| Document |
Document Title |
|
JP4713810B2 |
The invention provides a novel reductive alkylation method useful for selectively alkylating saccharide-amines of glycopeptide antibiotics.
|
|
JP4705093B2 |
The present invention relates compounds of the formula A oligosaccharide-spacer-GpIIb/IIIa antagonist wherein the oligosaccharide is a negatively charged oligosaccharide residue comprising four to twenty five monosaccharide units, the ch...
|
|
JP4674702B2 |
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
|
|
JP4669478B2 |
Disclosed are hydrochloride salts of telavancin having a chloride ion content of from 3.7 wt. % to 4.4 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts.
|
|
JP4657721B2 |
A method for preparing a grafted homodetic cyclopeptide forming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or unmodified amino acids, some of which carry or...
|
|
JP2011024579A |
To provide contulakin-G, analogs thereof, and uses therefor.There are provided contulakin-G, a des-glycosylated contulakin-G (termed Thr10-contulakin-G) and derivatives thereof, a cDNA clone encoding a precursor of this mature peptide, a...
|
|
JP2011016820A |
To improve the stability of telavancin at ambient temperatures.Disclosed are hydrochloride salts of telavancin having a chlorine ion content of from about 2.4 wt.% to 4.8 wt.%. The disclosed salts have improved stability at ambient tempe...
|
|
JP4619459B2 |
A novel method of covalently coupling polysaccharides to other biopolymers is provided, using an amino-thiol linker represented by formula 1 H2N-Ä(CH2)m-CHR<1>-CR<2>R<3>-AÜq-CHR<4>-(CHR<5>)p-CHR<6>-S
-R<7> wherein A is a direct bond or...
|
|
JP4618821B2 |
This invention relates to novel compounds of general formula (I): and to pharmaceutical compositions containing them.
|
|
JP4617296B2 |
The invention relates to low-molecular doxorubicin peptide derivatives containing MMP-2 or MMP-9 divisible peptide sequences and a protein-binding group.
|
|
JP4616928B2 |
|
|
JP4607017B2 |
An aminated complex-type oligosaccharide derivative, for example, of the formula (1) wherein R 1 is -NH-(CO)-CH 2 X, -NH-(CO)-(CH 2 ) b -CH 2 X, isocyanate group, -NH-(CO) a -(CH 2 ) b -CO 2 H or -NH-(CO) a -(CH 2 ) b -CHO, X being a hal...
|
|
JP2010279375A |
To provide a method, composition and library relating to a PNA dimer and PNA oligomer.The invention relates to a field of PNA dimers and PNA oligomers. It discloses a solid support composition. The solid support composition is (a) an aci...
|
|
JP4588451B2 |
This invention pertains to the field of PNA dimer and PNA oligomer synthesis.
|
|
JP2010254701A |
To provide a new crosslinked glycopeptide-cephalosporin antibiotic having a unique chemical structure.The crosslinked glycopeptide-cephalosporin compound and a pharmaceutically acceptable salt thereof are useful as antibiotics. A pharmac...
|
|
JP2010235606A |
To provide immunogenic glycopeptides derived from pathogenic micro-organisms, useful for vaccination and diagnosis of infections caused by pathogenic micro-organisms, and methods for selecting them and preparing them.The present inventio...
|
|
JP4555823B2 |
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...
|
|
JP4542874B2 |
|
|
JP4527407B2 |
A glycolipopeptide comprising at least one disease-associated epitope, and characterized by at least one lipidated interior amino acid or by the presence of a MUC1 epitope, may be used in a vaccine, preferably in conjunction with a lipos...
|
|
JP4458288B2 |
In this application are disclosed glycopeptides and peptides which have a taste improving function, particularly a kokumi taste imparting function, more specifically such glycopeptides and peptides per se, a method for imparting the koku...
|
|
JP4445028B2 |
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...
|
|
JP4413616B2 |
The present invention relates to polypeptides, more particularly polypeptides of Moraxella (Branhamella) catarrhalis which may be used to prevent, diagnose and/or treat Moraxella (Branhamella) catarrhalis infection.
|
|
JP4395398B2 |
|
|
JP2009291121A |
To provide an efficient method for purifying a sugar chain compound extended by a sugar chain primer method and an immobilization method.A sugar chain primer is administered to cultured cells, which are cultured so that an FLAG tag is in...
|
|
JP4381531B2 |
|
|
JP2009279006A |
To provide a method and a composition for accelerating a long term and directed cytotoxic T cell response against a target cell by inducing for an antigen-presenting cell to provide a specific epitope to the specific target cell.An epito...
|
|
JP4369052B2 |
The present invention relates to compounds of formula (1), wherein R1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (iso)quinolinyl, tetrahydro(iso)quinolinyl, 3,4-dihydro-1H-isoquinolinyl, chromanyl or the camphor group, which groups...
|
|
JP4362017B2 |
Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. ...
|
|
JP2009256358A |
To provide cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof, which are useful as antibiotics.Provided are pharmaceutical compositions containing a specific cross-linked glycopeptide-cephalos...
|
|
JP4347402B2 |
Cell-proliferation inhibitors contain anti-glypican 3 antibody as active ingredient, are new. An independent claim is also included for an antibody with cytotoxicity. ACTIVITY : Cytostatic. No Biological data is given. MECHANISM OF ACTIO...
|
|
JP4347799B2 |
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...
|
|
JP2009215207A |
To provide a method for efficiently producing a sugar peptide having an O-mannose type sugar chain.Provided are an amino acid bonded with an O-mannose type sugar chain and expressed by general formula [I] (in the formula, R1 is H or a me...
|
|
JP4308918B2 |
The present invention provides novel alpha-O-linked glycoconjugates such as alpha-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin mot...
|
|
JP4308912B2 |
This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics. The improvement residing in providing a source of copper which results in the initial production of a copper complex of the glycope...
|
|
JP4307723B2 |
Described herein are N'-acylated derivatives of desleucylA82846B. The compounds are useful as antibacterial agents.
|
|
JP4304073B2 |
This invention pertains to a TNF alpha-binding polypeptide composition comprising at least one of a modified heavy chain variable region polypeptide or a modified light chain variable region polypeptide that is capable of specifically bi...
|
|
JP4296295B2 |
To provide a method for inhibiting replication of a mammal DNA by which the replication of the DNA of a mammal creature is specifically inhibited and antitumor or antiviral effects are taken; and to provide a material usable therefor. A ...
|
|
JP2009143962A |
To provide cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof, which are useful as antibiotics.Pharmaceutical compositions containing the compounds, methods for treating bacterial infections i...
|
|
JP2009521917A |
The invention relates to phenylalanine, cysteine, derivatives of said amino acids, peptides comprising them, and to their use in diseases disorders or conditions whose pathology is caused by or associated with CXCR4 activity and/or cell ...
|
|
JP4272359B2 |
A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also described as well as the use of the complex...
|
|
JP2009102445A |
To identify new derivative compounds having improved antibiotic activity, low possibility of resistance appearance, improved effectiveness for bacterial infectious diseases resistant to the treatments of now available antibodies, or unpr...
|
|
JP2009091369A |
To provide: a novel glycopeptide derivative which expresses an excellent activity to vancomycin-resistant enterococcus, and also expresses a stronger activity to methicillin-resistant bacteria; and a pharmaceutically acceptable salt, a h...
|
|
JP4250776B2 |
|
|
JP2009069158A |
To provide some nucleic acid analogues in order to perform capture, recognition, detection, identification or quantification about one or more chemically or microbiologically individual units for example.The nucleic acid analogue with a ...
|
|
JP4249023B2 |
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...
|
|
JP4240544B2 |
The present invention is directed to N<1>-alkylated derivatives of desleucyl A82846B. These derivatives are useful as antibacterials and also as starting materials from which further antibacterial compounds are prepared.
|
|
JP4235283B2 |
A method for the determination of nucleic acids which is highly specific and simple comprises the formation of a triple stranded binding complex including two separate, different probe molecules and detecting the formation of the complex...
|
|
JP4223810B2 |
The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high yield and purity. In particular, there is...
|
|
JP4209673B2 |
The invention concerns agents with anti-bacterial activity and methods and intermediates for their production. The present invention further concerns the use of such agents for the treatment of bacterial infections in animals, including ...
|
|
JP4173124B2 |
Provided is a method of purifying a vancomycin from a fermentation broth of a microorganism containing vancomycin, including passing the fermentation broth of a microorganism containing vancomycin through a strong acid cation exchange re...
|
