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Matches 51 - 100 out of 17,564

Document Document Title
WO/2020/083636A1
The invention relates to a cosmetic composition comprising a low molecular weight silk fibroin and a cosmetically acceptable carrier; wherein said low molecular weight silk fibroin comprises at least 85 parts by weight peptides of molecu...  
WO/2020/082162A1
An adjuvant formulation includes a monophosphoryl Lipid A (MPLA) analogue, a Pam3CSK4 analogue, or a muramyldipeptide (MDP) analogue, or combinations thereof. The adjuvant may be formulated in soluble form or in a nanoparticle, such as p...  
WO/2020/083916A1
The present invention relates to virally expressed peptides with high affinity for the PDZ domains, such as the PDZ domain of PICK1. The invention furthermore relates to the therapeutic use of these peptides in prevention and/or treatmen...  
WO/2020/078933A1
The present invention encompasses compounds of formula (I) wherein the groups R1,A, G, LK and t have the meanings given in the claims and specification, their use as degraders of SMARCA2 and/or SMARCA4, pharmaceutical compositions which ...  
WO/2020/079165A1
The invention provides a compound of formula (I), or a pharmaceutically acceptable salt thereof (Formula I), wherein, each R1-R30 is independently selected from the group consisting of H and deuterium, and at least one of R1-R30 is deute...  
WO/2020/080495A1
The purpose of the present invention is to provide: a carboxylic acid-type lipid which can promote adhesion and coagulation of platelets without carrying a protein or peptide (e.g., GPIb or H12) which is involved in adhesion or coagulati...  
WO/2020/073121A1
The disclosure pertains to conformational epitopes in alpha-synuclein, antibodies thereto and methods of making and using immunogens and antibodies specific thereto. In particular antibodies raised to cyclic compounds comprising at least...  
WO/2020/072428A1
The present disclosure is directed to dipeptide repeat (DPR) peptide immunogen constructs, compositions containing the constructs, antibodies elicited by the constructs, and methods for making and using the constructs and compositions th...  
WO/2020/072580A1
The present invention provides compounds for inhibiting matriptase 2, or a mutant thereof, and compositions and methods of use thereof.  
WO/2020/069442A1
The present disclosure relates to tertiary amino lipidated and/or PEGylated cationic peptide compounds and complexes thereof with nucleic acids for endocellular delivery, methods for preparing the compounds and complexes, and methods for...  
WO/2020/064909A1
The invention relates to a compound of formula (A) wherein n is an integer from 1 to 6, and R1, R1', R2, R2', R3, R3' are cationic or hydrophobic residues.  
WO/2020/067302A1
Provided are: a mucosal adjuvant which is useful for the preparation of a mucosal vaccine having high mucosal immunogenicity and high safety; and a mucosal vaccine composition containing the mucosal adjuvant. A mucosal adjuvant comprisin...  
WO/2020/069176A1
A substrate composition for leukocyte esterases comprising a monoester, said monoester being one of an α-amino acid ester or an α-hydroxy acid ester, with specificity for leukocyte esterases, said monoester having a first moiety for pa...  
WO/2020/058889A1
The present patent application relates to the use of an innovative amino acid derivative of glucosamine having the Formula 1 of the general structure which follows, or of a pharmaceutical composition which contains it as a single active ...  
WO/2020/049286A1
The invention relates to a compound of formula (I): or pharmaceutically acceptable salts, solvates, tautomers, stereoisomers or mixtures thereof; wherein the fused ring moiety is a non-alkylating moiety; and wherein the compounds are use...  
WO/2020/050419A1
The present invention provides a cyclic peptide which has a unit structure selected from among the structures represented by formula (1) -X1-X2-X3-X4-X5-, or a pharmaceutically acceptable salt of the cyclic peptide. (In formula (1), X1 r...  
WO/2020/050427A1
The present invention relates to adiponectin-derived peptide fragments and a composition comprising same and, more specifically, to a cosmetic composition for preventing skin aging or improving skin wrinkles, comprising, as an active ing...  
WO/2020/051564A1
The present disclosure relates to bifunctional compounds, ULM— L—PTM, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A- RAF and/or B-RAF; the target protein). In particular, the present disc...  
WO/2020/045570A1
Provided are: a novel compound that forms a self-assembly; the self-assembly; production methods for the compound and the self-assembly; and pharmaceutical use of the compound and the self-assembly. The compound is represented by formula...  
WO/2020/040670A1
The invention relates to a novel zinc complex of gamma-L-glutamyl histamine with a metal/ligand ratio of 1/1. In particular, the invention relates to a compound of formula (I). The complex according to the invention promotes the recovery...  
WO/2020/041200A1
The present invention relates to solid forms of a substituted benzoxaborole compound, specifically crystalline forms of a compound of formula (I), compositions comprising crystalline forms of the compound of formula (I), and methods of t...  
WO/2020/035027A1
Provided are a linker represented by formula I or I', an antibody-drug conjugate including the same, a use thereof, a pharmaceutical composition including the antibody-drug conjugate, and a use of the antibody-drug conjugate in treating ...  
WO/2020/032622A1
The present invention provides a functional peptide having excellent antioxidant activity, the peptide having excellent biocompatibility and significantly better antioxidant activity than conventional GSHs in order to overcome the limita...  
WO/2020/023851A1
The present disclosure relates to bifunctional compounds, which find utility as modulators of focal adhesion kinase (FAK) or protein tyrosine kinase 2 (PTK2). In particular, the present disclosure is directed to bifunctional compounds, w...  
WO/2020/022892A1
The invention relates to novel means and methods for the synthesis of tubulysin and derivatives thereof, which find their use e.g. as cytotoxic agents in targeted drug delivery. Provided is a method for preparing a tubulysin derivative, ...  
WO/2020/019128A1
Provided are a compound as shown in formula I and the use of the compound in solid-phase synthesis of a polypeptide drug intermediate containing a peptide chain -Ala-Lys(X)- (X being a Glu-fatty alkyl side chain linked to a Lys side chai...  
WO/2020/017984A1
The invention relates to a compound defined by the general formula: ABZ1-Leu2-Glu3-Pro4-Val5-X6, where: ABZ denotes 2-aminobenzoic acid, X denotes ANB-NH2 or pNA, where ANB-NH2 is 5-amino-2-benzoic acid amide, pNA is 4-nitroaniline. The ...  
WO/2020/018455A1
The present disclosure provides novel methods for treating or preventing traumatic optic neuropathy (TON), methods for improving visual function in a subject having TON, methods for promoting retinal ganglion cell (RGC) survival or incre...  
WO/2020/013265A1
The purpose of the present invention is to provide a technology which is for promoting the permeation of drugs through a membrane and which has high versatility and higher safety. Said purpose can be achieved by this polymer compound hav...  
WO/2020/013974A1
The present disclosure relates to synthesis and characterization of novel polymorphic forms of Cyclo (-His-Pro) ("CHP"). The present disclosure provides Cyclo(-His-Pro) hydrate crystalline form ("CHP Hydrate" or "Pattern 2" compound) tha...  
WO/2020/010021A1
Disclosed herein are compounds of formula I: (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, and R3 may any of the values defined herein, as well as compositions comprising such compounds. Also disclosed are methods for...  
WO/2020/009176A1
The present invention aims to provide a compound that: has an excellent cytotoxic action on cancer cells, excellent induction of BET protein degradation in cancer cells, and an excellent binding-inhibiting action on BET protein and acety...  
WO/2019/242010A1
Provided is a compound or a salt thereof as a linking chain. The compound or a salt thereof can be loaded onto a solid-phase resin for solid-phase synthesis of a polypeptide drug, thereby improving the synthetic yield of the polypeptide ...  
WO/2019/243825A1
The present invention relates to conjugates of small molecule modulators of the Stimulator of Interferon Genes (STING) protein.  
WO/2019/239340A1
The invention relates to reduced glutathione in a highly water-soluble solid form, the process for the preparation thereof, and pharmaceutical, nutraceutical or veterinary formulations containing it.  
WO/2019/233281A1
Disclosed in the present invention is a chimeric antigen receptor (CAR), comprising: an antigen binding structural domain (scfv) and a signal transduction structural domain, the signal transduction structural domain comprising a first tr...  
WO/2019/235682A1
The present invention relates to novel tetra-peptides and derivatives thereof, and an anti-red tide or antimicrobial composition comprising same. The novel tetra-peptides and derivatives thereof of the present invention have an excellent...  
WO/2019/234108A1
Methods for the synthesis of arginine-containing peptides are provided. The methods include a deprotection step that minimizes the transfer of by-products deriving from cleaved sulfonyl-5 based side chain protecting groups from arginine ...  
WO/2019/233377A1
Disclosed are a novel self-assembled amino acid supramolecular polymer, a preparation method therefor, and an application thereof. The self-assembled supramolecular polymer is N-lauroyl-L-alanyl-L-alanine or a salt thereof, and the salt ...  
WO/2019/231175A1
The present invention relates to a peptide with amidated carboxy terminus having melanogenesis inhibitory activity and a composition comprising same, and more specifically, to a peptide with amidated (-NH2) carboxy terminus, composed of ...  
WO/2019/230441A1
[Problem] The present invention addresses the problem of developing a photoresponsive cell fixing agent that can be used repeatedly and continuously, and can selectively and reversibly control the fixing and releasing of cells by photost...  
WO/2019/227163A1
The present invention relates to peptides with alternating stereochemistry. In particular, the invention relates to peptides comprising alternating stereochemistry of (LDLD) in the first four amino acid residues. The invention further co...  
WO/2019/230939A1
Provided is a technique which delivers a hydrophilic drug having a large molecular weight, such as a protein, from the skin into the body. This percutaneous absorption preparation containing a hydrophilic drug and an oily base is charact...  
WO/2019/230614A1
The present invention addresses the problem of providing a flavin adenine dinucleotide-dependent glucose dehydrogenase having further improved substrate specificity and/or low-temperature reactivity and having higher practically value. D...  
WO/2019/223630A1
Disclosed is the use of an N-acetylglycylglutamine in animal feed additives, which belongs to the field of feed additives. In particular, disclosed is the use of a glutamine derivative, or a racemate, stereoisomer, geometric isomer, taut...  
WO/2019/224754A1
Peptides, peptidomimetics and small molecules, collectively referred to as "decoy peptides", are provided, which interfere with binding to a TIR domain of a toll-like receptor 4 (TLR4), and inhibit a TLR4-induced signaling pathway. These...  
WO/2019/218881A1
Disclosed is a method utilizing chromatography in purifying the compound of formula (I).  
WO/2019/220406A1
A solid support for use in non-aqueous DNA-conjugated molecule reactions, wherein the support comprises a solid body formed from a plurality of polyethylene glycol units, wherein the solid body includes at least one cationic moiety.  
WO/2019/218904A1
Provided are an unnatural amino acid derivative represented by formula (I) (X being a group which binds to arginase; Y being a linking group; and Z being a group which binds to an E3 ubiquitin-protein ligase), a pharmaceutical compositio...  
WO/2019/168654A3
The present invention provides nucleic acid templates (e.g., including orthogonal codon sets (e.g., codons from orthogonal codon sets depicted in Tables 5 or 7)) for DNA-templated methods of synthesizing, selecting, and amplifying compou...  

Matches 51 - 100 out of 17,564