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JP5788321B2 |
The present invention relates to the efficient commercial synthesis of Bivalirudin.
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JP5743368B2 |
The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble po...
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JP5739632B2 |
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
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JP2015110650A |
To discover that enzymatic glycoconjugation reactions can be specifically targeted to O-linked glycosylation sites and to glycosyl residues that are attached to the O-linked glycosylation sites.There is provided polypeptide comprising an...
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JP5709876B2 |
Novel oligopeptides, combinations thereof and fusion proteins composed of the above-mentioned oligopeptides are disclosed. Oligopeptides are homologous in amino acid sequence to the selected parts of the amino acid sequence of human myel...
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JP5690361B2 |
Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combi...
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JP2014218515A |
To provide improved compositions for providing immunity against meningococcal disease and/or meningococcal infection.A small number of defined antigens can provide broad protection against meningococcal infection, and the invention provi...
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JP5611105B2 |
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JP2014168715A |
To provide a device, a bandage, a method and a kit for remedy or prevention of a scar and/or a keloid.A device, a bandage, a kit and a method are described for improvement in formation of a scar and/or a keloid by controlling or adjustin...
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JP5591112B2 |
Glycopeptide antibiotics, such as oritavancin, demonstrate significant activity against both a vegetative form of C. difficile and C. difficile spores. Methods for the treatment, prophylaxis and prevention of C. difficile infection and d...
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JP5566226B2 |
It is an object of the present invention to provide a method for producing an 11-sugar sialylglycopeptide easily and with good yield and a high degree of purity on an industrial scale from defatted bird egg yolks. The present invention p...
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JP5563170B2 |
Processes for isolating nanoparticles from an aqueous solution are disclosed. The processes can include, for example, providing an aqueous mixture having a plurality of nanoparticles and at least one thermal hysteresis molecule; adjustin...
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JP5548838B2 |
Provided is a process for purifying a vancomycin wet body, comprising: dissolving a wet body obtained from a microorganism-fermented solution containing vancomycin into a water soluble solvent to a concentration of about 1 to 40 g/L and ...
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JP5517620B2 |
The present invention provides a method for producing a peptide, characterized in that it comprises converting an -SH group of a peptide comprising an amino acid residue having the -SH group to an -OH group, wherein said method comprises...
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JP5517153B2 |
The present invention provides novel glycopeptides antibiotic derivatives. These glycopeptide antibiotic derivatives are characterized in that a sugar residue (I) represented by the formula: (wherein n is an integer of 1 to 5; Sugs are e...
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JP5508851B2 |
Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combi...
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JP2014087370A |
To provide a more effective G-CSF factor.Provided are a method of covalently attaching a modifying group having a glycosyl group to a G-CSF factor, and a conjugate obtained by the method.
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JP5484668B2 |
The present invention provides a process for synthesizing a compound having the structure: ides useful as a vaccine for inducing antibodies to human breast cancer cells in an adjuvant therapy therefor.
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JP2014062102A |
To provide synthetic compositions and materials for cell culture and tissue engineering purposes that allow the creation of a cellular environment that mimics important features of the native cellular environment, but without the disadva...
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JP5412689B2 |
Methods for improving the specificity of assays for botulinum neurotoxins are described. Reporting constructs are provided that include cleavable linker sequence with genetically modified recognition and/or cleavage sites. These linker s...
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JP5396111B2 |
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JP5376912B2 |
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
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JP5322646B2 |
Disclosed herein are a class of compounds comprising peptides of the sequence (X-Y-Z) n , wherein X is an aminoacid selected from aspartic acid, glutamic acid, asparagine, alanine and glutamine, and Y and Z are amino acids selected from ...
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JP5285022B2 |
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JP5258809B2 |
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
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JP5232352B2 |
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.
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JP2013525329A |
There is described a group of novel self-assembling peptides (SAPs), comprising biotinylated and unbiotinylated sequences, hybrid peptide-peptoid sequences, branched sequences for a total of 48 tested motifs, showing a heterogeneous ense...
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JP5207734B2 |
The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial infection, in particular a Gram-positive bact...
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JP5160827B2 |
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JP5161269B2 |
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...
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JP2013047267A |
To provide new antibiotics that are highly effective against antibiotic-resistant strains.This invention provides a novel cross-linked glycopeptide-cephalosporin compound useful as an antibiotic and a pharmaceutically-acceptable salt the...
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JP5124475B2 |
The present invention concerns a process for the purification of macrolide antibiotics. More specifically it concerns a process for the purification of macrolide antibiotics that result in a white powder. The powder remains white also af...
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JP5111705B2 |
The present invention provides novel n-alkenyl glycosides and glycoconjugates, n-alkyl glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides novel clustered glycopeptides and methods f...
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JP2012224594A |
To provide a new technique for diagnosing rheumatoid arthritis (RA).As a result of preparing a peptide, in which a partial peptide of a glucose-6-phosphate isomerase is cyclic-citrullinated, and, in an RA patient, screening an autoantibo...
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JP2012167018A |
To provide a method capable of producing easily and effectively an objective designed glycopeptide.This method for producing a modified peptide in which an amino acid residue having at least one sugar binding capacity is modified by a mo...
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JP2012143250A |
To provide more effective granulocyte colony stimulating factor (G-CSF).A method for covalently bonding a modifying group having a glycosyl group to a G-CSF factor and a covalent conjugate obtained by the method are provided.
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JP2012132025A |
To provide novel constructs capable of eliciting a more sustained or effective, and preferably selective immune response.The present invention provides novel n-alkenyl glycosides and glycoconjugates, n-alkyl glycoamino acids, and methods...
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JP4948742B2 |
This invention relates to new peptide-based compounds and their use in therapeutically effective treatments as well as for diagnostic imaging techniques. More specifically the invention relates to the use of such peptide-based compounds ...
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JP4943848B2 |
An antibody or antibody fragment preparation being capable of specifically binding the amino acid sequence 60-76, 86-98, 135-149, 215-227, 363-377, 385-397, 405-419, 427-440, 509-522, 605-619, 635-649, 666-680, 696-711, 752-766, 836-851,...
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JP2012092109A |
To provide new strategies and protocols for oligosaccharide synthesis.There are provided a method for synthesizing a compound having the structure (I) (wherein R is H) and related oligosaccharides useful as a vaccine for inducing antibod...
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JP4927536B2 |
An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint ...
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JP4926114B2 |
The present invention relates to a method of concentrating low molecular weight peptides in the supernatant of serum-free cultured cells, said method comprising allowing the peptides to bind to a strong cation exchanger under an acid con...
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JP4888863B2 |
Novel glycopeptide antibiotic dimer derivatives. The derivatives are represented by the formula (X) [wherein A1 and A2 each independently represents the formula (aglycon moiety of glycopeptide antibiotic derivative)-(Sac-NH)-X1-Ar-X2-Y-X...
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JP4870314B2 |
Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administ...
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JP4820517B2 |
The present invention relates to compounds of the formula (I), wherein R is independently SO3<-> or CH3; the spacer is a flexible spacer of a length of 13-25 atoms; the charge of the pentasaccharide residue is compensated by positively c...
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JP4808315B2 |
Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.
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JP4774487B2 |
A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the com...
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JP4752001B2 |
Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method...
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JP4742029B2 |
The present invention provides tagged acyl phosphate probes ("TAPPs"), and methods of their preparation and use. The subject methods and compositions can provide enhanced simplicity and accuracy in identifying changes in the presence, am...
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JP4729047B2 |
The new pure vancomycin hydrochloride substantially free of impurities known in commercially available products is described. The term "substantially free of impurities" designates a purity of vancomycin hydrochloride between about 97% a...
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