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Patent Searching and Data


Matches 651 - 700 out of 17,204

Document Document Title
WO/2014/035364A3
Polypeptides are provided, where the polypeptides include one or more groups of formula -R1-C(0)R2, where R1 is an amino acid side chain, R2 is a C8-C24 polyunsaturated alkenyl group, and the polypeptide is a gelatin. The present technol...  
WO/2014/070964A1
Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.  
WO/2014/066936A1
The present invention relates to a supramolecular structure comprising a plurality of peptide foldamer units, where each foldamer unit: (i) independently comprises at least three sequential ß-amino acid residues, one of which is N-acyla...  
WO/2014/071032A1
Hepatitis C virus inhibitors having the general formula (I), are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.  
WO/2014/070974A1
Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.  
WO/2014/070757A1
Described herein are seed treatment compositions comprising one or more glutathiones for enhancing plant growth and methods thereof. Further described are seeds coated with the seed treatment compositions described herein.  
WO/2014/069523A1
A compound represented by formula (I) and a pharmaceutically acceptable salt thereof; and an antibacterial agent which contains the compound or the salt. (In the formula, R1 represents a hydrogen atom, a substituted or unsubstituted alky...  
WO/2012/162547A3
There are provided compounds having two peptide hormones bound to a central water-soluble polymeric spacer and methods of use thereof.  
WO/2014/061034A1
THE PRESENT INVENTION RELATES TO AN IMPROVED PROCESS FOR THE PREPARATION OF (1R,5S)-N-[3-AMINO-1-(CYCLOBUTYLMETHYL)-2,3-DIOXOPROPYL]-3-[ 2(S)-[[[(1,1-DIMETHYLETHYL)AMINO]CARBONYL] AMINO]-3,3-DIMETHYL-1-OXOBUTYL]-6,6-DIMETHYL-3-AZABICYCLO...  
WO/2014/056954A1
The invention is concerned with the compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R3 and R3 are defined in the detailed description and claims. In addition, the present invention relate...  
WO/2014/056748A1
The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein X, R1, R1´, R2, R2´, R3, R4, R4´ and R5 are defined in the detailed description and claims. In addition, the present ...  
WO/2014/055461A1
There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, su...  
WO/2014/055591A1
The present invention provides, among other things, methods and compositions for treating brain conditions. In some embodiments, the methods include administering to a subject suffering from or susceptible to a brain condition an angiote...  
WO/2014/047199A1
The present invention provides a compound having the structure: (Formula (I)) wherein X is a therapeutic agent containing at least one amine nitogen and the amine nitrogen on the therapeutic agent covalently bonds directly to carbon α; ...  
WO/2014/044622A1
Disclosed are compounds of Formula I or pharmaceutically acceptable salts thereof, wherein W, Y, Z, R1, R2, R3, R4 and R5 are described herein, and methods of using said compounds in the treatment of cancer.  
WO/2014/040709A1
The present invention relates to a compound of formula (1) wherein X1 represents O or NR6, X2 represents O or NR6, X3 represents O or NR1, R1 represents H or C1 to C3 alkyl, R2 represents H, or a linear or branched C1 - C8 alkyl optional...  
WO/2013/178682A3
It is described a general process, along with its possible variants, for the production of the compounds Telaprevir (I) and Boceprevir (II).  
WO/2013/184960A3
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor ("FGF") and the C-terminus includes a C-terminal por...  
WO/2013/190509A3
Processes for preparing intermediates of Boceprevir and their use in preparation of Boceprevir or its pharmaceutically acceptable salts are provided.  
WO/2013/181461A3
Compositions comprising peptides that are capable of binding a metal are disclosed. Such compositions can be used for binding metal in a variety of contexts and environments. In various embodiments, peptides are used for antioxidant acti...  
WO/2014/033667A1
Disclosed herein is a process for the preparation of telaprevir wherein (1S,3aR,6a S)-N-[(3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl] octahydrocyclopenta[c]pyrrole-1-carboximide and N-{(2S)-2-cyclohexyl-2-[(pyrazin-2-yl- carbonyl...  
WO/2014/030950A1
The present invention relates to oyster hydrolysate-derived novel peptides having the effects of inhibiting the activity of collagenase, to a pharmaceutical composition comprising the novel peptides as active ingredients for preventing o...  
WO/2014/029022A1
The present application relates to novel fluorinated epoxyketone-based tetrapeptide compounds, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions mediated by protea...  
WO/2014/030977A1
The present invention relates to peptides which are separated from the fractions of oyster enzyme hydrolysate and which exhibit inhibitory activity against angiotensin-converting enzyme (ACE), and to a pharmaceutical composition comprisi...  
WO/2014/030597A1
A compound represented by general formula (I); a method for producing the compound; a microorganism capable of producing the compound; a pharmaceutical composition containing the compound; an anti-tumor agent comprising the pharmaceutica...  
WO/2014/030746A1
An acyl dipeptide derivative represented by formula (1) (in the formula, the acyl group represented by R1-CO- represents a saturated or unsaturated, linear or branched C2-24 acyl group; each of R2 and R3 independently represents a hydrog...  
WO/2014/026282A1
The present application relates to novel fiuorinated epoxyketone-based compounds, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions mediated by proteasome inhibiti...  
WO/2013/040142A3
This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the ep...  
WO/2014/025023A1
Provided is a method for producing a γ-glutamyl-valyl-glycine crystal with high efficiency. Specifically provided is a method for producing a γ-glutamyl-valyl-glycine crystal, which comprises the steps of: preparing a mixed solution of...  
WO/2013/181584A3
The present disclosure pertains to the discovery of a new family of "first in class" small molecular inhibitors of hepatitis B virus (HBV) covalently closed circular (ccc) DNA for use as therapeutics in the management of chronic HBV. Pro...  
WO/2014/021389A1
The purpose of the present invention is to provide a peptide which can inhibit the multidrug efflux transport activity of MATE protein. The present invention provides a peptide which can inhibit the multidrug efflux transport activity of...  
WO/2013/184958A4
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor ("FGF") and the C-terminus includes a C-terminal por...  
WO/2013/184794A3
A method of treating of a mammalian subject suffering from an inflammatory disease or condition by administering a peripherally-restricted kappa opioid receptor agonist for reducing the inflammation is provided. The peripherally-restrict...  
WO/2014/015934A1
The present invention relates to compounds of the formula (I) and especially to medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states...  
WO/2014/018807A1
The present disclosure relates to novel compounds and pharmaceutical compositions thereof which are useful as inhibitors of proteasomes. The compounds provided herein are capable of inhibiting all three of CT-L, T-L, and PGPH activities ...  
WO/2014/013272A1
The present invention concerns rhodamine based fluorescent probes which have use in detecting coagulase-producing bacterial strains. In particular, wherein the bacterial strain is MRSA or MSSA.  
WO/2013/184962A4
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor ("FGF") and the C-terminus includes a C-terminal por...  
WO/2014/009774A1
A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a formula (I), wherein T, L, m, n, Y, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, and R13 are defined herein, can be used for targeted treatme...  
WO/2014/010755A1
The present invention describes novel bacterial L-amino acids α-ligases, which catalyzing reaction of dipeptide formation having an acidic L-amino acid such as L-Asp or L-Glu at the N-terminus. The method for producing dipeptides using ...  
WO/2014/010721A1
The purpose of the present invention is to provide an efficient production method capable of obtaining economically and in large quantities self-assembling peptide derivatives that are useful in the fields of regenerative medicine and su...  
WO/2014/010700A1
The purpose of the present invention is to provide: an amino compound of an amino acid derivative, a peptide or the like, which is produced by derivatizing a glycated protein decomposition product derivative including a final glycation p...  
WO/2013/151467A3
The invention relates to biochemistry and biotechnology and is directed to producing peptides with sex- and sexual-function-stimulating activity of general formula: A-Thr-Lys-Pro-B-C-D-Х, where А is 0, Met, Met(0), Thr, Ala, His, Ph...  
WO/2013/132317A9
The present invention relates to novel peptidomimetic compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also relates to derivatives of the therapeutic agents. The in...  
WO/2014/002571A1
[Problem] To provide a useful dipeptide-containing composition derived from dried bonito flakes and the like, having an angiotensin-converting-enzyme inhibiting activity that imparts a blood pressure reducing function. [Solution] A compo...  
WO/2013/189978A1
The invention relates to a process for preparing β-amino acid derivatives, which process can be used for the preparation of telaprevir or a pharmaceutically acceptable salt or solvate thereof, wherein the process includes an organocatal...  
WO/2013/191926A1
The present invention relates to methods of preparing β-turn cyclic peptidomimetic compounds and intermediates thereof. Particularly, the present invention relates to a process for the synthesis of β-turn cyclic peptidomimetic compound...  
WO/2013/188607A1
A selective method of modifying the N-terminus a protein using an aminoacyl tRNA transferase is provided. The method comprises reacting the protein with the aminoacyl adenosyl derivative, recognizable by AaT t-RNA transferase derived fro...  
WO/2013/185090A1
Provided are compounds of Formula (I) and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.  
WO/2013/184958A1
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor ("FGF") and the C-terminus includes a C-terminal por...  
WO/2013/184962A1
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor ("FGF") and the C-terminus includes a C-terminal por...  

Matches 651 - 700 out of 17,204