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Matches 701 - 750 out of 17,604

Document Document Title
WO/2014/191789A1
The present invention relates to new cationic amino acids pharmaceutical compositions containing the same and their use for the treatment of bacterial infections.  
WO/2014/190533A1
Provided are a ligand having the structure of formula (I) and a complex formed by platinum and the ligand, wherein the ligand is simple in structure, capable of coupling with a variety of reagents, has a low synthesis cost and good targe...  
WO/2014/138429A3
The present invention provides peptidomimetic macrocycles capable of regulating HIF1α and methods of using such macrocycles for the treatment of diseases.  
WO/2014/187271A1
A novel fluorinated HCV NS3/4A serine protease inhibitor, salt thereof, stereoisomer thereof, and preparation method thereof, as shown below in (1), and at least containing as an active ingredient a pharmaceutical formulation of the inhi...  
WO/2014/183214A1
The present disclosure concern fragments of the chondroadherin (CHAD) polypeptide which are generated during the proteolytic cleavage of the third leucine repeat motif of the CHAD polypeptide. Such fragments are generated and thus associ...  
WO/2014/184596A2
The invention relates to peptides and peptidomimetics useful for reducing the neurotoxicity of amyloid peptide aggregates or prion-like (prionoid) protein aggregates, the invention further relates to pharmaceutical compositions containin...  
WO/2014/183018A2
The present disclosure relates to compounds, compositions and methods for the treatment of diseases through inhibiting the activity of the transforming growth factor beta (TGF-β). More specifically, the disclosed compounds, compositions...  
WO/2014/080376A3
The invention is directed to the use of at least one peptide of formula: X –(Xaa1 ) n –Pro* –(Xaa2)m –Y (I) With: -n = 0, 1 or 2; -m =0 or 1and if m = 0 then n ≠ 0 -Xaa is: -An hydrophobic aminoacid selected from Alanine (Ala, ...  
WO/2014/177021A1
The present invention provides a strong secretory signal peptide enhancing small peptide motifs and the use thereof, the small peptide motif having the amino acid sequence of the following formula: M (αΧβΥγ / αΥβΧγ) n, wherein ...  
WO/2014/174060A1
The present invention concerns a compound of following formula (I): where: - R1 is H or OH, - R2 is a (C1-C6)alkyl, COOH, COO-((C1-C6)alkyl) or thiazolyl group, - R3 is H or a (C1-C6)alkyl group, and - R4 is: ■ a straight-chain or bran...  
WO/2014/174517A1
The present invention is directed to synthetic anti-inflammatory peptides and use thereof in the treatment and prevention of inflammatory and fibrotic conditions. Specifically, the invention relates in some embodiments to short isolated ...  
WO/2014/174064A1
The present invention concerns a compound of following formula (I) where: - R1 is H or OH, - R2 is a (C1-C6)alkyl, COOH, COO-((C1-C6)alkyl) or thiazolyl group, - R3 is H or a (C1-C6)alkyl group, and - R4 is an aryl-(C1-C8)alkyl group sub...  
WO/2014/174062A1
The present invention concerns a compound of following formula (I) where: - R1 is H or OH, - R2 is a (C1-C6)alkyl, COOH, COO-((C1-C6)alkyl) or thiazolyl group, - R3 is H or a (C1-C6)alkyl group, and - R4 is: - an aryl-(C1-C8)alkyl group ...  
WO/2014/176360A1
Provided herein are methods for treating an acute axonal injury by intranasally administering to a subject in need thereof an effective amount of a composition that includes a compound having the biological activity of inhibiting the eff...  
WO/2014/175445A1
Provided are a peptide that enables surface treatment of a scaffold for tissue repair that makes it possible to accelerate the repair of living tissue without using a material that negatively affects the repair of living tissue, a comple...  
WO/2014/173980A2
The stabilization of subtilisins by peptide aldehydes, hydrosulfite adducts thereof or peptide methyl ketones, is particularly effective in liquid ADW detergents which contain a strong sequestering builder.  
WO/2014/134203A9
Methods for preparation of novel amphiphilic derivatives of thioether containing block copolypeptides with narrow chain length distributions are described. These block copolymers can be chemically modified by oxidation and alkylation of ...  
WO/2014/170347A1
Compounds of general formula (I): their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, cosmetic and/or pharmaceutical compositions which contain them and their use in medicine, and in the ...  
WO/2014/060942A3
The disclosures herein provide aminoacid derivatives containing therapeutic copolymer of formula I or its pharmaceutical acceptable salts, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These salts may...  
WO/2014/170295A1
Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and A take various meanings, pharmaceutical compositions containing them and their use in medicine, particularly as agents able to potentiate the effect of antifungal drugs.  
WO/2014/169153A1
Compositions comprising peptides with a chemical tag are disclosed. Such compositions can be used to modulate formulation properties of a biomolecule. The peptides are useful as cancer therapeutics and for modulating the physiochemical p...  
WO/2014/076422A9
The invention relates to substituted anionic compounds consisting of a backbone consisting of a discrete number u between 1 and 8 (1 < u < 8) of identical or different saccharide units, bonded by identical or different glycosidic bonds, ...  
WO/2014/161072A1
This application pertains to α-boryl isocyanates, wherein the boronate moiety is in the form of an N-methyliminodiacetic acid (MIDA) boronate of the Formula (2) and the utility of said compounds in the synthesis of the borylamide motif ...  
WO/2014/161863A1
The present invention refers to peptides of general formula (I) and their salts for dermatological and cosmetic use, in particular for preventing or reducing the signs of cutaneous aging and for the treatment of wounds (i.e. burns, lacer...  
WO/2014/153666A1
Indoline Granzyme B inhibitor compounds, compositions that include the compounds, and methods for inhibiting Granzyme B in a subject or for treating a disease, disorder or condition treatable by inhibiting Granzyme B using said compounds...  
WO/2014/157485A1
The present invention addresses the problem of discovering a short chain peptide with an anti-aging effect and providing a novel anti-aging agent containing said peptide as an active ingredient. It was found that peptides, which have at ...  
WO/2014/152674A1
The invention relates to enzyme and protease inhibitor containing water-soluble films, and their use in detergents.  
WO/2014/147124A1
The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly...  
WO/2014/149440A1
An autophagy-inducing compound comprises an autophagy-inducing peptide comprising Beclin 1 peptides immediately N- and C-terminally flanked by moieties R1 and R2, respectively, wherein up to six of said peptide residues may be substitute...  
WO/2014/144004A1
Compositions with antifungal activity and methods of using such compositions are provided herein. In particular the compositions are peptides of SEQ ID NO; I and variations thereof. The peptides may contain L or D amino acids and may be ...  
WO/2014/145507A1
The invention provides a process of preparing 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Compound (I) and pharmaceutically acceptable salts thereof.  
WO/2014/139008A1
A compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or racemic mixture or stereoisomer thereof, and methods for preventing or treating an LDL-cholesterol-related disease or disorder using such compound(s),...  
WO/2014/144087A1
The disclosure provides crystalline Sovaprevir forms. The crystalline forms of Sovaprevir comprise a Form A polymorph, a Form B polymorph, a Form C polymorph, a Form D polymorph, and a Form E polymorph. The Form A, B, C, D, and E polymor...  
WO/2014/137869A1
Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.  
WO/2014/136780A1
[Problem] To provide a novel fluorescent probe for detecting the activity of calpain. [Solution] A compound represented by general formula (I) or a salt thereof.  
WO/2014/134203A1
Methods for preparation of novel amphiphilic derivatives of thioether containing block copolypeptides with narrow chain length distributions are described. These block copolymers can be chemically modified by oxidation and alkylation of ...  
WO/2014/134543A1
The invention described herein pertains to processes for preparing tubulysins and derivatives thereof. The invention described herein also pertains to processes for preparing tubulysin conjugates. The invention described herein also pert...  
WO/2014/132262A1
Compositions comprising self-assembled hydrogel particles formed of short peptides which comprise one or more aromatic amino acid residue(s) in an inverted emulsion are disclosed. Such hydrogel particles which encapsulate an active agent...  
WO/2014/134562A1
The disclosure provides methods of preventing, ameliorating or treating disruption of mitochondrial function and symptoms thereof. The methods provide administering aromatic-cationic peptides in effective amounts to prevent, treat or ame...  
WO/2014/133129A1
A method for manufacturing reduced glutathione using electrolytic reduction of oxidized glutathione involving the use of a cathode tank and an anode tank separated by a separating membrane, wherein the reduced glutathione is manufactured...  
WO/2014/129969A1
This disclosure relates to therapeutic agents comprising polypeptides and peptides that include the amino acid sequence motif arginine-lysine-aspartic acid [RKD] and their use in the treatment of conditions associated with abnormal angio...  
WO/2014/126836A1
Tubulysin compounds of the formula (I) where R1, R2 R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.  
WO/2014/121590A1
Flavonoids compounds of formula (I) or isoflavonoids compounds of formula (II), useful for treatment of HCV diseases, are disclosed. In the compounds, R1 is selected from formula(III), formula(IV) or formula(V); R2, R3, R4, R5 are select...  
WO/2014/121725A1
Provided is a polypeptide, the amino acid sequence of which is SLPQ. The polypeptide is prepared by fermented skimmed milk by Lactobacillus helveticus. The polypeptide can enhance immunity of a body, so also provided are food, health pro...  
WO/2013/049697A9
The present disclosure provides methods of preventing or treating renal ischemia-reperfusion injury in a mammalian subject and methods for chronic treatment of ARVD, including administering an effective amount of an aromatic-cationic pep...  
WO/2014/118779A1
The invention provided herein presents a novel family of antifouling agents based on hydroxylated and fluorinated compounds.  
WO/2014/116187A1
The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, ...  
WO/2014/066936A9
The present invention relates to a supramolecular structure comprising a plurality of peptide foldamer units, where each foldamer unit: (i) independently comprises at least three sequential ß-amino acid residues, one of which is N-acyla...  
WO/2014/102571A1
Novel peptidomimetics exhibiting affinity for opioid receptors, possessing general formula show on Figure 1, for gastrointestinal or peripheral administration in the form of a pill, infusion, injection or implant in the treatment of peri...  
WO/2014/104352A1
Provided is a means for diminishing the reaction interference which antithrombin III causes when used in a limulus test and for thereby enabling the limulus test with the antithrombin III to be carried out with high accuracy. Antithrombi...  

Matches 701 - 750 out of 17,604