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Matches 51 - 100 out of 17,204

Document Document Title
WO/2019/119117A1
There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis...  
WO/2019/115812A1
The present invention relates to peptides for the treatment or prevention of nonalcoholic fatty liver disease (NAFLD), non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), hepatic steatosis (fatty liver), liver inflamm...  
WO/2019/118878A1
Disclosed are non-natural peptides useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.  
WO/2019/116071A1
Compounds for treating neurodegenerative disorders The invention relates to compounds of formula (I), their method of synthesis as well as their use to treat neurodegenerative disorders.  
WO/2019/114666A1
The present invention relates to a bioactive conjugate, a preparation method therefor, and use thereof. In particular, the present invention relates to a novel type of bioactive molecular conjugates obtained by improving the coupling of ...  
WO/2019/112630A1
Compositions of foods, vitamin and mineral supplements, topical or oral drugs, and cosmetic products containing a small peptide or peptides for slowing degradation, for example by transition metals. The peptides are di, tri, terra-, and/...  
WO/2019/109188A1
The present application is directed to compounds of Formula (I)-(VI): (I), (II), (III), (IV), (V) (VI), (VII) and (VIII), compositions comprising these compounds and their uses, for example as medicaments and/or diagnostics.  
WO/2019/109934A1
The present invention provides a salt of a phenylpropionamide derivative and a preparation method therefor. The present invention specifically provides an acetate, hydrochloride, phosphate, citrate, benzoate, or fumarate of 4-amino-1-((2...  
WO/2019/108974A1
The present disclosure provides for albumin-binding prodrugs of auristatin E derivatives and uses thereof.  
WO/2019/104851A2
Beta-hydroxybutyryl-amino acid compounds represented by formulas I, II, III, Ⅳ, V, VI, VII, VIII, IX and X, a preparation method therefor and use thereof. The compounds have antitumor activity and can be used for weight loss, anti-agin...  
WO/2019/107057A1
[Problem] The purpose of the present invention is to provide a peptide, etc., that is capable of suppressing muscle atrophy. [Solution] A peptide comprising an amino acid sequence represented by any of SEQ ID NOS: 1-13. A composition hav...  
WO/2019/102397A1
A synthesis method for the production of N-acyl glutathione, comprising an acylation step, during which, in a water solution with a pH ranging from 8 to 10, glutathione is caused to react with an anhydride with formula (RCO)2O with a for...  
WO/2019/104318A1
Solid state forms of Ivosidenib, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof are disclosed.  
WO/2019/096870A1
The invention describes a composition containing a) a functionalized polymer (10) that comprises at least one polymer segment (13) and at least two polymer aggregating segments (11,12) capable of forming non-covalent bonds based on a sup...  
WO/2019/096365A1
The invention describes a composition containing a) a functionalized polymer (10) that comprises at least one polymer segment (13) and at least two polymer aggregating segments (11, 12) capable of forming non-covalent bonds based on a su...  
WO/2019/099481A1
Disclosed are deuterated analogs of SBT-20 and elamipretide (MTP-131). The compounds are useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.  
WO/2019/091472A1
An ultrasound-assisted simulated digestion method of a milk protein active peptide and an application thereof in health foods, pertaining to the technical field of intensive processing of dairy products and preparation of health foods. T...  
WO/2019/067498A3
Provided herein are compounds that form covalent bonds with peptidases, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptida...  
WO/2019/091492A1
Disclosed are a class of SMAC mimetics used as IAP inhibitors, and in particular disclosed are compounds as shown in formula (I), isomers thereof, and pharmaceutically acceptable salts thereof. The IAP inhibitors are drugs for treating c...  
WO/2019/092721A1
Complexes comprising a coordinated Cu(II) ion are described herein, which are capable of binding to an extracellular portion of Ctr1 such that the complex with the Cu(II) ion is transported through the Ctr1. The complexes may comprise a ...  
WO/2019/046937A9
Provided herein are nucleic acid delivery compositions, surfactants, kits comprising said materials, methods and uses thereof, and methods for the preparation thereof. In particular, nucleic acid delivery compositions described herein ma...  
WO/2019/089991A1
Disclosed herein, inter alia, are methods of use and composition of novel inhibitors that target the Smac binding site of a variety of inhibitor of apoptosis proteins that contain a Bir domain, including XIAP, cIAP1, cIAP2, or other IAP ...  
WO/2019/086361A1
The present invention relates to novel tetrapeptides as well as the use thereof as antimicrobial agents.  
WO/2019/084455A1
The present disclosure is concerned with dipeptide analogs that are capable of inhibiting TGF-β and methods of treating cancers such as, for example, multiple myeloma and a hematologic malignancy, methods for immunotherapy, and methods ...  
WO/2019/078349A1
The purpose of the present invention is to provide an adhesion prevention material capable of exhibiting excellent adhesion preventive effect. This adhesion prevention material concurrently uses: (A) a peptide (A-1) having an amino acid ...  
WO/2019/077507A1
The invention relates to an improved method for the solution phase synthesis of Lanreotide acetate (1) comprising coupling of two suitably protected tetrapeptide fragments wherein the threonine hydroxyl is protected, to give an octapepti...  
WO/2019/075583A1
This application relates to compounds of Formula (I-a) or Formula (I-b), or is salts or solvates thereof. R1 is -(CH2)5CH3 or comprises 2-4 fused benzene rings. R2 is I, Br, F, Cl, H, OH, OCH3, NH2, NO2 or CH3. R3 is a peptide-bonded gly...  
WO/2019/045248A3
The present invention relates to a peptide consisting of the amino acid sequence of SEQ ID NO: 1, 2, 3 or 4; a pharmaceutical composition for preventing or treating skin diseases comprising the peptide; a cosmetic composition for improvi...  
WO/2018/053135A9
The present disclosure provides a novel sweetener composition of improved taste of the sweetener (e.g., reduced bitterness and/or astringency, and improved overall sweet quality of the composition); food and beverage products containing ...  
WO/2019/075252A1
The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I'): where the substituents R, R1, R3 R4, R', W, X, Y, Z, k, and m are as defined herein and where the substituents R, R1, ...  
WO/2019/071110A1
Glutamine antagonists and their use for treating oncological, immunological, and neurological diseases are disclosed. Also disclosed are methods for treating an oncological, immunological, infectious or neurological disease or disorder, ...  
WO/2019/063705A1
The present invention relates to a polyplex for use in the treatment of castration resistant prostate cancer (CRPC) comprising a double stranded RNA (dsRNA) and a polymeric conjugate, wherein said polymeric conjugate consists of a linear...  
WO/2019/065774A1
The present invention relates to a compound or the like which can be labeled with a wide variety of atoms, including atoms having a relatively large atomic radius, and which can give a radioactive drug with which accumulation in the kidn...  
WO/2019/058389A1
The present invention provides a novel peptide as potent inhibitor of protein aggregation. A peptide for an inhibition of protein aggregation having the general Formula 1, [XiSACX1]mHHHH[X2X3CGG]m is provided. The m is 0 or 1; Xi is an a...  
WO/2019/058349A1
The present invention relates to a GABAA receptor-binding peptide comprising an amino acid sequence X1‒X2‒X3‒X4‒X5, wherein the amino acid residue X1 is histidine, arginine, threonine, L-cyclohexyl-alanine, 2-flouro-L-phenylalani...  
WO/2019/050564A1
This disclosure provides a peptide conjugate (PC) that can be used for targeted drug delivery, imaging a patient, or diagnosing a subject for a condition associated with overexpression and/or upregulation of CXCR4, including cancers, HIV...  
WO/2019/046937A1
Provided herein are nucleic acid delivery compositions, surfactants, kits comprising said materials, methods and uses thereof, and methods for the preparation thereof. In particular, nucleic acid delivery compositions described herein ma...  
WO/2019/047811A1
Disclosed is the use of a compound of formula (I) as shown below or a pharmaceutically acceptable salt thereof in the preparation of a drug for preventing or treating various immune diseases.  
WO/2019/051322A1
Improved processes for the preparation of tubulysin compounds, tubulysin drug linker compounds, and their intermediates are disclosed.  
WO/2019/049991A1
The present invention addresses the problem of providing a simpler and more efficient hydroxyhydrocarbon production technique using a cytochrome P450 monooxygenase decoy substrate, and provides: a cytochrome P450 monooxygenase decoy subs...  
WO/2019/041361A1
A compound of Formula (I), pharmaceutically acceptable salts thereof, and individual enantiomers or diastereomers thereof are disclosed. Compositions and methods useful for treatment or suppression of diseases, developmental delays and s...  
WO/2019/045248A2
The present invention relates to a peptide consisting of the amino acid sequence of SEQ ID NO: 1, 2, 3 or 4; a pharmaceutical composition for preventing or treating skin diseases comprising the peptide; a cosmetic composition for improvi...  
WO/2019/044947A1
Provided are a crystal of the compound represented by formula (1), a method for producing the crystal, and a method for producing an antibody-drug conjugate using said crystal.  
WO/2019/039676A1
Disclosed in the specification are a peptide having cell receptor binding affinity, a microcapsule having the peptide coupled thereto, and a cosmetic composition containing the same microcapsule. According to an aspect of the present inv...  
WO/2019/039544A1
The present invention provides: a compound having a structure represented by general formula (1) (in the formula, n is 2-100, P represents a (C1-C5) alkylene group substituted with one amino group, Q is general formula (2) (in general fo...  
WO/2018/215831A3
Aspects of the present invention disclose compounds that modulate the aggregation of amyloidogenic proteins or peptides. In some aspects, disclosed compounds modulate the aggregation of disease-associated proteins and natural β-amyloid ...  
WO/2019/033171A1
The present application describes a class of peptides comprising from (2) to (12) amino acid residues, wherein: the N-terminus of the peptide is linked to an optionally substituted, fused polycyclic group comprising an aromatic ring; at ...  
WO/2019/031615A1
Compounds represented by formula (1) or salts thereof. [In the formula, AA represents a specific amino acid residue or a C1–6 alkyl ester thereof, each AA being the same or different and the AAs being linked by an amide linkage when th...  
WO/2019/031614A1
Compounds represented by formula (1-1) or salts thereof. [In the formula, b represents an integer from 1 to 5, and Z is a group represented by formula (Z-1), formula (Z-2), formula (Z-3), formula (Za-1), formula (Za-2), formula (Za-3), f...  
WO/2019/028275A1
Compositions and methods for ameliorating skin laxity associated with body sculpting procedures are provided herein. These compositions preferably comprise two different peptides: a dipeptide, tripeptide, or tetrapeptide in combination w...  

Matches 51 - 100 out of 17,204