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Matches 1 - 50 out of 16,878

Document Document Title
WO/2018/223909A1
Provided is a chimeric molecule consisting of a small molecule compound unit of a target protein, an E3 ubiquitin ligase binding unit and a linkage unit. The chimeric molecule can bind to a BRD protein, enable the BRD protein to be more ...  
WO/2018/225790A1
The present application discloses a crystal of an oxidized glutathione dication salt and a production method for the crystal.  
WO/2018/223227A1
There are provided compositions and methods for prevention or treatment of atherosclerosis and related disorders. More specifically, there are provided desmocollin 1 inhibitor compounds and pharmaceutical compositions thereof for use in ...  
WO/2018/221445A1
The purpose of the present invention is to provide: a gelling agent having superior gelation ability and superior safety as well; and a hydrogel comprising said gelling agent. This gelling agent is characterized by comprising a peptide r...  
WO/2018/223032A1
Disclosed are various crystalline salt forms of L-Phe-D-Arg-L-Phe-L-Lys-NH2.  
WO/2018/218352A1
The disclosure pertains to conformational epitopes in TDP-43, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.  
WO/2018/216012A1
The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which are capable of detecting or imaging, more specifically, determining the presence, or measuring th...  
WO/2018/213228A1
The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3a, R3b, R4a, R4b, R5a, and R5b are as defined as set forth in the specification. The pr...  
WO/2018/210336A1
A GLYX-13 preparation method and an intermediate compound thereof. According to the provided method, Fmoc-O-tert-butyl-L-threonine, Fmoc-L-proline, N-carboxybenzyl-L-threonine amide, and proline benzyl ester hydrochloride are used as sta...  
WO/2018/209415A1
The present invention falls within the fields of pharmacy, medicine, chemistry and biotechnology. The compound of the present invention is a peptide and has shown surprising stability and ease of handling in comparison to the most simila...  
WO/2018/213263A1
Methods and pharmaceutical compositions for treating malaria and immune related disorders are provided. The pharmaceutical compositions include an effective amount a carmaphycin B analog that inhibits immunoproteasome activity in a subject.  
WO/2018/207036A1
The present invention relates to peptides capable of forming a gel and to their use in tissue engineering and bioprinting. The present invention furthermore relates to a gel comprising a peptide in accordance with the present invention, ...  
WO/2018/207115A1
The present invention relates to novel tumor-homing peptides, namely to a modified NGR motif and to peptides comprising said motif. The invention also relates to conjugation products comprising said modified motif and said peptides and t...  
WO/2018/204721A1
Provided herein are anti-aging compositions and methods for maintaining and/or improving eye health in a subject, comprising administering to the eye of the subject a therapeutically effective amount of a compound that modulates the ATP-...  
WO/2018/198124A1
Peptoids are described herein, as well as compositions comprising an aqueous liquid and a peptoid soluble in the aqueous liquid. The peptoids comprise a plurality of N-substituted glycine residues and/or N-substituted β-alanine residues...  
WO/2018/191999A1
The present invention relates to a process for preparing perindopril, the process mainly involving oxidizing ethyl 3-ketohexanoate as a raw material to synthesize ethyl 2-ketovalerate, then subjecting same to condensation ammoniation and...  
WO/2018/192944A1
A compound of formula I and salts and solvates thereof, wherein: R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR', nitro, Me3Sn and halo; where R and R' are independently selected from optionally substituted...  
WO/2018/191411A1
The present invention provides peptoid polymers and salts thereof that comprise hydrophobic and polar peptoid monomers and are capable of reducing or inhibiting the formation of ice crystals at sub 0° C temperatures. Also provided are p...  
WO/2018/189063A1
The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8,R 8', R9, R9', X1, X2, X3, X4, X5, X6, X7, X8, X9 and X10 are as described herein, as well as pharmaceutically acceptable salts thereof. Furth...  
WO/2018/189554A1
Compounds having the general structure A - L - B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1 B. Pharmaceutical compositions comprising these compounds and meth...  
WO/2018/189065A1
The present invention relates to compounds of formula (I) wherein X1 to X8 and R1 to R8 are as described herein, as well as pharmaceutically acceptable salts thereof for the use in the treatment or prevention of infections and resulting ...  
WO/2018/187400A1
Disclosed are various crystalline salt forms of Boc-D-Arg-DMT-Lys(Boc)-Phe-NH2.  
WO/2018/187740A1
Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of ag...  
WO/2018/178397A1
The invention relates to the synthesis of amphiphilic amino acid derivatives, in particular to a method for the N-alkylation of an unprotected amino acid or the N-terminus of an oligopeptide substrate, comprising reacting said unprotecte...  
WO/2018/177861A1
The present invention relates to tris-aryl-amide derivatives having an anti-heparanase activity, in particular it relates toureido/thioureido/ether tris-aryl-amide derivatives of formula (I). The invention also relates to the use of such...  
WO/2018/165765A9
Provided are peptides that are derived from probiotic bacteria that have use for preventing and/or treating non-enteric infections in a subject. The peptides derived from the probiotic bacteria also have use for reducing the virulence of...  
WO/2018/165765A1
Provided are peptides that are derived from probiotic bacteria that have use for preventing and/or treating non-enteric infections in a subject. The peptides derived from the probiotic bacteria also have use for reducing the virulence of...  
WO/2018/161976A8
Disclosed in the present invention are a tetrapeptide propylene oxide derivative or a pharmaceutically acceptable salt thereof, as well as a preparation method therefor, and the use thereof. The structure of the tetrapeptide propylene ox...  
WO/2018/161976A1
Disclosed in the present invention are a tetrapeptide propylene oxide derivative or a pharmaceutically acceptable salt thereof, as well as a preparation method therefor, and the use thereof. The structure of the tetrapeptide propylene ox...  
WO/2018/162806A1
The present invention relates to a compound of formula (I): (I) as defined in the description. The present invention also relates to a method for extracting biological membrane-associated membrane proteins, comprising a step of bringing ...  
WO/2018/164019A1
The present invention provides peptides, salts thereof, peptide conjugates, and salts thereof having an anxiolytic-like effect, for example a peptide comprising any amino acid sequence selected from (i) an amino acid sequence SYLPPLTT (S...  
WO/2018/149413A1
A CD20-targeted antibody coupling pharmaceutical preparation, specifically a preparation comprising a CD20-targeted antibody coupling medication represented by formula I and an excipient. The antibody coupling pharmaceutical preparation ...  
WO/2018/147517A1
The present invention relates to an osteogenic promotion peptide comprising sequence number 1 (AWLNH) or sequence number 2 (PHDL), and a composition, for preventing or treating bone diseases, comprising the peptide. The peptide promotes ...  
WO/2018/147624A1
Provided in the present invention are an insulin A-chain derived peptide fragment and a pharmaceutical composition for preventing or treating diabetes or diabetic wounds, containing the same as an active ingredient. The peptide of the pr...  
WO/2018/147458A1
The present invention provides a novel compound capable of imparting a sweet taste preferable to a food by enhancing the sweetness of a sweetener such as sucrose. This compound is represented by following formula (I) or a salt thereof.  
WO/2018/140145A1
Provided are compositions that include at least one two-dimensional layer of an inorganic compound and at least one layer of an organic compound in the form of one or more polypeptides. Methods of making and using the materials are provi...  
WO/2018/138541A1
The present invention relates to a compound of the following formula (I), as well as to a pharmaceutical composition comprising at least one compound of following formula (I) and at least one pharmaceutically acceptable excipient, for us...  
WO/2018/140275A3
A compound according to the general Formula (8): wherein R1 is hydrogen or C1-C4 alkyl; R2 is C1-C4 alkyl, benzyl, or 1H-indol-3-ylmethyl; T is selected from the group consisting of -CH(OR3)-R4, -C(=O)-OR3, or -C(=O)-NR3 R5, wherein R3 i...  
WO/2018/133766A1
Disclosed are a preparation and a use of a molecular site targeted and activated kinase inhibitor. Specifically, disclosed is a compound represented by the following formula: Lactobionic acid residue -XAN-PABC-Z or a pharmaceutically acc...  
WO/2018/136843A1
The present technology provides methods and medicaments useful for treating prostate cancer and breast cancer. Such methods include administering at least one of cyc/o[Phe-D-Pro-Phe-Trp] and cyc/o[Phe-D-Pro-Phe-D-Τrp] to a subject suffe...  
WO/2018/136198A1
Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or more compounds herein can be employed ...  
WO/2018/130790A1
The invention relates to an isolated peptide consisting of a sequence of 3 to 39 amino acids derived from the amino acid sequence SEQ ID NO : 1, said peptide having an amino acid sequence selected from the group consisting of: a) the seq...  
WO/2018/126523A1
The invention provides a synthesis method of a proline-histidine cyclodipeptide, comprising: preparing an amino-protected proline-histidine dipeptide methyl ester from histidine and proline, wherein one of histidine and valine is a methy...  
WO/2018/122419A1
The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use ...  
WO/2018/115924A1
The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe- N-Methyl- L-Val-L-Ala-OMe (SEQ ID NO :1 ), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium a...  
WO/2018/117000A1
The present invention provides food and beverages which have good flavor as a result of reducing an astringent taste caused by cyclo(aspartyl-glycine) contained therein. According to the present invention, both the cyclo(aspartyl-glycine...  
WO/2018/117140A1
The purpose of the present invention is to provide L-alanyl-L-glutamine crystals having a low rough specific volume, and a method for producing same. This invention pertains to L-alanyl-L-glutamine crystals having a rough specific ratio ...  
WO/2018/117186A1
The present invention relates to a crystals of glutathione trisulfide dihydrate and a method for producing the same. According to the present invention, for example, by concentrating a solution in which glutathione trisulfide is dissolve...  
WO/2018/113891A1
The present invention relates to co-amorphous formulation of a substance and a dipeptide. The present invention also relates to pharmaceutical, cosmetic or veterinary compositions comprising the co-amorphous formulation as well as to met...  
WO/2018/118902A1
An enzyme-responsive peptide and a method off using such enzyme-responsive peptide are disclosed. An enzyme-responsive peptide, the peptide comprising an amino acid having an α-amino group, an α-carboxylic acid group and a ε-amine gro...  

Matches 1 - 50 out of 16,878