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Matches 1 - 50 out of 1,580

Document Document Title
WO/2018/129328A1
Compositions and methods for optically-verified, sequence-controlled polymer synthesis are described.  
WO/2018/102889A1
A construct comprising: (i) an optionally derivatized glycopeptide antibiotic; (ii) a nanoparticle; and (iii) a first linker connecting (i) and (ii) is provided. The construct may further comprise a second linker located between the firs...  
WO/2018/102890A1
A visualization construct comprising: (i) an optionally derivatized glycopeptide antibiotic; (ii) a visualization component; and (iii) a first linker connecting (i) and (ii) is provided. The visualization component may be a fluorescent c...  
WO/2018/089858A1
The disclosed embodiments concern methods, devices, and systems for identifying candidate biomarkers useful for the diagnosis, prognosis, monitoring and screening and/or as targets for the treatment of diseases and conditions in subjects...  
WO/2018/085460A3
The present disclosure described herein provides compositions with a membrane-penetrating properties and methods for allowing translocation across a membrane without disruption.  
WO/2018/085460A8
The present disclosure described herein provides compositions with a membrane-penetrating properties and methods for allowing translocation across a membrane without disruption.  
WO/2018/051291A1
The present technology relates to vaccine compositions comprising at least one of the nine peptides defined by SEQ ID NO 1-9, capable of stimulating the development of a T helper 1 (Th1)-type cell immune response with high production of ...  
WO/2018/045889A1
Provided are a crystal form A of oritavancin diphosphate, and a preparation method and use thereof. The crystal form has excellent properties in the aspects of dissolution time, biological release, chemical stability, and processing adap...  
WO/2018/037343A1
The present technology relates to vaccine compositions for the treatment and/or prevention of visceral leishmaniasis in mammals, comprising six synthetic peptides that are free or expressed in the surface of non-infectious bacteriophages...  
WO/2018/031887A1
Methods and assays for detecting natalizumab in a sample, natalizumab-peptide complexes in a sample, and point-of-care devices for detecting natalizumab in a sample are described herein.  
WO/2018/014005A1
The disclosure provides for multiple-reporter systems that are capable of rapidly and indirectly screening cells for a certain cell type and/or cell function.  
WO/2018/010476A1
Provided are a glycopeptides based derivative represented by the general formula (I) and a pharmaceutically acceptable salt thereof. R1 is H, 2-alkylamine-ethyl group, a substituted benzyl group, a substituted phenylpropionyl group or a ...  
WO/2018/010475A1
A glycopeptide derivative represented by the general formula (I) and a pharmaceutically acceptable salt thereof, R1 is H, 2-alkylamine-ethyl, a substituted benzyl group, a substituted phenylpropionyl group, or a linear acyl group contain...  
WO/2017/186110A1
Provided are a class of vancomycin derivatives with a structure as shown in the general formula below, a preparation method, a pharmaceutical composition containing the compound thereof and the use of these compounds in preparing drugs f...  
WO/2017/161909A1
The present invention relates to a preparation and purification method of a norvancomycin and a norvancomycin derivative. The method uses a salt-free liquid phase HPLC. The invention further relates to a method for acquiring the norvanco...  
WO/2017/141961A1
The present invention addresses the problem of providing a means for making highly sensitive and stable measurements possible using electrochemical measurement methods. This problem is resolved by providing: a label represented by genera...  
WO/2017/123912A1
Liquid vancomycin containing compositions having extended shelf life are disclosed. The compositions contain vancomycin or a pharmaceutically acceptable salt thereof, a polyol such as glycerol, and lactic acid or a lactate. The compositi...  
WO/2017/112955A1
Provided herein, inter alia, are compositions and methods for generating a immune response in an individual and/or inducing the expression of neoantigens on the surface of abnormal (such as proliferative) cells via inhibition of nonsense...  
WO/2017/103625A1
Provided is the use of inactivated FABP5 proteins, or fragments or variants thereof, as a medicament. These may be used in the treatment of a FABP5 mediated disorders, such as cancer. The inactivated FABP5 proteins, or fragments or varia...  
WO/2017/105295A1
The invention relates to organic compound chemistry, pharmacology and medicine, and more particularly to developing and producing a novel medicinal agent for treating diseases caused by a human influenza virus. For this purpose, co-assoc...  
WO/2017/098529A1
The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof. R = alkyl (both linear and branched), aryl, substituted ...  
WO/2017/083914A1
The present invention provides compounds for use in treating and/or preventing influenza. The compound comprises a first and second domain in which the first domain comprises at least one anchoring group which binds to the surface of inf...  
WO/2017/020282A1
Provided is a multi-target compound with anticoagulation and platelet GPIIb/IIIa receptor antagonism. The formula of the multi-target compound is as follows: A-L-B-L'-C. A and B are binding sites with a thrombin, C is a binding site with...  
WO/2017/019952A1
Inflammatory cell recruitment to local sites of tissue injury and/or infection is controlled by many signaling processes influencing cell-to-cell interactions between vascular endothelial cells (EC) in post-capillary venules and circulat...  
WO/2016/169010A1
Disclosed are a use of teicoplanin against the Ebola virus, and a medicine comprising teicoplanin for inhibiting envelope protein GP.  
WO/2016/172615A1
The present invention provides N-acetyl-muramic acid (NAM) derivatives having Formula I, wherein Xa is selected from the group consisting of X1-X59, Ya is selected from the group consisting of H, monophosphate, uridine diphosphate and et...  
WO/2016/135513A1
The present application relates to materials and methods for exploiting synthetic lethality and/or chemo-sensitisation in DNA damage response (DDR) pathways. In particular, the application relates to ubiquitin hydrolase protein Ubiquitin...  
WO/2016/134622A1
Provided is a vancomycin derivative as shown in formula (I). Such compounds can be used for treating the infections of gram-positive bacteria or vancomycin-resistant bacteria, and can be prepared from vancomycin via a chemical synthesis ...  
WO/2016/134485A1
The present application provides methods and uses of O-oligosaccharyltransferase (O-OTases) for generating vaccines. In particular, the present application provides a method of synthesizing a glycoprotein comprising glycosylation of pili...  
WO/2016/136707A1
This polysaccharide derivative has a partial structure represented by general formula (1). It is preferable that at least one of the amino acids that constitutes X2 of general formula (1) is a basic amino acid. (In the formula, X1 repres...  
WO/2016/125193A1
Vancomycin conjugates of Formula I, its stereoisomers, prodrugs, pharmaceutically acceptable salts, and metal coordination complexes thereof is described in the present disclosure. Further, the present disclosure relates to pharmaceutica...  
WO/2016/120257A1
The present invention relates to compounds and compositions for use in enhancing flavor and umami taste of food products. Particularly, the present invention relates to compounds of the general formula I) and compositions comprising them.  
WO/2016/120250A1
The present invention relates to compounds and compositions for use in enhancing flavor and umami taste of food products. Particularly, the present invention relates to compounds of the general formula (I) and compositions comprising them.  
WO/2016/103284A1
The present disclosure provides a compound of Formula I or its stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure also relates to process of preparation of vancomycin-sugar conjugates of Formula...  
WO/2016/065083A1
This disclosure provides a method for treating a gastro-esophageal injury in a patient by topically applying a pharmaceutical composition to a lesion on a gastro-esophageal tissue, wherein the pharmaceutical composition comprises an effe...  
WO/2016/054114A1
Provided are compositions, including isolated, synthetic or recombinant peptides for: expanding regulatory T cells (Treg) populations; for treating or ameliorating a vascular inflammation, and Kawasaki disease (KD) or a pediatric acute v...  
WO/2016/034894A3
The invention provides a combination of an antibacterial agent (in particular vancomycin or moenomycin) and a delivery agent, in which the delivery agent is bonded, or capable of binding, to the antibacterial agent, and in which the deli...  
WO/2016/026841A1
The present invention relates to new compounds comprising a siderophore moiety as well as a core structure able to chelate a metal ion. Optionally, the compounds may have additionally a moiety with a functional element including a marker...  
WO/2016/007855A1
The total synthesis and evaluation of key analogs of vancomycin containing single atom changes in the binding pocket are disclosed as well as their peripherally modified, N- (hydrophobe-substituted) derivatives exemplified by a N-4- ( 4 ...  
WO/2015/184544A1
The present disclosure relates to an in vitro method for enhancing engraftment of isolated pancreatic cells comprising the step of contacting an isolated pancreatic cell prior to a transplantation in a subject in need thereof, with a gem...  
WO/2015/145797A1
[Problem] The present invention addresses the problem of providing a hemostatic pharmaceutical composition which has higher usability compared with conventional hemostatic agents each utilizing a biogel, and which can be formed into a tr...  
WO/2015/140178A1
The present invention relates to a compound of the following formula (I): in which at least one and only one group chosen among R5, R6 and R7 is a group of the following formula: The present invention relates also to uses thereof for pre...  
WO/2015/119180A1
The present invention provides: an antibody that has specificity for MUC 4 having a sugar chain structure that is expressed at a high level in cancer cells; a glycopeptide that constitutes an antigen that is suitable for producing this a...  
WO/2015/116537A9
Described herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting bacterial growth. Methods of using the com...  
WO/2015/116537A1
Described herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting bacterial growth. Methods of using the com...  
WO/2015/085421A1
The present disclosure provides glycosylated oligopeptides having the sequence Palmitoyl- X1-Lys-X2-X3-Lys-X4-OH, where: X1 is: absent, Ser having a glycosylated side chain, or Asn having a glycosylated side chain; X2 is: Thr, Thr having...  
WO/2015/084861A1
The invention relates to a method for selecting a glycopolypeptide that binds to a target protein, the method including the steps of providing a pool of glycopolypeptides fused via puromycin linker to an encoding mRNA-cDNA duplex; combin...  
WO/2015/062168A1
Provided is a separation and purification method for vancomycin hydrochloride of a high purity. The method comprises the following steps: (1) obtaining a vancomycin hydrochloride solution from a crude vancomycin product by ion exchange c...  
WO/2015/056011A1
A process for the production of a glycoconjugate by N-glycosylation of a protein or peptide comprising the sequence D/E-X-N-X-S/T, wherein each X is the same or different and is any natural amino acid other than proline, wherein the proc...  
WO/2015/024389A1
The present invention provides a vancomycin derivative, and a preparation method and an application thereof. The vancomycin derivative of the present invention is obtained by introducing a glyceric acid part between a vancomycin derivati...  

Matches 1 - 50 out of 1,580