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Patent Searching and Data


Matches 401 - 450 out of 17,592

Document Document Title
WO/2017/140997A1
The invention relates to a lipid nanoparticle comprising an SDKP peptide conjugate or a biological peptide analog thereof, a method for obtaining said lipid nanoparticle, and the cosmetic use thereof as an anti-wrinkle agent or skin rest...  
WO/2017/142372A1
The present invention relates to an antibody affinity ligand for use in purifying antibodies. In the present invention, it was revealed that an inter-amino acid site between amino acid residues existing at first and second positions towa...  
WO/2017/142254A1
The present invention provides a peptide which shows a hair growth-promoting activity. The peptide of the present invention promotes the growth of follicular cells and increases the expression of a hair growth-related growth factor and h...  
WO/2017/138013A1
In accordance with the present subject matter there is provided a compound of Formula I wherein, R1 is substituted C1 to C10 alkyl; and R2 is substituted C1 to C10 alkyl, a process for preparing a compound of Formula I, and a gel compris...  
WO/2017/132771A1
Formulations for treating burns and burn wound healing comprising a Granzyme B inhibitor and a pharmaceutically acceptable carrier, and methods for treating burns and for burn wound healing using the formulations.  
WO/2017/136348A1
Disclosed is a new process for preparing dipyrrolidine peptide compounds such as, for example, GLYX-13. Advantageously, the process may be industrially scalable and cost-effective and use less toxic reagents and/or solvents. Further, the...  
WO/2017/130148A1
The present disclosure relates to an in vitro method for enhancing engraftment of neurosensory precursor cell comprising the step of contacting an isolated neurosensory precursor cell prior to a transplantation in a subject in need there...  
WO/2017/130884A1
The present invention provides novel technology for improving the storage stability of peptides such as glutathione. The present invention relates to a peptide-containing composition that comprises a peptide and an alkaline mineral carri...  
WO/2017/132395A1
In various embodiments methods and compositions to increase the rate and/or activity of ligation reactions catalyzed by a sortase. In certain embodiments reagents are provided that comprises, inter alia, a polypeptide comprising an amino...  
WO/2017/132547A1
Disclosed herein is a personalized immunotherapy composition for a subject having a disease or condition, including therapeutic vaccine delivery vectors and methods of making the same comprising gene expression constructs expressing fram...  
WO/2017/127007A1
The invention discloses a method for the preparation of a peptide by liquid phase coupling of two fragments, an N-terminal fragment and a C-terminal fragment of the desired peptide, wherein the C-terminal fragment is protected on its C-t...  
WO/2017/125933A1
The present invention provides nanoparticle conjugates incorporating the self- assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanosphe...  
WO/2017/123634A1
This invention provides composition and methods to prevent, treat or alleviate a symptom of ulcerative colitis comprising administering to a patient dolcanatide.  
WO/2017/123977A1
Methods of treating osteonecrosis in a subject are provided. In some embodiments, the method comprises administering to a subject having or suspected of having osteonecrosis a pharmaceutical composition comprising a conjugate of an LLP2A...  
WO/2016/205738A3
The present invention provides a compound having the structure of Formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof, for the controlled delivery and release of Agent.  
WO/2017/121649A1
The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-l,3-diaza- spiro-[4.5]-decane derivatives of general formula (I), their preparation and their use in medicine, particularly in the treatment of pain.  
WO/2017/120470A1
The disclosure provides methods of preventing or treating DMD in a mammalian subject, reducing risk factors associated with DMD, and/or reducing the likelihood or severity of DMD. The methods comprise administering to the subject an effe...  
WO/2017/120350A1
This application is directed to compositions comprising of isolated aggregated peptide constructs that are formulated with inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase commonly known as statins as well as methods of trea...  
WO/2017/117684A1
The present invention relates to a SMAC mimetic compound and pharmaceutical compositions thereof, more specifically the present invention is directed to a Compound 1 with a following structure: (I) pharmaceutically acceptable salts there...  
WO/2017/107241A1
Provided in the present invention are a method for preparing a polypeptide of a KPV peptide and an analogue thereof, wherein same are synthesized by a whole solid phase synthesis method, comprising the following steps: 1. using a polymer...  
WO/2017/111215A1
The present invention relates to a composition for improving memory, learning ability and cognition. It has been identified that: a peptide, of the present invention, having a C-terminus ending with GAG, has an effect of improving memory...  
WO/2017/112947A1
Provided herein are compounds that activate CFTR and methods for treating constipation, dry eye disorders or other diseases and disorders.  
WO/2017/104880A1
The present invention provides a lactic acid bacterial strain having antibacterial activity for an antibacterial purpose, wherein lactobacillus plantarum IRWEE-01 produces high levels of various antibacterial, antifungal, and antiviral s...  
WO/2017/097193A1
The present invention provides a method for refining a lisinopril hydride crude product by means of solvent crystallization. The method specifically comprises: adding ketones solvents into a crude product which contains lisinopril hydrid...  
WO/2017/098532A1
The present disclosure provides crystalline carfilzomib form M1 and a process for the preparation thereof. Further disclosed are processes for the preparation of amorphous carfilzomib using crystalline form M1 as a starting material.The ...  
WO/2017/099319A1
The present invention relates to improved peptides for inhibiting angiogenesis, Ac-RLYE and R (D) LYE, and a composition for the prevention and treatment of cancers and diseases related to angiogenesis comprising the peptides as an activ...  
WO/2017/099475A1
The present invention relates to a peptide derivative having two or more amino acids linked to each other, a method for preparing the peptide derivative, and a feed additive and feed composition comprising the peptide derivative. The pep...  
WO/2017/092083A1
Disclosed are a DPP-4 inhibitor compound, a polymer and a preparation method and use. The structure of said compound is X-R1-R2-Y, X and Y respectively being a group formed of a DPP-4 inhibitor or a DPP-4 inhibitor analogue containing an...  
WO/2017/094023A1
In accordance with the present subject matter there is provided a process for separating hydrophobic material from a mixture of hydrophobic and hydrophilic material using peptide-based amphiphilic organogelators.  
WO/2017/093482A1
The present invention relates to a method for increasing the activity and/or the yield of a recombinant vitamin K-dependent protein expressed in cell culture. The present invention further relates to uses and compositions of matter.  
WO/2017/096311A1
Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characte...  
WO/2017/093897A1
Compositions comprising an antioxidant directed or indirectly conjugated to an aromatic-cationic peptide are provide. Said antioxidants are selected from TEMPO, Tro, PBN, AHDP, DBHP, Caf and Hem and may be conjugated to the aromatic-cati...  
WO/2017/096036A1
The present disclosure is directed to HER2-specific peptide reagents, methods for detecting pre-cancer (dysplasia), early cancer and/or cancer using the peptide reagents, and methods for targeting pre-cancerous (dysplastic) cells, and/or...  
WO/2017/085034A1
New gelatinase inhibitors, processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy and/or prophylaxis of conditions wherein inhibition of gelatinases is useful such as epilepsy, schizophreni...  
WO/2017/087034A1
Peptides, topical compositions, and methods of improving health and/or appearance of human integuments, such as keratinous surfaces and fibers are provided. The peptides have from 3-12 amino acid residues and comprise the sequence YNT (S...  
WO/2017/086303A1
The purpose of the present invention is to provide a peptide composition that includes a functional peptide. The present invention provides a peptide composition that includes one or more components selected from the group consisting of:...  
WO/2017/079832A1
The disclosure pertains to C-terminal epitopes identified in A-beta, including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.  
WO/2017/079831A1
The disclosure pertains to N-terminal epitopes identified in A-beta, including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.  
WO/2017/079835A1
The disclosure pertains to epitopes identified in A-beta including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.  
WO/2017/079833A1
The disclosure pertains to conformational epitopes in A-beta, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.  
WO/2017/082620A1
The present invention relates to a peptide thiourea derivative, a pharmaceutically acceptable salt thereof, a radioisotope labeled compound containing the same, and a pharmaceutical composition containing the same as an active ingredient...  
WO/2017/079834A1
The disclosure pertains to epitopes identified in A-beta including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.  
WO/2017/079391A1
The present invention provides compounds of Formula I and Formula II, and related compositions and methods.  
WO/2017/079262A1
The present invention provides compositions and methods for providing controllable local delivery of a conjugate of bortezomib (Btz) and a bisphosphonate to promote bone formation. In certain embodiments, the invention is used as a treat...  
WO/2017/072062A1
The present invention provides compounds of formula (I) wherein X1 to X8 and R1 to R8 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the c...  
WO/2008/076904A9
The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.  
WO/2017/062990A1
A compound comprising formula (I): wherein R1 is an alkylamino group or a group containing at least one aromatic group; R2 and R3 are independently an aliphatic group or hydrophobic group; R4 and R5 are independently H, a substituted or ...  
WO/2017/060533A1
The subject matter of the present invention concerns a novel family of peptide conjugates of formula (I): A-X1-X2-Pro-Ala-X-B in which: - A is a hydrogen atom, a C6 to C20 acyl group or a cholesterol residue; - X1 is a covalent bond, an ...  
WO/2017/058808A1
Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed he...  
WO/2017/054080A1
Compounds of general formula (I) having cytotoxic and/or anti-mitotic activity and methods of using such compounds, as well as pharmaceutical compositions comprising such compounds. The compounds may also be conjugated with a targeting m...  

Matches 401 - 450 out of 17,592