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JP2008253251A |
To provide a nucleic acid analog for performing capture, recognition, detection, identification or quantification about chemically or microbiologically individual units.The nucleic acid analogues provided are: (a) a PNA (peptide nucleic ...
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JP4166273B2 |
The present invention provides a process for synthesizing a compound having the structure: ides useful as a vaccine for inducing antibodies to human breast cancer cells in an adjuvant therapy therefor.
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JP4162491B2 |
The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of formula (1) in which Z 1 and Z 2 are moieties derived from sugar. The invention also provides methods for preparing such comp...
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JP2008231109A |
To provide a new pharmaceutical composition containing a glycopeptide antibiotic reducing undesirable characteristics.The composition contains a cyclodextrin and a lipidated glycopeptide antibiotic or pharmaceutically acceptable salt the...
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JP4157600B2 |
Prodrugs of formula W-Z-M (I) are new:. M = label or therapeutic agent having an active intracellular site (SA); W-Z is a ligand, comprising arm Z and end gp. W; the bond between Z and M inhibits intracellular penetration of (I) and/or i...
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JP4159110B2 |
The present invention is directed to certain glycopeptide dimers in which two glycopeptide units are covalently linked to one another through their disaccharide amine, via a linking radical. This invention is also directed to the monomer...
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JP2008222718A |
To provide a method useful for the selective alkylation of glycopeptide antibiotics at a saccharide-amino group.The invention relates to a method for alkylating a glycopeptide comprising a saccharide amine. The method comprises a process...
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JP4150430B2 |
The present invention is directed to glycopeptides and more particularly to derivatives of the glycopeptide A82846B. In these derivatives, the leucyl has been removed to create "hexapeptides" of A82846B and its N variations. These hexape...
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JP2008208130A |
To provide a method for preparing a glycopeptide phosphonate derivative having an amino-containing side chain.The invention relates to a new method for preparing the derivatives of glycopeptide antibiotics and concretely, to a multistep ...
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JP4138006B2 |
The invention provides a method of alleviating neuropathic pain in a subject by administering an effective amount of an active fragment of prosaposin to the subject. The invention also provides a method of preventing neuropathic pain in ...
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JP4119428B2 |
A glycopeptide having at least one asparagine-linked oligosaccharide at a desired position of the peptide chain thereof, which is obtained by: (1) esterifying a hydroxyl group of a resin having the hydroxyl group and a carboxyl group of ...
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JP4116547B2 |
Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The methods include contacting a solution of the gl...
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JP4116546B2 |
Disclosed are processes for preparing glycopeptide antibiotic derivatives having an amino-containing side chain. The multi-step process is conducted in a single reaction vessel without isolation of intermediate reaction products.
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JP4116555B2 |
Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products,...
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JPWO2006030840A1 |
The subject of the present invention is a novel compound useful as a primer in the production of mucin-type glycopeptides, which is useful in a wide range of fields such as biochemical research materials, pharmaceuticals, and foods, and ...
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JP4086326B2 |
The present invention is directed to N-carbamoyl and thiocarbamoyl derivatives of A82846B and N variations thereof. These derivatives are useful as antibacterials and also as starting materials from which further antibacterial compounds ...
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JP4086318B2 |
The present invention is directed to amides of antibiotic A82846B (also known as chloroorienticin A), and of N<4>-derivatives of A82846B. The present amide compounds are useful as antibacterials, especially for the control of gram positi...
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JP2008512427A |
The invention relates to a method and a device for commissioning articles from a first number of pick-up sections (16) into a corresponding number of order placement sections (18), by means of a second number of commissioners (20). Thus,...
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JP2008069175A |
To provide a new compound containing a therapeutic agent or a marker.The compound (W-Z-M) has a ligand (W-Z) in which a terminal group (W) and an arm (Z) are bonded and a component (M) selected from the therapeutic agent and the marker a...
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JP4063879B2 |
The present invention provides compositions and methods of inducing immune response in patients. In particular, it provides compositions useful in inducing humoral responses against desired immunogens, particularly polysaccharides.
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JP2008506360A |
Disclosed is a method of producing teicoplanin. The method includes purifying teicoplanin from a culture broth, obtained by culturing microorganisms capable of producing teicoplanin by a porous adsorption resin under selective elution co...
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JP4056306B2 |
Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant...
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JP4051421B2 |
PCT No. PCT/EP96/02769 Sec. 371 Date Dec. 18, 1997 Sec. 102(e) Date Dec. 18, 1997 PCT Filed Jun. 25, 1996 PCT Pub. No. WO97/02288 PCT Pub. Date Jan. 23, 1997Method for purifying antibiotic compounds of the dalbaheptide family by means of...
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JPWO2005095331A1 |
General formula (I): XYZ (I) [In the formula, X is H2N- or HS-; Y is -A1-, -A1-OA2-,-(CH2CH2O)n-A1-,-(CH2CH2O)n-A1-OA2-, -A1-NH-C (= O) -A2-, -A1-C (= O) -NH-A2-, -A1-(CH2CH2O)n-NH-C (= O) -A2-, -A1-(CH2CH2O)n-C (= O) -NH-A2-Etc .; and Z...
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JP2008031181A |
To provide truncated HCV (Hepatitis C Virus) envelope proteins useful for an immunoassay and a therapeutic/prophylactic vaccine.The HCV truncated glycoprotein is selected from the group consisting of a glycoprotein which is expressed fro...
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JP2007314575A |
To provide a method for promoting nerve cell growth or myelination increase; to provide a pharmaceutical preparation for therapy of nerve or myelin drop diseases in nervous tissues; to provide a pharmaceutical preparation for treating ce...
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JP2007306926A |
To obtain some nucleic acid analogs, e.g., for performing capture, recognition, detection, identification or quantification about one or more chemically or microbiologically individual units, in order to solve problems which can not be s...
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JP2007530697A |
Amphipathic glycopeptides, the amino acid sequence of which comprises an N-terminal opioid message sequence, a C-terminal helical address sequence, and a linker sequence between the message sequence and the helical address sequence, wher...
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JP2007527864A |
The present invention provides a method for preparing polyfunctionalized peptides and/or proteins at non-adjacent designated sites via native chemical ligation. In certain embodiments, the inventive method is a method for preparing a pol...
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JP3982828B2 |
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attac...
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JP2007526872A |
The present invention provides a new prodrug technology and new prodrugs in order to increase the solubility, to modulate plasma protein binding or to enhance the biovailability of a drug. In the present invention the prodrugs are conjug...
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JP2007224013A |
To produce a nucleic acid containing an unnatural base causing little mismatch with natural base, enabling stable replication and having high uptake efficiency with enzymes. The invention provides an unnatural base, etc., capable of form...
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JP3970811B2 |
To provide a novel linker compound, a novel ligand, and a ligand carrier capable of arranging sugar molecules in two dimensions on a carrier surface for a protein analysis with high reproducibility and a method of preparing the same. The...
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JP2007522155A |
A throat, mouth and/or gum sprayable pharmaceutical preparation in the form of an aqueous solution. One embodiment of such a solution may comprise: a non-steroidal anti-inflammatory drug (NSAID) also having analgesic activity; a biologic...
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JP3954644B2 |
PCT No. PCT/GB94/02167 Sec. 371 Date Jun. 29, 1996 Sec. 102(e) Date Jun. 29, 1996 PCT Filed Oct. 5, 1994 PCT Pub. No. WO95/10293 PCT Pub. Date Apr. 20, 1995Muramyl peptide compounds are useful in the prophylaxis of cancers and particular...
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JP2007516157A |
The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and methods of using said specificity exchangers t...
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JP2007126433A |
To provide a new peptide having a prolylendopeptidase inhibitory activity by extracting seaweed glycoprotein from seaweed extract and producing the same from the seaweed glycoprotein.This seaweed-derived glycoprotein is obtained by extra...
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JP3918953B2 |
PURPOSE: To provide a tunable bisconjugate that comprises two saccharides which contain a plurality of monosaccharide units, at least one unit being uronic acid, and a spacer, and the spacer links one saccharide to the other saccharide a...
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JP2007511607A |
Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
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JP3900491B2 |
Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives...
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JP3896430B2 |
To provide a method for producing a saccharified protein, enabling to simply carry out the production in a short time and hard to cause the denaturation of the protein. A saccharide is mixed with a protein. For example, glucose as the sa...
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JP2007505905A |
Provided are synthetic polysaccharide antigens (SPAs) with anti-inflammatory or inflammatory immunomodulatory properties, depending on their structure. Also provided are compositions comprising these SPAs, and methods of using these SPAs...
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JP2007505841A |
A Teicoplanin composition with improved antibiotic activity.
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JP2007045842A |
To provide glycopeptide derivatives which are effective against a wide range of pathogenic microorganisms (including vancomycin-resistant microorganisms) and reduce accumulation in tissues and/or nephrotoxicity.Disclosed are derivatives ...
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JP3872813B2 |
Polypeptide compositions comprising two distinct subunits which can form alpha -helical coiled-coil heterodimers are described. The two subunits can each have a different compound or bioactive moiety attached in a precisely-defined orien...
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JP2007500222A |
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; ...
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JP2006525235A |
The present invention provides a new prodrug technology and new prodrugs in order to increase the solubility, to modulate plasma protein binding or to enhance the biovailability of a drug. In the present invention the prodrugs are conjug...
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JP2006524676A |
A method for modulating Nod1 activity wherein said method comprises the steps of providing cells expressing a functional Nod1: and bringing said cells into contact with a molecule related to compositions comprising a molecule related to ...
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JPWO2004101619A1 |
The present invention provides a glycopeptide in which glutamine, a biologically active form of peptide having glutamine at least one amino acid residue, is modified with a sugar chain. Furthermore, the present invention comprises a func...
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JP2006257095A |
To provide a synthetic immunogenic polypeptide complex which can exhibit two different type antigens with a preliminarily defined accurate stoichiometry and molecular arrangement.A heterodimer polypeptide immunogen comprises a carrier ha...
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