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Matches 251 - 300 out of 17,226

Document Document Title
WO/2017/211272A1
The present invention provides a phenyl propanamide derivative as represented by formula (I), a manufacturing method of the derivative, application of the derivative as a κ-opioid receptor (KOR) agonist, and application of the derivativ...  
WO/2017/207546A1
The present invention relates to washing or cleaning compositions, preferably liquid washing compositions, comprising at least one protease, at least one compound of the formula (I) and/or of the formula (II) that acts as a protease inhi...  
WO/2017/209805A1
A variety of hydrophobically modified polypeptoids are provided. The hydrophobically modified polypeptoids can include a polyamide backbone having a random copolymer of two or more different types of repeat units, where one or more of th...  
WO/2017/205392A1
The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein. The invention also provides methods of maki...  
WO/2017/204606A1
The present invention relates to a cytosol-penetrating antibody and a use thereof, and specifically, to a light chain variable region and/or heavy chain variable region positioned in a cytosol, a cytosol-penetrating antibody containing s...  
WO/2017/201624A1
A transdermal formulation which can be applied to the skin as a latex-free hypoallergenic adhesive patch or transdermal delivery cream using a combination of glutathione, Vitamin D, glycol, sodium bicarbonate and base cream resilient in ...  
WO/2017/201433A1
The disclosure provides methods of preventing or treating mitochondrial myopathy in a mammalian subject, reducing risk factors associated with mitochondrial myopathy, and/or reducing the likelihood or severity of mitochondrial myopathy. ...  
WO/2017/197386A1
Methods for diagnosing, treating, and monitoring the treatment of mucormycosis are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having m...  
WO/2017/193562A1
A water soluble rapamycin derivative modified by glutathione and represented by formula I and a preparation method therefor. Definition to R1 and R2 is described in the specification. A compound represented by the formula I can be used f...  
WO/2017/193757A1
Provided are a water-soluble Epothilone derivative represented by formula (I), a preparation method therefor and an intermediate thereof, and an application thereof in preparation of drugs for inhibiting growth of tumor cells.  
WO/2017/197303A1
This disclosure is directed to novel apicidin methods and compositions for the inhibition of quorum sensing in bacterial infections and novel apicidin methods and compositions for treating a staphylococcal infection.  
WO/2017/181437A1
Provided is a non-amino acid method for chemical total synthesis of polypeptides. Said non-amino acid method for chemical total synthesis of polypeptides uses as a raw material ketoamide compounds, which are synthesized into a polypeptid...  
WO/2017/184520A1
Embodiments of the invention include compounds and compositions thereof to inhibit protease activated receptor-4. Also described are methods of preparation of compositions and methods for treating diseases related to thrombotic disorders...  
WO/2017/184670A2
Provided are methods for treating Zika virus infections by administering a compound of Formula I, Formula II, Formula III, or Formula IV, or combinations thereof.  
WO/2017/179838A1
The present invention provides a peptide having anti-inflammatory activity, composed of an amino acid sequence of a sequence listing of SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3. The peptide inhibits the expression of inflammatory cytok...  
WO/2017/178333A1
The present invention discloses retro-inverso peptides and pharmaceutical composition containing them. The peptides of the invention prevent key events occurring during the metastatic process, i.e. invasion of the extracellular matrix, f...  
WO/2017/180064A1
The invention relates to medicine and veterinary applications, in particular, as a means for effective control of acute and/or chronic pain, and may be used in emergency medicine for the treatment of acute and/or chronic pain, including ...  
WO/2017/178950A1
Disclosed herein is an improved 4+4 solution phase synthesis of Lanreotide acetate. The process comprises coupling of two suitably protected tetrapeptide fragments which on deprotection, oxidation, followed by treatment with acetic acid ...  
WO/2017/179647A1
A peptide is provided which has a binding inhibitory function that inhibits binding between amylospheroids (ASPD) and neurons. The polypeptide, represented by expression (I) or (II), is synthesized, isolated or purified. X1X2X3X4 (I) In ...  
WO/2017/175107A1
Disclosed herein is an improved 4+4 solution phase synthesis of octreotide acetate. The process comprises coupling of two suitably protected tetrapeptide fragments which on deprotection, oxidation, and treatment with acetic acid provides...  
WO/2017/176460A2
Neuropeptide S receptor agonists are provided. The NPS agonists include trimeric, tetrameric, pentameric or hexameric peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The peptidomimetic molecule...  
WO/2017/170637A1
The purpose of the present invention is to provide a compound that has at the C-terminus a functional group utilizable for formation of a complex and that exhibits cell toxicity. Provided by the present invention is a peptide derivative ...  
WO/2017/170924A1
The purpose of the present invention is to provide a peptide which has a neuroprotective action, a neuroprotective drug and neuropathic treatment containing said peptide, and a preventive or alleviative pharmaceutical composition. This i...  
WO/2017/160124A2
The present invention relates to a recombinant expression vector for producing a water-soluble norovirus vaccine, and more particularly, to a recombinant expression vector for producing a water-soluble norovirus vaccine, and a method for...  
WO/2017/160118A2
The present invention relates to a novel peptide for improving the expression efficiency of a target protein, and to a fusion protein including same. A novel peptide according to the present invention may improve the expression efficienc...  
WO/2017/161144A1
The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of carbonic anhydrase IX inhibitors as therapeutics and imaging agents. The prese...  
WO/2017/159554A1
The invention provides a crystal of glutathione having excellent flowability and pulverizability, and a method for producing the same. The invention relates to a crystal of reduced-form glutathione, wherein the average crystal thickness ...  
WO/2017/159555A1
The purpose of the invention is to provide: a crystal of reduced-form glutathione in which the content of impurities, particularly L-cysteinyl-L-glycine, is reduced; and a method for producing the same. The invention relates to a crystal...  
WO/2017/157213A1
The present invention relates to a compound represented by formula (I), chemical synthesis preparation of dual-functional conjugates capable of inhibiting tumors and tumor metastasis, and tumor resistance effects. In the present inventio...  
WO/2017/156071A1
The present technology relates to cyclic keto-amide compounds of general formulae I to XXXII, compositions and kits thereof as calpain modulators and methods useful for the treatment of various diseases or disorders such as fibrotic dise...  
WO/2017/156403A1
Disclosed are various crystalline salt forms of D-Arg-Dmt-Lys-Phe-NH2.  
WO/2017/148967A1
The invention provides novel compounds having the general formula (I) wherein wherein R1, R2, R3, R4, R5, R6, R7, R3, R8, R9, R10, R11, R12 and R23 are as described herein, compositions including the compounds and methods of using the co...  
WO/2017/150549A1
The present invention pertains to a compound, etc., from which is obtained a radiolabeled drug capable of reducing accumulation in the kidneys from early administration. [1] A compound, etc., represented by formula (1); [2] a compound, e...  
WO/2017/151886A1
The disclosure provides methods of preventing or treating pulmonary arterial hypertension (PAH) in a mammalian subject, reducing risk factors associated with PAH, and/or reducing the likelihood or severity of PAH. The methods comprise ad...  
WO/2017/150997A1
The subject of the invention is a new compound of the following chemical formula: ABZ1 -Dap(02(Cbz))2-Dap(01 )3-Dap(02)4-Arg5-ANB6-NH2 where: ABZ stands for 2-aminobenzoic acid; DAP stands for diaminopropanoic acid (Dap) derivatives, mod...  
WO/2017/151587A1
The present disclosure relates to compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the invention include aza-peptide aldehyde and ketone ...  
WO/2017/150732A1
It has become clear that if a peptide having a thiol group near an amino group, and having, at the N-terminal, an amino acid residue, which introduced a specific protective group into the thiol group and amino group, undergoes translatio...  
WO/2017/148964A1
The invention provides serine protease HTRA1 inhibiting compounds having the general formula (I) wherein R 2, R 3, R 4, R 5, R 6, R 7, R 3, R 8, R 10, R 11and R 23 are as described herein. These compounds are suitable for the treatment o...  
WO/2017/151617A1
Structurally stabilized, e.g., stapled, peptides with the ability to translocate through microbial cell membranes to the interior of microbial cells and exert a biological activity there are provided, as are methods of designing, making ...  
WO/2017/150327A1
The present invention addresses the problem of providing a food material that is added to food to promote in-brain secretion of neurotrophins including BDNF, and that can endow the food with a brain function improvement function and a cr...  
WO/2017/143449A1
The present invention includes methods and compositions for enhancing the efficacy of SMCs in the treatment of cancer. In particular, the present invention includes methods and compositions for combination therapies that include an SMC a...  
WO/2017/140997A1
The invention relates to a lipid nanoparticle comprising an SDKP peptide conjugate or a biological peptide analog thereof, a method for obtaining said lipid nanoparticle, and the cosmetic use thereof as an anti-wrinkle agent or skin rest...  
WO/2017/142372A1
The present invention relates to an antibody affinity ligand for use in purifying antibodies. In the present invention, it was revealed that an inter-amino acid site between amino acid residues existing at first and second positions towa...  
WO/2017/142254A1
The present invention provides a peptide which shows a hair growth-promoting activity. The peptide of the present invention promotes the growth of follicular cells and increases the expression of a hair growth-related growth factor and h...  
WO/2017/138013A1
In accordance with the present subject matter there is provided a compound of Formula I wherein, R1 is substituted C1 to C10 alkyl; and R2 is substituted C1 to C10 alkyl, a process for preparing a compound of Formula I, and a gel compris...  
WO/2017/132771A1
Formulations for treating burns and burn wound healing comprising a Granzyme B inhibitor and a pharmaceutically acceptable carrier, and methods for treating burns and for burn wound healing using the formulations.  
WO/2017/136348A1
Disclosed is a new process for preparing dipyrrolidine peptide compounds such as, for example, GLYX-13. Advantageously, the process may be industrially scalable and cost-effective and use less toxic reagents and/or solvents. Further, the...  
WO/2017/130148A1
The present disclosure relates to an in vitro method for enhancing engraftment of neurosensory precursor cell comprising the step of contacting an isolated neurosensory precursor cell prior to a transplantation in a subject in need there...  
WO/2017/130884A1
The present invention provides novel technology for improving the storage stability of peptides such as glutathione. The present invention relates to a peptide-containing composition that comprises a peptide and an alkaline mineral carri...  
WO/2017/132395A1
In various embodiments methods and compositions to increase the rate and/or activity of ligation reactions catalyzed by a sortase. In certain embodiments reagents are provided that comprises, inter alia, a polypeptide comprising an amino...  

Matches 251 - 300 out of 17,226