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Patent Searching and Data


Matches 1 - 50 out of 16,942

Document Document Title
WO/2019/033171A1
The present application describes a class of peptides comprising from (2) to (12) amino acid residues, wherein: the N-terminus of the peptide is linked to an optionally substituted, fused polycyclic group comprising an aromatic ring; at ...  
WO/2019/028275A1
Compositions and methods for ameliorating skin laxity associated with body sculpting procedures are provided herein. These compositions preferably comprise two different peptides: a dipeptide, tripeptide, or tetrapeptide in combination w...  
WO/2019/027366A1
The present invention relates to peptides containing guanidine and halogenated biphenyl moieties of the formula (I), and to salts and solvates of each of these peptides and to processes for the preparation thereof, compositions containin...  
WO/2019/022461A1
The present invention can provide a method for preparing a compound, comprising a step of polymerizing an amino acid carboxy anhydride-based compound by using a catalyst. The method for preparing a compound can improve the rate of a poly...  
WO/2019/023479A1
Disclosed is a new process and intermediates for preparing dipyrrolidine peptide compounds such as, for example, rapastinel. Advantageously, the process may be industrially scalable and cost-effective and use less toxic reagents and/or s...  
WO/2019/018892A1
There is provided a range of novel disulfide bond containing compounds. These disulfide bond containing compounds can be used in a variety of applications such as solid phase peptide synthesis, solid phase organic synthesis, formation of...  
WO/2019/023275A1
The present technology is directed to compounds, compositions, and methods related to treatment of cancers and viral infections mediated by lAPs. In particular the present compounds and compositions may be used to treat lAP-mediated ovar...  
WO/2019/015644A1
A peptide amide compound shown in general formula (I) and a preparation method and medical use thereof. The compound is used to treat or prevent a disease or condition related to κ-opioid receptor in mammals. (I)  
WO/2019/013122A1
A novel substance which adds body to a food product, and a body-adding agent for food products that uses said substance are provided. More specifically, the body adding agent for food products is characterized by having as an active comp...  
WO/2019/012545A1
Hybrid hydrogels, made of a three-dimensional network of fibrillar nanostructures, at least a portion of the fibrillar nanostructures being formed of at least two different types of aromatic moieties, at least one type of the aromatic mo...  
WO/2019/006951A1
The invention relates to an application of a dipeptide for preparing antihypertensive drug or health care product. Virtual screening has been performed on a dipeptide based on ACE inhibitory effects according to a previously detected ACE...  
WO/2019/006953A1
Disclosed is the use of a non-ionized polar dipeptide in the preparation of antihypertensive drugs or healthcare products. According to the crystal structure of a determined ACE enzyme, virtual screening for the ACE inhibition of the dip...  
WO/2019/009426A1
The present invention can provide: a low-molecular-weight peptide which has a potent antibacterial or antifungal activity that is not affected by the concentration of a salt and has extremely low toxicity to eukaryotic cells; an antibact...  
WO/2019/006952A1
The invention relates to the application of a cyclic nonpolar dipeptide for preparing an antihypertensive drug or a health care product. Virtual screening has been performed on a dipeptide based on ACE inhibitory effects according to a p...  
WO/2019/006954A1
The invention relates to an application of sulfur dipeptide for preparing an antihypertensive drug or a health care product. Virtual screening has been performed on a dipeptide based on ACE inhibitory effects according to a previously de...  
WO/2018/232491A1
There is described herein compound comprising a mitochondrial targeting portion, a cargo portion including a drug unit, and a linker conjugating the mitochondrial targeting portion and the cargo portion, the linker portion cleavable in a...  
WO/2018/234586A1
The present invention relates to a sensitizer-peptide conjugate for use in the treatment of cancer. In particular, the present invention relates to a sensitizer-peptide conjugate for use in the treatment of melanoma. The use of such sens...  
WO/2018/236931A1
Peptide compositions and methods for inhibiting neovascularization or development of pathological or aberrant blood vessels in human or other animal subjects,  
WO/2018/228617A1
Title: Chemical Compounds The present invention relates to compounds of formula I (I) wherein R1, R2, R3, R4, R5, R6, R7 and W are as described in the claims. Said compounds are useful in particular in the treatment of a condition select...  
WO/2018/232285A1
The invention relates to macrocyclic peptides and pharmaceutical compositions thereof. The invention further relates to pharmaceutical compositions for modulating opioid receptor activity.  
WO/2018/223909A1
Provided is a chimeric molecule consisting of a small molecule compound unit of a target protein, an E3 ubiquitin ligase binding unit and a linkage unit. The chimeric molecule can bind to a BRD protein, enable the BRD protein to be more ...  
WO/2018/225790A1
The present application discloses a crystal of an oxidized glutathione dication salt and a production method for the crystal.  
WO/2018/223227A1
There are provided compositions and methods for prevention or treatment of atherosclerosis and related disorders. More specifically, there are provided desmocollin 1 inhibitor compounds and pharmaceutical compositions thereof for use in ...  
WO/2018/221445A1
The purpose of the present invention is to provide: a gelling agent having superior gelation ability and superior safety as well; and a hydrogel comprising said gelling agent. This gelling agent is characterized by comprising a peptide r...  
WO/2018/223032A1
Disclosed are various crystalline salt forms of L-Phe-D-Arg-L-Phe-L-Lys-NH2.  
WO/2018/222773A3
The measurement of Factor Xa (FXa) enzymatic activity using novel fluorogenic peptide substrates that have a C-terminus cleavable fluorophore and optionally the ability to attach to a solid support. Fluorogenic measurements increase sens...  
WO/2018/218352A1
The disclosure pertains to conformational epitopes in TDP-43, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.  
WO/2018/216012A1
The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which are capable of detecting or imaging, more specifically, determining the presence, or measuring th...  
WO/2018/213228A1
The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3a, R3b, R4a, R4b, R5a, and R5b are as defined as set forth in the specification. The pr...  
WO/2018/210336A1
A GLYX-13 preparation method and an intermediate compound thereof. According to the provided method, Fmoc-O-tert-butyl-L-threonine, Fmoc-L-proline, N-carboxybenzyl-L-threonine amide, and proline benzyl ester hydrochloride are used as sta...  
WO/2018/209415A1
The present invention falls within the fields of pharmacy, medicine, chemistry and biotechnology. The compound of the present invention is a peptide and has shown surprising stability and ease of handling in comparison to the most simila...  
WO/2018/213263A1
Methods and pharmaceutical compositions for treating malaria and immune related disorders are provided. The pharmaceutical compositions include an effective amount a carmaphycin B analog that inhibits immunoproteasome activity in a subject.  
WO/2018/207036A1
The present invention relates to peptides capable of forming a gel and to their use in tissue engineering and bioprinting. The present invention furthermore relates to a gel comprising a peptide in accordance with the present invention, ...  
WO/2018/208954A3
The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combi...  
WO/2018/207115A1
The present invention relates to novel tumor-homing peptides, namely to a modified NGR motif and to peptides comprising said motif. The invention also relates to conjugation products comprising said modified motif and said peptides and t...  
WO/2018/204721A1
Provided herein are anti-aging compositions and methods for maintaining and/or improving eye health in a subject, comprising administering to the eye of the subject a therapeutically effective amount of a compound that modulates the ATP-...  
WO/2018/198124A1
Peptoids are described herein, as well as compositions comprising an aqueous liquid and a peptoid soluble in the aqueous liquid. The peptoids comprise a plurality of N-substituted glycine residues and/or N-substituted β-alanine residues...  
WO/2018/191999A1
The present invention relates to a process for preparing perindopril, the process mainly involving oxidizing ethyl 3-ketohexanoate as a raw material to synthesize ethyl 2-ketovalerate, then subjecting same to condensation ammoniation and...  
WO/2018/192944A1
A compound of formula I and salts and solvates thereof, wherein: R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR', nitro, Me3Sn and halo; where R and R' are independently selected from optionally substituted...  
WO/2018/191411A1
The present invention provides peptoid polymers and salts thereof that comprise hydrophobic and polar peptoid monomers and are capable of reducing or inhibiting the formation of ice crystals at sub 0° C temperatures. Also provided are p...  
WO/2018/189063A1
The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8,R 8', R9, R9', X1, X2, X3, X4, X5, X6, X7, X8, X9 and X10 are as described herein, as well as pharmaceutically acceptable salts thereof. Furth...  
WO/2018/189554A1
Compounds having the general structure A - L - B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1 B. Pharmaceutical compositions comprising these compounds and meth...  
WO/2018/189065A1
The present invention relates to compounds of formula (I) wherein X1 to X8 and R1 to R8 are as described herein, as well as pharmaceutically acceptable salts thereof for the use in the treatment or prevention of infections and resulting ...  
WO/2018/187400A1
Disclosed are various crystalline salt forms of Boc-D-Arg-DMT-Lys(Boc)-Phe-NH2.  
WO/2018/187740A1
Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of ag...  
WO/2018/178397A1
The invention relates to the synthesis of amphiphilic amino acid derivatives, in particular to a method for the N-alkylation of an unprotected amino acid or the N-terminus of an oligopeptide substrate, comprising reacting said unprotecte...  
WO/2018/177861A1
The present invention relates to tris-aryl-amide derivatives having an anti-heparanase activity, in particular it relates toureido/thioureido/ether tris-aryl-amide derivatives of formula (I). The invention also relates to the use of such...  
WO/2018/165765A9
Provided are peptides that are derived from probiotic bacteria that have use for preventing and/or treating non-enteric infections in a subject. The peptides derived from the probiotic bacteria also have use for reducing the virulence of...  
WO/2018/165765A1
Provided are peptides that are derived from probiotic bacteria that have use for preventing and/or treating non-enteric infections in a subject. The peptides derived from the probiotic bacteria also have use for reducing the virulence of...  
WO/2018/161976A8
Disclosed in the present invention are a tetrapeptide propylene oxide derivative or a pharmaceutically acceptable salt thereof, as well as a preparation method therefor, and the use thereof. The structure of the tetrapeptide propylene ox...  

Matches 1 - 50 out of 16,942