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Matches 1 - 50 out of 17,640

Document Document Title
WO/2020/237375A1
The disclosure pertains to conformational epitopes in oligomeric tau, antibodies thereto and methods of making and using immunogens and antibodies specific thereto. The antibodies bind activity neutralizing sites in tau. Also provided ar...  
WO/2020/235567A1
[Problem] To provide a novel fluorescent probe which can be used in a spray mode, has excellent specificity to sensitivity, also has immediacy, and enables the detection of brain tumor. [Solution] A fluorescent probe for use in the detec...  
WO/2020/236146A1
Embodiments of the present disclosure pertain to methods of selecting cyclic peptides that bind to a target by transforming a phage display library with a plurality of nucleic acids into bacterial host cells, where the nucleic acids incl...  
WO/2020/236808A1
This disclosure relates to processes for preparing compounds that are useful in the treatment of disease, such as cancer, in mammals. In particular, the invention described herein pertains to processes for preparing compounds capable of ...  
WO/2020/230884A1
Provided is a cell culturing scaffold material having excellent adhesiveness for cells. This cell culturing scaffold material contains a peptide-including polyvinyl alcohol derivative that has a polyvinyl alcohol derivative part and a pe...  
WO/2020/229693A1
This invention relates pharmaceutical compositions comprising a protein as the active ingredient together with one or more dipeptides as stabilising agents, and optionally an enzyme inhibitor. The compositions are particularly useful for...  
WO/2020/228097A1
Provided are a cyclic peptide compound simulating a natural product structure, and a method for preparation thereof. The preparation method is: the compound of formula I, a divalent palladium catalyst, and a silver salt undergoing an int...  
WO/2020/230886A1
Provided is a resin film formed of a scaffold material for cell culture, said resin film enabling excellent fixation of cells after seeding and thus contributing to an increase in the cell proliferation rate. The resin film is formed o...  
WO/2020/230885A1
Provided is a cell culturing scaffolding material having excellent extensibility of a pseudopodium and an excellent cell-proliferation property. A cell culturing scaffolding material according to the present invention includes a peptid...  
WO/2020/228642A1
Provided are a crystallization of an SMAC mimic used as an IAP inhibitor and a preparation method thereof; also comprised is the use of said crystallization in the preparation of a drug for treating cancer benefiting from cIAP1 inhibitio...  
WO/2020/227134A1
A method for treating opioid use disorder comprises administering to a subject a pharmaceutical composition comprising a cyclic peptide of Formula I or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier; ...  
WO/2020/227376A1
The present invention generally relates to transplantation rejection. In particular, the present invention provides compositions, kits, assays, and methods of determining if a subject has allograft rejection, or an increased risk of deve...  
WO/2020/227625A1
Systems and methods for treatment of squamous cell carcinoma or other cancer utilizing targeting peptides are described. The targeting peptides interact with SCC cells or other cancerous cells to block or interfere with 14-3-3ε heterodi...  
WO/2020/206447A3
Provided herein are methods of obtaining and applying measurements of metabolites to quantifying maternal risk of having a child with autism spectrum disorder (ASD), with high specificity and sensitivity.  
WO/2020/223403A1
Embodiments provide for compositions and methods concerning lipid modification of Smacs for use in treating cancer.  
WO/2020/223581A1
A poly-N-substituted glycine compound of a formula A-(X-Y-Z)n-B is provided, wherein A is a terminal N-alkyl substituted glycine residue; n is an integer; B is selected from the group consisting of NH2, one and two N-substituted glycine ...  
WO/2020/223730A1
The present disclosure provides a supramolecular (self-assembling) polypeptide complex that comprises a plurality of randomized polyamino acids that self-assemble into nanofibers and methods of making and using same.  
WO/2020/220023A1
The present disclosure relates to compounds according to Formula I. These compounds display very good binding affinities to the PSMA binding sites. They comprise a radioactive isotope or a chelating moiety that can be labeled with a radi...  
WO/2020/215156A1
There are provided compounds of Formula I, and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for inhibition or modulation of the activity of cyclin dependent kinases (CDK) and/or glyc...  
WO/2020/218727A2
The present invention relates to peptides isolated from a protein hydrolysate of Tenebrio molitor mealworm and a composition comprising same as an active ingredient for prevention or treatment of liver injury. According to the present in...  
WO/2020/218450A1
The present invention addresses the problem of providing a novel peptide which can treat, prevent or ameliorate anorexia. The present invention provides a peptide described in any one of the following items (1) to (3). (1) A peptide co...  
WO/2020/216240A1
The present invention belongs to the field of medicine, and specifically discloses a compound of formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and use thereof in the preparation of a me...  
WO/2020/186155A3
A pharmaceutical composition comprising a synthetic neuromodulatory peptide is described. The invention discloses neuromodulatory peptides as defined in the claims and methods of using such molecules for therapeutic application. The neur...  
WO/2020/215034A1
The present disclosure provides a method of preventing and/or treating hepatocellular apoptosis and liver damage in a liver disease, particularly NASH, by targeting the AMPK/caspase-6 axis to inhibit caspase-6 activity and/or activate AM...  
WO/2020/210689A1
Compounds useful as biologically active compounds are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L, L1, L2, M and n are as defined herein. Methods a...  
WO/2020/206000A1
The present technology is directed to compounds, compositions, and methods related to treatment of cancers and viral infections mediated by IAPs, e.g., compounds of Formula I (including Formulas IA, IB, IC, ID, IE, IF, and IG), a stereoi...  
WO/2020/200880A1
A conjugate comprising the following topoisomerase inhibitor derivative (A*): with a linker for connecting to a Ligand Unit, wherein the linker is attached in a cleavable manner to the amino residue. The Ligand Unit is preferably an anti...  
WO/2020/194058A1
The invention relates in various aspects to a salt form S-(N, N-diethylcarbamoyl)glutathione, a method of producing the salt form, a pharmaceutical composition comprising said salt form. The invention also relates to a method of preventi...  
WO/2020/194304A1
A piezoelectric transducer is provided herein, comprising a three-dimensional structure made of a plurality of peptides, the peptides being self-assembling and the structure being piezoelectric, wherein at least a portion, or each, of sa...  
WO/2020/193673A1
The present invention relates to a family of peptides which are able to increase synthesis of homeodomain protein Mohawk and, hence, are useful as anti-aging 5 agents and as rejuvenating agents.  
WO/2020/187721A1
A compound of formula IV: as well as drug-linkers and conjugates comprising this compound, and the use of the conjugates in treating cancer.  
WO/2020/181687A1
A preparation method for and an intermediate of a drug-linker for an antibody drug conjugate MC-MMAF. The reaction activity of the N-terminus is improved, so that the occurrence of a racemic reaction is effectively controlled. The toxin ...  
WO/2020/181688A1
The present invention sets forth a preparation method for a drug-linker MC-MMAF used as an antibody-drug conjugate, and an intermediate thereof. The preparation method of the present invention improves the reactivity of an N-terminal, th...  
WO/2020/178841A1
Self-assembled structures formed of a plurality of cyclic peptides which are in association with metal ions is provided. The cyclic peptides are each of from 2 to 6 amino acid residues, and two or more of the amino acid residues are each...  
WO/2020/172749A1
Provided herein in aspects is an antibacterial combination comprising a thiopeptide antibiotic and an iron inhibitor. Methods of treatment and/or prevention of bacterial infections using the combination are also provided as well as metho...  
WO/2020/175570A1
A brain function regulator that comprises a peptide containing an amino acid sequence represented by Glu-Hyp-Gly, a salt thereof or a chemical modification of the same.  
WO/2020/172072A1
This disclosure relates to glycoengineering, and methods of utilizing glycoengineering for treating various diseases or disorders (e.g., IgE-mediated disorders). The methods include administering to the subject an effective amount of a c...  
WO/2020/172197A1
The present disclosure provides labeling reagents for labeling substrates such as nucleotides, proteins, antibodies, lipids, and cells. The labeling reagents provided herein may comprise fluorescent labels and semi-rigid linkers. Methods...  
WO/2020/170185A1
The present invention provides substantially pure Lanreotide or its salt and preparation thereof. In another aspect present invention provides a method of preparing Lanreotide dmg product which involves measuring D-Allo-Threonine Lanreot...  
WO/2020/166600A1
A compound represented by formula (1) or a salt thereof. [In formula (1), b is an integer of 1-5, X represents -NH- or -CO-, Z represents a group represented by, for example, formula (Z-1), R1 represents a hydrogen atom or (AB)m, AB repr...  
WO/2020/166592A1
A compound or represented by formula (1) or a salt thereof (in the formula, R1 represents a hydrogen atom or a sulfonyl group, and Z represents a group represented by formula (Z-1), etc.).  
WO/2020/132658A3
Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein (e.g., antibody) drug conjugates thereof.  
WO/2020/161683A1
The invention relates to a compound of formula (I) R1 - Wm-Xn-AAi - AA2-AA3-AA4-AA5-AA6- Yp-Zq-Ra, a stereoisomer and/or cosmetically acceptable salt thereof wherein: AA1 is Asp, Gly, Asn, Gln, Ala or no amino acid; AA2 is Val, Ile, Leu ...  
WO/2020/159441A1
The present disclosure relates generally to compounds or a salt, solvate, stereoisomer and prodrug thereof for forming synthetic membrane channels. The present disclosure also relates to methods of synthesizing the compounds, methods of ...  
WO/2020/154679A1
The present invention relates to novel small molecules Formula I and pharmaceutically acceptable salts thereof as well as the preparation and the use thereof to inhibit FGFl3-lb.  
WO/2020/117099A4
The invention relates to the field of biologically active compounds and concerns novel dipeptides of the formula R1-C(O)-X-AA1-Y-AA2-R2, where X=L or D configuration, Y=L or D configuration; АA1 is Trp or Gly; АA2 is Leu or Gly; and...  
WO/2020/145584A1
The present invention relates to a novel serine derivative compound having improved blood-brain barrier (BBB) permeability, and a use of same, and more specifically, to a novel serine derivative compound having further improved BBB perme...  
WO/2020/142825A1
It is provided an achiral, non-nucleosidic backbone for phosphoramidites that can be inserted with high yields in nucleic acid strands and sequence-controlled oligo(phosphodiester)s through solid phase synthesis (SPS) using a DNA synthes...  
WO/2020/132597A8
The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS...  
WO/2020/144294A1
The present application is directed to a sensor for detection and/or concentration determination of metal ions in a fluid comprising a complexing agent suitable for binding the metal ions to be detected, detection means and a linker moie...  

Matches 1 - 50 out of 17,640