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Matches 551 - 600 out of 17,226

Document Document Title
WO/2015/036553A1
The invention relates to an immobilized reducing agent suited for reduction of mixed disulfides. The immobilized reducing agent comprises a reactive sulfur group that enables selected reduction of disulfide bonds.  
WO/2015/036927A1
The present invention relates to immunomodulating peptidomimetic derivatives as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also refers to derivatives of the therapeutic ag...  
WO/2015/009678A3
The present invention provides small molecule compounds that can form covalent adducts with specific sequences of RNA, such as the hairpin loop r(CUG)exp sequence which is a cause of myotonic dystrophy type 1 (DM1), or the r(CGG)exp sequ...  
WO/2015/038764A1
Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria using modified dipeptides containing a bioorthogonal tag and applying novel post-labeling methods to label the bioorthogonal tag. The resultant, label...  
WO/2014/193237A3
The invention relates to a peptide comprising the amino acid sequence A/P- A/P-V/P/I/C/T-P as a substrate for the protease CD2830 of Clostridium difficile. The invention further relates to kit or device comprising the peptide for determi...  
WO/2015/032622A1
An improved process for preparing Carfilzomib of Formula 13 is provided, as well as novel compounds that can be used as intermediates in the process for preparing Carfilzomib.  
WO/2015/032621A1
It is provided an improved process for preparing peptide epoxy ketones, including novel compounds that can be used as intermediates in the process for preparing Carfilzomib and other peptide epoxy ketones.  
WO/2015/006728A3
The present invention relates to methods and reagents for use in site-selective modification of proteins having lysine residues with functionalized peptides using a chemoenzymatic microbial transglutaminase-mediated reaction. The functio...  
WO/2014/205317A3
Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I):(I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1 Y2 and S...  
WO/2015/027959A1
The present invention relates to a cyclic peptide compound, and a preparation method, pharmaceutical composition and use thereof. In particular, the cyclic peptide compound of the present invention has a structure as shown by general for...  
WO/2015/026082A1
According to the present invention, a method is provided wherein a basic aqueous phase containing an optically active α-amino acid is brought into contact with an organic phase containing a racemisation catalyst in the form of a copper ...  
WO/2015/026251A1
25 Abstract We disclose novel peptidomimetics with antiangiogenic activity and their uses, particularly in the treatment of neoplasms and chronic inflammation (in particular of: rheumatoid arthritis, colitis), in eczema, diabetes, age-re...  
WO/2015/022854A1
A compound having a structure shown below was discovered. (1) (R1 and R2 are each independently a hydrogen atom or an alkyl group.)  
WO/2015/022930A1
[Problem] To provide a possibility to more efficiently utilize scallop mantle that is a fishery waste. [Solution] A lipid absorption promoter that comprises a decomposition product of scallop mantle proteins as an active ingredient, and ...  
WO/2014/145561A3
The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, condi...  
WO/2015/010436A1
Disclosed is a new Carfilzomib intermediate and a preparation method therefor, and a preparation method for Carfilzomib using the intermediate. The Carfilzomib intermediate provided by the invention is easily separated from the isomers t...  
WO/2014/145524A3
Tolerance inducing peptide (TIP) derived from the amino acid reference locus (AARL) within a FVIII replacement product (FVIIIrp) based on the differences between the expression product of a subject's F8 gene (sFVIII) and the FVIIIrp to p...  
WO/2015/006524A1
There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, su...  
WO/2015/005219A1
[Problem] To provide a dispersion liquid containing: a lipid peptide compound useful as a low-molecular-weight gelling agent such as a lipid dipeptide or a lipid tripeptide; and a solvent that can dissolve the lipid peptide compound more...  
WO/2015/002230A1
The present invention relates to compounds (I), which have RORγt inhibitory effects, and salts thereof. In formula (I), each notation is as described in the Specification. (I)  
WO/2015/000868A1
A compound of formula (I) or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, c...  
WO/2014/209886A1
Described herein are peptide analogs of glucagon-like peptide 1 (GLP-1) that retain agonist activity, but are more resistant to proteolytic degradation than native GLP-1. In the analogs, at least one a-amino acid found in the native GLP-...  
WO/2014/162190A3
This invention is related to medicine and concerns peptides with cytoprotective activity selected from a group that includes Ac-Asp-Glu-OH, H-Asp-Glu-OCH3, H-Asp-Glu-NH - CH2-CH3, H-Val-Asp-Glu-OH, H-Leu-Asp- Glu-OH and H-Ala-Asp-Glu-Arg...  
WO/2014/203224A1
The present invention provides a process for the preparation of telaprevir and its intermediates.  
WO/2014/203208A1
The present invention provides a process for the preparation of telaprevir and intermediates thereof.  
WO/2014/173980A3
The stabilization of subtilisins by peptide aldehydes, hydrosulfite adducts thereof or peptide methyl ketones, is particularly effective in liquid ADW detergents which contain a strong sequestering builder.  
WO/2014/199644A1
The purpose of the present invention is to provide a pharmaceutical composition that is useful for the treatment of diseases that are caused by an increase in bone resorption and that does not cause serious side effects even when used in...  
WO/2014/199780A1
According to the present invention, a peptide compound having an activity of inhibiting dipeptidyl peptidase-IV (DPPIV), said peptide compound being capable of contributing to the prevention of the onset of the pathologic symptom and pro...  
WO/2014/200000A1
Provided are: a diketopiperazine mixture suitable for mixing in food and beverages; and a method for producing same. By means of high-temperature, high-pressure processing of plant-based peptides in a liquid, it is possible to produce a ...  
WO/2014/194809A1
Provided in the present invention are new compounds having the triple activities of thrombolysis, antithrombotic and radical scavenging as represented by general formula (I), wherein T is a connecting arm having at least two groups for c...  
WO/2014/193237A2
The invention relates to a peptide comprising the amino acid sequence A/P- A/P-V/P/I/C/T-P as a substrate for the protease CD2830 of Clostridium difficile. The invention further relates to kit or device comprising the peptide for determi...  
WO/2014/194073A1
Compounds of Formulas I: and shorter variants thereof are described, along with solid supports having such compounds coupled thereto, and the use thereof as affinity ligands for antibodies.  
WO/2014/191392A1
The present invention relates to new cationic amino acids pharmaceutical compositions containing the same and their use for the treatment of bacterial infections.  
WO/2014/190665A1
The present invention provides a method for stabilizing polypeptide as an alpha helical secondary structure. The method comprises the following steps: (1) connecting an amino terminal of polypeptide to an unnatural amino acid, and perfor...  
WO/2014/127155A3
The present invention provides methods of predicting the virulence of Hand Foot and Mouth Disease viruses and outbreaks of said viruses comprising comparing Replikin concentrations in different isolates of virus and identifying relativel...  
WO/2014/191997A1
The present invention discloses self-assembled bioadhesive anti-microbial, anti-fouling and/or anti-oxidant micro- and nano-structures comprising a plurality of amino acids or peptides, wherein each amino acid is an aromatic amino acid c...  
WO/2014/191789A1
The present invention relates to new cationic amino acids pharmaceutical compositions containing the same and their use for the treatment of bacterial infections.  
WO/2014/190533A1
Provided are a ligand having the structure of formula (I) and a complex formed by platinum and the ligand, wherein the ligand is simple in structure, capable of coupling with a variety of reagents, has a low synthesis cost and good targe...  
WO/2014/138429A3
The present invention provides peptidomimetic macrocycles capable of regulating HIF1α and methods of using such macrocycles for the treatment of diseases.  
WO/2014/187271A1
A novel fluorinated HCV NS3/4A serine protease inhibitor, salt thereof, stereoisomer thereof, and preparation method thereof, as shown below in (1), and at least containing as an active ingredient a pharmaceutical formulation of the inhi...  
WO/2014/183214A1
The present disclosure concern fragments of the chondroadherin (CHAD) polypeptide which are generated during the proteolytic cleavage of the third leucine repeat motif of the CHAD polypeptide. Such fragments are generated and thus associ...  
WO/2014/184596A2
The invention relates to peptides and peptidomimetics useful for reducing the neurotoxicity of amyloid peptide aggregates or prion-like (prionoid) protein aggregates, the invention further relates to pharmaceutical compositions containin...  
WO/2014/183018A2
The present disclosure relates to compounds, compositions and methods for the treatment of diseases through inhibiting the activity of the transforming growth factor beta (TGF-β). More specifically, the disclosed compounds, compositions...  
WO/2014/080376A3
The invention is directed to the use of at least one peptide of formula: X –(Xaa1 ) n –Pro* –(Xaa2)m –Y (I) With: -n = 0, 1 or 2; -m =0 or 1and if m = 0 then n ≠ 0 -Xaa is: -An hydrophobic aminoacid selected from Alanine (Ala, ...  
WO/2014/177021A1
The present invention provides a strong secretory signal peptide enhancing small peptide motifs and the use thereof, the small peptide motif having the amino acid sequence of the following formula: M (αΧβΥγ / αΥβΧγ) n, wherein ...  
WO/2014/174060A1
The present invention concerns a compound of following formula (I): where: - R1 is H or OH, - R2 is a (C1-C6)alkyl, COOH, COO-((C1-C6)alkyl) or thiazolyl group, - R3 is H or a (C1-C6)alkyl group, and - R4 is: ■ a straight-chain or bran...  
WO/2014/174517A1
The present invention is directed to synthetic anti-inflammatory peptides and use thereof in the treatment and prevention of inflammatory and fibrotic conditions. Specifically, the invention relates in some embodiments to short isolated ...  
WO/2014/174064A1
The present invention concerns a compound of following formula (I) where: - R1 is H or OH, - R2 is a (C1-C6)alkyl, COOH, COO-((C1-C6)alkyl) or thiazolyl group, - R3 is H or a (C1-C6)alkyl group, and - R4 is an aryl-(C1-C8)alkyl group sub...  
WO/2014/174062A1
The present invention concerns a compound of following formula (I) where: - R1 is H or OH, - R2 is a (C1-C6)alkyl, COOH, COO-((C1-C6)alkyl) or thiazolyl group, - R3 is H or a (C1-C6)alkyl group, and - R4 is: - an aryl-(C1-C8)alkyl group ...  
WO/2014/176360A1
Provided herein are methods for treating an acute axonal injury by intranasally administering to a subject in need thereof an effective amount of a composition that includes a compound having the biological activity of inhibiting the eff...  

Matches 551 - 600 out of 17,226