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Patent Searching and Data


Matches 401 - 450 out of 17,226

Document Document Title
WO/2016/164305A1
Provided herein are de novo binding domain containing polypeptides (DBDpp) that specifically bind a target of interest. Nucleic acids encoding the DBDpp, and vectors and host cells containing the nucleic acids are also provided. Librarie...  
WO/2016/162495A1
The present invention provides a nano particle comprising: a core comprising metal atoms; a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprises: at least one carbohydrate li...  
WO/2016/155661A1
Provided is a compound capable of being used to treat diseases caused by cell proliferation and/or angiogenesis or diseases associated with or accompanied by the cell proliferation and/or the angiogenesis.  
WO/2016/159317A1
Provided are a crystal of reduced glutathione, said crystal being stable and easy to process, and a method for producing the same. According to the present invention, a crystal of a reduced glutathione metal salt is produced by suspendin...  
WO/2016/159886A1
The invention relates to cyclic peptides of 3-9 amino acids comprising 2-7 aliphatic and 0-2 polar amino acids that are capable of self-assembling, wherein said aliphatic amino acids are arranged in decreasing hydrophobicity from N- to C...  
WO/2016/154580A1
The instant disclosure is directed to solution phase fragment coupling methods for preparing etelcalcetide and its pharmaceutically acceptable salts.  
WO/2016/144905A1
The present technology provides methods of generating the peptides, and pharmaceutically acceptable salts of the peptides and intermediates thereof. In some embodiments, the peptide is D-Arg-2´6´-Dmt-Lys-Phe-NH2.  
WO/2016/144654A1
The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of u...  
WO/2016/140957A1
The invention described herein pertains to drug delivery conjugates for targeted therapy. The invention described herein relates to methods of treating PSMA expressing cancers with a PSMA ligand-tubulysin compound. The invention describe...  
WO/2016/137004A1
[Problem] To provide a fluorescent probe that highly accurately detects intracellular calpain activity. [Solution] A compound represented by general formula (I) or a salt thereof.  
WO/2016/097957A3
The present invention describes a new peptide aldehyde produced naturally by Streptomyces lividans 66, which we have called livipeptin. Using genome mining of natural products, we predicted that SLl0883-5 genes encode an unprecedented bi...  
WO/2016/130143A2  
WO/2016/127257A1
Disclosed herein are chimeric antigen receptors (CARs) comprising an intracellular segment comprising an interleukin receptor chain, a JAK-binding motif, a Signal Transducer and Activator of Transcription (STAT) 5 association motif and/o...  
WO/2016/123699A1
There is provided herein compounds of formula I, wherein R1 is H or linear or branched C1-C6 lower alkyl; R2 is H, linear or branched C1-C6 lower alkyl, or a proteinogenic amino acid side chain; R3 is H, linear or branched C1-C6 lower al...  
WO/2016/123582A1
Provided herein are hemiasterlin derivatives, conjugates thereof, compositions comprising the derivatives or conjugates thereof, methods of producing the derivatives and conjugates thereof, and methods of using the derivatives, conjugate...  
WO/2016/114341A1
The present invention addresses the problem of providing a compound for removing pluripotent cells from a cell population potentially including pluripotent cells. This problem is solved by bringing a polyphenylalanine derivative into con...  
WO/2016/038040A3
The present invention relates to the use of dipeptidyl ketoamide compounds for preventing accumulation of triglycerides in adipose tissue or for reducing the amount of triglycerides in adipose tissue in a subject in need thereof and to n...  
WO/2016/112293A1
The present disclosure relates to imaging agent formulations, methods for preparing imaging agent formulations and methods for using the same. The present disclosure also relates to kits for imaging agent formulations.  
WO/2014/104974A3
The present invention relates to hydrogels comprising a first peptide with a covalently linked bioactive agent and optionally a second peptide. The present invention further relates to uses of the hydrogel for delivery of the bioactive a...  
WO/2016/097966A1
Tripeptide X-KGH-Z or X-KHG-Z; at the N-terminal end X is selected from H, -CO-R1 and -S02- R1; at the C-terminal end Z is selected from OH, OR1, NH2, NHR1 or NR1R2; R1 and R2 being, independently from each other, selected from an alkyl,...  
WO/2016/097957A2
The present invention describes a new peptide aldehyde produced naturally by Streptomyces lividans 66, which we have called livipeptin. Using genome mining of natural products, we predicted that SLl0883-5 genes encode an unprecedented bi...  
WO/2016/096804A1
Compounds in the family of N-acylamino-amides, compositions comprising them, and uses The present application relates to compounds in the family of N-acylamino-amides having formula (I), compositions, in particular cosmetic compositions ...  
WO/2016/095830A1
Provided is a pentacyclic triterpene-peptide conjugate, and a preparation method, a pharmaceutical composition and a use thereof. The pentacyclic triterpene-peptide conjugate has an antibacterial effect, and in particular has a significa...  
WO/2016/090540A1
The present invention provides a minimal motif peptide of antigen epitope in human papilloma virus (HPV) 18-type cancerigenic E6 and E7 protein. The peptide can be specifically bound with an HPV18-type antibody and can be used in combina...  
WO/2015/080670A9
The present invention relates to hydrophobic peptides and/or peptidomimetics capable of forming a (nanofibrous) hydrogel and hydrogels comprising said hydrophobic peptides and/or peptidomimetics and to various uses, such as in regenerati...  
WO/2016/094316A1
Compounds for treating reward deficiency syndrome (RDS) behaviors and methods of use and administration of such compounds to induce dopamine homeostasis. These compounds synergistically combine two or more of (a) DP A, (b) NAC, and (c) k...  
WO/2016/092069A1
The invention relates to chemical compounds that can be used in particular as structural mimetics of proline-rich peptides. The compounds of the invention are capable of selectively inhibiting ena/VASP-EVH1-mediated protein-protein inter...  
WO/2016/091036A1
Provided are a compound represented by general formula (I) and pharmaceutically acceptable salts thereof, and a perpetration method and a usage in preparing medicines for resisting a hepatitis virus and especially a usage in resisting a ...  
WO/2016/085208A1
The present invention provides: a peptide fragment derived from secreted frizzled protein 5 (Sfrp5), that is, a peptide fragment selected from the group consisting of peptides composed of amino acid sequences of SEQ ID NOs: 1 to 9; and a...  
WO/2016/082786A1
Provided are a tripeptide compound, a preparation method therefor, and an application thereof. The structure of the related compound is represented by formula (I). The provided compound has angiotensin converting enzyme inhibiting bioact...  
WO/2015/151081A3
Provided are linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule, methods of making such linkers, a...  
WO/2016/079682A1
The present invention relates to cyclic amino acid molecules and methods of preparing the same, and in particular the macrocyclization of amino acids or linear peptides bound to a solid support.  
WO/2016/076647A1
A method for preparing collagenase of the present invention comprises: a first step for centrifuging a Bacillus subtilis strain; a second step for concentrating the centrifuged supernatant; and a third step for purifying the supernatant ...  
WO/2016/077260A1
Tubulysin analogs of the formula (I), where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.  
WO/2016/073733A1
This invention relates to, in part, methods and compositions that are useful for the treatment of various diseases, including cancer and side effects of cancer treatments, for example. The invention relates to, in part, combination thera...  
WO/2015/151079A3
Provided are analogues of auristatins, in particular monomethyl auristatin F (MMAF), as cytotoxic agents, conjugates of such agents with a cell-binding agent, the preparation and the therapeutic uses of these cytotoxic agents and conjuga...  
WO/2016/065174A1
The present disclosure relates to glycine-containing probes that are capable of binding to active caspases and can be used for detecting apoptosis. In particular, the probes can be used to determine the degree or incidence of caspase-med...  
WO/2016/064245A1
A novel peptide compound, a production method therefor, and a use thereof are provided. The compound has an anticancer activity, and thus the compound can be used for preventing or treating cancer.  
WO/2016/055810A1
The present invention relates to a method of predicting the propensity of tripeptides to from aggregates in solution. The present invention also provides tripeptides which are able to form aggregates in solution, as well as uses thereof....  
WO/2016/057306A1
The present disclosure describes peptide inhibitors of Rho-associtated-kinase (ROCK) and their use in treating disorders including heart failure, the leading cause of combined morbidity and mortality in the United States. An inhibitory p...  
WO/2016/051752A1
Provided is a peptide substrate for protease comprising the amino acid sequence of Gly-Xaa-Yaa (where Xaa is any amino acid selected from Phe, Leu, Ile, and Trp, and Yaa is any amino acid selected from Tyr, His, Ser, and Gly) as the subs...  
WO/2016/049677A1
The present invention provides a method of treating cancer in a subject wherein the method comprising administering to the subject an IAP antagonist and a p38 and/or a MK2 inhibitor.  
WO/2016/051289A1
The object of the present invention are novel peptide derivatives of diaryl esters of 1 - aminoalkylphosphonic acids and their use as inhibitors of NS3/4A protease expressed by human HCV virus in prophylaxis and therapy of viral hepatiti...  
WO/2016/051013A1
The present invention relates to the field of wood rosin and resin acid derivatives and more particularly to abietane-type diterpenoids as well as different uses thereof. Furthermore, the present invention relates to methods of coating s...  
WO/2016/047638A1
Provided is: a cyclic peptide derivative which is derived from Paecilomyces tenuipes having an astrocyte proliferative activity; or a salt thereof.  
WO/2016/043661A1
This invention relates to a peptide nucleic acid comprising the base N4-(2-guanidoethyl)-5-methylcytosine and method for their manufacture. Further, the invention relates to the use of said compounds as medicaments and to methods of targ...  
WO/2016/041082A1
Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed ar...  
WO/2016/041080A1
Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as primitive hematopoietic cells, are described. These methods and compositions are b...  
WO/2015/200242A3
The present disclosure relates to the field of molecular biology and immunology. More specifically, the present disclosure provides compositions and methods for detecting anti-Th/To autoantibodies in the serum of subject with a systemic ...  
WO/2016/037530A1
The present invention relates to a novel polymorph form O of romidepsin. Said polymorph can be expressed by an X-ray powder diffraction (XRPD) spectrogram, a differential scanning calorimetry (DSC) spectrogram, and an infrared (IR) absor...  

Matches 401 - 450 out of 17,226