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Matches 501 - 550 out of 17,226

Document Document Title
WO/2015/148923A1
The invention provides cell therapy compositions and associated methods. In particular embodiments, improved therapeutic cells and improved cell-based gene therapies for promoting cell or tissue formation, regeneration, repair or mainten...  
WO/2015/140807A1
A reverse-osmosis membrane filter comprising: a porous support layer; a porous skin layer, and at least one water binding composition predominantly bound between the skin layer and the support layer.  
WO/2015/140481A1
Antimicrobial compound, as well as the salts, derivatives and analogues thereof, said compound being represented by the general formula (I): where R1 is a peptide part P1 or a peptide part P2.  
WO/2015/100423A3
Embodiments of the present disclosure are directed to methods to treat a subject having cancer. In one embodiment, a method of treating a subject with cancer may comprise administering a therapeutically effective amount of at least one G...  
WO/2015/137846A1
This invention relates to the field of medicine and concerns a method for the prophylaxis or treatment of diseases caused by RNA- and DNA-containing viruses, and concomitant diseases, which envisages the use of an effective amount of a c...  
WO/2015/138819A1
In some embodiments, a chemical composition may include C60, serrapeptase, or a tetrapeptide. The tetrapeptide may include ALA, GLU, ASP, GLY. In some embodiments, the chemical composition may include a dipeptide. The dipeptide may inclu...  
WO/2015/131355A1
A compound of formula I is an intermediate in a method for preparing a natural product histone deacetylase inhibitor Thailandepsin B. The method comprises the following steps: 1) adding an elemental iodine into a mixed solvent of dichlor...  
WO/2015/106200A3
The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immun...  
WO/2015/095301A3
Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: Formula (I) and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody...  
WO/2015/112558A3
The invention provides populations of isolated peptides useful for the detection of antibodies that bind to Anaplasma antigens. The peptide populations comprise peptides derived from immunogenic fragments of the Anaplasma Outer Membrane ...  
WO/2015/123783A1
Compounds that are cathepsin B substrates and that are useful as imaging probes, for example in positron emission tomography (PET) or fluorescence imaging are described.  
WO/2015/124540A1
The invention provides a blood brain barrier shuttle comprising a brain effector entity and a brain targeting peptide.  
WO/2015/126269A1
The invention relates to a method of synthesis of a biopolymer derivative, preferably a chitosan derivative, comprising the formation of a peptide bond. The invention also relates to the biopolymer derivative, and use of the biopolymer d...  
WO/2015/121769A1
The present invention provides a process for the preparation of methyl N- [(benzyloxy)carbonyl]-L-leucyl-L-phenylalaninate of Formula (II), which can be used as an intermediate for the preparation of carfilzomib.  
WO/2015/117196A1
The invention concerns agents with antibacterial activity, their production and use in the treatment of bacterial infections in animals, including man. The agents are derivatives of vancomycin- type antibiotics, of structure X-W-L-V, whe...  
WO/2015/118546A1
Mucolytic compositions comprising short peptides are provided, and methods for promoting mucus clearance and treating diseases or disorders where mucus is accumulated or disturbing breathing.  
WO/2015/113481A1
Disclosed are oligopeptide molecules, preparation methods therefor and uses thereof. Said oligopeptides comprise CD1、CD2、CD3、CD4、CD5、CD6、CD7、CD8、CD9、CD10 CD11、CD12、CD13 and CD14. The amino acid sequences are show...  
WO/2015/116806A1
Provided are pro-substrates useful in assays of living cells. The pro-substrates can be used to detect the presence or absence of enzymes, such as luciferase, in living cells. The pro-substrates can be coelenterazine derivatives or analo...  
WO/2015/113760A1
The present invention provides one or more compounds of formula (I) for conjugation to small molecules, polymers, peptides, proteins, antibodies, antibody fragments etc.  
WO/2015/107170A1
The present invention relates to the field of molecular biochemistry and medicine, and in particular to ligands comprising modified amino acid residues, targeting the amyloid-β peptide associated with Alzheimer's disease for prevention ...  
WO/2015/096725A1
Provided are a linear lipopeptide with an end group having a lipophilic structure, a preparation method for the lipopeptide, and a use thereof in preparing an anti-radiation injury medicament. The lipopeptide is one lipophilic structural...  
WO/2015/100145A1
The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic...  
WO/2015/100144A1
Crystalline forms of the anti-HCV compound (1R,5S,8S,9S,10R,22aR )-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcy clopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difl uoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,...  
WO/2015/094111A1
The embodiments relate to surface-binding peptides having the capability of binding to surfaces of biocompatible materials and can thereby be used to immobilize various heterologous molecules of interest onto the surface. This means that...  
WO/2013/188676A3
The present invention relates to compositions and methods for the inhibition of edema, including, but not limited to, edema associated with ischemic injury in the CNS. For example, in certain embodiments, the instant invention relates to...  
WO/2013/101724A3
The present disclosure pertains to compositions and methods related to intracellular inhibition of the virulence factors Toxin A and Toxin B produced by the pathogenic bacterium Clostridium difficile.  
WO/2015/083816A1
 Provided is a new NK3 receptor selective ligand which is expected to have high activity and high selectivity, and to act in a sustained manner in vivo. A compound expressed by formula (I) X1 - A2 - A3 - X4 - X5 - Met - NH2 [the symb...  
WO/2015/080671A1
The present invention relates to the use of peptides, peptoids and/or peptidomimetics capable of self-assembling and forming a (nanofibrous) hydrogel in biofabrication. The present invention further relates to methods for preparing hydro...  
WO/2015/080670A1
The present invention relates to hydrophobic peptides and/or peptidomimetics capable of forming a (nanofibrous) hydrogel and hydrogels comprising said hydrophobic peptides and/or peptidomimetics and to various uses, such as in regenerati...  
WO/2015/050199A3
[Problem] To provide a heretofore completely different and novel peptide synthesis technique, and to provide a novel compound that enables the synthesis/creation of a novel artificial functional protein and the synthesis/creation of a no...  
WO/2015/077763A1
The present invention provides a novel class of medicament based on CXCR antagonistic peptides. Among other things, the present invention provides peptides, compositions and methods for treating diseases, disorders and conditions in whic...  
WO/2015/043729A3
The invention relates to an improved cell-free protein synthesis method using a eukaryotic cell lysate in the presence of a caspase inhibitor, to a device for carrying out said method, and to the use of a caspase inhibitor for increasing...  
WO/2014/160037A3
Activatable and detectable membrane-interacting peptides capable of interacting with phospholipid bilayers, such as cell membranes, upon activation. The peptides have the general structure X1a-A-X2-Z-X1b, where A is a membrane-interactin...  
WO/2015/067450A1
The invention relates to a method for producing amines, comprising the following steps: a. reacting a (i) carboxylic acid amide of general formula (I) or (ii) carboxylic acid diamide of general formula (II) or (iii) di-, tri-, or polypep...  
WO/2015/069876A1
IDE-binding probes and assays for the identification of IDE-binding and IDE- inhibiting compounds are provided. Pharmaceutical compositions of macrocyclic IDE inhibitors are also provided, including compositions in which such IDE inhibit...  
WO/2015/067708A1
Disclosed are two crystalline forms of S-acetyl glutathione (SAG) called Form A and Form B, obtained by crystallisation of SAG from mixtures of water-acetone, water-ethanol or water-methanol, preferably acetone, under controlled conditio...  
WO/2015/067493A1
The invention relates to Lysyl-Prolyl- Threonine lyophilized formulations, in particular to L-Lysyl-D-Prolyl-L-Threonine lyophilized formulations, that are stable in storage, and to a process for preparing the lyophilized formulations. M...  
WO/2015/063326A1
The present invention relates to peptidyl phosphonate esters compounds and their use selective inhibitors of proteinase 3, in particular for treating or diagnosing inflammator autoimmune and cancer disorders. More specifically, the inven...  
WO/2015/034710A3
This invention provides biosensors, cell models, and methods of their use for monitoring ionic or voltage responses to contact with bioactive agents. Biosensors can include targeting domains, sensing domains and reporting domains. Biosen...  
WO/2015/060462A1
The present invention is to provide a method for the efficient production on an industrial scale of SS-31 (D-Arg-Dmt-Lys-Phe-NH2), which is an SS peptide. According to the present invention, the desired SS-31 is produced by efficiently s...  
WO/2014/205317A9
Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I), including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1 Y2 and SEQ ...  
WO/2015/056619A1
 Provided is a composition excellent for preventing diabetes, treating diabetes, enhancing insulin sensitivity, improving sugar metabolism, and the like. The invention is an isolated peptide of nine or fewer amino acids including QW (S...  
WO/2014/184596A3
The invention relates to peptides and peptidomimetics useful for reducing the neurotoxicity of amyloid peptide aggregates or prion-like (prionoid) protein aggregates, the invention further relates to pharmaceutical compositions containin...  
WO/2015/050199A2
[Problem] To provide a heretofore completely different and novel peptide synthesis technique, and to provide a novel compound that enables the synthesis/creation of a novel artificial functional protein and the synthesis/creation of a no...  
WO/2014/083578A8
The invention disclosed herein relates to novel solomonamide analogues of formula I having anti-inflammatory activity and viable synthetic route for the preparation thereof.  
WO/2014/140890A3
The invention provides compositions for stimulating the formation of one or more extracellular matrix components that contain a lipoaminoacid derivative of the tripeptide carnosine such as N-Octanoyl Carnosine. Also provided are composit...  
WO/2015/048819A1
Herein are provided, inter alia, methods for treating fibrosis by pharmacological modulation of the alphavbeta 1 integrin. Compositions small molecule inhibitors are presented as one route to test the role of the alphavbeta1, integrin in...  
WO/2015/040235A1
The present invention relates to tripeptide compounds according to the general formula (1) and their use as a medicament, in particular as anti-inflammatory agents.  
WO/2015/041430A1
Provided is a pharmaceutical or cosmetic composition comprising, as an active ingredient, a peptide fragment derived from adiponectin, that is, a peptide selected from the group consisting of peptides comprising amino acid sequences havi...  
WO/2015/036522A1
The present invention refers to processes for preparing (1S,3aR,6aS)-2-[(2Sv)-2-[[(2S)-2- Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dim ethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3 -yl]-3,3a,4,5,6,6a-hexahy...  

Matches 501 - 550 out of 17,226