of the genus Acinetobacter including laboratory or clinical isolates of A.baumannii wi...  
WO/2009/057281A1
Disclosed is an agent for promoting the differentiation of an osteoblast and inhibiting the differentiation of an osteoclast, which comprises a milk protein fraction having the following chracteristic properties (1) to (4): (1) the milk ...  
WO/2009/057287A1
Disclosed is an agent for inhibiting the formation of an osteoclast, which comprises a milk protein fraction having the characteristic properties (1) to (4) shown below, which has an excellent inhibitory activity on bone resorption, and ...  
WO/2009/057282A1
Disclosed is a milk protein fraction having the characteristic properties (1) to (4) shown below, which has an excellent inhibitory activity on bone resorption and is therefore useful for the prevention or treatment of a bone disease: (1...  
WO/2009/054873A2
The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RAN...  
WO/2009/032978A3
The present invention relates to methods and compositions for treating urinary tract infections. In particular, the present invention relates to vaccines and immune modulators for treating urinary tract infections.  
WO/2007/008848A3
Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The res...  
WO/2006/104778A3
The invention provides a method of determining activity of a protease. The method can include the steps of (a) providing a protease substrate including a protein moiety attached to a nucleic acid moiety and a ligand moiety; (b) contactin...  
WO/2005/035714A3
The present invention provides tumor-associated HLA-restricted antigens, and in particular HLA-A2 restricted antigens, as vaccines for treating or preventing cancers in a patient. In specific aspects, neutrophil elastase peptides other t...  
WO/2008/070672A3
The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The present invention includes specific CpG DNAs from Pseudomonas aeruginosa that are u...  
WO/2008/147426A3
Compositions for immunomodulation that include acylated peptide antigens recognized by CD1c-restricted T cells, and methods of using the compositions, are provided herein.  
WO/2009/043163A1
Paralytic shellfish toxins (PSTs) are the agents of paralytic shellfish poisoning (PSP). a potentially fatal foodborne illness linked to the consumption of PST-contaminated shellfish worldwide. We have isolated bacteria from toxic blue m...  
WO/2008/070666A3
The present invention relates to compositions comprising CpG rich DNA from Pseudomonas aeruginosa. The compositions optionally comprise a cupredoxin. The present invention includes specific CpG DNAs from Pseudomonas aeruginosa that are u...  
WO/2008/143668A3
The nucleotide and amino acid sequences of indoleamine 2, 3-dioxygenase-2 (ID02) and methods of use thereof are provided.  
WO/2009/039413A2
The invention provides methods and compositions for the detection of Ehrlichia chaffeensis.  
WO/2009/026622A1
The present invention relates to a peptide for modulating an immune response, said peptide comprising an amino acid sequence corresponding to at least a portion of one of a Src homology 3 (SH3) domain, a Src homology 2 (SH2) domain, or a...  
WO/2008/024374A3
Disclosed herein are methods for regulation of fat and/or cholesterol uptake from the gastrointestinal tract and/or regulation of plasma fat and/or cholesterol levels comprising administering to a mammal in need thereof an effective amou...  

Matches 201 - 250 out of 1,561