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WO/2012/027850 |
Described herein is a peptide, referred to as a GlycoTag peptide, that includes repeats of an N-linked glycosylation sequon that is naturally present in C. jejuni. The GlycoTag peptide can be in a purified and isolated form following exp...
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WO/2011/156751 |
A glycolipopeptide comprising a carbohydrate component, a lipid component, and a MUC1 peptide component that induces both a humoral and a cellular immune response for use as a therapeutic or prophylactic vaccine.
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WO/2011/145055 |
The invention relates to novel cyclodecapeptide compounds having formula (I) for use as drugs and, more specifically, for use in the diagnosis, prevention and/or treatment of neurodegenerative diseases, such as Wilson's disease and Alzhe...
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WO/2011/140009 |
Methods of using semi-synthetic glycopeptides of formula I-XIV having antibacterial activity are described.
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WO/2011/097733 |
An isolated or purified compound is provided, comprising A- GlcNAc[GlcNAc]-GalNAc-GalNAc-QuiNAc4NAc, wherein A is GIcNAc or GIc. There is further provided a vaccine based on such compound, having particular use to treat or prevent an inf...
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WO/2011/047047 |
This document provides methods and materials related to composites or coatings containing polypeptides attached to polysaccharides and/or molecules. For example, methods and materials related to composites or coatings containing polypept...
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WO/2011/047097 |
The present invention provides peptides consisting of L- and/or D-amino acids and combinations thereof, which affect myeloid cells by action on the triggering receptors expressed on myeloid cells (TREMs), including TREM-I and TREM-2. Mor...
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WO/2011/047097 |
The present invention provides peptides consisting of L- and/or D-amino acids and combinations thereof, which affect myeloid cells by action on the triggering receptors expressed on myeloid cells (TREMs), including TREM-I and TREM-2. Mor...
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WO/2011/047047 |
This document provides methods and materials related to composites or coatings containing polypeptides attached to polysaccharides and/or molecules. For example, methods and materials related to composites or coatings containing polypept...
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WO/2011/018496 |
The invention relates to a method for modifying and functionalizing saccharides, comprising the process steps: a) activating the carboxyl groups of the saccharides by a primarily reacting each of the carboxyl groups with a carbodiimide o...
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WO/2011/011879 |
Helicobacter pylori, one of the most common human pathogens, is associated with the development of human chronic gastritis, peptic ulcers and gastric cancer. The invention relates to a α1,6-glucan-containing Helicobacter pylori compound...
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WO/2011/007764 |
Disclosed is a sugar chain marker which can detect hepatic diseases. More specifically disclosed is a sugar chain marker which can be used as a measure of the disease conditions of hepatic diseases. Further specifically disclosed is a su...
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WO/2011/005959 |
Compounds useful in the preparation of telavancin, for example, were prepared. These compounds include decylaminoethanal dialkyl acetals and N-protected decylaminoethanal dialkyl acetals, imidazolidine derivatives, and N-protected- decyl...
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WO/2010/150558 |
It is possible to easily and effectively produce an intentionally designed glycopeptide. For this, disclosed is a method for producing a modified peptide in which at least one amino acid residue capable of binding to a sugar is modified ...
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WO/2010/117753 |
Oral care compositions, oral care systems, oral surface-binding peptides, and a method for applying particles to an oral surface are provided. The oral care system comprises at least one peptidic component comprising a first binding elem...
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WO/2010/113035 |
Beta-mimetic compositions and methods of making and using such compositions in preparing bioactive peptides, such as antimicrobial peptides, are disclosed. In particular, spirocyclic proline hybrids are provided that may be used to alter...
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WO/2010/113035 |
Beta-mimetic compositions and methods of making and using such compositions in preparing bioactive peptides, such as antimicrobial peptides, are disclosed. In particular, spirocyclic proline hybrids are provided that may be used to alter...
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WO/2010/108040 |
Described herein are compositions and methods for inhibiting HIV integrase activity. Also described are methods of identifying agents that inhibit HIV integrase for use in treating or preventing HIV. Also disclosed are methods of identif...
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WO/2010/089341 |
The present invention relates to novel vancomycin-aminoquinoline hybrid molecules designated "vancomyquines®", preparation thereof and application thereof in therapeutics. The present invention notably relates to novel hybrid molecules ...
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WO/2010/068817 |
Provided are lectenz molecules, which are mutated carbohydrate processing enzyme enzymes that are catalytically inactive and that have had their substrate affinity increased by at least 1.2 fold. Further provided are methods for making a...
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WO/2010/065174 |
Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi¬ synthetic glycopeptides described herein are made by chemical modification of a glycopeptide (Compound A, Compound B, Compound H or Compo...
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WO/2010/049611 |
The invention relates to a new type of polysaccharide-block-polypeptide diblock copolymer which is bioresorbable or biodegradable and biocompatible, to a method for preparing same, to the micellar vesicles constituted of this copolymer, ...
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WO/2010/006343 |
Glycopeptide conjugates, and methods of making and using such conjugates are disclosed. Certain glycopeptide conjugates comprise tumor associated carbohydrate antigens and peptide epitopes. Certain glycopeptide conjugates comprise cyclic...
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WO/2010/006343 |
Glycopeptide conjugates, and methods of making and using such conjugates are disclosed. Certain glycopeptide conjugates comprise tumor associated carbohydrate antigens and peptide epitopes. Certain glycopeptide conjugates comprise cyclic...
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WO/2009/120022 |
The present invention relates to an immunopeptide and to a composition for the prophylaxis or treatment of HPV-related medical conditions comprising the same. More specifically, it relates to an E7 immunopeptide derived from the E7 prote...
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WO/2009/120022 |
The present invention relates to an immunopeptide and to a composition for the prophylaxis or treatment of HPV-related medical conditions comprising the same. More specifically, it relates to an E7 immunopeptide derived from the E7 prote...
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WO/2009/115782 |
The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (Il), wherein R1 R4 R5 R6 and R7 are each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid moiety and a lipid acyl moiety; R2 is a...
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WO/2009/115782 |
The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (Il), wherein R1 R4 R5 R6 and R7 are each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid moiety and a lipid acyl moiety; R2 is a...
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WO/2009/108807 |
In one embodiment, the invention provides glycopeptides (or carbohydrate-peptide conjugates) comprising TACAs that direct against (e.g., bind specifically to) cytotoxic T lymphocytes (CTLs) or helper T cells for, e.g., CTL- or T-helper-b...
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WO/2009/102859 |
Polypeptides which can be activated to cause the formation of pores in a lipid membrane are disclosed. Also disclosed are polypeptide compositions for the detection of target microorganisms and methods of using said compositions.
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WO/2009/088949 |
This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-...
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WO/2009/081958 |
Disclosed is a novel glycopeptide antibiotic derivative. The glycopeptide antibiotic derivative is characterized by having a sugar residue (I) represented by formula (I) [wherein n represents an integer of 1 to 5; Sug's independently rep...
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WO/2009/054967 |
The present invention relates to a composition for delivering glycopeptide antibiotic, the composition comprising peptide having binding specificity for glycopeptide antibiotic, wherein noncovalently bound to the peptide is glycopeptide ...
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WO/2009/046618 |
A deshydroxy vancomycin compound,a method of its preparation and a pharmaceutical composition comprising a pharmaceutically effective amount of the deshydroxy vancomycin and the use of the said composition in the preparation of drugs for...
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WO/2009/037592 |
Aminoglycoside-amino acid and -peptide conjugates comprising a triazolyl linker are provided along with efficient methods of their preparation. The aminoglycoside may be an aminoglycoside antibiotic. Conjugates comprising an aminoglycosi...
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WO/2009/039185 |
This invention provides method of making and using of a porous 3 dimensional cyclic RGD peptide-modified alginate scaffold that can be loaded with different cell types and/or growth factors for implantation at sites of tissue damage to p...
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WO/2009/037592 |
Aminoglycoside-amino acid and -peptide conjugates comprising a triazolyl linker are provided along with efficient methods of their preparation. The aminoglycoside may be an aminoglycoside antibiotic. Conjugates comprising an aminoglycosi...
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WO/2009/016384 |
A peptide inhibitor of glycogen synthase kinase-3 (GSK-3) comprising a peptide having between 6 and 50 amino acid residues and an amino acid sequence selected from PYYVNSGYA (SEQ ID No: 7), EPVNPYYVNSGYALAP (SEQ ID No: 6), and REPVNPYYVN...
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WO/2009/017154 |
It is intended to provide a method for producing a peptide characterized by, in a peptide containing an amino acid residue having an -SH group, converting the -SH group into an -OH group, and including the following steps (a) to (c): (a)...
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WO/2009/006620 |
Provided are methods of producing, and compositions comprising, isolated alpha (2→8) or (2→9) oligosialic acid derivatives bearing a non-reducing end enriched for one or more de-N-acetyl residues and resistant to degradation by exone...
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WO/2008/140973 |
Semi- synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described hereins are made by subjecting the a glycopeptide (Compound A, Compound B, COMPOUND H or Compound C) in ...
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WO/2008/110868 |
The present application relates to proliferated islet cells (PI) that are useful in islet cell transplantation. Said cells produce a protein that is not produced in a fresh islet cell. Examples of such proteins include reverse transcript...
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WO/2008/108505 |
Disclosed is a peptide comprising amino acid sequences RI, FI and RIGC and is composed of 25 or less amino acid residues, which can transport a functional molecule into the inside of a cell as well as into the inside of a nucleus more ef...
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WO/2008/100966 |
Compositions that include peptides derived from glial-derived neurotrophic factor (GDNF) (e.g., substantially pure polypeptides comprising a fragment of a GDNF precursor protein) and biologically active variants thereof are provided. The...
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WO/2008/093165 |
Described herein are methods and systems for O-glycosylating proteins in vivo or in vitro in any prokaryotic organism. In these methods and systems, DNA comprising a gene that produces a PglL-like oligosaccharyltransferase and DNA compri...
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WO/2008/093165 |
Described herein are methods and systems for O-glycosylating proteins in vivo or in vitro in any prokaryotic organism. In these methods and systems, DNA comprising a gene that produces a PglL-like oligosaccharyltransferase and DNA compri...
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WO/2008/077241 |
The present invention is directed to antimicrobial compounds which have an affinity for binding bones. More particularly, the invention is directed to phosphonated derivatives of glycopeptide or lipoglycopeptide antibiotics. These compou...
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WO/2008/076483 |
The present invention generally relates to methods and compositions for generating vancomycin analogs. Specifically the invention relates to generating a vancomycin library through chemoselective ligation of a sugar moiety with a vancomy...
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WO/2008/076483 |
The present invention generally relates to methods and compositions for generating vancomycin analogs. Specifically the invention relates to generating a vancomycin library through chemoselective ligation of a sugar moiety with a vancomy...
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WO/2008/070049 |
A compound of the formula X1 -M-SEQ ID NO.l, or a derivative thereof, is provided, wherein X1 -M- represents an optional group comprising a protein transduction domain conjugated to the N-terminus of the amino acid sequence SEQ ID NO:1. ...
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