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Matches 1 - 50 out of 1,451

Document Document Title
WO/2018/005608A1
In an aspect of the present application, compositions and methods are provided for preventing bone loss and/or stimulating bone healing in a subject in need thereof. Compositions can comprise a pharmaceutically acceptable carrier and a t...  
WO/2017/213158A1
The present invention addresses the problem of providing: a ribosome complex which can be prepared without involving a complicated reaction procedure, and in which a presented polypeptide is modified without impairing the function of a r...  
WO/2017/214076A1
The present invention describes rhomboid protease inhibitors having high specificity and inhibition characteristics providing novel antibiotics, anti-malarial pharmaceutical agents, and provides a strategy for designing RiBns (rhomboid-i...  
WO/2017/185250A1
Provided in the present application is a peptide containing the amino acid sequence YEKLTTLDTGGV (SEQ ID NO:1) or a functional variant thereof, the peptide being an active peptide for treating central nervous system injury. Also provided...  
WO/2017/181979A1
Disclosed is a mussel mucin or applications thereof in inhibiting organ inflammation. Specifically disclosed is the mussel mucin or the applications thereof in treating inflammation of the heart, stomach, intestines, lungs, liver, spleen...  
WO/2017/167870A1
The invention concerns a synthetic compound for enabling transfection of eukaryotic cells by means of an amphiphilic block copolymer which synthetic compound comprises a peptide residue having at least one targeting sequence and a nuclei...  
WO/2017/173356A1
Methods and apparatus for identifying and screening hydrogen bond networks are provided. A computing device can determine a search space for hydrogen bond networks related to one or more molecules, where the search space can include a pl...  
WO/2017/155949A1
The invention features methods and kits use in for preventing and treating vulvovaginal candidiasis (VVC), in particular, recurrent VVC.  
WO/2017/147182A1
Disclosed herein are ActRII antagonists and methods for increasing immune responses and/or activity in patients in need thereof including, for example, cancer patients. In some embodiments, the disclosure relates to methods for treating ...  
WO/2017/124921A1
The present invention provides a walnut oligopeptide powder, and a preparation method and application thereof. The oligopeptide powder has a peptide content of 80 wt% or higher, wherein 95% or more of the peptides have a molecular weight...  
WO/2017/124066A1
Described herein are methods of modifying a peptide with a chemical agent. The peptide may be an amphipathic peptide, such as a melittin-like peptide. The reactants are dissolved in an organic solvent and the reaction is allowed to proce...  
WO/2017/101026A1
Disclosed in the present invention is a composition comprising a mussel adhesive protein and a growth factor. The growth factor is selected from platelet growth factors (platelet derived growth factor, PDGF; osteosarcoma derived growth f...  
WO/2017/100697A1
This disclosure relates to specific nanometer-sized nanoparticles made from unmodified dextran (DNPs), DNP conjugates, and related compositions and methods of use.  
WO/2017/096036A1
The present disclosure is directed to HER2-specific peptide reagents, methods for detecting pre-cancer (dysplasia), early cancer and/or cancer using the peptide reagents, and methods for targeting pre-cancerous (dysplastic) cells, and/or...  
WO/2017/068577A1
A molecular structure comprising a targeting moiety, a multi-functional peptide platform and a plurality of controllably released bioactive agents attached thereto is provided herein.  
WO/2017/070182A1
The inefficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. Previously, it has been demonstrated that superpositively charged proteins are efficiently endocyt...  
WO/2017/046172A1
The invention relates to carbohydrate ligands and moieties, respectively, mimicking glycoepitopes comprised by glycosphingolipids of the nervous system, particularly glycoepitopes comprised by glycosphingolipids of the cerebroside, the g...  
WO/2017/045080A1
Functional three-dimensional constructs incorporating biological materials produced by additive manufacturing techniques are provided. The biological material can be a protein that is incorporated into the three-dimensional construct via...  
WO/2017/037196A1
The present invention provides stable pre-fusion class I fusion protein in the pre-fusion conformation, comprising one or more mutations in the hinge-loop that is present between the base helix and the RR1.  
WO/2017/028025A1
Disclosed is a use of a mussel adhesive protein or a preparation thereof for inhibiting a mucosal inflammation. The mucosal inflammation comprises oral mucositis, rhinitis, otitis media, conjunctivitis, pharyngitis, laryngitis, tracheiti...  
WO/2017/028026A1
Disclosed is a use of a mussel adhesive protein or a preparation thereof for mucosal protection, comprising: protecting mucosa from damage caused by ultraviolet, radiation, a high- and low-temperature object, seawater, environmental poll...  
WO/2017/024292A1
A method of immunizing a subject. The method includes administering to the subject an immunogenic amount of a filament including one or more hybrid flagellin proteins, each hybrid protein including a heterologous polypeptide antigen and ...  
WO/2017/020568A1
Provided are a coupling peptide chain capable of dissolving an indissolvable polypeptide and an application of same in a liquid chromatogram. A hydrophilic polypeptide chain and an indissolvable polypeptide chain are connected by means o...  
WO/2017/014816A1
The invention provides compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the HER3 protein. Such compositions include epitopes of the ...  
WO/2016/205902A2
The present invention relates to a novel composition for use in inhibiting or treating microbial biofilm formation, said composition comprising a plant defensin or a peptide derivative thereof and an antifungal compound, preferably caspo...  
WO/2016/205902A8
The present invention relates to a novel composition for use in inhibiting or treating microbial biofilm formation, said composition comprising a plant defensin or a peptide derivative thereof and an antifungal compound, preferably caspo...  
WO/2016/205902A3
The present invention relates to a novel composition for use in inhibiting or treating microbial biofilm formation, said composition comprising a plant defensin or a peptide derivative thereof and an antifungal compound, preferably caspo...  
WO/2016/210442A1
The invention provides antimicrobial polypeptides (AMPs) with high radial amphiphilicity. Unlike typical AMPs characterized by facial amphiphilicity or biomimetic antimicrobial polymers with randomly distributed charged and hydrophobic g...  
WO/2016/208761A1
[Problem] To provide a drug delivery system that can deliver a drug into a cell expressing a VEGF receptor. [Solution] Provided is a VEGF binding peptide-drug complex which is incorporated into VEGF receptor-expressing cells by VEGF rece...  
WO/2016/190940A1
The present embodiments relate to an FDA- approved injectable multi-dose antigen pulsed dendritic cell (DC) vaccine. In one embodiment, the activated antigen-loaded DC vaccine comprises an initial immunizing dose and multiple "booster"do...  
WO/2016/187157A1
The present invention relates to methods of treating a vascular malformation in a subject expressing a gain-of-function mutation in a PIK3CA gene comprising administering, to the subject, an effective amount of an agent that inhibits pho...  
WO/2016/176649A1
The present, invention provides a process for characterizing a glatiramer acetate related drug substance (GARDS) or a glatiramer acetate related drug product (GARDP) comprising separating a batch of a GARDS or GARDP according to hydropho...  
WO/2016/172855A1
Provided is a high performance liquid chromatography method for polypeptide mixtures. Specifically, the method comprises the following steps of (1) formulating a Glatiramer acetate solution to be tested; (2) subjecting the sample to be t...  
WO/2016/176649A9
The present, invention provides a process for characterizing a glatiramer acetate related drug substance (GARDS) or a glatiramer acetate related drug product (GARDP) comprising separating a batch of a GARDS or GARDP according to hydropho...  
WO/2016/149363A1
Provided herein are compositions and systems comprising contrast-agent (e.g., Gd(III))-labeled peptide amphiphile nanofibers and methods of reporting on biomaterial localization in vivo therewith.  
WO/2016/141269A1
The present disclosure relates to the discovery, production and isolation of novel agents that bind to keratin 17 (K17). The present disclosure is also directed to the use of these novel agents, to identify the presence of K17, and to tr...  
WO/2016/136708A1
This polymer compound has a group represented by general formula (1) or general formula (2) in a side chain. (In formula (1), X1 represents a residue of a neutral amino acid or an ω-aminoalkanoic acid; X2 represents a residue of a membr...  
WO/2016/121840A1
Provided are a cell culture method that makes it possible to control the diameter of aggregated cell masses and to obtain cells in large quantities, cell aggregates obtained by this method, a cell aggregation control agent, and a medium ...  
WO/2016/111935A1
A device useful for collecting a target cell or compound from a composition containing the same is formed from the coupling of a construct having a functional group to a substrate. The construct includes: (a) a functional group for attac...  
WO/2016/057306A1
The present disclosure describes peptide inhibitors of Rho-associtated-kinase (ROCK) and their use in treating disorders including heart failure, the leading cause of combined morbidity and mortality in the United States. An inhibitory p...  
WO/2016/044392A1
This disclosure provides a method for determining male fertility status. The method comprises determining GM1 distribution patterns following induced sperm capacitation, identifying the frequency of distribution of various patterns, and ...  
WO/2016/029131A1
Disintegrin variants that bind specifically to one or more of α5β1 and αv integrins, such as ανβ1, ανβ3, ανβ5, ανβ6 and ανβ8, but with reduced binding activity to αIIbβ3, are described. Also described are uses of the ...  
WO/2016/007856A1
Disclosed herein is a multiple drugs delivery system and its uses in treating diseases. The multiple drugs delivery system includes, an anti-PEG antibody for directing the PEGylated therapeutic to the treatment site; and a hydrogel for r...  
WO/2015/191951A3
The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.  
WO/2015/176035A1
The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of α4β7 to the mucosal addressing cell adhesion molecule (MAdCAM) in vivo.  
WO/2015/144932A1
The present invention relates to enzyme variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; methods of using the variants...  
WO/2015/137883A1
Provided is a method for the conjugation of two or more polypeptides, by incorporating during translation a target lysine residue, or analog thereof, protected by a first protecting group in a first polypeptide, deprotecting said target ...  
WO/2015/050199A2
[Problem] To provide a heretofore completely different and novel peptide synthesis technique, and to provide a novel compound that enables the synthesis/creation of a novel artificial functional protein and the synthesis/creation of a no...  
WO/2015/050199A3
[Problem] To provide a heretofore completely different and novel peptide synthesis technique, and to provide a novel compound that enables the synthesis/creation of a novel artificial functional protein and the synthesis/creation of a no...  
WO/2015/051373A1
Methods are provided for engineering non-naturally occurring proteins comprising artificial pH-sensitive conformational switches that respond to a change in pH by causing a global unfolding of the proteins. Non-naturally occurring protei...  

Matches 1 - 50 out of 1,451