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Matches 201 - 250 out of 1,624

Document Document Title
WO/2010/121125A1
A targeting peptide that specifically binds to an IL13 receptor (e.g., wherein said targeting peptide is not an IL13 fragment) is described. The targeting peptide is optionally conjugated to at least one effector molecule. In some embodi...  
WO/2010/112911A2
The invention relates to an article having a substantially non-cell adhesive surface and comprising on said surface a coating effective to render the article cell adhesive, wherein the coating comprises an oligomer having terminal amine ...  
WO/2010/096418A2
The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.  
WO/2010/081731A2
The present invention relates to syringolin A derivatives, the use of the syringolin A derivatives for prophylaxis and treatment of neurodegenerative diseases and proliferative diseases such as cancer, pharmaceutical compositions contain...  
WO/2010/014236A3
The present invention provides cleavable linker compounds of Formula (I): wherein: X is a cleavable linker comprising an acylhydrazone; and Y and R are each independently selected from the group consisting of covalent coupling groups and...  
WO/2010/054212A1
Hybrid antibodies and antibody binding fragments thereof having decreased immunogenicity and methods of making them are provided. The methods involve replacing one or more amino acid residues within at least one donor framework region of...  
WO/2010/053518A2
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion p...  
WO/2010/048582A1
Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and ...  
WO/2010/045723A1
A peptide-comprising extract derived from fish is described. Also disclosed is a process for obtaining a peptide-comprising extract derived from fish, as well as an extract obtained by this process. Compositions comprising such an extrac...  
WO/2010/039899A2
The invention relates in general to tyrosine dephosphorylation. More specifically, the invention relates to methods and compositions for monitoring intracellular tyrosine dephosphorylation at the single cell level. The invention further ...  
WO/2009/149339A3
The present invention relates to novel polypeptides that activate p53, and the polynucleotides encoding these p53 activator peptides. The present invention also relates to pharmaceutical compositions comprising the p53 activator peptides...  
WO/2009/018500A8
The present invention discloses compositions which induce cross-activation of immune mediated and direct death signaling in targeted cells by exploiting the properties of a antibody/peptide-nucleic acid conjugate. The conjugate is able t...  
WO/2009/118375A3
Peptide aldehydes or ketone derivatives are particularly efficient for stabilizing subtilisin-type proteases in aqueous compositions such as liquid detergents, including peptide compounds with OH-substituted phenylalanine aldehyde as the...  
WO/2010/014236A2
The present invention provides cleavable linker compounds of Formula (I): wherein: X is a cleavable linker comprising an acylhydrazone; and Y and R are each independently selected from the group consisting of covalent coupling groups and...  
WO/2010/011928A1
Various methods for diagnosing and treating heart conditions are disclosed herein. According to one method, nitric oxide is delivered to a patient's lungs when the patient has one or more symptoms of a heart condition. The patient is dia...  
WO/2008/106662A3
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increa...  
WO/2005/097421A9  
WO/2009/108340A3
Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, insulin resistance, lipodystrophy and hypothalamic amenorrhea, anorexia-related infertility, among other diseases and conditions...  
WO/2009/108695A3
The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a ra...  
WO/2009/117473A3
A structure includes a substrate and a first plurality of bilayers on the substrate. The first plurality of bilayers includes a first layer including an antimicrobial peptide having a charge, and a second layer including a poly electroly...  
WO/2009/158704A2
The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, i...  
WO/2009/149554A1
The bioassay guided isolation and characterization of a novel antimicrobial peptide called myxinidin from an acidic extract of the epidermal mucus of hagfish (Myxine glutinosa L.) is disclosed. Detection of myxinidin in the extract of ex...  
WO/2009/151591A2
Disclosed herein are methods and compositions for generation of Bak- and/or Bax-deficient cell lines using engineered nucleases.  
WO/2009/149339A2
The present invention relates to novel polypeptides that activate p53, and the polynucleotides encoding these p53 activator peptides. The present invention also relates to pharmaceutical compositions comprising the p53 activator peptides...  
WO/2009/108812A3
The present invention relates to methods using cleaning compositions for the reduction of nucleic acid contamination. More particularly, the present invention relates to cationic compositions that bind to, and can remove, extraneous nucl...  
WO/2009/140833A1
A collagen peptide having immunoenhancing activity from Cyanea nozakii and the preparation method thereof are provided. The collagen peptide comprises 80-90 wt.% protein and 10-20 wt.% sugar, whose average molecular weight is ranged from...  
WO/2008/147536A8
This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Uspl4 (human), an...  
WO/2009/133408A2
A composition comprises a biological molecule that is susceptible to aggregation, dimerisation or hydrolysis, wherein the ionic strength is less than 40 mM.  
WO/2007/131218A8
A novel class of embryo derived peptides are described (Preimplantation factor) that were generated synthetically and were tested on peripheral blood immune cells and shown to block activated but not basal immunity, inhibiting cell proli...  
WO/2009/131052A1
Disclosed is a method for improving the filtering properties of a defatted soymilk peptide. Also disclosed is a defatted soymilk peptide having improved filtering properties. The filtering properties of a defatted soymilk peptide can be ...  
WO/2009/127130A1
Provided are an Achyranthes bidentata polypeptide and production methods and uses thereof. The Achyranthes bidentata polypeptide is prepared by adding ammonium sulfate into Achyranthes bidentata water solution, centrifuging the solution,...  
WO/2009/089066A3
The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma i...  
WO/2009/118375A2
Peptide aldehydes or ketone derivatives are particularly efficient for stabilizing subtilisin-type proteases in aqueous compositions such as liquid detergents, including peptide compounds with OH-substituted phenylalanine aldehyde as the...  
WO/2007/126415A3
The invention features methods for identifying compounds that inhibit cell death, and methods for identifying compounds that promote cell death, by blocking or accelerating, respectively, the translocation of the catalytic domain of toxi...  
WO/2009/108252A2
Provided is a method for stimulating in an individual an immune response against M. catarrhalis. The method is performed by administering to an individual a composition that contains at least one isolated M. catarrhalis protein in an amo...  
WO/2009/108812A2
The present invention relates to methods using cleaning compositions for the reduction of nucleic acid contamination. More particularly, the present invention relates to cationic compositions that bind to, and can remove, extraneous nucl...  
WO/2008/140834A3
This invention provides novel antimicrobial peptides that are effective to inhibit growth and/or proliferation of various gram positive bacteria. In particular, the peptides are effective against Streptococcus mutans a common oral pathog...  
WO/2009/075881A3
Methods, compounds, compositions, kits and articles of manufacture comprising one or more gap junction modulating agents for treatment of wounds that do not heal at expected rates, including chronic wounds, delayed healing wounds, incomp...  
WO/2009/089066A2
The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma i...  
WO/2009/079693A1
The present invention relates generally to the field of medicaments in the form of therapeutic molecules including inflammatory modulators and their design and selection. More specifically, the present invention relates to a target site ...  
WO/2009/054873A9
The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RAN...  
WO/2009/075881A2
Methods, compounds, compositions, kits and articles of manufacture comprising one or more gap junction modulating agents for treatment of wounds that do not heal at expected rates, including chronic wounds, delayed healing wounds, incomp...  
WO/2009/075788A1
Synthetic amino acids containing one or more non-fouling groups or moieties are described herein. In one embodiment, the amino acid has the following chemical formula: (I), where L is a linker group and Z is a non-fouling group including...  
WO/2009/076581A1
The present invention provides biomarkers for Alzheimer's disease, as well as methods of using the biomarkers to diagnose Alzheimer's disease, monitor the progression of Alzheimer's disease, monitor the treatment of Alzheimer's disease, ...  
WO/2002/099058A3
Human KCNMA genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that mod...  
WO/2009/070786A2
This invention encompasses compositions and methods for treating and imaging vulnerable plaque and other inflamed regions in a subject.  
WO/2007/008732A3
The invention provides compositions and methods for interfering with Nogo-receptor mediated signaling and mediating axonal growth. The invention also provides methods for treating central nervous system diseases, disorders or injuries.  
WO/2006/126188A3
The present invention provides novel uses for CXCR4 antagonists, including specifically peptides of the T-140 family, in the treatment of skin burns and other injuries. The invention further provides methods for increasing epithelializat...  
WO/2009/046129A3
We have discovered that the activated phosphorylated form of focal adhesion kinase (hereafter "FAKp") strengthens the microvascular endothelial cell (EC) junctions that form a barrier in pulmonary endothelia, and the increased barrier he...  
WO/2009/059379A1
The present invention provides antimicrobial peptides and analogs thereof that are cytostatic or cytotoxic toward at least one gram-negative bacterium of the genus Acinetobacter including laboratory or clinical isolates of A.baumannii wi...  

Matches 201 - 250 out of 1,624